2-Minute Neuroscience: Restless Legs Syndrome
  • View Times: 0
  • |
  • Release Date: 2023-11-21
Neuroscience Made Simpler
2-Minute Neuroscience: Zolpidem (Ambien)
2-Minute Neuroscience: Zolpidem (Ambien)
10-Minute Neuroscience: Depression
10-Minute Neuroscience: Depression
2-Minute Neuroscience: Sleepwalking
2-Minute Neuroscience: Sleepwalking
2-Minute Neuroscience: Vertigo
2-Minute Neuroscience: Vertigo
2-Minute Neuroscience: Migraine
2-Minute Neuroscience: Migraine
2-Minute Neuroscience: Methylphenidate
2-Minute Neuroscience: Methylphenidate
2-Minute Neuroscience: DMT
2-Minute Neuroscience: DMT
2-Minute Neuroscience: Cochlear Implants
2-Minute Neuroscience: Cochlear Implants
2-Minute Neuroscience: Frontotemporal Dementia
2-Minute Neuroscience: Frontotemporal Dementia
2-Minute Neuroscience: Spina Bifida
2-Minute Neuroscience: Spina Bifida
2-Minute Neuroscience: Sleep Paralysis
2-Minute Neuroscience: Sleep Paralysis
2-Minute Neuroscience: Fatal Insomnia
2-Minute Neuroscience: Fatal Insomnia
2-Minute Neuroscience: PTSD
2-Minute Neuroscience: PTSD
2-Minute Neuroscience: Schizophrenia
2-Minute Neuroscience: Schizophrenia
2-Minute Neuroscience: COVID-19 & the Brain
2-Minute Neuroscience: COVID-19 & the Brain
2-Minute Neuroscience: Obsessive-Compulsive Disorder
2-Minute Neuroscience: Obsessive-Compulsive Disorder
2-Minute Neuroscience: ADHD
2-Minute Neuroscience: ADHD
2-Minute Neuroscience: Restless Legs Syndrome
2-Minute Neuroscience: Restless Legs Syndrome
2-Minute Neuroscience: Autism
2-Minute Neuroscience: Autism
2-Minute Neuroscience: Narcolepsy
2-Minute Neuroscience: Narcolepsy
2-Minute Neuroscience: MDMA
2-Minute Neuroscience: MDMA
2-Minute Neuroscience: Brain Aneurysms
2-Minute Neuroscience: Brain Aneurysms
2-Minute Neuroscience: Bell's Palsy
2-Minute Neuroscience: Bell's Palsy
2-Minute Neuroscience: Tinnitus
2-Minute Neuroscience: Tinnitus
2-Minute Neuroscience: Ketamine
2-Minute Neuroscience: Ketamine
2-Minute Neuroscience: Chronic Traumatic Encephalopathy
2-Minute Neuroscience: Chronic Traumatic Encephalopathy
2-Minute Neuroscience: Motor Neurons
2-Minute Neuroscience: Motor Neurons
2-Minute Neuroscience: Phantom Limb
2-Minute Neuroscience: Phantom Limb
10-Minute Neuroscience: Visual Pathways
10-Minute Neuroscience: Visual Pathways
10-Minute Neuroscience: Action Potentials
10-Minute Neuroscience: Action Potentials
10-Minute Neuroscience: Synapses
10-Minute Neuroscience: Synapses
10-Minute Neuroscience: Neurons
10-Minute Neuroscience: Neurons
2-Minute Neuroscience: Tourette Syndrome
2-Minute Neuroscience: Tourette Syndrome
2-Minute Neuroscience: Withdrawal Reflex
2-Minute Neuroscience: Withdrawal Reflex
2-Minute Neuroscience: Serotonin-Norepinephrine Reuptake Inhibitors
2-Minute Neuroscience: Serotonin-Norepinephrine Reuptake Inhibitors
2-Minute Neuroscience: Cerebral Cortex
2-Minute Neuroscience: Cerebral Cortex
2-Minute Neuroscience: Deep Brain Stimulation
2-Minute Neuroscience: Deep Brain Stimulation
2-Minute Neuroscience: Meningitis
2-Minute Neuroscience: Meningitis
2-Minute Neuroscience: Wernicke-Korsakoff Syndrome
2-Minute Neuroscience: Wernicke-Korsakoff Syndrome
2-Minute Neuroscience: Corneal Reflex
2-Minute Neuroscience: Corneal Reflex
2-Minute Neuroscience: CBD
2-Minute Neuroscience: CBD
