2-Minute Neuroscience: Direct Pathway of the Basal Ganglia

Subjects: Neurosciences
|
Submitted by:
Neuroscientifically Challenged

View Times: 0
|
Release Date: 2024-01-26

Neuroscience Made Simpler

2-Minute Neuroscience: Zolpidem (Ambien)

10-Minute Neuroscience: Depression

2-Minute Neuroscience: Sleepwalking

2-Minute Neuroscience: Vertigo

2-Minute Neuroscience: Migraine

2-Minute Neuroscience: Methylphenidate

2-Minute Neuroscience: DMT

2-Minute Neuroscience: Cochlear Implants

2-Minute Neuroscience: Frontotemporal Dementia

2-Minute Neuroscience: Spina Bifida

2-Minute Neuroscience: Sleep Paralysis

2-Minute Neuroscience: Fatal Insomnia

2-Minute Neuroscience: PTSD

2-Minute Neuroscience: Schizophrenia

2-Minute Neuroscience: COVID-19 & the Brain

2-Minute Neuroscience: Obsessive-Compulsive Disorder

2-Minute Neuroscience: ADHD

2-Minute Neuroscience: Restless Legs Syndrome

2-Minute Neuroscience: Autism

2-Minute Neuroscience: Narcolepsy

2-Minute Neuroscience: MDMA

2-Minute Neuroscience: Brain Aneurysms

2-Minute Neuroscience: Bell's Palsy

2-Minute Neuroscience: Tinnitus

2-Minute Neuroscience: Ketamine

2-Minute Neuroscience: Chronic Traumatic Encephalopathy

2-Minute Neuroscience: Motor Neurons

2-Minute Neuroscience: Phantom Limb

10-Minute Neuroscience: Visual Pathways

10-Minute Neuroscience: Action Potentials

10-Minute Neuroscience: Synapses

10-Minute Neuroscience: Neurons

2-Minute Neuroscience: Tourette Syndrome

2-Minute Neuroscience: Withdrawal Reflex

2-Minute Neuroscience: Serotonin-Norepinephrine Reuptake Inhibitors

2-Minute Neuroscience: Cerebral Cortex

2-Minute Neuroscience: Deep Brain Stimulation

2-Minute Neuroscience: Meningitis

2-Minute Neuroscience: Wernicke-Korsakoff Syndrome

2-Minute Neuroscience: Corneal Reflex

2-Minute Neuroscience: CBD

2-Minute Neuroscience: THC

2-Minute Neuroscience: Alien Hand Syndrome

2-Minute Neuroscience: Melatonin

2-Minute Neuroscience: Psilocybin

2-Minute Neuroscience: Agonism, Antagonism, & Allosteric Modulation

2-Minute Neuroscience: LSD

2-Minute Neuroscience: Beta-Endorphin

2-Minute Neuroscience: L-DOPA

2-Minute Neuroscience: Parasympathetic Nervous System

2-Minute Neuroscience: Sympathetic Nervous System

2-Minute Neuroscience: Indirect Pathway of the Basal Ganglia

2-Minute Neuroscience: Direct Pathway of the Basal Ganglia

2-Minute Neuroscience: Functional Magnetic Resonance Imaging (fMRI)

2-Minute Neuroscience: Norepinephrine

2-Minute Neuroscience: Sodium-Potassium Pump

2-Minute Neuroscience: Electroencephalography (EEG)

2-Minute Neuroscience: Trochlear Nerve (Cranial Nerve IV)

2-Minute Neuroscience: Oculomotor Nerve (Cranial Nerve III)

2-Minute Neuroscience: Touch Receptors

2-Minute Neuroscience: Hypoglossal Nerve (Cranial Nerve XII)

2-Minute Neuroscience: Accessory Nerve (Cranial Nerve XI)

2-Minute Neuroscience: Prefrontal Cortex

2-Minute Neuroscience: Vagus Nerve (Cranial Nerve X)

2-Minute Neuroscience: Phototransduction

2-Minute Neuroscience: Glossopharyngeal Nerve (Cranial Nerve IX)

2-Minute Neuroscience: Methadone

2-Minute Neuroscience: Vestibulocochlear Nerve (Cranial Nerve VIII)

2-Minute Neuroscience: Nicotine

2-Minute Neuroscience: Facial Nerve (Cranial Nerve VII)

