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Topic Review
Data-Driven Fault Diagnosis Methods for Nuclear Power Plants
Fault diagnosis plays an important role in complex and safety-critical systems such as nuclear power plants (NPPs). With the development of artificial intelligence (AI), extensive research has been carried out for fast and efficient fault diagnosis based on data-driven algorithms.
  • 1.5K
  • 23 Feb 2023
Topic Review
The Golgi Associated Retrograde Protein Complex
The Golgi associated retrograde protein complex (GARP) is an evolutionarily conserved component of Golgi membrane trafficking machinery that belongs to the Complexes Associated with Tethering Containing Helical Rods (CATCHR) family.
  • 1.5K
  • 31 Mar 2023
Topic Review
Mood Stabilizers of  First and Second Generation
Mood stabilizers can be classified into two generations based on the chronology of their introduction into the psychiatric armamentarium. First-generation mood stabilizers (FGMS) such as lithium, valproates and carbamazepine were introduced in the years 1960-1970s. Second-generation mood stabilizers (SGMS) started in 1995, with a discovery of the mood-stabilizing properties of clozapine. The SGMS include atypical antipsychotics such as clozapine, olanzapine, quetiapine, aripiprazole, and risperidone as well as a new anticonvulsant drug, lamotrigine. Recently as a candidate for SGMS, a novel antipsychotic, lurasidone, has been suggested. Several other atypical antipsychotics and anticonvulsants, as well as memantine showed some usefulness in the treatment and prophylaxis of bipolar disorder; however, they have not fully met the author’s criteria for mood stabilizers. 
  • 1.5K
  • 19 May 2023
Topic Review
Cloud Battery Management System
Given the immense amount of battery data produced over its operational life, the scientific community is increasingly turning to cloud computing for data storage and analysis. This cloud-based digital solution presents a more flexible and efficient alternative to traditional methods that often require significant hardware investments. The integration of machine learning is becoming an essential tool for extracting patterns and insights from vast amounts of observational data. As a result, the future points towards the development of a cloud-based artificial intelligence (AI)-enhanced battery management system (BMS). This will notably improve the predictive and modeling capacity for long-range connections across various timescales, by combining the strength of physical process models with the versatility of machine learning techniques.
  • 1.5K
  • 07 Jun 2023
Topic Review
Fruits and Beverages as Functional Foods
It is largely accepted that the daily intake of fruits, vegetables, herbal products and derivatives is an added value in promoting human health, given their capacity to counteract oxidative stress markers and suppress uncontrolled pro-inflammatory responses. Given that, natural-based products seem to be a promising strategy to attenuate, or even mitigate, the development of chronic diseases, such as diabetes, and to boost the immune system.
  • 1.5K
  • 01 Aug 2023
Topic Review
Work-Related Hand Eczema in Healthcare Workers
Work-related skin diseases are among the most common work-related diseases, ranking second in frequency after musculoskeletal diseases. The majority of work-related skin diseases (80–95%) are contact dermatitis, which can be both irritant and allergic in nature. Lesions are most commonly described as hand eczema and occur as a result of contact with various substances (irritants and allergens) in the workplace. The term “eczema” is generally used to describe a group of skin lesions in which the skin is itchy, dry, and inflamed. However, the term eczema usually involves a non-specific clinical picture but is commonly used in real-life and medical settings when working with patients.
  • 1.5K
  • 07 Oct 2023
Topic Review
Electrochemical Biosensing of Dopamine Neurotransmitter
Neurotransmitters are biochemical molecules that transmit a signal from a neuron across the synapse to a target cell, thus being essential to the function of the central and peripheral nervous system. Dopamine is one of the most important catecholamine neurotransmitters since it is involved in many functions of the human central nervous system, including motor control, reward, or reinforcement. It is of utmost importance to quantify the amount of dopamine since abnormal levels can cause a variety of medical and behavioral problems. 
