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Colorectal cancer remains one of the leading causes of cancer-related mortality worldwide. Although chemotherapy is widely used to treat this disease, conventional anticancer drugs often lack specificity and may affect both malignant and healthy tissues, leading to significant side effects. For this reason, developing drug delivery systems that can transport therapeutic agents directly to the target site has become an important research focus. In this context, a recent study published in MDPI Gels, “The Influence of Synthesis Parameters on the Properties of Dextran-Based Hydrogels for Colon-Targeted Antitumor Drug Delivery Part I: Room Temperature Synthesis of Dextran/Inulin Hydrogels for Colon-Targeted Antitumor Drug Delivery”, explores a new strategy for colon-targeted therapy. The researchers developed biopolymer-based hydrogels composed of methacrylated dextran and inulin, two naturally derived polysaccharides that can be selectively degraded by microbial enzymes in the large intestine, enabling enzyme-triggered drug release in the colon. 1. Hydrogels as Drug Carriers Hydrogels are three-dimensional networks of hydrophilic polymers that can absorb large amounts of water while maintaining their structural integrity. Their porous structure allows them to encapsulate therapeutic molecules and release them in a controlled manner, making them attractive candidates for drug delivery applications. One particularly important feature of hydrogel systems is their ability to respond to environmental stimuli. Drug release can be triggered by changes in pH, the presence of specific enzymes, or other biological signals. These properties make hydrogels highly adaptable platforms for designing targeted delivery systems. Biopolymer-based hydrogels are especially promising because they combine biocompatibility, biodegradability, and low toxicity. Natural polysaccharides contain functional groups such as hydroxyl, carboxyl, and amino groups that facilitate the formation of hydrogel networks through chemical or physical crosslinking. Owing to these characteristics, polysaccharide hydrogels have been widely investigated as carriers for anticancer drugs. However, many existing hydrogel systems rely primarily on pH-sensitive drug release, which can be unreliable in the gastrointestinal tract. The pH varies significantly between different digestive organs and can also fluctuate due to diet, disease, or other physiological factors. This variability may cause drugs to be released before the carrier reaches the intended site. 2. Exploiting the Microbial Environment of the Colon An alternative strategy is to exploit the unique enzymatic environment of the colon. The large intestine hosts a diverse microbial community capable of producing enzymes that selectively degrade certain polysaccharides. By designing carriers that respond specifically to these enzymes, it becomes possible to trigger drug release precisely in the colon. Two polysaccharides particularly suited for this approach are dextran and inulin. Dextran can be degraded by the enzyme dextranase, while inulin can be broken down by inulinase. Both enzymes are produced by bacteria within the intestinal microbiota. Dextran has already been widely investigated as a potential carrier for colon-targeted drug delivery because of its excellent biocompatibility and susceptibility to enzymatic degradation by intestinal bacteria. However, dextran has a limitation: its glycosidic bonds can undergo hydrolysis under the acidic conditions present in the stomach. This may lead to premature degradation of the carrier and unwanted drug release before it reaches the colon. To overcome this issue, the researchers incorporated inulin into the hydrogel network. Inulin contains β-(2→1) fructan bonds that are highly resistant to acid hydrolysis. As a result, it helps protect the hydrogel structure from degradation in the stomach. In addition, inulin is widely recognized as a prebiotic, meaning that it can promote the growth of beneficial intestinal bacteria that may contribute to the enzymatic degradation process in the colon. 