2-Minute Neuroscience: L-DOPA

Subjects: Neurosciences
|
Submitted by:
Neuroscientifically Challenged

View Times: 0
|
Release Date: 2024-01-26

Neuroscience Made Simpler

2-Minute Neuroscience: Zolpidem (Ambien)

10-Minute Neuroscience: Depression

2-Minute Neuroscience: Sleepwalking

2-Minute Neuroscience: Vertigo

2-Minute Neuroscience: Migraine

2-Minute Neuroscience: Methylphenidate

2-Minute Neuroscience: DMT

2-Minute Neuroscience: Cochlear Implants

2-Minute Neuroscience: Frontotemporal Dementia

2-Minute Neuroscience: Spina Bifida

2-Minute Neuroscience: Sleep Paralysis

2-Minute Neuroscience: Fatal Insomnia

2-Minute Neuroscience: PTSD

2-Minute Neuroscience: Schizophrenia

2-Minute Neuroscience: COVID-19 & the Brain

2-Minute Neuroscience: Obsessive-Compulsive Disorder

2-Minute Neuroscience: ADHD

2-Minute Neuroscience: Restless Legs Syndrome

2-Minute Neuroscience: Autism

2-Minute Neuroscience: Narcolepsy

2-Minute Neuroscience: MDMA

2-Minute Neuroscience: Brain Aneurysms

2-Minute Neuroscience: Bell's Palsy

2-Minute Neuroscience: Tinnitus

2-Minute Neuroscience: Ketamine

2-Minute Neuroscience: Chronic Traumatic Encephalopathy

2-Minute Neuroscience: Motor Neurons

2-Minute Neuroscience: Phantom Limb

10-Minute Neuroscience: Visual Pathways

10-Minute Neuroscience: Action Potentials

10-Minute Neuroscience: Synapses

10-Minute Neuroscience: Neurons

2-Minute Neuroscience: Tourette Syndrome

2-Minute Neuroscience: Withdrawal Reflex

2-Minute Neuroscience: Serotonin-Norepinephrine Reuptake Inhibitors

2-Minute Neuroscience: Cerebral Cortex

2-Minute Neuroscience: Deep Brain Stimulation

2-Minute Neuroscience: Meningitis

2-Minute Neuroscience: Wernicke-Korsakoff Syndrome

2-Minute Neuroscience: Corneal Reflex

2-Minute Neuroscience: CBD

2-Minute Neuroscience: THC

2-Minute Neuroscience: Alien Hand Syndrome

2-Minute Neuroscience: Melatonin

2-Minute Neuroscience: Psilocybin

2-Minute Neuroscience: Agonism, Antagonism, & Allosteric Modulation

2-Minute Neuroscience: LSD

2-Minute Neuroscience: Beta-Endorphin

2-Minute Neuroscience: L-DOPA

2-Minute Neuroscience: Parasympathetic Nervous System

2-Minute Neuroscience: Sympathetic Nervous System

2-Minute Neuroscience: Indirect Pathway of the Basal Ganglia

2-Minute Neuroscience: Direct Pathway of the Basal Ganglia

2-Minute Neuroscience: Functional Magnetic Resonance Imaging (fMRI)

2-Minute Neuroscience: Norepinephrine

2-Minute Neuroscience: Sodium-Potassium Pump

2-Minute Neuroscience: Electroencephalography (EEG)

2-Minute Neuroscience: Trochlear Nerve (Cranial Nerve IV)

2-Minute Neuroscience: Oculomotor Nerve (Cranial Nerve III)

2-Minute Neuroscience: Touch Receptors

2-Minute Neuroscience: Hypoglossal Nerve (Cranial Nerve XII)

2-Minute Neuroscience: Accessory Nerve (Cranial Nerve XI)

2-Minute Neuroscience: Prefrontal Cortex

2-Minute Neuroscience: Vagus Nerve (Cranial Nerve X)

2-Minute Neuroscience: Phototransduction

2-Minute Neuroscience: Glossopharyngeal Nerve (Cranial Nerve IX)

2-Minute Neuroscience: Methadone

2-Minute Neuroscience: Vestibulocochlear Nerve (Cranial Nerve VIII)

2-Minute Neuroscience: Nicotine

2-Minute Neuroscience: Facial Nerve (Cranial Nerve VII)

