Your browser does not fully support modern features. Please upgrade for a smoother experience.
Submitted Successfully!
Thank you for your contribution! You can also upload a video entry or images related to this topic. For video creation, please contact our Academic Video Service.
Version Summary Created by Modification Content Size Created at Operation
1 handwiki Vivi Li -- 2037 2022-09-29 01:40:36

Video Upload Options

We provide professional Academic Video Service to translate complex research into visually appealing presentations. Would you like to try it?
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
HandWiki. Bloodstream Infections. Encyclopedia. Available online: https://encyclopedia.pub/entry/28010 (accessed on 20 September 2026).
HandWiki. Bloodstream Infections. Encyclopedia. Available at: https://encyclopedia.pub/entry/28010. Accessed September 20, 2026.
HandWiki. "Bloodstream Infections" Encyclopedia, https://encyclopedia.pub/entry/28010 (accessed September 20, 2026).
HandWiki. (2022, September 29). Bloodstream Infections. In Encyclopedia. https://encyclopedia.pub/entry/28010
HandWiki. "Bloodstream Infections." Encyclopedia. Web. 29 September, 2022.
Bloodstream Infections
Edit

Bloodstream infections (BSIs), which include bacteremias when the infections are bacterial and fungemias when the infections are fungal, are infections present in the blood. Blood is normally a sterile environment, so the detection of microbes in the blood (most commonly accomplished by blood cultures) is always abnormal. A bloodstream infection is different from sepsis, which is the host response to bacteria. Bacteria can enter the bloodstream as a severe complication of infections (like pneumonia or meningitis), during surgery (especially when involving mucous membranes such as the gastrointestinal tract), or due to catheters and other foreign bodies entering the arteries or veins (including during intravenous drug abuse). Transient bacteremia can result after dental procedures or brushing of teeth. Bacteremia can have several important health consequences. The immune response to the bacteria can cause sepsis and septic shock, which has a high mortality rate. Bacteria can also spread via the blood to other parts of the body (which is called hematogenous spread), causing infections away from the original site of infection, such as endocarditis or osteomyelitis. Treatment for bacteremia is with antibiotics, and prevention with antibiotic prophylaxis can be given in high risk situations.

