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Topic Review
Paramaeters that Affect Biomass Gasification
Gasification is a thermochemical process commonly used for bioenergy production, and it is particularly attractive mainly due to its high efficiency. However, its performance is influenced by parameters such as type of feedstock, size of biomass particle, feed rate, type of reactor, temperature, pressure, equivalence ratio, steam to biomass ratio, gasification agent, catalyst, and residence time.
  • 1.8K
  • 12 Apr 2023
Topic Review
AI Applications for Virtual Sensing of Underground Utilities
Accurately identifying the location and depth of buried utility assets became a considerable challenge in the construction industry, for which accidental strikes can cause important economic losses and safety concerns. While the collection of as-built utility locations is becoming more accurate, there still exists an important need to be capable of accurately detecting buried utilities in order to eliminate risks associated with digging. With advances in artificial intelligence (AI), an opportunity arose in conducting virtual sensing of buried utilities by combining robotics (e.g., drones), knowledge, and logic.
  • 1.8K
  • 18 May 2023
Topic Review
Embryogenesis
Embryogenesis is the process by which the embryo forms and develops. In mammals, the term refers chiefly to early stages of prenatal development, whereas the terms fetus and fetal development describe later stages. Embryogenesis starts with the fertilization of the egg cell (ovum) by a sperm cell, (spermatozoon). Once fertilized, the ovum is referred to as a zygote, a single diploid cell. The zygote undergoes mitotic divisions with no significant growth (a process known as cleavage) and cellular differentiation, leading to development of a multicellular embryo. Although embryogenesis occurs in both animal and plant development, this article addresses the common features among different animals, with some emphasis on the embryonic development of vertebrates and mammals.
  • 1.8K
  • 10 Nov 2022
Topic Review
Endothelial Dysfunction and Arterial Stiffness under Cardiovascular Risk
Pathophysiological conditions such as endothelial dysfunction and arterial stiffness, characterized by low nitric oxide bioavailability, deficient endothelium-dependent vasodilation and heart effort, predispose individuals to atherosclerotic lesions and cardiac events. Nitrate (NO3−), L-arginine, L-citrulline and potassium (K+) can mitigate arterial dysfunction and stiffness by intensifying NO bioavailability. Dietary compounds such as L-arginine, L-citrulline, NO3− and K+ exert vasoactive effects as demonstrated in clinical interventions by noninvasive flow-mediated vasodilation (FMD) and pulse-wave velocity (PWV) prognostic techniques.
  • 1.8K
  • 07 Jun 2023
Topic Review
High-Entropy Alloys
Microstructural phase evolution during melting and casting depends on the rate of cooling, the collective mobility of constituent elements, and binary constituent pairs. Parameters used in mechanical alloying and spark plasma sintering, the initial structure of binary alloy pairs, are some of the factors that influence phase evolution in powder-metallurgy-produced HEAs. Factors such as powder flowability, laser power, powder thickness and shape, scan spacing, and volumetric energy density (VED) all play important roles in determining the resulting microstructure in additive manufacturing technology. Large lattice distortion could hinder dislocation motion in HEAs, and this could influence the microstructure, especially at high temperatures, leading to improved mechanical properties in some HEAs. Mechanical properties of some HEAs can be influenced through solid solution hardening, precipitation hardening, grain boundary strengthening, and dislocation hardening. Despite the HEA system showing reliable potential engineering properties if commercialized, there is a need to examine the effects that processing routes have on the microstructure in relation to mechanical properties. 
  • 1.8K
  • 09 Jun 2021
Topic Review
Acinetobacter Baumannii Infections
Antibiotic resistance is one of the biggest challenges for the clinical sector and industry, environment and societal development. One of the most important pathogens responsible for severe nosocomial infections is Acinetobacter baumannii, a Gram-negative bacterium from the Moraxellaceae family, due to its various resistance mechanisms. The enormous adaptive capacity of A. baumannii and the acquisition and transfer of antibiotic resistance determinants contribute to the ineffectiveness of most current therapeutic strategies, including last-line or combined antibiotic therapy. In this review, we will present the current progress in developing innovative strategies for combating multidrug-resistant A. baumannii (MDRAB) infections.