2-Minute Neuroscience: Abducens Nerve (Cranial Nerve VI)

2-Minute Neuroscience: Concussions

2-Minute Neuroscience: Trigeminal Nerve (Cranial Nerve V)

2-Minute Neuroscience: Opioids

2-Minute Neuroscience: Optic Nerve (Cranial Nerve II)

2-Minute Neuroscience: Olfactory Nerve (Cranial Nerve I)

2-Minute Neuroscience: Brain Tumors

2-Minute Neuroscience: Glial Cells

2-Minute Neuroscience: Stages of Sleep

2-Minute Neuroscience: HPA Axis

2-Minute Neuroscience: Huntington's Disease

2-Minute Neuroscience: Amphetamine

2-Minute Neuroscience: Corpus Callosum

2-Minute Neuroscience: Pons

2-Minute Neuroscience: Parkinson's Disease

2-Minute Neuroscience: Hydrocephalus

2-Minute Neuroscience: Dopamine

2-Minute Neuroscience: Stroke

2-Minute Neuroscience: Glutamate

2-Minute Neuroscience: Blood Supply of the Brain

2-Minute Neuroscience: Neurotransmitter Release

2-Minute Neuroscience: Serotonin

2-Minute Neuroscience: Oxytocin

2-Minute Neuroscience: Long-Term Potentiation (LTP)

2-Minute Neuroscience: Wernicke's Area

2-Minute Neuroscience: Broca's Area

2-Minute Neuroscience: Acetylcholine

2-Minute Neuroscience: GABA

2-Minute Neuroscience: Taste

2-Minute Neuroscience: Alcohol

2-Minute Neuroscience: Olfaction

2-Minute Neuroscience: Selective Serotonin Reuptake Inhibitors (SSRIs)

2-Minute Neuroscience: Midbrain

2-Minute Neuroscience: Periaqueductal Gray (PAG)

2-Minute Neuroscience: Benzodiazepines

2-Minute Neuroscience: Caffeine

2-Minute Neuroscience: Long-Term Depression (LTD)

2-Minute Neuroscience: Amyotrophic Lateral Sclerosis (ALS)

2-Minute Neuroscience: Pineal Gland

2-Minute Neuroscience: Primary Somatosensory Cortex

2-Minute Neuroscience: Suprachiasmatic Nucleus

2-Minute Neuroscience: Nucleus Accumbens

2-Minute Neuroscience: Ventral Tegmental Area (VTA)

2-Minute Neuroscience: Medulla Oblongata

2-Minute Neuroscience: Vestibular System

2-Minute Neuroscience: Amygdala

2-Minute Neuroscience: Striatum

2-Minute Neuroscience: Epilepsy

2-Minute Neuroscience: Multiple Sclerosis

2-Minute Neuroscience: Alzheimer's Disease

2-Minute Neuroscience: Neuromuscular Junction

2-Minute Neuroscience: Knee-Jerk Reflex

2-Minute Neuroscience: Substantia Nigra

2-Minute Neuroscience: Corticospinal Tract

2-Minute Neuroscience: Basal Ganglia

2-Minute Neuroscience: Motor Cortex

2-Minute Neuroscience: Cerebellum

2-Minute Neuroscience: Effects of Cocaine

2-Minute Neuroscience: Blood-Brain Barrier

2-Minute Neuroscience: Myelin

2-Minute Neuroscience: Pain and the Anterolateral System

2-Minute Neuroscience: Touch and the Dorsal Columns-Medial Lemniscus

2-Minute Neuroscience: The Cochlea

2-Minute Neuroscience: The Retina

2-Minute Neuroscience: The Hippocampus

2-Minute Neuroscience: The Thalamus

2-Minute Neuroscience: The Brainstem

2-Minute Neuroscience: The Meninges

2-Minute Neuroscience: The Ventricles

2-Minute Neuroscience: Directional Terms in Neuroscience

2-Minute Neuroscience: Spinal Cord Cross-Section

2-Minute Neuroscience: Exterior of the Spinal Cord

2-Minute Neuroscience: Reward System

2-Minute Neuroscience: Limbic System

2-Minute Neuroscience: Hypothalamus & Pituitary Gland

2-Minute Neuroscience: Neuroimaging

2-Minute Neuroscience: Early Neural Development

2-Minute Neuroscience: Receptors & Ligands

2-Minute Neuroscience: Lobes/Landmarks of the Brain Surface

2-Minute Neuroscience: Divisions of the Nervous System

2-Minute Neuroscience: Action Potential

2-Minute Neuroscience: Membrane Potential

2-Minute Neuroscience: Synaptic Transmission

2-Minute Neuroscience: The Neuron

Playlist

2-Minute Neuroscience: Zolpidem (Ambien)