antibiotic prophylaxis osteomyelitis bloodstream infection

References

  1. Perez-Chaparro, P. J.; Meuric, V.; De Mello, G.; Bonnaure-Mallet, M. (2011-11-01). "[Bacteremia of oral origin]". Revue de Stomatologie et de Chirurgie Maxillo-Faciale 112 (5): 300–303. doi:10.1016/j.stomax.2011.08.012. ISSN 1776-257X. PMID 21940028.  https://dx.doi.org/10.1016%2Fj.stomax.2011.08.012
  2. Scott, Michael C. (2017-02-01). "Defining and Diagnosing Sepsis". Emergency Medicine Clinics of North America 35 (1): 1–9. doi:10.1016/j.emc.2016.08.002. ISSN 1558-0539. PMID 27908326.  https://dx.doi.org/10.1016%2Fj.emc.2016.08.002
  3. Cervera, Carlos; Almela, Manel; Martínez-Martínez, José A.; Moreno, Asunción; Miró, José M. (2009-01-01). "Risk factors and management of Gram-positive bacteraemia". International Journal of Antimicrobial Agents 34 Suppl 4: S26–30. doi:10.1016/S0924-8579(09)70562-X. ISSN 1872-7913. PMID 19931813.  https://dx.doi.org/10.1016%2FS0924-8579%2809%2970562-X
  4. Biedenbach, Douglas J.; Moet, Gary J.; Jones, Ronald N. (2004-09-01). "Occurrence and antimicrobial resistance pattern comparisons among bloodstream infection isolates from the SENTRY Antimicrobial Surveillance Program (1997-2002)". Diagnostic Microbiology and Infectious Disease 50 (1): 59–69. doi:10.1016/j.diagmicrobio.2004.05.003. ISSN 0732-8893. PMID 15380279.  https://dx.doi.org/10.1016%2Fj.diagmicrobio.2004.05.003
  5. Lowy, Franklin D. (1998-08-20). "Staphylococcus aureus Infections". New England Journal of Medicine 339 (8): 520–532. doi:10.1056/NEJM199808203390806. ISSN 0028-4793. PMID 9709046.  https://dx.doi.org/10.1056%2FNEJM199808203390806
  6. Schwartz, Brian (2016). Current Medical Diagnosis and Treatment 2017. New York: McGraw Hill. pp. Chapter 33. ISBN 978-1-25-958511-1. 
  7. Cohen-Poradosu, Ronit (2015). Harrison's Principles of Internal Medicine 19th Edition. New York: McGraw Hill. pp. Chapter 201. ISBN 978-0-07-180215-4. 
  8. Mayer, Robert (2015). Harrison's Principles of Internal Medicine 19th Edition. New York: McGraw Hill. pp. Chapter 110. ISBN 978-0-07-180215-4. 
  9. Arias, Cesar (2015). Harrison's Principles of Internal Medicine 19th Edition. New York: McGraw Hill. pp. Chapter 174. ISBN 978-0-07-180215-4. 
  10. Kasper, Dennis (2015). Harrison's Manual of Medicine. New York: McGraw Hill. pp. Chapter 87. ISBN 978-0-07-182852-9. 
  11. Gaynes, Robert; Edwards, Jonathan R.; National Nosocomial Infections Surveillance System (2005-09-15). "Overview of nosocomial infections caused by gram-negative bacilli". Clinical Infectious Diseases 41 (6): 848–854. doi:10.1086/432803. ISSN 1537-6591. PMID 16107985.  https://dx.doi.org/10.1086%2F432803
  12. Diekema, D. J.; Beekmann, S. E.; Chapin, K. C.; Morel, K. A.; Munson, E.; Doern, G. V. (2003-08-01). "Epidemiology and outcome of nosocomial and community-onset bloodstream infection". Journal of Clinical Microbiology 41 (8): 3655–3660. doi:10.1128/JCM.41.8.3655-3660.2003. ISSN 0095-1137. PMID 12904371.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=179863
  13. High, Kevin (2017). Geriatric Medicine and Gerontology 7th Edition. New York: McGraw Hill. pp. Chapter 125. ISBN 978-0-07-183345-5. 
  14. Luzzaro, F.; Viganò, E. F.; Fossati, D.; Grossi, A.; Sala, A.; Sturla, C.; Saudelli, M.; Toniolo, A. et al. (2002-12-01). "Prevalence and drug susceptibility of pathogens causing bloodstream infections in northern Italy: a two-year study in 16 hospitals". European Journal of Clinical Microbiology & Infectious Diseases 21 (12): 849–855. doi:10.1007/s10096-002-0837-7. ISSN 0934-9723. PMID 12525919.  https://dx.doi.org/10.1007%2Fs10096-002-0837-7
  15. Deen, Jacqueline; von Seidlein, Lorenz; Andersen, Finn; Elle, Nelson; White, Nicholas J.; Lubell, Yoel (2012-06-01). "Community-acquired bacterial bloodstream infections in developing countries in south and southeast Asia: a systematic review". The Lancet. Infectious Diseases 12 (6): 480–487. doi:10.1016/S1473-3099(12)70028-2. ISSN 1474-4457. PMID 22632186.  https://dx.doi.org/10.1016%2FS1473-3099%2812%2970028-2
  16. Peleg, Anton Y.; Hooper, David C. (2010-05-13). "Hospital-Acquired Infections Due to Gram-Negative Bacteria". The New England Journal of Medicine 362 (19): 1804–1813. doi:10.1056/NEJMra0904124. ISSN 0028-4793. PMID 20463340.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3107499
  17. Graff, Larissa R.; Franklin, Kristal K.; Witt, Lana; Cohen, Neal; Jacobs, Richard A.; Tompkins, Lucy; Guglielmo, B. Joseph (2002-02-15). "Antimicrobial therapy of gram-negative bacteremia at two university-affiliated medical centers". The American Journal of Medicine 112 (3): 204–211. doi:10.1016/s0002-9343(01)01092-0. ISSN 0002-9343. PMID 11893347.  https://dx.doi.org/10.1016%2Fs0002-9343%2801%2901092-0
  18. Brigden, M. L. (2001-02-01). "Detection, education and management of the asplenic or hyposplenic patient". American Family Physician 63 (3): 499–506, 508. ISSN 0002-838X. PMID 11272299.  http://www.worldcat.org/issn/0002-838X
