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Topic Review
Senescence in Physiological Processes and Age-Related Diseases
Cellular senescence is a physiological mechanism that has both beneficial and detrimental consequences. Senescence limits tumorigenesis, lifelong tissue damage, and is involved in different biological processes, such as morphogenesis, regeneration, and wound healing. 
  • 4.2K
  • 28 Mar 2023
Topic Review
Springfield Armory XDM
The Springfield Armory XDM (X-Treme Duty, the M is for the match grade barrel and match grade trigger) are a series of semi-automatic pistols that are polymer-framed and striker-fired. They closely resemble their predecessor, the HS2000 pistol (most widely known in the United States as Springfield Armory XD). Manufactured in the city of Karlovac, Croatia by HS Produkt (formerly I.M. Metal), the Springfield Armory XDM is the marketing name for the firearm, which is licensed and sold in the United States by Springfield Armory, Inc..
  • 4.2K
  • 25 Oct 2022
Topic Review
Sting-Related Deaths in Europe (1994–2016)
Bees and wasps provide an important service to ecosystems, contributing to the improvement of biodiversity while helping to maintain ecological balance. Although not frequent, hornet, wasp, and bee stings may be life-threatening. With each sting, Hymenopterans inject a small amount of venom that can cause reactions of varying intensity: (i) normal local reactions (NLR), (ii) large local reactions (LLR), (iii) systemic anaphylactic reactions (SAR), (iv) systemic toxic reactions (STR) and (v) unusual reactions (UR).  Hymenopteran stings have recently become a worldwide public health concern. However, this health problem can be underestimated despite the number of cases presented. With the expansion of non-native Hymenopteran species across Europe, allergists should be aware that their community’s exposures are continually changing.
  • 4.2K
  • 28 Feb 2022
Topic Review
YUC in Plant Developmental Processes
The YUC gene family encodes the rate-limiting enzymes in the TAA/YUC pathway, which stands as the primary endogenous auxin biosynthesis pathway in plants. YUC-medicated local auxin biosynthesis is important for establishing auxin gradient within cells/tissues and precisely regulating various major developmental processes such as root development, leaf morphogenesis, and reproductive development. The spatiotemporal expressions of different YUC genes enable function specialization across different plant species.
  • 4.2K
  • 23 Oct 2020
Topic Review
XPS Analysis of Carbon Materials
The surface chemistry of carbon materials is predominantly explored using x-ray photoelectron spectroscopy (XPS). However, many journal articles have critical failures in the published analysis which typically stems from an ill-informed approach to analyzing the spectroscopic data. The presented work presents a discussion on lineshapes and associated changes in the spectral envelope of predominantly graphitic materials, which together with the use of the D-parameter to verify levels of the graphitic content, using this information to highlight a simple and logical approach to strengthen confidence in the functionalization derived from the carbon core-level spectra.
  • 4.2K
  • 16 Jul 2021
Topic Review
Content-Control Software
Content-control software, commonly referred to as an Internet filter, is software that restricts or controls the content an Internet user is capable to access, especially when utilised to restrict material delivered over the Internet via the Web, Email, or other means. Content-control software determines what content will be available or be blocked. Such restrictions can be applied at various levels: a government can attempt to apply them nationwide (see Internet censorship), or they can, for example, be applied by an ISP to its clients, by an employer to its personnel, by a school to its students, by a library to its visitors, by a parent to a child's computer, or by an individual user to their own computer. The motive is often to prevent access to content which the computer's owner(s) or other authorities may consider objectionable. When imposed without the consent of the user, content control can be characterised as a form of internet censorship. Some content-control software includes time control functions that empowers parents to set the amount of time that child may spend accessing the Internet or playing games or other computer activities. In some countries, such software is ubiquitous. In Cuba, if a computer user at a government-controlled Internet cafe types certain words, the word processor or web browser is automatically closed, and a "state security" warning is given.
  • 4.2K
  • 08 Nov 2022
Topic Review
Three-Dimensional Printing of Living Mycelium-Based Composites
The construction industry makes a significant contribution to global CO2 emissions. Material extraction, processing, and demolition account for most of its environmental impact. As a response, there is an increasing interest in developing and implementing innovative biomaterials that support a circular economy, such as mycelium-based composites. The mycelium is the network of hyphae of fungi. Mycelium-based composites are renewable and biodegradable biomaterials obtained by ceasing mycelial growth on organic substrates, including agricultural waste.
  • 4.2K
  • 04 Sep 2023
Topic Review
Structure of the Earth
The internal structure of the Earth is layered in spherical shells: an outer silicate solid crust, a highly viscous asthenosphere and mantle, a liquid outer core that is much less viscous than the mantle, and a solid inner core. Scientific understanding of the internal structure of the Earth is based on observations of topography and bathymetry, observations of rock in outcrop, samples brought to the surface from greater depths by volcanoes or volcanic activity, analysis of the seismic waves that pass through the Earth, measurements of the gravitational and magnetic fields of the Earth, and experiments with crystalline solids at pressures and temperatures characteristic of the Earth's deep interior.
