10-Minute Neuroscience: Depression
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  • Release Date: 2024-05-13
Playlist
  • neuroscience
  • depression
  • serotonin
  • neuroplasticity
  • antidepressants
Video Introduction

The content is sourced from: https://youtu.be/1euK8OSIR9E

This video discusses the neuroscience of depression. First, it covers the serotonin hypothesis, which suggests depression is caused by low levels of serotonin in the brain, and  explains why this hypothesis does not fully explain what’s happening in the brain to cause depression. Then, it covers several other hypotheses, including those that focus on dysregulation in the HPA axis, immune system dysfunction, and impaired neuroplasticity and neurogenesis (linked to low levels of BDNF). Along the way, the video also explains the mechanisms behind some common antidepressants, such as SSRIs. [1][2][3][4][5][6]

References
  1. Dean J, Keshavan M. The neurobiology of depression: An integrated view. Asian J Psychiatr. 2017 Jun;27:101-111. doi: 10.1016/j.ajp.2017.01.025. Epub 2017 Jan 29. PMID: 28558878.
  2. Krishnan V, Nestler EJ. The molecular neurobiology of depression. Nature. 2008 Oct 16;455(7215):894-902. doi: 10.1038/nature07455. PMID: 18923511; PMCID: PMC2721780.
  3. López-Muñoz F, Alamo C. Monoaminergic neurotransmission: the history of the discovery of antidepressants from 1950s until today. Curr Pharm Des. 2009;15(14):1563-86. doi: 10.2174/138161209788168001. PMID: 19442174.
  4. López-Muñoz F, Alamo C, Juckel G, Assion HJ. Half a century of antidepressant drugs: on the clinical introduction of monoamine oxidase inhibitors, tricyclics, and tetracyclics. Part I: monoamine oxidase inhibitors. J Clin Psychopharmacol. 2007 Dec;27(6):555-9. doi: 10.1097/jcp.0b013e3181bb617. PMID: 18004120.
  5. Moncrieff J, Cooper RE, Stockmann T, Amendola S, Hengartner MP, Horowitz MA. The serotonin theory of depression: a systematic umbrella review of the evidence. Mol Psychiatry. 2023 Aug;28(8):3243-3256. doi: 10.1038/s41380-022-01661-0. Epub 2022 Jul 20. PMID: 35854107; PMCID: PMC10618090.
  6. Otte C, Gold SM, Penninx BW, Pariante CM, Etkin A, Fava M, Mohr DC, Schatzberg AF. Major depressive disorder. Nat Rev Dis Primers. 2016 Sep 15;2:16065. doi: 10.1038/nrdp.2016.65. PMID: 27629598.
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Challenged, N. 10-Minute Neuroscience: Depression. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/1260 (accessed on 25 May 2024).
Challenged N. 10-Minute Neuroscience: Depression. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/1260. Accessed May 25, 2024.
Challenged, Neuroscientifically. "10-Minute Neuroscience: Depression" Encyclopedia, https://encyclopedia.pub/video/video_detail/1260 (accessed May 25, 2024).
Challenged, N. (2024, May 13). 10-Minute Neuroscience: Depression. In Encyclopedia. https://encyclopedia.pub/video/video_detail/1260
Challenged, Neuroscientifically. "10-Minute Neuroscience: Depression." Encyclopedia. Web. 13 May, 2024.
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