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Topic Review
Properties of Moringa Oleifera Seeds
Because the seeds of Moringa Oleifera contain a water-soluble cationic coagulant protein, they are used as a primary coagulant in drinking water clarification and wastewater treatment through their ability to reduce the turbidity of treated water. These proteins are considered the most widely investigated plant-based coagulant, having been researched by several scholars.The seeds of Moringa Oleifera possess good coagulating properties comparable to commercial alum used in turbidity removal.
  • 1.5K
  • 08 Mar 2023
Topic Review
Microgrids in Harbor
Energy efficiency and low-carbon energy systems are increasingly taken into account in seaports, due to climate change challenges and the evolution of environmental regulations. Thus, technological breakthroughs must be brought to numerous systems in harbors, such as harbor cranes, seaport vehicles, or the power supply of berthed vessels. These aspects may require the establishment of a microgrid in the harbor area. Microgrids have been subjected to a wide development on the mainland and islands, mostly for domestic loads. However, these are still scarce in harbor areas. Their development in such places faces several challenges, such as high power requirements, monitoring and management of a wide range of loads, energy policy framework, etc. Moreover, the establishment of a microgrid involves a study of sizing and of energy management, to avoid prohibitive costs and to verify load requirements.
  • 1.5K
  • 27 Oct 2020
Topic Review
Interleukin-6
Interleukin-6 (IL-6) is a cytokine of a pro-inflammatory nature, and it can be produced by various cell types of the immune system as well as by some nonimmune cells, including fibroblasts. IL-6 is cytokine important for the initial phase of immune response that is recognized by 2 types of receptor. Overproduction of IL-6 is associated with aging, chronic inflammation, cancer and severe viral infections such is COVID-19.  This molecule is not produced by immune cells but also by cancer-associated fibroblasts and cancer cells. Control of its production or inhibition of IL-6 receptors could have the therapeutic consequences. 
  • 1.5K
  • 26 Nov 2020
Topic Review
Interstitial Atom Engineering
Interstitial light elements play an important role in magnetic materials. Especially, Mn-based compounds with interstitial atoms are important for the easy fabrication of highly functional magnetic devices.
  • 1.5K
  • 11 Dec 2020
Topic Review
Bannayan-Riley-Ruvalcaba Syndrome
Bannayan-Riley-Ruvalcaba syndrome is a genetic condition characterized by a large head size (macrocephaly), multiple noncancerous tumors and tumor-like growths called hamartomas, and dark freckles on the penis in males. The signs and symptoms of Bannayan-Riley-Ruvalcaba syndrome are present from birth or become apparent in early childhood.
  • 1.5K
  • 24 Dec 2020
Topic Review
Extracellular vesicles from adipose-derived stem-cells
Adipose tissue-derived stem cells (ADSCs) are pluripotent mesenchymal stem cells found in relatively high percentages in the adipose tissue and able to self-renew and differentiate into many different types of cells. Extracellular vesicles (EVs), small membrane vesicular structures released during cell activation, senescence, or apoptosis, act as mediators for long distance communication between cells, transferring their specific bioactive molecules into host target cells.  Metabolic syndrome and type 2 diabetes mellitus (T2DM) are mainly caused by abnormal adipose tissue size, distribution and metabolism and so ADSCs and their secretory factors such as EVs are currently investigated as therapeutics in these diseases. Here we provide a comprehensive summary of the current knowledge on EVs secreted from ADSCs both as diagnostic biomarkers and therapeutics in diabetes and associated cardiovascular disease, the molecular mechanisms involved, as well as on the use of ADSC differentiation potential in cardiovascular tissue repair and prostheses.
  • 1.5K
  • 06 Jan 2021
Topic Review
Techniques for Antifungal Combinations
The general approach of studying antifungal combinations is (i) to choose an experimental technique, (ii) to obtain raw numerical data, (iii) to analyze these data either graphically or numerically; (iv) to interpret the results, and (v) to conclude on the mode of interaction: synergy, indifference (no interaction), or antagonism.
  • 1.5K
  • 25 Mar 2021
Topic Review
Specialty Cut Flowers
The objective of the study was to give an overview of the specialty cut flowers, their advantages and disadvantages and comparisons to the traditionally grown plants. 
  • 1.5K
  • 30 Apr 2021
Topic Review
Ras Proteins
Ras proteins are essential mediators of a multitude of cellular processes, and its deregulation is frequently associated with cancer appearance, progression, and metastasis. Ras-driven cancers are usually aggressive and difficult to treat. Although the recent Food and Drug Administration (FDA) approval of the first Ras G12C inhibitor is an important milestone, only a small percentage of patients will benefit from it.