  • 1.5K
  • 17 Jun 2021
Topic Review
Plant Performance and Interaction with Microorganisms
Plant performance can be improved under adverse environmental conditions by integrated soil–water–plant solutions or integrated soil fertility and plant nutrient management. Microorganisms living in the soil, the rhizobiome, are distinguished from endophytes living inside plants.
  • 1.5K
  • 04 Jul 2022
Topic Review
Human iPSCs into Cardiomyocytes
Reprogramming of adult somatic cells into induced pluripotent stem cells (iPSCs) has revolutionized the complex scientific field of disease modeling and personalized therapy. Cardiac differentiation of human iPSCs into cardiomyocytes (hiPSC-CMs) has been used in a wide range of healthy and disease models by deriving CMs from different somatic cells. Unfortunately, hiPSC-CMs have to be improved because existing protocols are not completely able to obtain mature CMs recapitulating physiological properties of human adult cardiac cells. Therefore, improvements and advances able to standardize differentiation conditions are needed. Lately, evidences of an epigenetic memory retained by the somatic cells used for deriving hiPSC-CMs has led to evaluation of different somatic sources in order to obtain more mature hiPSC-derived CMs.
  • 1.5K
  • 23 Oct 2020
Topic Review
OmniSCV
OmniSCV is a tool for generating datasets of omnidirectional images with semantic and depth information. 
  • 1.5K
  • 30 Oct 2020
Topic Review
Fuzzy Algorithms in Multi-Motor Systems
Multi-motor systems are strong coupled multiple-input–multiple-output systems with independent or mechanically interconnected motors. The main objective in multi-motor drive control is to achieve synchronized operation of all motors in the system. In this paper, multi-motor systems are classified in accordance with their control demands. The review of recent research literature indicates that fuzzy algorithms are widely used in multi-motor control.
  • 1.5K
  • 13 Nov 2020
Topic Review
Tourette Syndrome
Tourette syndrome is a complex disorder characterized by repetitive, sudden, and involuntary movements or noises called tics. Tics usually appear in childhood, and their severity varies over time. In most cases, tics become milder and less frequent in late adolescence and adulthood.  
  • 1.5K
  • 23 Dec 2020
Topic Review
Epithelial–Mesenchymal Transition and Aging
Epithelial–Mesenchymal Transition (EMT) was first discovered during the transition of cells from the primitive streak during embryogenesis in chicks. 
  • 1.5K
  • 27 Apr 2021
Topic Review
New treatment strategies for β-thalassemia
Beta-thalassemia (β-thalassemia) is an autosomal recessive inherited disease characterized by decreased production of the β-globin chains of hemoglobin (Hb) A. The normal structure of HbA is two α- and two β-globin chains. Individuals with β-thalassemia are either homozygous or double heterozygotes for mutations in the β-globin gene.
  • 1.5K
  • 13 Jul 2021
Topic Review
Open MHC Class I Conformers
Open MHC-I conformers are mature fully glycosylated plasma membrane molecules (HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HLA-E, and CD1d in humans; H-2D, H-2L, and H-2K in mice) that have dissociated from the β2m light chain and the peptide. Given the flexibility and mobility of the α1 domain of the heavy chain, the open MHC-I conformers are free to interact with any nearby complementary amino acid sequences or peptides in a covalent and a non-covalent manner. Open MHC-I conformers are functional cis-trans structures capable of establishing physical cis-associations with themselves (i.e., homodimers), with other surface receptors (i.e., heterodimers), and shed into the extracellular milieu (i.e., soluble open conformers). In turn, the open conformers and the homodimers trans-interact with several receptors expressed by lymphomyeloid cells. Overall, the open MHC-I conformers impact cellular physiology and clinical and biomedical settings, including autoimmune responses, tumor escape, graft rejection, and neuronal development and cognition. 
