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Topic Review
May 23: Release of the Java Programming Language
On May 23, 1995, Sun Microsystems officially launched the Java programming language, a major milestone in the history of software development. Introduced at the SunWorld conference in San Francisco by Sun engineer James Gosling and his team, Java was designed to solve many of the limitations of existing programming languages at the time. Its defining features—platform independence, security, and object-oriented design—quickly made Java one of the most influential and enduring languages in computing.
  • 1.9K
  • 21 May 2025
Topic Review
Smart ECM-Based Electrospun Biomaterials
Electrospinning is a well-known technique to produce fibers that mimic the three dimensional microstructural arrangements of the extracellular matrix fibers. Natural and synthetic polymers are used in the electrospinning process; moreover, a blend of them provides composite materials that have demonstrated the potential advantage of supporting cell function and adhesion. Recently, the decellularized extracellular matrix (dECM), which is the noncellular component of tissue that retains relevant biological cues for cells, has been evaluated as a starting biomaterial to realize composite electrospun constructs. The properties of the electrospun systems can be further improved with innovative procedures of functionalization with biomolecules. Among the various approaches, great attention is devoted to the “click” concept in constructing a bioactive system, due to the modularity, orthogonality, and simplicity features of the “click” reactions. Here, we provide an overview of current approaches that can be used to obtain biofunctional composite electrospun biomaterials and propose a design of a smart ECM-based electrospun system suitable for skeletal muscle tissue regeneration.
  • 1.9K
  • 24 Sep 2020
Topic Review
Flavonoids as Potential Anti-Inflammatory Molecules
Hydroxylated polyphenols, also called flavonoids, are richly present in vegetables, fruits, cereals, nuts, herbs, seeds, stems, and flowers of numerous plants. They possess numerous medicinal properties such as antioxidant, anti-cancer, anti-microbial, neuroprotective, and anti-inflammation. Studies show that flavonoids activate antioxidant pathways that render an anti-inflammatory effect. They inhibit the secretions of enzymes such as lysozymes and β-glucuronidase and inhibit the secretion of arachidonic acid, which reduces inflammatory reactions. Flavonoids such as quercetin, genistein, apigenin, kaempferol, and epigallocatechin 3-gallate modulate the expression and activation of a cytokine such as interleukin-1beta (IL-1β), Tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-8 (IL-8); regulate the gene expression of many pro-inflammatory molecules such s nuclear factor kappa-light chain enhancer of activated B cells (NF-κB), activator protein-1 (AP-1), intercellular adhesion molecule-1 (ICAM), vascular cell adhesion molecule-1 (VCAM), and E-selectins; and also inhibits inducible nitric oxide (NO) synthase, cyclooxygenase-2, and lipoxygenase, which are pro-inflammatory enzymes.
  • 1.9K
  • 24 May 2022
Topic Review
Plant Nutrition and Sustainable Agriculture
There is no human nutrition without crop production, which itself must be supported by proper and sufficient plant nutrients. These plant nutrients can play a crucial role in sustainably promoting agricultural production on cultivated lands, facilitating soil carbon sequestration, and taking pressure off global peatlands and forests
  • 1.9K
  • 11 Jul 2022
Topic Review
Periphylla
The helmet jellyfish (Periphylla periphylla) is a luminescent, red-colored jellyfish of the deep sea, belonging to the order Coronatae of the phylum Cnidaria. It is the only species in the monotypic genus Periphylla. They are the only known scyphozoan to undergo sexual propagation that lacks a planula stage. Not only is their reproductive cycle unique, so are their living conditions. They are found in deeper parts of the ocean due to them being photophobic.