2-Minute Neuroscience: Abducens Nerve (Cranial Nerve VI)

2-Minute Neuroscience: Concussions

2-Minute Neuroscience: Trigeminal Nerve (Cranial Nerve V)

2-Minute Neuroscience: Opioids

2-Minute Neuroscience: Optic Nerve (Cranial Nerve II)

2-Minute Neuroscience: Olfactory Nerve (Cranial Nerve I)

2-Minute Neuroscience: Brain Tumors

2-Minute Neuroscience: Glial Cells

2-Minute Neuroscience: Stages of Sleep

2-Minute Neuroscience: HPA Axis

2-Minute Neuroscience: Huntington's Disease

2-Minute Neuroscience: Amphetamine

2-Minute Neuroscience: Corpus Callosum

2-Minute Neuroscience: Pons

2-Minute Neuroscience: Parkinson's Disease

2-Minute Neuroscience: Hydrocephalus

2-Minute Neuroscience: Dopamine

2-Minute Neuroscience: Stroke

2-Minute Neuroscience: Glutamate

2-Minute Neuroscience: Blood Supply of the Brain

2-Minute Neuroscience: Neurotransmitter Release

2-Minute Neuroscience: Serotonin

2-Minute Neuroscience: Oxytocin

2-Minute Neuroscience: Long-Term Potentiation (LTP)

2-Minute Neuroscience: Wernicke's Area

2-Minute Neuroscience: Broca's Area

2-Minute Neuroscience: Acetylcholine

2-Minute Neuroscience: GABA

2-Minute Neuroscience: Taste

2-Minute Neuroscience: Alcohol

2-Minute Neuroscience: Olfaction

2-Minute Neuroscience: Selective Serotonin Reuptake Inhibitors (SSRIs)

2-Minute Neuroscience: Midbrain

2-Minute Neuroscience: Periaqueductal Gray (PAG)

2-Minute Neuroscience: Benzodiazepines

2-Minute Neuroscience: Caffeine

2-Minute Neuroscience: Long-Term Depression (LTD)

2-Minute Neuroscience: Amyotrophic Lateral Sclerosis (ALS)

2-Minute Neuroscience: Pineal Gland

2-Minute Neuroscience: Primary Somatosensory Cortex

2-Minute Neuroscience: Suprachiasmatic Nucleus

2-Minute Neuroscience: Nucleus Accumbens

2-Minute Neuroscience: Ventral Tegmental Area (VTA)

2-Minute Neuroscience: Medulla Oblongata

2-Minute Neuroscience: Vestibular System

2-Minute Neuroscience: Amygdala

2-Minute Neuroscience: Striatum

2-Minute Neuroscience: Epilepsy

2-Minute Neuroscience: Multiple Sclerosis

2-Minute Neuroscience: Alzheimer's Disease

2-Minute Neuroscience: Neuromuscular Junction

2-Minute Neuroscience: Knee-Jerk Reflex

2-Minute Neuroscience: Substantia Nigra

2-Minute Neuroscience: Corticospinal Tract

2-Minute Neuroscience: Basal Ganglia

2-Minute Neuroscience: Motor Cortex

2-Minute Neuroscience: Cerebellum

2-Minute Neuroscience: Effects of Cocaine

2-Minute Neuroscience: Blood-Brain Barrier

2-Minute Neuroscience: Myelin

2-Minute Neuroscience: Pain and the Anterolateral System

2-Minute Neuroscience: Touch and the Dorsal Columns-Medial Lemniscus

2-Minute Neuroscience: The Cochlea

2-Minute Neuroscience: The Retina

2-Minute Neuroscience: The Hippocampus

2-Minute Neuroscience: The Thalamus

2-Minute Neuroscience: The Brainstem

2-Minute Neuroscience: The Meninges

2-Minute Neuroscience: The Ventricles

2-Minute Neuroscience: Directional Terms in Neuroscience

2-Minute Neuroscience: Spinal Cord Cross-Section

2-Minute Neuroscience: Exterior of the Spinal Cord

2-Minute Neuroscience: Reward System

2-Minute Neuroscience: Limbic System

2-Minute Neuroscience: Hypothalamus & Pituitary Gland

2-Minute Neuroscience: Neuroimaging

2-Minute Neuroscience: Early Neural Development

2-Minute Neuroscience: Receptors & Ligands

2-Minute Neuroscience: Lobes/Landmarks of the Brain Surface

2-Minute Neuroscience: Divisions of the Nervous System

2-Minute Neuroscience: Action Potential

2-Minute Neuroscience: Membrane Potential

2-Minute Neuroscience: Synaptic Transmission

2-Minute Neuroscience: The Neuron

Playlist

2-Minute Neuroscience: Zolpidem (Ambien)