  • 1.5K
  • 27 Oct 2021
Topic Review
Green Finance & Green Monetary Policy: Different Approaches
Strictly speaking, green finance is part of the broader concept of sustainable finance, a term that explicitly includes social issues, while climate finance is a narrower element of green finance. However, in practice, the distinction between sustainable and green finance and sustainable and green monetary policy is often not made but the terms are used synonymously. Hence, we follow this tradition and use the term green finance and green monetary policy to refer to both. Green finance and green monetary monetary policy are related to each other and can be classified on a common ground. In general, neoliberal, reformist and progressive forms of green finance and green monetary policy can be distinguished. 
  • 1.5K
  • 25 Nov 2021
Topic Review
Konkokyo
Konkōkyō (金光教, Konkō-kyō), or just Konkō, is a religion and spiritual way of living of Japan ese origin. Originating in Shinbutsu-shūgō beliefs, it is now both an independent religion as well as Sect Shintō, it is now a member of the Kyoha Shintō Rengokai (Association of Sectarian Shinto). It is henotheistic and worships the spirit and energy that flows through all things (musubi, one of the core beliefs of Shintoisim) as Tenchi Kane No Kami, or the Golden Kami of the Heavens and Earth (in Japanese, "Heavens and Earth" also means the Universe). Tenchi Kane No Kami is also referred to as "Tenchi No Kami-Sama," "Oyagami-Sama," "Kami-Sama," and "Kami." In English, Kami can also be called "Divine Parent of the Universe," "Principle Parent," "Parent Kami," "Kami-Sama," or "Kami." many other sects of Shinto believe this energy to be "divine nature", existing on its own. Konkokyo is sometimes called pantheistic, due to the belief that Kami is omnipresent and is the spirit and energy of the universe. This is also the reason the universe is referred to as “Kami’s body”. However, the difference is that Tenchi Kane no Kami has a consciousness and a will. Kami is seen as our divine parent, offering love, affection, support, protection, and nurturing us through his blessings. It is taught that Kami loves all people of the world no matter their race, religion, gender, and so on. Although mentioned as 'he' in materials for linguistic convenience, Kami is neither male or female.
  • 1.5K
  • 21 Oct 2022
Topic Review
Hydrophilic Modification of Dialysis Membranes
The dialyzer is the core element in the hemodialysis treatment of patients with end-stage kidney disease (ESKD). During hemodialysis treatment, the dialyzer replaces the function of the kidney by removing small and middle-molecular weight uremic toxins, while retaining essential proteins. Meanwhile, a dialyzer should have the best possible hemocompatibility profile as the perpetuated contact of blood with artificial surfaces triggers complement activation, coagulation and immune cell activation, and even low-level activation repeated chronically over years may lead to undesired effects. During hemodialysis, the adsorption of plasma proteins to the dialyzer membrane leads to a formation of a secondary membrane, which can compromise both the uremic toxin removal and hemocompatibility of the dialyzer. Hydrophilic modifications of novel dialysis membranes have been shown to reduce protein adsorption, leading to better hemocompatibility profile and performance stability during dialysis treatments.
  • 1.5K
  • 07 Nov 2022
Biography
Menas Kafatos
Menas C. Kafatos (Greek: Μηνάς Καφάτος; born 25 March 1945) is an American physicist of Greek descent and a writer on spirituality and science. His publications include: The Nonlocal Universe and The Conscious Universe. Kafatos has written and lectured extensively promoting discourse between science, spirituality, and religion. He has held numerous positions at institutions including
  • 1.5K
  • 16 Nov 2022
Topic Review
The Applications of Cationic Polymers
Nucleic acid therapy can achieve lasting and even curative effects through gene augmentation, gene suppression, and genome editing. However, it is difficult for naked nucleic acid molecules to enter cells. As a result, the key to nucleic acid therapy is the introduction of nucleic acid molecules into cells. Cationic polymers are non-viral nucleic acid delivery systems with positively charged groups on their molecules that concentrate nucleic acid molecules to form nanoparticles, which help nucleic acids cross barriers to express proteins in cells or inhibit target gene expression. Cationic polymers are easy to synthesize, modify, and structurally control, making them a promising class of nucleic acid delivery systems.
  • 1.5K
  • 05 Jun 2023
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