  • 1.9K
  • 27 Oct 2022
Topic Review
Munchausen by Internet
Munchausen by Internet is a pattern of behavior akin to Munchausen syndrome (renamed factitious disorder imposed on self), a psychiatric disorder, wherein those affected feign disease, illness, or psychological trauma to draw attention, sympathy, or reassurance to themselves. In Munchausen by Internet, users seek attention by feigning illnesses in online venues such as chat rooms, message boards, and Internet Relay Chat (IRC). It is different from catfishing, where the person feigns an identity to seek attention by online dating. It has been described in medical literature as a manifestation of factitious disorder imposed on self, or if claiming illness of a child or other family member, factitious disorder imposed on another. Reports of users who deceive Internet forum participants by portraying themselves as gravely ill or as victims of violence first appeared in the 1990s due to the relative newness of Internet communications. The pattern was identified in 1998 by psychiatrist Marc Feldman, who created the term "Münchausen by Internet" in 2000. It is not included in the fifth revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). The development of factitious disorders in online venues is made easier by the availability of medical literature on the Internet, the anonymous and malleable nature of online identities, and the existence of communication forums established for the sole purpose of giving support to members facing significant health or psychological problems. Several high-profile cases have demonstrated behavior patterns which are common among those who pose as gravely ill or as victims of violence, or whose deaths are announced to online forums. The virtual communities that were created to give support, as well as general non-medical communities, often express genuine sympathy and grief for the purported victims. When fabrications are suspected or confirmed, the ensuing discussion can create schisms in online communities, destroying some and altering the trusting nature of individual members in others.
  • 1.9K
  • 07 Nov 2022
Biography
Clyde Cowan
Clyde Lorrain Cowan Jr (December 6, 1919 in Detroit, Michigan – May 24, 1974 in Bethesda, Maryland) was an American physicist, the co-discoverer of the neutrino along with Frederick Reines. The discovery was made in 1956 in the neutrino experiment.[1] Frederick Reines received the Nobel Prize in Physics in 1995 in both their names. Born the oldest of four children in Detroit, Michigan, Cowa
  • 1.9K
  • 15 Nov 2022
Topic Review
Structure of Endohedral Fullerenes
Fullerenes have a unique structure, capable of both encapsulating other molecules and reacting with those on the exterior surface. Fullerene derivatives have also been found to have enormous potential to address the challenges of the renewable energy sector and current environmental issues, such as in the production of n-type materials in bulk heterojunction solar cells, as antimicrobial agents, in photocatalytic water treatment processes, and in sensor technologies. Endohedral metallofullerenes, in particular, can possess unpaired electron spins, driven by the enclosed metal atom or cluster, which yield valuable magnetic properties. These properties have significant potential for applications in molecular magnets, spin probes, quantum computing, and devices such as quantum information processing,, atomic clocks, and molecular magnets. 
  • 1.9K
  • 02 Feb 2024
Biography
Miguel Ángel Fernández Sanjuán
Miguel Angel Fernández Sanjuán (Miguel A. F. Sanjuán) is a Spanish Theoretical Physicist from Leon, Spain. He is known for his contributions in nonlinear dynamics, chaos theory, and control of chaos,[1] and has published several scientific papers and popular news articles. He has supervised around 20 PhD students in Nonlinear Dynamics, Chaos and Complex Systems. He was a Professor at the U
  • 1.9K
  • 29 Nov 2022
Topic Review
Pharmacological Activities of E. ferox
Euryale ferox Salisb. (prickly water lily) is the only extent of the genus Euryale that has been widely distributed in China, India, Korea, and Japan. The seeds of E. ferox (EFS) have been categorized as superior food for 2000 years in China, based on their abundant nutrients including polysaccharides, polyphenols, sesquineolignans, tocopherols, cyclic dipeptides, glucosylsterols, cerebrosides, and triterpenoids. These constituents exert multiple pharmacological effects, such as antioxidant, hypoglycemic, cardioprotective, antibacterial, anticancer, antidepression, and hepatoprotective properties. 