10-Minute Neuroscience: Depression

2-Minute Neuroscience: Sleepwalking

2-Minute Neuroscience: Vertigo

2-Minute Neuroscience: Migraine

2-Minute Neuroscience: Methylphenidate

2-Minute Neuroscience: DMT

2-Minute Neuroscience: Cochlear Implants

2-Minute Neuroscience: Frontotemporal Dementia

2-Minute Neuroscience: Spina Bifida

2-Minute Neuroscience: Sleep Paralysis

2-Minute Neuroscience: Fatal Insomnia

2-Minute Neuroscience: PTSD

2-Minute Neuroscience: Schizophrenia

2-Minute Neuroscience: COVID-19 & the Brain

2-Minute Neuroscience: Obsessive-Compulsive Disorder

2-Minute Neuroscience: ADHD

2-Minute Neuroscience: Restless Legs Syndrome

2-Minute Neuroscience: Autism

2-Minute Neuroscience: Narcolepsy

2-Minute Neuroscience: MDMA

2-Minute Neuroscience: Brain Aneurysms

2-Minute Neuroscience: Bell's Palsy

2-Minute Neuroscience: Tinnitus

2-Minute Neuroscience: Ketamine

2-Minute Neuroscience: Chronic Traumatic Encephalopathy

2-Minute Neuroscience: Motor Neurons

2-Minute Neuroscience: Phantom Limb

10-Minute Neuroscience: Visual Pathways

10-Minute Neuroscience: Action Potentials

10-Minute Neuroscience: Synapses

10-Minute Neuroscience: Neurons

2-Minute Neuroscience: Tourette Syndrome

2-Minute Neuroscience: Withdrawal Reflex

2-Minute Neuroscience: Serotonin-Norepinephrine Reuptake Inhibitors

2-Minute Neuroscience: Cerebral Cortex

2-Minute Neuroscience: Deep Brain Stimulation

2-Minute Neuroscience: Meningitis

2-Minute Neuroscience: Wernicke-Korsakoff Syndrome

2-Minute Neuroscience: Corneal Reflex

2-Minute Neuroscience: CBD

2-Minute Neuroscience: THC

2-Minute Neuroscience: Alien Hand Syndrome

2-Minute Neuroscience: Melatonin

2-Minute Neuroscience: Psilocybin

2-Minute Neuroscience: Agonism, Antagonism, & Allosteric Modulation

2-Minute Neuroscience: LSD

2-Minute Neuroscience: Beta-Endorphin

2-Minute Neuroscience: L-DOPA

2-Minute Neuroscience: Parasympathetic Nervous System

2-Minute Neuroscience: Sympathetic Nervous System

2-Minute Neuroscience: Indirect Pathway of the Basal Ganglia

2-Minute Neuroscience: Direct Pathway of the Basal Ganglia

2-Minute Neuroscience: Functional Magnetic Resonance Imaging (fMRI)

2-Minute Neuroscience: Norepinephrine

2-Minute Neuroscience: Sodium-Potassium Pump

2-Minute Neuroscience: Electroencephalography (EEG)

2-Minute Neuroscience: Trochlear Nerve (Cranial Nerve IV)

2-Minute Neuroscience: Oculomotor Nerve (Cranial Nerve III)

2-Minute Neuroscience: Touch Receptors

2-Minute Neuroscience: Hypoglossal Nerve (Cranial Nerve XII)

2-Minute Neuroscience: Accessory Nerve (Cranial Nerve XI)

2-Minute Neuroscience: Prefrontal Cortex

2-Minute Neuroscience: Vagus Nerve (Cranial Nerve X)

2-Minute Neuroscience: Phototransduction

2-Minute Neuroscience: Glossopharyngeal Nerve (Cranial Nerve IX)