3. A Room-Temperature Method for Hydrogel Synthesis A key innovation of the study lies in the room-temperature synthesis method used to prepare the hydrogels. Dextran and inulin were first chemically modified with glycidyl methacrylate under mild conditions. The modified polymers were then crosslinked through free radical polymerization in an aqueous solution using N,N′-methylenebisacrylamide as the crosslinking agent. This synthesis approach offers several advantages. Because the reaction occurs at room temperature, it is energy-efficient and environmentally friendly. The mild conditions also make the method suitable for encapsulating thermolabile molecules, which might otherwise degrade during high-temperature processing. Furthermore, the hydrogels can form within only a few minutes, demonstrating the potential for rapid and scalable production. Another important aspect of the study is the preparation of the hydrogels in granulated form, allowing them to be incorporated into capsules for oral administration. Encapsulation helps protect the hydrogel during its passage through the stomach and ensures that it reaches the colon before significant degradation occurs. 4. Tuning Hydrogel Properties Through Composition To understand how the composition of the hydrogel influences its properties, the researchers systematically varied the proportion of inulin in the polymer network. The inulin content ranged from 0 to 20 wt%, allowing the team to evaluate how this parameter affects swelling behavior, structural characteristics, and mechanical properties. Swelling experiments were conducted at pH 3 and pH 6, conditions relevant to different regions of the gastrointestinal tract. The results showed that hydrogels containing 20 wt% inulin exhibited the highest swelling capacity at both pH values. Increased swelling was associated with a lower crosslink density, resulting in a more flexible and less rigid polymer network. Mechanical analysis confirmed this relationship. Hydrogels with higher inulin content displayed lower elastic modulus values, indicating reduced mechanical stiffness. To better characterize these materials, the researchers also introduced a new methodology for evaluating the mechanical properties of granulated hydrogels, providing valuable insight into how these materials might perform in practical pharmaceutical formulations. 5. Evaluating Drug Release Behavior To test the hydrogels as drug carriers, the researchers incorporated uracil as a model compound. Uracil was selected because of its structural similarity to 5-fluorouracil, a widely used chemotherapeutic agent for colorectal cancer treatment. The in vitro digestion experiments demonstrated that dextran-based hydrogels exhibited the most pronounced enzyme-triggered drug release in the simulated colorectal environment. This finding indicates that dextran plays the primary role in enabling targeted drug delivery through enzymatic degradation. Interestingly, increasing the proportion of inulin did not significantly enhance biodegradation-driven drug release when combined with dextran. Instead, inulin mainly functioned as a protective component, helping prevent premature hydrolysis of the hydrogel in the acidic gastric medium. These findings highlight the complementary roles of the two polysaccharides. Dextran governs the enzyme-triggered release mechanism in the colon, while inulin improves stability during the carrier’s transit through the upper digestive tract. 6. Implications for Future Drug Delivery Systems Overall, this study demonstrates the potential of dextran-based hydrogels synthesized under mild conditions as carriers for colon-targeted drug delivery. The combination of dextran and inulin leverages the unique properties of both polymers: dextran enables enzymatic degradation by colonic bacteria, while inulin provides protection against premature degradation in acidic environments. The room-temperature synthesis method offers a practical and energy-efficient approach to hydrogel production. At the same time, the ability to tune hydrogel composition allows researchers to optimize swelling behavior, mechanical properties, and degradation profiles. Taken together, these findings suggest that dextran-based hydrogel systems—particularly those with carefully controlled compositions—represent promising platforms for enzyme-responsive drug delivery strategies aimed at colorectal cancer therapy. For more information about topic, you can view the online video entitled "Room-Temperature-Synthesized Hydrogels for Colon-Targeted Antitumor Drug Delivery".
