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Topic Review
Role of Innovation in Sustainable Development
Innovation and innovative activity are powerful tools for increasing the competitiveness of enterprises, regions, and countries. The level of innovative activity is an excellent indicator of a country’s efforts towards sustainable development and its ability to be up to date. Innovations are fundamental tools for high-tech product manufacturing and technological improvement in industries. This theme is deeply developed by world organisations and agencies and presents increasing evidence in academic and scientific spheres.
  • 1.5K
  • 08 Aug 2023
Topic Review
14-3-3σ and Its Modulators
14-3-3σ is an acidic homodimer protein with more than one hundred different protein partners associated with oncogenic signaling and cell cycle regulation. 
  • 1.5K
  • 18 May 2021
Topic Review
Beta
In finance, the beta (β or market beta or beta coefficient) is a measure of how an individual asset moves (on average) when the overall stock market increases or decreases. Thus, beta is a useful measure of the contribution of an individual asset to the risk of the market portfolio when it is added in small quantity. Thus, beta is referred to as an asset's non-diversifiable risk, its systematic risk, market risk, or hedge ratio. Beta is not a measure of idiosyncratic risk.
  • 1.5K
  • 07 Nov 2022
Topic Review
Senile Osteoporosis by BMSCs
Senile osteoporosis has become a worldwide bone disease with the aging of the world population. Unlike postmenopausal osteoporosis which is linked to menopause in women, senile osteoporosis is due to aging, hence, affecting both men and women. Evidence has shown that with age increase, bone marrow stromal cells (BMSCs) differentiate into more adipocytes rather than osteoblasts and undergo senescence, which leads to decreased bone formation and contributes to senile osteoporosis. Therefore, modulating BMSCs to stimulate them either differentiate into more osteoblasts than adipocytes or eliminate their senescence will be wonderful strategies for treating senile osteoporosis. Here, the treatment of senile osteoporosis by aiming at BMSCs is introduced.
  • 1.5K
  • 01 Nov 2020
Topic Review
Spinal Muscular Atrophy
Spinal muscular atrophy (SMA) is a congenital neuromuscular disorder characterized by motor neuron loss, resulting in progressive weakness. SMA is notable in the health care community because it accounts for the most common cause of infant death resulting from a genetic defect. SMA is caused by low levels of the survival motor neuron protein (SMN) resulting from SMN1 gene mutations or deletions. However, patients always harbor various copies of SMN2, an almost identical but functionally deficient copy of the gene. A genotype–phenotype correlation suggests that SMN2 is a potent disease modifier for SMA, which also represents the primary target for potential therapies. Increasing comprehension of SMA pathophysiology, including the characterization of SMN1 and SMN2 genes and SMN protein functions, has led to the development of multiple therapeutic approaches. Until the end of 2016, no cure was available for SMA, and management consisted of supportive measures. Two breakthrough SMN-targeted treatments, either using antisense oligonucleotides (ASOs) or virus-mediated gene therapy, have recently been approved. These two novel therapeutics have a common objective: to increase the production of SMN protein in MNs and thereby improve motor function and survival. However, neither therapy currently provides a complete cure. Treating patients with SMA brings new responsibilities and unique dilemmas. As SMA is such a devastating disease, it is reasonable to assume that a unique therapeutic solution may not be sufficient. Current approaches under clinical investigation differ in administration routes, frequency of dosing, intrathecal versus systemic delivery, and mechanisms of action. Besides, emerging clinical trials evaluating the efficacy of either SMN-dependent or SMN-independent approaches are ongoing.
  • 1.5K
  • 30 Oct 2020
Topic Review
Polarization-Sensitive Digital Holographic Imaging
Polarization-sensitive digital holographic imaging (PS-DHI) is a recent imaging technique based on interference among several polarized optical beams. PS-DHI allows simultaneous quantitative three-dimensional reconstruction and quantitative evaluation of polarization properties of a given sample with micrometer scale resolution. Since this technique is very fast and does not require labels/markers, it finds application in several fields, from biology to microelectronics and micro-photonics.
  • 1.5K
  • 10 Aug 2020
Topic Review
MDM2 Amplified Sarcomas
Murine Double Minute Clone 2, located at 12q15, is an oncogene that codes for an oncoprotein of which the association with p53 was discovered 30 years ago. The most important function of MDM2 is to control p53 activity. The sarcomas that typically have an amplification of MDM2.