  • 1.9K
  • 01 Jun 2023
Topic Review
September 5: Rudolf Virchow Died
Rudolf Ludwig Carl Virchow (13 October 1821 – 5 September 1902) was a renowned German physician, pathologist, anthropologist, and statesman, widely celebrated as the "Father of Modern Pathology." Born in Schivelbein, Prussia (now Świdwin, Poland), he revolutionized medicine by establishing that diseases originate at the cellular level, famously declaring that "every cell arises from another existing cell." Beyond his scientific achievements, Virchow was a dedicated public health reformer and politician, advocating for social medicine and significantly improving Berlin's sanitation systems. He passed away in Berlin at the age of 80.
  • 1.9K
  • 05 Sep 2025
Topic Review
Polyphenolic Compounds in Wine/Beer
Phenolic compounds present in beer and wine have shown high antioxidant and anti-inflammatory features, and in the last decades beneficial effects on human health due to moderate beer and wine consumption have been indicated by many research studies. Due to the different used raw material and technological processes, there are differences between wine and beer in the presence, as well in the concentrations, of phenolic substances. It was shown that some polyphenol classes can only be found in beer (chalcones and flavanones) and other are mainly found in wine (stilbenes, proanthocyanidins), while flavanols and flavan-3-ols are found in similar concentrations in both beverages. Both beverages represent natural fermented products, and minor changes within the growth of raw material and clime conditions, as well as within the used technology, will impact the final chemical composition of these products. The brewing industry and winemakers put a lot of effort in obtaining a final product that will be unique, with more potent antioxidant activity, and with satisfying sensory characteristics, to attract consumers, who are now more aware of alcoholic beverages influence on human health. From the winemaker's point of view, the aim is to produce wine that will satisfy all required safety conditions, and with this added value, and at the same time attempting not to increase the costs. In the brewing industry, besides changing hopping regimes and influencing other technology phases, craft breweries that have expanded rapidly all over the world, are doing their best to produce authentic beer, in terms of flavor and in same time improving the antioxidant capacity. Both industries should consider changes in clime conditions, and research on new modified technologies is always an open issue, like the use of some by-products and additives within the production.
  • 1.9K
  • 18 Nov 2020
Topic Review
Exchange Bias
The exchange bias (EB) is an effect occurring in coupled ferromagnetic/antiferromagnetic materials of diverse shapes, from core–shell nanoparticles to stacked nanostructures and thin films.
  • 1.9K
  • 18 Feb 2021
Topic Review
FNDC5/Irisin
Irisin is a portion of the cell membrane protein known as FNDC5 (FNDC5 Fibronectin type III domain-containing protein 5). FNDC5 consists of a signal peptide, a fibronectin III domain, and a C-terminal domain. FNDC5 comprises 209 amino acid residues, having a signal sequence of 29 amino acids at the N-terminal end, followed by a 94-amino-acid residue fibronectin III (FNIII) 2 domains (irisin domain), a linking peptide comprising 28 amino acid residues, a 19-amino-acid residue transmembrane domain, and a cytoplasmic domain consisting of 39 amino acid residues.
  • 1.9K
  • 04 Mar 2022
Topic Review
Sertraline in Hemodialysis Patients
Depression and anxiety are the most common psychiatric disorders in end-stage renal disease (ESRD) patients treated with hemodialysis (HD) and may correlate with lower quality of life and increased mortality. Depression treatment in HD patients is still a challenge both for nephrologists and psychiatrists. The possible treatment of depressive disorders can be pharmacological and non-pharmacological. In our article, we focus on the use of sertraline, the medication which seems to be relatively safe and efficient in the abovementioned population, taking under consideration several limitations regarding the use of other selective serotonin reuptake inhibitors (SSRIs).
  • 1.9K
  • 23 Sep 2021
Topic Review
Pistachio as a Regular Food
The pistachio is regarded as a relevant source of biologically active components that, compared to other nuts, possess a healthier nutritional profile with low-fat content composed mainly of monounsaturated fatty acids, a high source of vegetable protein and dietary fibre, remarkable content of minerals, especially potassium, and an excellent source of vitamins, such as vitamins C and E. A rich composition in terms of phytochemicals, such as tocopherols, carotenoids, and, importantly, phenolic compounds, makes pistachio a powerful food to explore its involvement in the prevention of prevalent pathologies. 