2-Minute Neuroscience: Methadone

2-Minute Neuroscience: Vestibulocochlear Nerve (Cranial Nerve VIII)

2-Minute Neuroscience: Nicotine

2-Minute Neuroscience: Facial Nerve (Cranial Nerve VII)

2-Minute Neuroscience: Abducens Nerve (Cranial Nerve VI)

2-Minute Neuroscience: Concussions

2-Minute Neuroscience: Trigeminal Nerve (Cranial Nerve V)

2-Minute Neuroscience: Opioids

2-Minute Neuroscience: Optic Nerve (Cranial Nerve II)

2-Minute Neuroscience: Olfactory Nerve (Cranial Nerve I)

2-Minute Neuroscience: Brain Tumors

2-Minute Neuroscience: Glial Cells

2-Minute Neuroscience: Stages of Sleep

2-Minute Neuroscience: HPA Axis

2-Minute Neuroscience: Huntington's Disease

2-Minute Neuroscience: Amphetamine

2-Minute Neuroscience: Corpus Callosum

2-Minute Neuroscience: Pons

2-Minute Neuroscience: Parkinson's Disease

2-Minute Neuroscience: Hydrocephalus

2-Minute Neuroscience: Dopamine

2-Minute Neuroscience: Stroke

2-Minute Neuroscience: Glutamate

2-Minute Neuroscience: Blood Supply of the Brain

2-Minute Neuroscience: Neurotransmitter Release

2-Minute Neuroscience: Serotonin

2-Minute Neuroscience: Oxytocin

2-Minute Neuroscience: Long-Term Potentiation (LTP)

2-Minute Neuroscience: Wernicke's Area

2-Minute Neuroscience: Broca's Area

2-Minute Neuroscience: Acetylcholine

2-Minute Neuroscience: GABA

2-Minute Neuroscience: Taste

2-Minute Neuroscience: Alcohol

2-Minute Neuroscience: Olfaction

2-Minute Neuroscience: Selective Serotonin Reuptake Inhibitors (SSRIs)

2-Minute Neuroscience: Midbrain

2-Minute Neuroscience: Periaqueductal Gray (PAG)

2-Minute Neuroscience: Benzodiazepines

2-Minute Neuroscience: Caffeine

2-Minute Neuroscience: Long-Term Depression (LTD)

2-Minute Neuroscience: Amyotrophic Lateral Sclerosis (ALS)

2-Minute Neuroscience: Pineal Gland

2-Minute Neuroscience: Primary Somatosensory Cortex

2-Minute Neuroscience: Suprachiasmatic Nucleus

2-Minute Neuroscience: Nucleus Accumbens

2-Minute Neuroscience: Ventral Tegmental Area (VTA)