10-Minute Neuroscience: Depression

2-Minute Neuroscience: Sleepwalking

2-Minute Neuroscience: Vertigo

2-Minute Neuroscience: Migraine

2-Minute Neuroscience: Methylphenidate

2-Minute Neuroscience: DMT

2-Minute Neuroscience: Cochlear Implants

2-Minute Neuroscience: Frontotemporal Dementia

2-Minute Neuroscience: Spina Bifida

2-Minute Neuroscience: Sleep Paralysis

2-Minute Neuroscience: Fatal Insomnia

2-Minute Neuroscience: PTSD

2-Minute Neuroscience: Schizophrenia

2-Minute Neuroscience: COVID-19 & the Brain

2-Minute Neuroscience: Obsessive-Compulsive Disorder

2-Minute Neuroscience: ADHD

2-Minute Neuroscience: Restless Legs Syndrome

2-Minute Neuroscience: Autism

2-Minute Neuroscience: Narcolepsy

2-Minute Neuroscience: MDMA

2-Minute Neuroscience: Brain Aneurysms

2-Minute Neuroscience: Bell's Palsy

2-Minute Neuroscience: Tinnitus

2-Minute Neuroscience: Ketamine

2-Minute Neuroscience: Chronic Traumatic Encephalopathy

2-Minute Neuroscience: Motor Neurons

2-Minute Neuroscience: Phantom Limb

10-Minute Neuroscience: Visual Pathways

10-Minute Neuroscience: Action Potentials

10-Minute Neuroscience: Synapses

10-Minute Neuroscience: Neurons

2-Minute Neuroscience: Tourette Syndrome

2-Minute Neuroscience: Withdrawal Reflex

2-Minute Neuroscience: Serotonin-Norepinephrine Reuptake Inhibitors

2-Minute Neuroscience: Cerebral Cortex

2-Minute Neuroscience: Deep Brain Stimulation

2-Minute Neuroscience: Meningitis

2-Minute Neuroscience: Wernicke-Korsakoff Syndrome

2-Minute Neuroscience: Corneal Reflex

2-Minute Neuroscience: CBD

2-Minute Neuroscience: THC

2-Minute Neuroscience: Alien Hand Syndrome

2-Minute Neuroscience: Melatonin

2-Minute Neuroscience: Psilocybin

2-Minute Neuroscience: Agonism, Antagonism, & Allosteric Modulation

2-Minute Neuroscience: LSD

2-Minute Neuroscience: Beta-Endorphin

2-Minute Neuroscience: L-DOPA

2-Minute Neuroscience: Parasympathetic Nervous System

2-Minute Neuroscience: Sympathetic Nervous System

2-Minute Neuroscience: Indirect Pathway of the Basal Ganglia

2-Minute Neuroscience: Direct Pathway of the Basal Ganglia

2-Minute Neuroscience: Functional Magnetic Resonance Imaging (fMRI)

2-Minute Neuroscience: Norepinephrine

2-Minute Neuroscience: Sodium-Potassium Pump

2-Minute Neuroscience: Electroencephalography (EEG)

2-Minute Neuroscience: Trochlear Nerve (Cranial Nerve IV)

2-Minute Neuroscience: Oculomotor Nerve (Cranial Nerve III)

2-Minute Neuroscience: Touch Receptors

2-Minute Neuroscience: Hypoglossal Nerve (Cranial Nerve XII)

2-Minute Neuroscience: Accessory Nerve (Cranial Nerve XI)

2-Minute Neuroscience: Prefrontal Cortex

2-Minute Neuroscience: Vagus Nerve (Cranial Nerve X)

2-Minute Neuroscience: Phototransduction

2-Minute Neuroscience: Glossopharyngeal Nerve (Cranial Nerve IX)