  • 1.5K
  • 29 Apr 2021
Topic Review
Pharmaceutical Removal on Wastewater
Pharmaceuticals enhance our quality of life; consequently, their consumption is growing as a result of the need to treat ageing-related and chronic diseases and changes in the clinical practice. The market revenues also show an historic growth worldwide motivated by the increase on the drug demand. However, this positivism on the market is fogged because the discharge of pharmaceuticals and their metabolites into the environment, including water, also increases due to their inappropriate management, treatment and disposal; now, worldwide, this fact is recognized as an environmental concern and human health risk. 
  • 1.5K
  • 08 May 2021
Topic Review
Applications of Nanominerals in Ruminants
A novel approach in livestock production is applying nanominerals, especially selenium (Se) and zinc (Zn), which can serve as a platform to incorporate these elements into the body. This approach enables direct transportation of active compounds to target organs, avoiding their fast degradability and encouraging several health benefits.
  • 1.5K
  • 09 Jul 2021
Topic Review
Natural Products from Actinomycetes of Marine Organisms
The actinomycetes have proven to be a rich source of bioactive secondary metabolites and play a critical role in the development of pharmaceutical researches. With interactions of host organisms and having special ecological status, the actinomycetes associated with marine animals, marine plants, macroalgae, cyanobacteria, and lichens have more potential to produce active metabolites acting as chemical defenses to protect the host from predators as well as microbial infection. This entry focuses on 536 secondary metabolites (SMs) from actinomycetes associated with these marine organisms covering the literature to mid-2021, which will highlight the taxonomic diversity of actinomycetes and the structural classes, biological activities of SMs. Among all the actinomycetes listed, members of Streptomyces (68%), Micromonospora (6%), and Nocardiopsis (3%) are dominant producers of secondary metabolites. Additionally, alkaloids (37%), polyketides (33%), and peptides (15%) comprise the largest proportion of natural products with mostly antimicrobial activity and cytotoxicity. Furthermore, the data analysis and clinical information of SMs have been summarized in this article, suggesting that some of these actinomycetes with multiple host organisms deserve more attention to their special ecological status and genetic factors.
  • 1.5K
  • 22 Nov 2021
Topic Review
Lonomia obliqua Envenoming
The hemorrhagic syndrome is one of the most serious complications in patients who have  been in contact with the Lonomia caterpillar bristles. Although 26 species of the genus Lonomia (Saturniidae family) are distributed in the American continent, the most studied species are L. obliqua and L. achelous caterpillars; both are capable of inducing hemorrhagic effects in humans. Envenoming by L. obliqua caterpillars was considered a public health problem in southern Brazil. The hemostatic disturbances observed in the envenoming by L. obliqua caterpillars, result in a consumption coagulopathy, resembling a disseminated intravascular coagulation (DIC) and secondary fibrinolysis, which can lead to the hemorrhagic syndrome. The main complication of L. obliqua envenomation is acute renal failure, which can occur in up to 12% of the cases, being frequent in patients over 45 years old and in those with heavy bleeding. Besides that, some deaths related to hemorrhage and renal failure have been reported. However, the early diagnosis and proper treatment with  antilonomic serum (ALS), produced by the Butantan Institute (SP/Brazil), within 12 h of contact can prevent severe coagulopathy and hemorrhage events. 
  • 1.5K
  • 22 Dec 2021
Topic Review
Cathodoluminescence of Diamond
Cathodoluminescence (CL) microscopy revealed heterogeneities in diamonds in a very detailed manner with high spatial resolution.
  • 1.5K
  • 21 Jan 2022
Topic Review
Nuclear Envelope Integrity in Health and Disease
The dynamic nature of the nuclear envelope (NE) is often underestimated. The NE morphology is characterized by a wide range of diversity and abnormality such as invagination and blebbing, and it is a diagnostic factor for pathologies such as cancer.
  • 1.5K
  • 15 Feb 2022
Topic Review
Religion and Health in Macau
Macau, a Portuguese colony until 1999, remains a diversified culture because of its intermixed historical background from the East and the West. Through structural equation modelling, the analysis of data collected from a representative sample of Macau residents, using a multistage stratified sampling procedure, indicated a positive link between religiosity and health. Moreover, altruism and prejudice mediated a portion of the relationship between religiosity and health. Additionally, Macau residents who were more religious had a higher level of altruism and a lower level of prejudice. The link between religion and prejudice in Macau differs from that of many other cultures, indicating that the effect of religion on prejudice varies by cultural context.