  • 1.8K
  • 26 Oct 2020
Topic Review
Subtype-Specific Cardiomyocytes
Cardiogenesis produces multiple cardiac muscle cell subtypes, including the contractile cardiomyocytes constituting the four heart chambers and the non-contractile cardiomyocytes forming the cardiac conduction system. The various cardiac cellular subtypes (e.g. atrial, ventricular, nodal) are highly specified, with each subtype expressing a unique set of structural proteins, ion channels and transcription factors. Stringent spatiotemporal molecular, transcriptomic, and electrophysiological regulation gives rise to the differentiation and maturation of the multiple cardiomyocyte subtypes. The precise generation of subtype-specific cardiomyocytes is necessary for translational applications of stem cell-derived cardiomyocytes for regenerative medicine.  
  • 1.8K
  • 21 Apr 2021
Topic Review
The Genetics of Hereditary Angioedema
Hereditary angioedema is a rare inherited disorder characterized by recurrent episodes of the accumulation of fluids outside of the blood vessels, causing rapid swelling of tissues in the hands, feet, limbs, face, intestinal tract, or airway.
  • 1.8K
  • 23 Jun 2021
Topic Review
Modified Citrus Pectin Pleiotropic Effects
Modified citrus pectin (MCP) has a low-molecular-weight degree of esterification to allow absorption from the small intestinal epithelium into the circulation. MCP produces pleiotropic effects, including but not limited to its antagonism of galectin-3, which have shown benefit in preclinical and clinical models. Regarding cancer, MCP modulates several rate-limiting steps of the metastatic cascade. MCP can also affect cancer cell resistance to chemotherapy. Regarding fibrotic diseases, MCP modulates many of the steps involved in the pathogenesis of aortic stenosis. MCP also reduces fibrosis to the kidney, liver, and adipose tissue. Other benefits of MCP include detoxification and improved immune function.
  • 1.8K
  • 10 Aug 2021
Topic Review
Non-Coding RNAs and Hereditary Hemorrhagic Telangiectasia
Non-coding RNAs (ncRNAs) are functional ribonucleic acid (RNA) species that include microRNAs (miRs), a class of short non-coding RNAs (∼21–25 nucleotides), and long non-coding RNAs (lncRNAs) consisting of more than 200 nucleotides. They regulate gene expression post-transcriptionally and are involved in a wide range of pathophysiological processes. Hereditary hemorrhagic telangiectasia (HHT) is a rare disorder inherited in an autosomal dominant fashion characterized by vascular dysplasia. Patients can develop life-threatening vascular malformations and experience severe hemorrhaging.
  • 1.8K
  • 05 Nov 2021
Topic Review
Commercialization of Electric Vehicles
Electric Vehicles (EVs) are a promising alternative to internal combustion engine vehicles as the city is transitioning to clean energy.
  • 1.8K
  • 10 Feb 2022
Topic Review
Artificial Intelligence in Water–Energy–Food Model
The role of artificial intelligence (AI) in the Water–Energy–Food (WEF) nexus under the lens of institutional, stakeholder, and innovation theories has been studied recently. Research on AI for WEF nexus management has adopted mostly a technical perspective, neglecting the relevance of management tools and the business model concept. An integrated approach for managing the nexus through AI technologies is proposed to meet sustainable and responsible business models. The gap between research and policy making could be filled by combining scientific data and policy needs with inclusive tools that are technically viable for sustainable resource utilization.
  • 1.8K
  • 20 Mar 2022
Topic Review
Digitalization for Energy Saving and Emission Reduction
Digital technologies find a wide use on the energy market both on the energy supply and demand side. Many digital technologies such as smart home systems reduce the production of the energy necessary to produce goods and services in all aspects of our lives.
  • 1.8K
  • 18 Mar 2022
Topic Review
Ocean Remote Sensing Techniques and Applications
Oceans cover over 70% of the Earth’s surface and provide numerous services to humans and the environment. Therefore, it is crucial to monitor these valuable assets using advanced technologies. In this regard, Remote Sensing (RS) provides a great opportunity to study different oceanographic parameters using archived consistent multitemporal datasets in a cost-efficient approach. Various types of RS techniques have been developed and utilized for different oceanographic applications.
  • 1.8K
  • 15 Nov 2022
Topic Review
Biological Activity of Flavones, Flavonols, and Aurones
Flavonoids are a widely distributed group of natural polyphenolic compounds that are found in plants usually in glycosylated form and have been shown to possess a wide range of biological activities, including antioxidant, anti-inflammatory, antibacterial, antiviral, and anticancer properties, making them an attractive target for synthesis and further research.