2-Minute Neuroscience: THC
2-Minute Neuroscience: THC
2-Minute Neuroscience: Alien Hand Syndrome
2-Minute Neuroscience: Alien Hand Syndrome
2-Minute Neuroscience: Melatonin
2-Minute Neuroscience: Melatonin
2-Minute Neuroscience: Psilocybin
2-Minute Neuroscience: Psilocybin
2-Minute Neuroscience: Agonism, Antagonism, & Allosteric Modulation
2-Minute Neuroscience: Agonism, Antagonism, & Allosteric Modulation
2-Minute Neuroscience: LSD
2-Minute Neuroscience: LSD
2-Minute Neuroscience: Beta-Endorphin
2-Minute Neuroscience: Beta-Endorphin
2-Minute Neuroscience: L-DOPA
2-Minute Neuroscience: L-DOPA
2-Minute Neuroscience: Parasympathetic Nervous System
2-Minute Neuroscience: Parasympathetic Nervous System
2-Minute Neuroscience: Sympathetic Nervous System
2-Minute Neuroscience: Sympathetic Nervous System
2-Minute Neuroscience: Indirect Pathway of the Basal Ganglia
2-Minute Neuroscience: Indirect Pathway of the Basal Ganglia
2-Minute Neuroscience: Direct Pathway of the Basal Ganglia
2-Minute Neuroscience: Direct Pathway of the Basal Ganglia
2-Minute Neuroscience: Functional Magnetic Resonance Imaging (fMRI)
2-Minute Neuroscience: Functional Magnetic Resonance Imaging (fMRI)
2-Minute Neuroscience: Norepinephrine
2-Minute Neuroscience: Norepinephrine
2-Minute Neuroscience: Sodium-Potassium Pump
2-Minute Neuroscience: Sodium-Potassium Pump
2-Minute Neuroscience: Electroencephalography (EEG)
2-Minute Neuroscience: Electroencephalography (EEG)
2-Minute Neuroscience: Trochlear Nerve (Cranial Nerve IV)
2-Minute Neuroscience: Trochlear Nerve (Cranial Nerve IV)
2-Minute Neuroscience: Oculomotor Nerve (Cranial Nerve III)
2-Minute Neuroscience: Oculomotor Nerve (Cranial Nerve III)
2-Minute Neuroscience: Touch Receptors
2-Minute Neuroscience: Touch Receptors
2-Minute Neuroscience: Hypoglossal Nerve (Cranial Nerve XII)
2-Minute Neuroscience: Hypoglossal Nerve (Cranial Nerve XII)
2-Minute Neuroscience: Accessory Nerve (Cranial Nerve XI)
2-Minute Neuroscience: Accessory Nerve (Cranial Nerve XI)
2-Minute Neuroscience: Prefrontal Cortex
2-Minute Neuroscience: Prefrontal Cortex
2-Minute Neuroscience: Vagus Nerve (Cranial Nerve X)
2-Minute Neuroscience: Vagus Nerve (Cranial Nerve X)
2-Minute Neuroscience: Phototransduction
2-Minute Neuroscience: Phototransduction
2-Minute Neuroscience: Glossopharyngeal Nerve (Cranial Nerve IX)
2-Minute Neuroscience: Glossopharyngeal Nerve (Cranial Nerve IX)
2-Minute Neuroscience: Methadone
2-Minute Neuroscience: Methadone
2-Minute Neuroscience: Vestibulocochlear Nerve (Cranial Nerve VIII)
2-Minute Neuroscience: Vestibulocochlear Nerve (Cranial Nerve VIII)
2-Minute Neuroscience: Nicotine
2-Minute Neuroscience: Nicotine
2-Minute Neuroscience: Facial Nerve (Cranial Nerve VII)
2-Minute Neuroscience: Facial Nerve (Cranial Nerve VII)
2-Minute Neuroscience: Abducens Nerve (Cranial Nerve VI)
2-Minute Neuroscience: Abducens Nerve (Cranial Nerve VI)
2-Minute Neuroscience: Concussions
2-Minute Neuroscience: Concussions
2-Minute Neuroscience: Trigeminal Nerve (Cranial Nerve V)
2-Minute Neuroscience: Trigeminal Nerve (Cranial Nerve V)
2-Minute Neuroscience: Opioids
2-Minute Neuroscience: Opioids
2-Minute Neuroscience: Optic Nerve (Cranial Nerve II)
2-Minute Neuroscience: Optic Nerve (Cranial Nerve II)