2-Minute Neuroscience: Methadone

2-Minute Neuroscience: Vestibulocochlear Nerve (Cranial Nerve VIII)

2-Minute Neuroscience: Nicotine

2-Minute Neuroscience: Facial Nerve (Cranial Nerve VII)

2-Minute Neuroscience: Abducens Nerve (Cranial Nerve VI)

2-Minute Neuroscience: Concussions

2-Minute Neuroscience: Trigeminal Nerve (Cranial Nerve V)

2-Minute Neuroscience: Opioids

2-Minute Neuroscience: Optic Nerve (Cranial Nerve II)

2-Minute Neuroscience: Olfactory Nerve (Cranial Nerve I)

2-Minute Neuroscience: Brain Tumors

2-Minute Neuroscience: Glial Cells

2-Minute Neuroscience: Stages of Sleep

2-Minute Neuroscience: HPA Axis

2-Minute Neuroscience: Huntington's Disease

2-Minute Neuroscience: Amphetamine

2-Minute Neuroscience: Corpus Callosum

2-Minute Neuroscience: Pons

2-Minute Neuroscience: Parkinson's Disease

2-Minute Neuroscience: Hydrocephalus

2-Minute Neuroscience: Dopamine

2-Minute Neuroscience: Stroke

2-Minute Neuroscience: Glutamate

2-Minute Neuroscience: Blood Supply of the Brain

2-Minute Neuroscience: Neurotransmitter Release

2-Minute Neuroscience: Serotonin

2-Minute Neuroscience: Oxytocin

2-Minute Neuroscience: Long-Term Potentiation (LTP)

2-Minute Neuroscience: Wernicke's Area

2-Minute Neuroscience: Broca's Area

2-Minute Neuroscience: Acetylcholine

2-Minute Neuroscience: GABA

2-Minute Neuroscience: Taste

2-Minute Neuroscience: Alcohol

2-Minute Neuroscience: Olfaction

2-Minute Neuroscience: Selective Serotonin Reuptake Inhibitors (SSRIs)

2-Minute Neuroscience: Midbrain

2-Minute Neuroscience: Periaqueductal Gray (PAG)

2-Minute Neuroscience: Benzodiazepines

2-Minute Neuroscience: Caffeine

2-Minute Neuroscience: Long-Term Depression (LTD)

2-Minute Neuroscience: Amyotrophic Lateral Sclerosis (ALS)

2-Minute Neuroscience: Pineal Gland

2-Minute Neuroscience: Primary Somatosensory Cortex

2-Minute Neuroscience: Suprachiasmatic Nucleus

2-Minute Neuroscience: Nucleus Accumbens

2-Minute Neuroscience: Ventral Tegmental Area (VTA)