  19. Agarwal, Anil; Aggarwal, Aditya N. (2016-08-01). "Bone and Joint Infections in Children: Acute Hematogenous Osteomyelitis". Indian Journal of Pediatrics 83 (8): 817–824. doi:10.1007/s12098-015-1806-3. ISSN 0973-7693. PMID 26096866.  https://dx.doi.org/10.1007%2Fs12098-015-1806-3
  20. Guay, David R. (2012-02-01). "Antimicrobial prophylaxis in noncardiac prosthetic device recipients". Hospital Practice 40 (1): 44–74. doi:10.3810/hp.2012.02.947. ISSN 2154-8331. PMID 22406882.  https://dx.doi.org/10.3810%2Fhp.2012.02.947
  21. "UpToDate". https://www.uptodate.com/contents/fever-without-a-source-in-children-3-to-36-months-of-age. 
  22. Coburn, Bryan; Morris, Andrew M.; Tomlinson, George; Detsky, Allan S. (2012-08-01). "Does This Adult Patient With Suspected Bacteremia Require Blood Cultures?". JAMA 308 (5): 502–11. doi:10.1001/jama.2012.8262. ISSN 0098-7484. PMID 22851117.  https://dx.doi.org/10.1001%2Fjama.2012.8262
  23. Hall, Keri K.; Lyman, Jason A. (2016-12-16). "Updated Review of Blood Culture Contamination". Clinical Microbiology Reviews 19 (4): 788–802. doi:10.1128/CMR.00062-05. ISSN 0893-8512. PMID 17041144.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1592696
  24. Holland, TL; Arnold, C; Fowler VG, Jr (1 October 2014). "Clinical management of Staphylococcus aureus bacteremia: a review.". JAMA 312 (13): 1330–41. doi:10.1001/jama.2014.9743. PMID 25268440.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4263314
  25. Seifert, Harald (2009-05-15). "The Clinical Importance of Microbiological Findings in the Diagnosis and Management of Bloodstream Infections" (in en). Clinical Infectious Diseases 48 (Supplement 4): S238–S245. doi:10.1086/598188. ISSN 1058-4838. PMID 19374579.  https://dx.doi.org/10.1086%2F598188
  26. "IDP200 Pathophysiology of Infectious Diseases, Fall 2004/2005 - Tufts OpenCourseWare". http://ocw.tufts.edu/Content/6/readings/207697. 
  27. Medical Microbiology, 27e. New York: McGraw-Hill Education. 2016. pp. Chapter 9. ISBN 9780-0-71-82498-9. 
  28. Sherris Medical Microbiology, 6e. New York: McGraw-Hill. 2014. pp. Infectious Diseases: Syndromes and Etiologies. ISBN 9780-0-7-181821-6. 
  29. Cohen-Poradosu, Ronit (2015). Harrison's Principles of Internal Medicine, 19e. New York: McGraw-Hill. pp. Chapter 201. ISBN 978-0-07-180215-4. 
  30. Forner, Lone; Larsen, Tove; Kilian, Mogens; Holmstrup, Palle (2006-06-01). "Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation" (in en). Journal of Clinical Periodontology 33 (6): 401–407. doi:10.1111/j.1600-051X.2006.00924.x. ISSN 1600-051X. PMID 16677328.  https://dx.doi.org/10.1111%2Fj.1600-051X.2006.00924.x
  31. Kaplan, MD, Lewis (2016-08-16). "Systemic Inflammatory Response Syndrome: Background, Pathophysiology, Etiology". Medscape. http://emedicine.medscape.com/article/168943-overview?pa=gdxcETkDmptKtfQmQBhj5R9jmxYFH11JUVmLoUSKvyQIfoYQZtZjDwqZOIoSMcqXd/sGPYa+ToEoLjuhFnUEHw==#a3. 
  32. Hooper, David (2016). Harrison's Principles of Internal Medicine 19th Edition. New York: McGraw Hill. pp. Chapter 170. ISBN 978-0-07-180215-4. 
  33. Liu, Catherine; Bayer, Arnold; Cosgrove, Sara E.; Daum, Robert S.; Fridkin, Scott K.; Gorwitz, Rachel J.; Kaplan, Sheldon L.; Karchmer, Adolf W. et al. (2011-02-01). "Clinical practice guidelines by the infectious diseases society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children". Clinical Infectious Diseases 52 (3): e18–55. doi:10.1093/cid/ciq146. ISSN 1537-6591. PMID 21208910.  https://dx.doi.org/10.1093%2Fcid%2Fciq146
  34. Russo, Thomas (2016). Harrison's Principles of Internal Medicine 19th Edition. New York: McGraw Hill. pp. Chapter 186. ISBN 978-0-07-180215-4. 
  35. Mermel, Leonard A.; Allon, Michael; Bouza, Emilio; Craven, Donald E.; Flynn, Patricia; O'Grady, Naomi P.; Raad, Issam I.; Rijnders, Bart J. A. et al. (2009-07-01). "Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America". Clinical Infectious Diseases 49 (1): 1–45. doi:10.1086/599376. ISSN 1537-6591. PMID 19489710.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4039170
More
Upload a video for this entry
Information
Subjects: Microbiology
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
View Times: 1.5K
Entry Collection: HandWiki
Revision: 1 time (View History)
Update Date: 29 Sep 2022
Notice
You are not a member of the advisory board for this topic. If you want to update advisory board member profile, please contact office@encyclopedia.pub.
OK
Confirm
Only members of the Encyclopedia advisory board for this topic are allowed to note entries. Would you like to become an advisory board member of the Encyclopedia?
Yes
No
${ textCharacter }/${ maxCharacter }
Submit
Cancel
There is no comment~
${ textCharacter }/${ maxCharacter }
Submit
Cancel
${ selectedItem.replyTextCharacter }/${ selectedItem.replyMaxCharacter }
Submit
Cancel
Confirm
Are you sure to Delete?
Yes No
Academic Video Service