2-Minute Neuroscience: Olfactory Nerve (Cranial Nerve I)
2-Minute Neuroscience: Olfactory Nerve (Cranial Nerve I)
2-Minute Neuroscience: Brain Tumors
2-Minute Neuroscience: Brain Tumors
2-Minute Neuroscience: Glial Cells
2-Minute Neuroscience: Glial Cells
2-Minute Neuroscience: Stages of Sleep
2-Minute Neuroscience: Stages of Sleep
2-Minute Neuroscience: HPA Axis
2-Minute Neuroscience: HPA Axis
2-Minute Neuroscience: Huntington's Disease
2-Minute Neuroscience: Huntington's Disease
2-Minute Neuroscience: Amphetamine
2-Minute Neuroscience: Amphetamine
2-Minute Neuroscience: Corpus Callosum
2-Minute Neuroscience: Corpus Callosum
2-Minute Neuroscience: Pons
2-Minute Neuroscience: Pons
2-Minute Neuroscience: Parkinson's Disease
2-Minute Neuroscience: Parkinson's Disease
2-Minute Neuroscience: Hydrocephalus
2-Minute Neuroscience: Hydrocephalus
2-Minute Neuroscience: Dopamine
2-Minute Neuroscience: Dopamine
2-Minute Neuroscience: Stroke
2-Minute Neuroscience: Stroke
2-Minute Neuroscience: Glutamate
2-Minute Neuroscience: Glutamate
2-Minute Neuroscience: Blood Supply of the Brain
2-Minute Neuroscience: Blood Supply of the Brain
2-Minute Neuroscience: Neurotransmitter Release
2-Minute Neuroscience: Neurotransmitter Release
2-Minute Neuroscience: Serotonin
2-Minute Neuroscience: Serotonin
2-Minute Neuroscience: Oxytocin
2-Minute Neuroscience: Oxytocin
2-Minute Neuroscience: Long-Term Potentiation (LTP)
2-Minute Neuroscience: Long-Term Potentiation (LTP)
2-Minute Neuroscience: Wernicke's Area
2-Minute Neuroscience: Wernicke's Area
2-Minute Neuroscience: Broca's Area
2-Minute Neuroscience: Broca's Area
2-Minute Neuroscience: Acetylcholine
2-Minute Neuroscience: Acetylcholine
2-Minute Neuroscience: GABA
2-Minute Neuroscience: GABA
2-Minute Neuroscience: Taste
2-Minute Neuroscience: Taste
2-Minute Neuroscience: Alcohol
2-Minute Neuroscience: Alcohol
2-Minute Neuroscience: Olfaction
2-Minute Neuroscience: Olfaction
2-Minute Neuroscience: Selective Serotonin Reuptake Inhibitors (SSRIs)
2-Minute Neuroscience: Selective Serotonin Reuptake Inhibitors (SSRIs)
2-Minute Neuroscience: Midbrain
2-Minute Neuroscience: Midbrain
2-Minute Neuroscience: Periaqueductal Gray (PAG)
2-Minute Neuroscience: Periaqueductal Gray (PAG)
2-Minute Neuroscience: Benzodiazepines
2-Minute Neuroscience: Benzodiazepines
2-Minute Neuroscience: Caffeine
2-Minute Neuroscience: Caffeine
2-Minute Neuroscience: Long-Term Depression (LTD)
2-Minute Neuroscience: Long-Term Depression (LTD)
2-Minute Neuroscience: Amyotrophic Lateral Sclerosis (ALS)
2-Minute Neuroscience: Amyotrophic Lateral Sclerosis (ALS)
2-Minute Neuroscience: Pineal Gland
2-Minute Neuroscience: Pineal Gland
2-Minute Neuroscience: Primary Somatosensory Cortex
2-Minute Neuroscience: Primary Somatosensory Cortex
2-Minute Neuroscience: Suprachiasmatic Nucleus
2-Minute Neuroscience: Suprachiasmatic Nucleus
2-Minute Neuroscience: Nucleus Accumbens
2-Minute Neuroscience: Nucleus Accumbens
2-Minute Neuroscience: Ventral Tegmental Area (VTA)
2-Minute Neuroscience: Ventral Tegmental Area (VTA)
2-Minute Neuroscience: Medulla Oblongata
2-Minute Neuroscience: Medulla Oblongata
2-Minute Neuroscience: Vestibular System
2-Minute Neuroscience: Vestibular System
2-Minute Neuroscience: Amygdala
2-Minute Neuroscience: Amygdala