Blog 17 Mar 2026
The Encyclopedia platform, together with the journals Biology and Nutrients, launches the Best Video Abstract Awards to increase the visibility and reach of published research and to inspire researchers to explore the power of visual storytelling. Video abstracts have become an increasingly important medium for scientific communication. By integrating narration, visualizations, animations, and experimental footage, they make complex research more accessible, engaging, and memorable. This initiative recognizes video abstracts that are not only scientifically rigorous but also creatively compelling and educational, thereby promoting broader dissemination and deeper community engagement. To learn more about the awards or to participate directly, please visit the event page via the links provided below. https://encyclopedia.pub/best-video-abstract-award 1. Event Duration 9 February 2026 – 2 February 2027 2. Awards Biology Best Video Abstract AwardOpen to video abstracts based on papers published in Biology between 1 January 2024 and 31 December 2025. This award will be granted to two video abstracts based on the evaluation of the Award Evaluation Committee. Nutrients Best Video Abstract AwardOpen to video abstracts based on papers published in Nutrients between 1 January 2024 and 31 December 2025. This award will be granted to two video abstracts based on the evaluation of the Award Evaluation Committee. Prize For each journal award, the winner will receive: CHF 500 A voucher waiving the Article Processing Charges (APCs) for one journal submission (subject to peer review, valid for one year) A free Academic Video Service production (no matter where the paper is published), valid for one year. An electronic certificate Participant Incentive All participants will receive a CHF 100 discount voucher for the Encyclopedia Academic Video Service. 3. Participation The event will be conducted in three stages. Submission Stage 9 February 2026 – 31 August 2026 Independent Submission Authors may create and submit video abstracts independently using their own tools and creative approach. Professional Support Option Authors who do not currently have a video abstract but intend to apply for the award may opt for the Academic Video Service, which offers a one-stop, end-to-end solution covering script development, animation, voiceover recording, and editing. Please submit your video abstract here: https://encyclopedia.pub/user/video_add?activity=b57ab0910b456a5e4eebd960867ce205 Or place your video service order here: https://encyclopedia.pub/user/video_service_order All video abstracts will be assessed by the editorial team for editorial suitability and overall quality. Submissions that meet the guidelines will be assessed equally. Voting Stage 1 November 2026 – 31 December 2026 Public voting will be conducted during this period. Voting results and video performance metrics, including views, likes, shares, and collections, will contribute to the final evaluation. Winner Announcement 2 February 2027 Final winners will be determined based on a combined assessment of public voting results and a comprehensive evaluation by the Award Evaluation Committee, which carries the primary weight in the final decision. Winners will be announced on the Encyclopedia platform and journal websites. 4. Others If you have any other questions, please contact office@encyclopedia.pub
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Encyclopedia 2026, 6(3), 62; https://doi.org/10.3390/encyclopedia6030062

Imitative coinage is understood to be any currency issued outside of the official known coin series. This currency could have been issued by individuals or state agents, and its main function was not profit, but rather it responded to currency shortages and acted as a currency of necessity. It must be distinguished from the currency itself, which had a lucrative intent on the part of the issuers. Coin imitation was a phenomenon that occurred during various chronological periods throughout the Roman Imperial era, essentially linked to historical events that caused a monetary shortage. This refers to a phenomenon where coinage not issued by the official authority was introduced into circulation and utilized in commercial exchanges of various kinds, a fact that can be demonstrated archaeologically. Imitative coinage can be detected through detailed numismatic studies, revealing variability in stylistic elements, as well as physical characteristics (such as weight or diameter) when compared to the official issue. Coin imitation should not be confused with monetary counterfeiting, as its intention was not to profit the unofficial issuer, but rather to facilitate daily commercial exchanges. Even so, the characteristics of both can be similar in some cases, which can make it difficult to assign them to one type or the other. The imitative pieces, primarily in bronze types though not limited to them, played a highly significant role in maintaining Roman economic systems during periods of decline in official currency.

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Encyclopedia 2026, 6(3), 63; https://doi.org/10.3390/encyclopedia6030063

The term “plant awareness disparity”, also referred to as “lack of plant awareness”, describes a tendency for individuals to overlook and underestimate plants, especially compared to animals. This phenomenon is still referred to in parts of the literature as “plant blindness”, a term increasingly replaced due to its ableist connotations, which was introduced to capture the idea that people often fail to notice plants in their surroundings or recognize their significance for environmental sustainability and human well-being. Research has shown that this lack of awareness manifests in several interconnected ways, including: (a) failure to notice plants in everyday environments, (b) limited understanding of fundamental concepts in plant biology and ecology, (c) a tendency to undervalue or misunderstand the unique biological features of plants—such as their growth patterns, physiological processes, and adaptive strategies—and (d) the perception of plants as less complex than or inferior to animals. Plant awareness disparity has been linked to multiple contributing factors, including evolutionary, biological and educational factors. These influences reinforce anthropocentric and zoocentric views of nature, shaping how individuals conceptualize living organisms and their relative importance. In this entry, we trace the historical evolution of the concept from plant blindness to lack of plant awareness, examine the cognitive, evolutionary, and educational factors that contribute to its persistence, and discuss its broader implications for education and sustainability.

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