  • 4.2K
  • 26 Oct 2022
Topic Review
Wearable Stretch Sensors
Wearable sensors are beneficial for continuous health monitoring, movement analysis, rehabilitation, evaluation of human performance. Wearable stretch sensors are increasingly being used for human movement monitoring. The content presented provides a review of wearable stretch sensors as well the design, development and validation of a wearable soft-robotic-stretch sensors. 
  • 4.2K
  • 25 Feb 2021
Topic Review
Existential Suffering in Palliative Care
Existential suffering refers to one's angst due to a perceived loss of meaning, hope, relationships, and a sense of self in thinking about death and dying. Quality palliative care not only takes care of patients’ physical and existential suffering but also fills their last days with opportunities for redemption, spiritual growth, and reconciliation. We propose a holistic approach as illustrated by the healing wheel, involving health care providers, the community, patients, and a Higher Power.
  • 4.2K
  • 29 Sep 2021
Topic Review
Rodrigues
Rodrigues (French: Île Rodrigues [il ʁɔdʁiɡ]; Creole: Rodrig) is a 108 km2 (42 sq mi) autonomous outer island of the Republic of Mauritius in the Indian Ocean, about 560 km (350 mi) east of Mauritius. It is part of the Mascarene Islands, which include Mauritius and Réunion. Rodrigues is of volcanic origin and is surrounded by coral reef, and some tiny uninhabited islands lie just off its coast. The island used to be the tenth District of Mauritius; it gained autonomous status on 10 December 2002, and it is governed by the Rodrigues Regional Assembly. The capital of the island is Port Mathurin. Its inhabitants are Mauritian citizens. (As of 2014), the island's population was about 41,669, according to Statistics Mauritius. Most of the inhabitants are of African descent. Its economy is based mainly on fishing, farming, handicraft and a developing tourism sector. The island (together with Agaléga and Saint Brandon) forms part of the larger territory of the Republic of Mauritius with the President as head of state and the Chief Commissioner as head of government.
  • 4.2K
  • 11 Nov 2022
Topic Review
Cat-Scratch Disease’s Neuro-Ophthalmological Effects
Cat-scratch disease is an illness caused by Bartonella henselae that occurs as a result of contact with an infected kitten or dog, such as a bite or scratch. It is more prevalent in children and young adults, as well as immunocompromised individuals. Among the ophthalmologic disorders caused by cat-scratch disease in humans, Parinaud oculoglandular syndrome, uveitis, vitritis, retinitis, retinochoroiditis and optic neuritis are the most prevalent. The neurological disorders caused by cat-scratch disease in humans include encephalopathy, transverse myelitis, radiculitis, and cerebellar ataxia.
  • 4.1K
  • 21 Feb 2022
Topic Review
Mitochondrial Metabolism of Fatty Acids
Mitochondria are the powerhouse of the cells, generating up to 90% of the energy within a cell in the form of adenosine triphosphate (ATP). There is a close connection between fatty acid metabolism and mitochondria, involving a considerable number of cellular processes that go well beyond mitochondrial fatty acid metabolism. Fatty acids are essential for ATP and energy production, and are therefore highly relevant in the regulation of energy homeostasis. The processes of β-oxidation, linked to ATP production, and mitochondrial fatty acid biosynthesis (mtFAS) are both localized in the mitochondria. This last pathway, in particular, produces molecules that are used as cellular structural components for post-translational modifications of proteins and in signaling cascades.
  • 4.1K
  • 22 Sep 2021
Topic Review
Background on Computing Paradigms
General overview of the different mentioned paradigms needs to be provided in order to be oriented in the computing field. For clarity and consistency, each paradigm is carefully discussed concisely in the oncoming text. The reason for discussing each of these paradigms is to have an overview that will guide the understanding of the research goal for this entry, which is primarily the information security and privacy aspects for each paradigm.
  • 4.1K
  • 25 Feb 2022
Topic Review
Translation
In molecular biology and genetics, translation is the process in which ribosomes in the cytoplasm or endoplasmic reticulum synthesize proteins after the process of transcription of DNA to RNA in the cell's nucleus. The entire process is called gene expression. In translation, messenger RNA (mRNA) is decoded in a ribosome, outside the nucleus, to produce a specific amino acid chain, or polypeptide. The polypeptide later folds into an active protein and performs its functions in the cell. The ribosome facilitates decoding by inducing the binding of complementary tRNA anticodon sequences to mRNA codons. The tRNAs carry specific amino acids that are chained together into a polypeptide as the mRNA passes through and is "read" by the ribosome. Translation proceeds in three phases: In prokaryotes (bacteria and archaea), translation occurs in the cytosol, where the large and small subunits of the ribosome bind to the mRNA. In eukaryotes, translation occurs in the cytoplasm or across the membrane of the endoplasmic reticulum in a process called co-translational translocation. In co-translational translocation, the entire ribosome/mRNA complex binds to the outer membrane of the rough endoplasmic reticulum (ER) and the new protein is synthesized and released into the ER; the newly created polypeptide can be stored inside the ER for future vesicle transport and secretion outside the cell, or immediately secreted. Many types of transcribed RNA, such as transfer RNA, ribosomal RNA, and small nuclear RNA, do not undergo translation into proteins. A number of antibiotics act by inhibiting translation. These include anisomycin, cycloheximide, chloramphenicol, tetracycline, streptomycin, erythromycin, and puromycin. Prokaryotic ribosomes have a different structure from that of eukaryotic ribosomes, and thus antibiotics can specifically target bacterial infections without any harm to a eukaryotic host's cells.