  • 1.5K
  • 10 Sep 2021
Topic Review
Dendritic Spine
Dendritic spines are small, bulbous protrusions along neuronal dendrites where most of the excitatory synapses are located. Dendritic spine density in normal human brain increases rapidly before and after birth achieving the highest density around 2–8 years. Density decreases during adolescence, reaching a stable level in adulthood. The changes in dendritic spines are considered structural correlates for synaptic plasticity as well as the basis of experience-dependent remodeling of neuronal circuits. Alterations in spine density correspond to aberrant brain function observed in various neurodevelopmental and neuropsychiatric disorders. Dendritic spine initiation affects spine density. In this review, we discuss the importance of spine initiation in brain development, learning, and potential complications resulting from altered spine initiation in neurological diseases. Current literature shows that two Bin Amphiphysin Rvs (BAR) domain-containing proteins, MIM/Mtss1 and SrGAP3, are involved in spine initiation. We review existing literature and open databases to discuss whether other BAR-domain proteins could also take part in spine initiation. Finally, we discuss the potential molecular mechanisms on how BAR-domain proteins could regulate spine initiation. 
  • 1.5K
  • 24 Sep 2021
Topic Review
NF-κB-Dependent and -Independent IκBα Functions
IκBα is considered to play an almost exclusive role as inhibitor of the NF-κB signaling pathway. However, previous results have demonstrated that SUMOylation imposes a distinct subcellular distribution, regulation, NF-κB-binding affinity and function to the IκBα protein. In this review we discuss the main alterations of IκBα found in cancer and whether they are (most likely) associated with NF-κB-dependent or NF-κB-independent (moonlighting) activities of the protein.
  • 1.5K
  • 19 Oct 2021
Topic Review
Recent Advances in Wind Turbine Noise Research
A review of current research on many aspects of wind turbine noise generation and propagation, as well as its effects on humans and fauna has been undertaken. Research areas considered include turbine noise generation, turbine designs to minimize noise generation, noise propagation to surrounding communities, effects of noise on surrounding communities (including fauna) and regulation (including compliance checking).
  • 1.5K
  • 09 Dec 2021
Topic Review
“Brick-and-Mortar” Composites Made of 2D Carbon Nanoparticles
Among all biomimetic materials, nacre has drawn great attention from the scientific community, thanks to superior levels of strength and toughness and its brick-and-mortar (B&M) architecture. However, achieving the desired performances is challenging since the mechanical response of the material is influenced by many factors, such as the filler content, the matrix molecular mobility and the compatibility between the two phases. Most importantly, the properties of a macroscopic bulk material strongly depend on the interaction at atomic levels and on their synergetic effect. In particular, the formation of highly-ordered brick-and-mortar structures depends on the interaction forces between the two phases. Consequently, poor mechanical performances of the material are associated with interface issues and low stress transfer from the matrix to the nanoparticles. Therefore, improvement of the interface at the chemical level enhances the mechanical response of the material. 
  • 1.5K
  • 27 Apr 2022
Topic Review
Rating Site
A rating site (less commonly, a rate-me site) is a website designed for users to vote on or rate people, content, or other things. Rating sites are typically organized around attributes such as physical appearance, body parts, voice, personality, etc. They may also be devoted to the subjects' occupational ability, for example teachers, professors, lawyers, doctors, etc.
  • 1.5K
  • 19 Oct 2022
Topic Review
Hypoxia (Medical)
Hypoxia is a condition in which the body or a region of the body is deprived of adequate oxygen supply at the tissue level. Hypoxia may be classified as either generalized, affecting the whole body, or local, affecting a region of the body. Although hypoxia is often a pathological condition, variations in arterial oxygen concentrations can be part of the normal physiology, for example, during hypoventilation training or strenuous physical exercise. Hypoxia differs from hypoxemia and anoxemia in that hypoxia refers to a state in which oxygen supply is insufficient, whereas hypoxemia and anoxemia refer specifically to states that have low or zero arterial oxygen supply. Hypoxia in which there is complete deprivation of oxygen supply is referred to as anoxia. Generalized hypoxia occurs in healthy people when they ascend to high altitude, where it causes altitude sickness leading to potentially fatal complications: high altitude pulmonary edema (HAPE) and high altitude cerebral edema (HACE). Hypoxia also occurs in healthy individuals when breathing mixtures of gases with a low oxygen content, e.g. while diving underwater especially when using closed-circuit rebreather systems that control the amount of oxygen in the supplied air. Mild, non-damaging intermittent hypoxia is used intentionally during altitude training to develop an athletic performance adaptation at both the systemic and cellular level. In acute or silent hypoxia, a person's oxygen level in blood cells and tissue can drop without any initial warning, even though the individual's chest x-ray shows diffuse pneumonia with an oxygen level below normal. Doctors report cases of silent hypoxia with COVID-19 patients who did not experience shortness of breath or coughing until their oxygen levels had plummeted to such a degree that the patients risked acute respiratory distress (ARDS) and organ failure. In a The New York Times opinion piece (April 20, 2020), emergency room doctor Richard Levitan reports: "A vast majority of Covid pneumonia patients I met had remarkably low oxygen saturations at triage—seemingly incompatible with life—but they were using their cellphones as we put them on monitors." Hypoxia is a common complication of preterm birth in newborn infants. Because the lungs develop late in pregnancy, premature infants frequently possess underdeveloped lungs. To improve lung function, doctors frequently place infants at risk of hypoxia inside incubators (also known as humidicribs) that provide warmth, humidity, and oxygen. More serious cases are treated with CPAP. The 2019 Nobel Prize in Physiology or Medicine was awarded to William G. Kaelin Jr., Sir Peter J. Ratcliffe, and Gregg L. Semenza in recognition of their discovery of cellular mechanisms to sense and adapt to different oxygen concentrations, establishing a basis for how oxygen levels affect physiological function.