  • 1.5K
  • 14 Sep 2022
Topic Review
Biomarkers in Veterinary Medicine
New biomarkers promise to transform veterinary practice through rapid diagnosis of diseases, effective monitoring of animal health and improved welfare and production efficiency. However, the road from biomarker discovery to translation is not always straightforward. The use of biomarkers has been identified as an increasing trend in the animal health industry and has been applied to the evaluation of a variety of health parameters. In particular, it is useful in clinical applications such as diagnosing illness, predicting and/or tracking the response to treatment, and determining the toxicity or failure of an organ.
  • 1.5K
  • 02 Sep 2022
Topic Review
Bloodstream Infections
Bloodstream infections (BSIs), which include bacteremias when the infections are bacterial and fungemias when the infections are fungal, are infections present in the blood. Blood is normally a sterile environment, so the detection of microbes in the blood (most commonly accomplished by blood cultures) is always abnormal. A bloodstream infection is different from sepsis, which is the host response to bacteria. Bacteria can enter the bloodstream as a severe complication of infections (like pneumonia or meningitis), during surgery (especially when involving mucous membranes such as the gastrointestinal tract), or due to catheters and other foreign bodies entering the arteries or veins (including during intravenous drug abuse). Transient bacteremia can result after dental procedures or brushing of teeth. Bacteremia can have several important health consequences. The immune response to the bacteria can cause sepsis and septic shock, which has a high mortality rate. Bacteria can also spread via the blood to other parts of the body (which is called hematogenous spread), causing infections away from the original site of infection, such as endocarditis or osteomyelitis. Treatment for bacteremia is with antibiotics, and prevention with antibiotic prophylaxis can be given in high risk situations.
  • 1.5K
  • 29 Sep 2022
Topic Review
Stone Runs of Weddell Island
Weddell Island (Spanish: Isla San José) is one of the Falkland Islands in the South Atlantic, lying off the southwest extremity of West Falkland. It is situated 1,545 km (960 mi) west-northwest of South Georgia Island, 1,165 km (724 mi) north of Livingston Island, 606 km (377 mi) northeast of Cape Horn, 358 km (222 mi) northeast of Isla de los Estados, and 510 km (320 mi) east of the Atlantic entrance to Magellan Strait. With an area of 265.8 km2 (102.6 sq mi) Weddell is the third largest island in the archipelago after East Falkland and West Falkland, and one of the largest private islands in the world. It has only one inhabited location, Weddell Settlement, with a single digit population engaged in sheep farming and tourism services. The island offers walks to wildlife watching sites and scenery destinations including some spectacular landscapes featuring the famous Falklands stone runs. Weddell is both an Important Plant Area and a priority Key Biodiversity Area. It is a remote place, infrequently visited by a resupply ship and occasionally by private yachts, accessible by air with a short (some 200 km (120 mi)) if expensive flight from the Falklands capital, Stanley.
  • 1.5K
  • 07 Nov 2022
Biography
Jason Halbert
Jason Halbert (born June 3, 1974) is an American producer, music director,[1][2] musician, engineer and songwriter.[3] He has been Kelly Clarkson's music director since 2003, shortly after her American Idol win.[2][4] He has also served as music director for Nick Carter (musician), Clay Aiken, Justin Guarini[5] in addition to touring as keyboardist for Paulina Rubio and Reba McEntire.[6][7][8][9
  • 1.5K
  • 21 Nov 2022
Topic Review
Drying Biomass Using Solar Energy
In the world, energy used for drying processes consumes 7–15% of industrial energy. Therefore, the cost of this energy is a crucial challenge to looking for an alternative source of energy, for example, solar energy. Solar energy is available in almost all the world, is free and provides a clean and free pollution energy source. Furthermore, solar energy has a higher development potential than other alternative energy sources, such as the ocean, biomass and geothermal.
  • 1.5K
  • 28 Dec 2022
Topic Review
Control and Prevention Strategies of Vibrios in Asia
It is estimated that vibriosis account for about half of the economic losses in Asian fish culture. Consequently, the prevention and control of vibriosis is one of the priority research topics in the field of Asian fish culture disease. Relevant measures have been proposed to control some Vibrios that pose a threat to Asian fish culture, there are currently only a few effective vaccines available to combat these Vibrios.
  • 1.5K
  • 12 Jan 2023
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