2-Minute Neuroscience: Medulla Oblongata

2-Minute Neuroscience: Vestibular System

2-Minute Neuroscience: Amygdala

2-Minute Neuroscience: Striatum

2-Minute Neuroscience: Epilepsy

2-Minute Neuroscience: Multiple Sclerosis

2-Minute Neuroscience: Alzheimer's Disease

2-Minute Neuroscience: Neuromuscular Junction

2-Minute Neuroscience: Knee-Jerk Reflex

2-Minute Neuroscience: Substantia Nigra

2-Minute Neuroscience: Corticospinal Tract

2-Minute Neuroscience: Basal Ganglia

2-Minute Neuroscience: Motor Cortex

2-Minute Neuroscience: Cerebellum

2-Minute Neuroscience: Effects of Cocaine

2-Minute Neuroscience: Blood-Brain Barrier

2-Minute Neuroscience: Myelin

2-Minute Neuroscience: Pain and the Anterolateral System

2-Minute Neuroscience: Touch and the Dorsal Columns-Medial Lemniscus

2-Minute Neuroscience: The Cochlea

2-Minute Neuroscience: The Retina

2-Minute Neuroscience: The Hippocampus

2-Minute Neuroscience: The Thalamus

2-Minute Neuroscience: The Brainstem

2-Minute Neuroscience: The Meninges

2-Minute Neuroscience: The Ventricles

2-Minute Neuroscience: Directional Terms in Neuroscience

2-Minute Neuroscience: Spinal Cord Cross-Section

2-Minute Neuroscience: Exterior of the Spinal Cord

2-Minute Neuroscience: Reward System

2-Minute Neuroscience: Limbic System

2-Minute Neuroscience: Hypothalamus & Pituitary Gland

2-Minute Neuroscience: Neuroimaging

2-Minute Neuroscience: Early Neural Development

2-Minute Neuroscience: Receptors & Ligands

2-Minute Neuroscience: Lobes/Landmarks of the Brain Surface

2-Minute Neuroscience: Divisions of the Nervous System

2-Minute Neuroscience: Action Potential

2-Minute Neuroscience: Membrane Potential

2-Minute Neuroscience: Synaptic Transmission

2-Minute Neuroscience: The Neuron

Parkinson’s disease
neurotransmitter dopamine
L-DOPA
amino acid

Video Introduction

L-DOPA is an amino acid involved in the synthesis of the neurotransmitter dopamine. When dopamine is produced in the brain, the amino acid tyrosine is first converted to L-DOPA and then L-DOPA is converted to dopamine. While dopamine administered as a drug cannot pass the blood-brain barrier to enter the brain, L-DOPA can, and this characteristic has helped to make L-DOPA the most common treatment for Parkinson’s disease.

Parkinson’s disease is characterized by the death of dopamine neurons in a region of the brainstem called the substantia nigra, and a subsequent deficiency of dopamine in a group of structures known as the basal ganglia. This dopamine deficiency is thought to contribute to the problems Parkinson’s patients experience with movement.

L-DOPA has a remarkable ability to reduce the symptoms of Parkinson’s disease in some patients. The generally accepted mechanism for this action is that the brain is able to use L-DOPA to synthesize more dopamine and replenish its depleted dopamine stores. While this does seem to be a main characteristic of L-DOPA’s mechanism, however, it is thought that L-DOPA may exert a therapeutic effect through other mechanisms as well, such as by acting as a neurotransmitter on its own. While L-DOPA can effectively treat the symptoms of Parkinson’s disease, it is not able to stop the neurodegeneration caused by the disease. Thus, Parkinson’s disease continues to progress even with L-DOPA treatment. Additionally, over time L-DOPA’s effectiveness begins to decrease and eventually movement problems, known as L-DOPA dyskinesias, may occur in response to L-DOPA treatment. L-DOPA dyskinesias typically involve quick involuntary movements, but may also include a number of other complications like uncontrolled muscle contractions or writhing movements. The mechanisms underlying L-DOPA dyskinesias are still not completely understood, and may involve factors like the continued death of dopamine neurons in the substantia nigra and fluctuations in dopamine levels caused by L-DOPA treatment. ^[1]^[2]

References

Halbig TD, Koller WC. 2007. Levodopa. In: Koller WC, Melamed E, eds. Parkinson's disease and related disorders, Part II. Amsterdam: Elsevier.
Obeso JA, Stamelou M, Goetz CG, et al. Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy. Mov Disord. 2017 Sep;32(9):1264-1310. doi: 10.1002/mds.27115.

Full Transcript

1000/1000

Hot Most Recent

©Text is available under the terms and conditions of the Creative Commons-Attribution ShareAlike (CC BY-SA) license; additional terms may apply. By using this site, you agree to the Terms and Conditions and Privacy Policy.

Confirm

Name: 2-Minute Neuroscience: L-DOPA
Uploaded: 2024-01-29T02:32:48+00:00
Description: L-DOPA is an amino acid involved in the synthesis of the neurotransmitter dopamine

Are you sure to Delete?

Yes No

Cite

If you have any further questions, please contact Encyclopedia Editorial Office.

Select a Style

Challenged, N. 2-Minute Neuroscience: L-DOPA. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/1081 (accessed on 15 November 2024).

Challenged N. 2-Minute Neuroscience: L-DOPA. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/1081. Accessed November 15, 2024.

Challenged, Neuroscientifically. "2-Minute Neuroscience: L-DOPA" Encyclopedia, https://encyclopedia.pub/video/video_detail/1081 (accessed November 15, 2024).

Challenged, N. (2024, January 26). 2-Minute Neuroscience: L-DOPA. In Encyclopedia. https://encyclopedia.pub/video/video_detail/1081

Challenged, Neuroscientifically. "2-Minute Neuroscience: L-DOPA." Encyclopedia. Web. 26 January, 2024.