  • 1.5K
  • 01 Dec 2022
Topic Review
Biomedical Applications of Microfluidic Devices
Both passive and active microfluidic chips are used in many biomedical and chemical applications to support fluid mixing, particle manipulations, and signal detection. Passive microfluidic devices are geometry-dependent, and their uses are rather limited. Active microfluidic devices include sensors or detectors that transduce chemical, biological, and physical changes into electrical or optical signals. Also, they are transduction devices that detect biological and chemical changes in biomedical applications, and they are highly versatile microfluidic tools for disease diagnosis and organ modeling. Microfluidic devices are fabricated using a range of techniques, including molding, etching, three-dimensional printing, and nanofabrication. Their broad utility lies in the detection of diagnostic biomarkers and organ-on-chip approaches that permit disease modeling in cancer, as well as uses in neurological, cardiovascular, hepatic, and pulmonary diseases. Biosensor applications allow for point-of-care testing, using assays based on enzymes, nanozymes, antibodies, or nucleic acids (DNA or RNA). 
  • 1.5K
  • 02 Dec 2022
Topic Review
Soyuz TMA-03M
Soyuz TMA-03M was a spaceflight to the International Space Station (ISS). It launched on 21 December 2011 from Site One at the Baikonur Cosmodrome, Kazakhstan, carrying three members of Expedition 30 to the ISS. TMA-03M was the 112th flight of a Russian Soyuz spacecraft, since the first in 1967, and the third flight of the modernised Soyuz-TMA-M version. The docking with the International Space Station took place at 19:19 Moscow Time on 23 December, three minutes ahead of schedule. The crew were Oleg Kononenko (Russia , commander), André Kuipers (the Netherlands) and Donald Pettit (United States ). The Soyuz remained aboard the space station for the Expedition 30 increment to serve as an emergency escape vehicle if needed. The capsule used in the mission can be seen at the Space Expo visitors center at the European Space Research and Technology Centre in Noordwijk, Netherlands.
  • 1.5K
  • 05 Dec 2022
Topic Review
Java Transaction API
The Java Transaction API (JTA), one of the Java Enterprise Edition (Java EE) APIs, enables distributed transactions to be done across multiple X/Open XA resources in a Java environment. JTA is a specification developed under the Java Community Process as JSR 907. JTA provides for:
  • 1.5K
  • 05 Dec 2022
Biography
John McMullen
John J. McMullen, Ph.D (May 10, 1918 – September 16, 2005) was an American naval architect, businessman, and marine engineer, and former owner of the New Jersey Devils and Houston Astros. He founded the engineering firm John J. McMullen & Associates, and was the owner of Norton Lilly International[1] a shipping agent now based out of Mobile, Alabama, from 1972 until 2002.[2] McMullen was bo
  • 1.5K
  • 13 Dec 2022
Topic Review
Real-Time Polymerase Chain Reaction
Successful detection of the first SARS-CoV-2 cases using the real-time polymerase chain reaction (real-time PCR) method reflects the power and usefulness of this technique. Real-time PCR is a variation of the PCR assay to allow monitoring of the PCR progress in actual time. PCR itself is a molecular process used to enzymatically synthesize copies in multiple amounts of a selected DNA region for various purposes. Real-time PCR is one of the most powerful molecular approaches and is widely used in biological sciences and medicine because it is quantitative, accurate, sensitive, and rapid. Applications of real-time PCR include gene expression analysis, mutation detection, detection and quantification of pathogens, detection of genetically modified organisms, detection of allergens, monitoring of microbial degradation, species identification, and determination of parasite fitness. The technique has been used as a gold standard for COVID-19 diagnosis. Modifications of the standard real-time PCR methods have also been developed for particular applications. 
  • 1.5K
  • 26 Dec 2022
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