  • 1.9K
  • 29 Sep 2022
Topic Review
Commercial Antimicrobial Wound Dressings Based on Polyhexanide-Releasing Membranes
The prevalence of chronic, non-healing skin wounds in the general population, most notably diabetic foot ulcers, venous leg ulcers and pressure ulcers, is approximately 2% and is expected to increase, driven mostly by the aging population and the steady rise in obesity and diabetes. Non-healing wounds often become infected, increasing the risk of life-threatening complications, which poses a significant socioeconomic burden. Aiming at an improved management of infected wounds, a variety of wound dressings that release the antiseptic polyhexanide (poly(hexamethylene biguanide); PHMB), has been introduced in the wound-care market. An overview of the main characteristics and applications of PHMB and of the main fabrication methods and characteristics of commercial PHMB-releasing wound dressings is presented.
  • 1.9K
  • 05 Jan 2023
Topic Review
Cytoplasmic Actin Mutations
Cytoplasmic actins are abundant molecules in non-muscle cells, including white blood cells. Two forms exist which are referred to as beta- or gamma-cytoplasmic actin encoded by ACTB and ACTG1, respectively. They form the building blocks of the dynamic actin polymers of the cytoskeleton that are involved in migration and motility processes of cells. Whereas mutations in cytoplasmic actins have been discovered in congenital diseases, their prevalence in cancer types has not been studied in detail. We show that within hematological cancer cytoplasmic actin mutations occur with higher frequency in two specific subtypes. Beta-actin mutations occur mainly in the subtype diffuse large B-cell lymphoma or DLBCL whereas gamma-actin mutations occur mainly in multiple myeloma. Mapping these mutations on the three dimensional structure reveals they map to regions of actin that are important in actin polymer formation and, for gamma-actin also for myosin interaction. Given their occurrence in these functionally important regions, their role as potential driver mutations or in disease progression merits further investigation.
  • 1.9K
  • 28 Oct 2020
Topic Review
Entosis and Cell Adhesion
Entosis is a phenomenon, in which one cell enters a second one. New clinico-histopathological studies of entosis prompted us to summarize its significance in cancer. It appears that entosis might be a novel, independent prognostic predictor factor in cancer histopathology. We briefly discuss the biological basis of entosis, followed by a summary of published clinico-histopathological studies on entosis significance in cancer prognosis. The correlation of entosis with cancer prognosis in head and neck squamous cell carcinoma, anal carcinoma, lung adenocarcinoma, pancreatic ductal carcinoma and breast ductal carcinoma, is shown. Numerous entotic figures are associated with a more malignant cancer phenotype and poor prognosis in many cancers. We also showed that some anticancer drugs could induce entosis in cell culture, even as an escape mechanism. Thus, entosis is likely beneficial for survival of malignant cells, i.e., an entotic cell can hide from unfavourable factors in another cell and subsequently leave the host cell remaining intact, leading to failure in therapy or cancer recurrence. Finally, we highlight the potential relationship of cell adhesion with entosis in vitro, based on the model of the BxPc3 cells cultured in full adhesive conditions, comparing them to a commonly used MCF7 semiadhesive model of entosis.
  • 1.9K
  • 08 Sep 2020
Topic Review
TCES Systems Based on Hydroxides
The exploitation of solar energy, an unlimited and renewable energy resource, is of prime interest to support the replacement of fossil fuels by renewable energy alternatives. Solar energy can be used via concentrated solar power (CSP) combined with thermochemical energy storage (TCES) for the conversion and storage of concentrated solar energy via reversible solid–gas reactions, thus enabling round the clock operation and continuous production. This entry is about High-temperature thermochemical energy storage using the enthalpy of reversible reactions.
  • 1.9K
  • 19 Dec 2020
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