  • 1.8K
  • 12 Sep 2023
Topic Review
Dorzagliatin in Type 2 Diabetes Treatment
Achieving glycemic control and sustaining functional pancreatic β-cell activity remains an unmet medical need in the treatment of type 2 diabetes mellitus (T2DM). Glucokinase activators (GKAs) constitute a class of anti-diabetic drugs designed to regulate blood sugar levels and enhance β-cell function in patients with diabetes. A significant progression in GKA development is underway to address the limitations of earlier generations. Dorzagliatin, a dual-acting GKA, targets both the liver and pancreas and has successfully completed two phase III trials, demonstrating favorable results in diabetes treatment. 
  • 1.8K
  • 09 Jan 2024
Topic Review
True Range Multilateration
True range multilateration is a method to determine the location of a movable vehicle or stationary point in space using multiple ranges (distances) between the vehicle/point and multiple spatially-separated known locations (often termed 'stations'). True range multilateration is both a mathematical topic and an applied technique used in several fields. A practical application involving a fixed location is the trilateration method of surveying. Applications involving vehicle location are termed navigation when on-board persons/equipment are informed of its location, and are termed surveillance when off-vehicle entities are informed of the vehicle's location. Two slant-ranges from two known locations can be used to locate a third point in a two-dimensional Cartesian space (plane), which is a frequently applied technique (e.g., in surveying). Similarly, two spherical ranges can be used to locate a point on a sphere, which is a fundamental concept of the ancient discipline of celestial navigation — termed the altitude intercept problem. Moreover, if more than the minimum number of ranges are available, it is good practice to utilize those as well. This article addresses the general issue of position determination using multiple ranges. In two-dimensional geometry, it is known that if a point lies on two circles, then the circle centers and the two radii provide sufficient information to narrow the possible locations down to two – one of which is the desired solution and the other is an ambiguous solution. Additional information often narrow the possibilities down to a unique location. In three-dimensional geometry, when it is known that a point lies on the surfaces of three spheres, then the centers of the three spheres along with their radii also provide sufficient information to narrow the possible locations down to no more than two (unless the centers lie on a straight line). True range multilateration can be contrasted to the more frequently encountered (pseudorange) multilateration, which employs range differences to locate a (typically, movable) point. Pseudo range multilateration is almost always implemented by measuring times-of-arrival (TOAs) of energy waves. True range multilateration can also be contrasted to triangulation, which involves the measurement of angles. Multiple, sometimes overlapping and conflicting terms are employed for similar concepts – e.g., multilateration without modification has been used for aviation systems employing both true ranges and pseudo ranges. Moreover, different fields of endeavor may employ different terms. In geometry, trilateration is defined as the process of determining absolute or relative locations of points by measurement of distances, using the geometry of circles, spheres or triangles. In surveying, trilateration is a specific technique. The term true range multilateration is accurate, general and unambiguous. Authors have also used the terms range-range and rho-rho multilateration for this concept.
  • 1.8K
  • 25 Oct 2022
Topic Review
Electric Noise Spectroscopy
Electric noise spectroscopy is a non-destructive and a very sensitive method for studying the dynamic behaviors of the charge carriers and the kinetic processes in several condensed matter systems, with no limitation on operating temperatures. This technique has been extensively used to investigate several perovskite compounds, manganese oxides (La1−xSrxMnO3, La0.7Ba0.3MnO3, and Pr0.7Ca0.3MnO3), and a double perovskite (Sr2FeMoO6), whose properties have recently attracted great attention.
  • 1.8K
  • 22 Jan 2021
Topic Review
Irosustat: Clinical Steroid Sulfatase Inhibitor
Irosustat: (6-oxo-8,9,10,11-tetrahydro-7H-cyclohepta[c]chromen-3-yl) sulfamate; 6-oxo-8,9,10,11-tetrahydro-7H-cyclohepta-(c)(1)benzopyran-3-O-sulfamate; also known as STX64, 667 Coumate, BN83495, Oristusane is a tricyclic synthetic clinical drug of the aryl sulfamate ester class, designed mainly for applications in oncology as a steroid sulfatase inhibitor and has shown clinical benefit in patients.
  • 1.8K
  • 09 Feb 2021
Topic Review
Limosilactobacillus fermentum CECT5716
Limosilactobacillus fermentum CECT5716 has become one of the most promising probiotics and it has been described to possess potential beneficial effects on inflammatory processes and immunological alterations.
  • 1.8K
  • 15 Apr 2021
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