2-Minute Neuroscience: Striatum
2-Minute Neuroscience: Striatum
2-Minute Neuroscience: Epilepsy
2-Minute Neuroscience: Epilepsy
2-Minute Neuroscience: Multiple Sclerosis
2-Minute Neuroscience: Multiple Sclerosis
2-Minute Neuroscience: Alzheimer's Disease
2-Minute Neuroscience: Alzheimer's Disease
2-Minute Neuroscience: Neuromuscular Junction
2-Minute Neuroscience: Neuromuscular Junction
2-Minute Neuroscience: Knee-Jerk Reflex
2-Minute Neuroscience: Knee-Jerk Reflex
2-Minute Neuroscience: Substantia Nigra
2-Minute Neuroscience: Substantia Nigra
2-Minute Neuroscience: Corticospinal Tract
2-Minute Neuroscience: Corticospinal Tract
2-Minute Neuroscience: Basal Ganglia
2-Minute Neuroscience: Basal Ganglia
2-Minute Neuroscience: Motor Cortex
2-Minute Neuroscience: Motor Cortex
2-Minute Neuroscience: Cerebellum
2-Minute Neuroscience: Cerebellum
2-Minute Neuroscience: Effects of Cocaine
2-Minute Neuroscience: Effects of Cocaine
2-Minute Neuroscience: Blood-Brain Barrier
2-Minute Neuroscience: Blood-Brain Barrier
2-Minute Neuroscience: Myelin
2-Minute Neuroscience: Myelin
2-Minute Neuroscience: Pain and the Anterolateral System
2-Minute Neuroscience: Pain and the Anterolateral System
2-Minute Neuroscience: Touch and the Dorsal Columns-Medial Lemniscus
2-Minute Neuroscience: Touch and the Dorsal Columns-Medial Lemniscus
2-Minute Neuroscience: The Cochlea
2-Minute Neuroscience: The Cochlea
2-Minute Neuroscience: The Retina
2-Minute Neuroscience: The Retina
2-Minute Neuroscience: The Hippocampus
2-Minute Neuroscience: The Hippocampus
2-Minute Neuroscience: The Thalamus
2-Minute Neuroscience: The Thalamus
2-Minute Neuroscience: The Brainstem
2-Minute Neuroscience: The Brainstem
2-Minute Neuroscience: The Meninges
2-Minute Neuroscience: The Meninges
2-Minute Neuroscience: The Ventricles
2-Minute Neuroscience: The Ventricles
2-Minute Neuroscience: Directional Terms in Neuroscience
2-Minute Neuroscience: Directional Terms in Neuroscience
2-Minute Neuroscience: Spinal Cord Cross-Section
2-Minute Neuroscience: Spinal Cord Cross-Section
2-Minute Neuroscience: Exterior of the Spinal Cord
2-Minute Neuroscience: Exterior of the Spinal Cord
2-Minute Neuroscience: Reward System
2-Minute Neuroscience: Reward System
2-Minute Neuroscience: Limbic System
2-Minute Neuroscience: Limbic System
2-Minute Neuroscience: Hypothalamus & Pituitary Gland
2-Minute Neuroscience: Hypothalamus & Pituitary Gland
2-Minute Neuroscience: Neuroimaging
2-Minute Neuroscience: Neuroimaging
2-Minute Neuroscience: Early Neural Development
2-Minute Neuroscience: Early Neural Development
2-Minute Neuroscience: Receptors & Ligands
2-Minute Neuroscience: Receptors & Ligands
2-Minute Neuroscience: Lobes/Landmarks of the Brain Surface
2-Minute Neuroscience: Lobes/Landmarks of the Brain Surface
2-Minute Neuroscience: Divisions of the Nervous System
2-Minute Neuroscience: Divisions of the Nervous System
2-Minute Neuroscience: Action Potential
2-Minute Neuroscience: Action Potential
2-Minute Neuroscience: Membrane Potential
2-Minute Neuroscience: Membrane Potential
2-Minute Neuroscience: Synaptic Transmission
2-Minute Neuroscience: Synaptic Transmission
2-Minute Neuroscience: The Neuron
2-Minute Neuroscience: The Neuron
Playlist
  • restless legs syndrome
  • RLS
Video Introduction