2-Minute Neuroscience: Medulla Oblongata

2-Minute Neuroscience: Vestibular System

2-Minute Neuroscience: Amygdala

2-Minute Neuroscience: Striatum

2-Minute Neuroscience: Epilepsy

2-Minute Neuroscience: Multiple Sclerosis

2-Minute Neuroscience: Alzheimer's Disease

2-Minute Neuroscience: Neuromuscular Junction

2-Minute Neuroscience: Knee-Jerk Reflex

2-Minute Neuroscience: Substantia Nigra

2-Minute Neuroscience: Corticospinal Tract

2-Minute Neuroscience: Basal Ganglia

2-Minute Neuroscience: Motor Cortex

2-Minute Neuroscience: Cerebellum

2-Minute Neuroscience: Effects of Cocaine

2-Minute Neuroscience: Blood-Brain Barrier

2-Minute Neuroscience: Myelin

2-Minute Neuroscience: Pain and the Anterolateral System

2-Minute Neuroscience: Touch and the Dorsal Columns-Medial Lemniscus

2-Minute Neuroscience: The Cochlea

2-Minute Neuroscience: The Retina

2-Minute Neuroscience: The Hippocampus

2-Minute Neuroscience: The Thalamus

2-Minute Neuroscience: The Brainstem

2-Minute Neuroscience: The Meninges

2-Minute Neuroscience: The Ventricles

2-Minute Neuroscience: Directional Terms in Neuroscience

2-Minute Neuroscience: Spinal Cord Cross-Section

2-Minute Neuroscience: Exterior of the Spinal Cord

2-Minute Neuroscience: Reward System

2-Minute Neuroscience: Limbic System

2-Minute Neuroscience: Hypothalamus & Pituitary Gland

2-Minute Neuroscience: Neuroimaging

2-Minute Neuroscience: Early Neural Development

2-Minute Neuroscience: Receptors & Ligands

2-Minute Neuroscience: Lobes/Landmarks of the Brain Surface

2-Minute Neuroscience: Divisions of the Nervous System

2-Minute Neuroscience: Action Potential

2-Minute Neuroscience: Membrane Potential

2-Minute Neuroscience: Synaptic Transmission

2-Minute Neuroscience: The Neuron

basal ganglia

Video Introduction

The basal ganglia are a group of structures that are generally considered to include the caudate and putamen (which are collectively known as the striatum), the globus pallidus, subthalamic nucleus, and substantia nigra. The globus pallidus is further divided into internal and external segments, and the substantia nigra is divided into the substantia nigra pars compacta and substantia nigra pars reticulata. The direct pathway is a circuit in the basal ganglia best-known for its hypothesized role in movement.

The direct pathway model involves glutamate neurons that project from the thalamus to motor regions of the cerebral cortex. These excitatory projections are thought to be involved with stimulating movement. Neurons from the globus pallidus internal and substantia nigra pars reticulata, however, project to the thalamus and maintain a steady release of the neurotransmitter GABA which acts to inhibit the thalamic neurons and suppress movement. This mechanism is thought to be important in keeping unwanted movements from occurring. When we want to make a movement, however, information about the movement is sent from the cortex to the striatum via the corticostriatal pathway. Glutamate neurons in this pathway excite neurons in the striatum, and the activated striatal neurons release GABA in the globus pallidus internal and substantia nigra pars reticulata, inhibiting the activity of these regions and stopping the inhibition of neurons in the thalamus that are involved with movement. This effectively opens a gate for movement to occur. Activity along this pathway tends to occur just prior to a movement, and thus has been linked to the facilitation of movement.

The substantia nigra pars compacta is thought to modulate the activity of the direct pathway. Neurons from the substantia nigra pars compacta travel to the striatum via the nigrostriatal pathway, and release dopamine in the striatum. One effect of this seems to be the facilitation of activity in the direct pathway. ^[1]^[2]

References

Lanciego JL, Luquin N, Obeso JA. Functional neuroanatomy of the basal ganglia. Cold Spring Harb Perspect Med. 2012 Dec 1;2(12):a009621. doi: 10.1101/cshperspect.a009621.
Purves D, Augustine GJ, Fitzpatrick D, Hall WC, Lamantia AS, Mooney RD, Platt ML, White LE, eds. Neuroscience. 6th ed. New York. Sinauer Associates; 2018.

Full Transcript

1000/1000

Hot Most Recent

©Text is available under the terms and conditions of the Creative Commons-Attribution ShareAlike (CC BY-SA) license; additional terms may apply. By using this site, you agree to the Terms and Conditions and Privacy Policy.

Confirm

Name: 2-Minute Neuroscience: Direct Pathway of the Basal Ganglia
Uploaded: 2024-01-29T02:54:23+00:00
Description: The basal ganglia are a group of structures that are generally considered to include the caudate and putamen (which are collectively known as the striatum), the globus pallidus, subthalamic nucleus, and substantia nigra

Are you sure to Delete?

Yes No

Cite

If you have any further questions, please contact Encyclopedia Editorial Office.

Select a Style

Challenged, N. 2-Minute Neuroscience: Direct Pathway of the Basal Ganglia. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/1085 (accessed on 15 November 2024).

Challenged N. 2-Minute Neuroscience: Direct Pathway of the Basal Ganglia. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/1085. Accessed November 15, 2024.

Challenged, Neuroscientifically. "2-Minute Neuroscience: Direct Pathway of the Basal Ganglia" Encyclopedia, https://encyclopedia.pub/video/video_detail/1085 (accessed November 15, 2024).

Challenged, N. (2024, January 26). 2-Minute Neuroscience: Direct Pathway of the Basal Ganglia. In Encyclopedia. https://encyclopedia.pub/video/video_detail/1085

Challenged, Neuroscientifically. "2-Minute Neuroscience: Direct Pathway of the Basal Ganglia." Encyclopedia. Web. 26 January, 2024.