  • 4.1K
  • 14 Nov 2022
Topic Review
Early-Age Cracking in Concrete
Cracking is a common problem in concrete structures in real-life service conditions. In fact, crack-free concrete structures are very rare to find in real world. Concrete can undergo early-age cracking depending on the mix composition, exposure environment, hydration rate, and curing conditions.
  • 4.1K
  • 27 Jun 2021
Topic Review
Computus
The computus (Latin for 'computation') is a calculation that determines the calendar date of Easter.:xviii Easter is traditionally celebrated on the first Sunday after the Paschal full moon, which is the first full moon on or after 21 March (an approximation of the March equinox). Determining this date in advance requires a correlation between the lunar months and the solar year, while also accounting for the month, date, and weekday of the calendar.:xviii-xx The calculations produce different results depending on whether the Julian calendar or the Gregorian calendar is used. In late antiquity, it was feasible for the entire Christian church to receive the date of Easter each year through an annual announcement from the Pope. By the early third century, however, communications had deteriorated to the point that the church put great value in a system that would allow the clergy to independently and consistently determine the date for themselves.:xx Additionally, the church wished to eliminate dependencies on the Hebrew calendar, by deriving Easter directly from the vernal equinox.:xxxvi In The Reckoning of Time (725), Bede uses computus as a general term for any sort of calculation, although he refers to the Easter cycles of Theophilus as a "Paschal computus." By the end of the 8th century, computus came to refer specifically to the calculation of time.
  • 4.1K
  • 15 Nov 2022
Topic Review
Magnesium and Stress
Magnesium deficiency and stress are both common conditions among the general population, which, over time, can increase the risk of health consequences.  Clinical and pre-clinical evidence suggest that stress could increase magnesium loss, causing a deficiency; and in turn, magnesium deficiency could enhance the body’s susceptibility to stress, resulting in a magnesium and stress vicious circle.
  • 4.1K
  • 20 Jan 2021
Topic Review
Purple Tomatoes
Purple tomatoes represent a recent variant of tomato fruits characterized by a purple coloration, not present in the more common red fruited varieties. This peculiar pigmentation is due to the presence of anthocyanins. These are plant secondary metabolites responsible for red, purple and blue colorations of flowers, fruits and leaves in many species. They are usually assumed with the diet, being rich sources mostly represented by red and purple fruits or dark vegetables (e.g., berries, cherries, plums, grapes, black beans, red onions, eggplant, red cabbage, purple sweet potatoes). As other polyphenolic compounds, they can provide many health benefits, and, as a consequence, their consumption can be helpful in reducing the incidence of cardiovascular, metabolic and degenerative or chronic diseases and of certain types of cancer. Tomato fruits are naturally rich of carotenoids, vitamins and polyphenols, but do not contain anthocyanins, due to mutations in their specific biosynthetic pathway. However, in recent years, either through genetic engineering or introgression by breeding of specific gene variants using wild relatives, this biosynthetic block has been overcome. This allowed the production of the new tomatoes’ phenotypes characterized by purple pigmentation localized only on the fruit peel or in both peel and flesh. In purple tomatoes, the high concentrations of anthocyanins that can be achieved, and not to the detriment of other metabolites, represent a real added nutritional value of these fruits.
  • 4.1K
  • 15 Jan 2021
Topic Review
EPR (Nuclear Reactor)
The EPR is a third generation pressurised water reactor (PWR) design. It has been designed and developed mainly by Framatome (part of Areva between 2001 and 2017) and Électricité de France (EDF) in France, and Siemens in Germany. In Europe this reactor design was called European Pressurised Reactor, and the internationalised name was Evolutionary Power Reactor, but it is now simply named EPR. The first two EPR units, at Olkiluoto in Finland and Flamanville in France, are both facing costly construction delays (to at least 2019). Construction commenced on two Chinese units at Taishan in 2009 and 2010. Taishan 1 achieved criticality on 6 June 2018. Taishan 2 is expected to begin operation in 2019. Two units at Hinkley Point in the United Kingdom received final approval in September 2016 and are expected to be completed by 2025. EDF has acknowledged severe difficulties in building the EPR design. In September 2015 EDF stated that the design of a "New Model" EPR was being worked on, which will be easier and cheaper to build.
  • 4.1K
  • 15 Nov 2022
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