This video is adapted from: https://www.youtube.com/watch?v=D6WmNTQTAfc

Restless legs syndrome (RLS) is a condition that causes an urge to move the legs that often occurs along with uncomfortable sensations in the legs. In this video, I discuss RLS and the neurological mechanisms that might underlie it. [1][2][3][4]

TRANSCRIPT:

Restless legs syndrome or RLS is a condition that causes an urge to move the legs that often occurs along with uncomfortable sensations in the legs or sometimes in other body parts. The unpleasant sensations and urges to move the legs typically begin or become worse when someone is at rest, and they often only occur in the evening or at night. Movement tends to relieve the unpleasant sensations and urges to move, at least for as long as the movement lasts. Patients with RLS also often have insomnia and experience involuntary periodic leg movements during sleep or resting wakefulness.

The mechanisms underlying RLS are not well understood. Genetic factors play a large role in susceptibility, but it’s thought that in most patients environmental factors must interact with genetics to bring about the condition. The most commonly-identified environmental factor in RLS is iron deficiency, and iron deficiency in the brain is the best-known neurological feature of RLS. It’s thought that this brain iron deficiency might be the result of an impaired ability of the brain to take iron up out of the blood and import it into neurons, and it may have multiple effects on brain function. For example, brain iron deficiency may disrupt oxygen transport and impair myelination, and it might be related to abnormal signaling in multiple neurotransmitter systems.

Abnormalities in dopamine signaling are thought to play an important role in RLS, and drugs that increase dopamine activity can offer therapeutic benefits to RLS patients. Research, however, suggests RLS patients do not have low dopamine levels, and thus the reason for the benefit offered by dopamine-increasing drugs is not completely understood. Despite the short-term benefits, long-term use of dopamine-increasing drugs tends to cause what is known as augmentation, where RLS symptoms worsen with continued use of medication. Thus, alternative drugs are often used when possible.

References
  1. Allen RP. Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology. Sleep Med Clin. 2015 Sep;10(3):207-14, xi. doi: 10.1016/j.jsmc.2015.05.022. Epub 2015 Jul 15. PMID: 26329430; PMCID: PMC4559751.
  2. Allen RP, Earley CJ. The role of iron in restless legs syndrome. Mov Disord. 2007;22 Suppl 18:S440-8. doi: 10.1002/mds.21607. Erratum in: Mov Disord. 2008 Jun;23(8):1200-2. PMID: 17566122.
  3. Manconi M, Garcia-Borreguero D, Schormair B, Videnovic A, Berger K, Ferri R, Dauvilliers Y. Restless legs syndrome. Nat Rev Dis Primers. 2021 Nov 3;7(1):80. doi: 10.1038/s41572-021-00311-z. PMID: 34732752.
  4. Trenkwalder C, Allen R, Högl B, Clemens S, Patton S, Schormair B, Winkelmann J. Comorbidities, treatment, and pathophysiology in restless legs syndrome. Lancet Neurol. 2018 Nov;17(11):994-1005. doi: 10.1016/S1474-4422(18)30311-9. Epub 2018 Sep 21. PMID: 30244828.
Full Transcript
1000/1000
Hot Most Recent
©Text is available under the terms and conditions of the Creative Commons-Attribution ShareAlike (CC BY-SA) license; additional terms may apply. By using this site, you agree to the Terms and Conditions and Privacy Policy.

Confirm

Are you sure to Delete?
Yes No
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
Challenged, N. 2-Minute Neuroscience: Restless Legs Syndrome. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/981 (accessed on 21 December 2024).
Challenged N. 2-Minute Neuroscience: Restless Legs Syndrome. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/981. Accessed December 21, 2024.
Challenged, Neuroscientifically. "2-Minute Neuroscience: Restless Legs Syndrome" Encyclopedia, https://encyclopedia.pub/video/video_detail/981 (accessed December 21, 2024).
Challenged, N. (2023, November 21). 2-Minute Neuroscience: Restless Legs Syndrome. In Encyclopedia. https://encyclopedia.pub/video/video_detail/981
Challenged, Neuroscientifically. "2-Minute Neuroscience: Restless Legs Syndrome." Encyclopedia. Web. 21 November, 2023.
Video Production Service
Feedback