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Topic Review
Enhancing Smart Home Design with AI Models
The normal development of “smart buildings,” which calls for integrating sensors, rich data, and artificial intelligence (AI) simulation models, promises to usher in a new era of architectural concepts. AI simulation models can improve home functions and users’ comfort and significantly cut energy consumption through better control, increased reliability, and automation. 
  • 2.0K
  • 15 Mar 2023
Topic Review
Fiber Metal Laminates
Composite materials such as Fibre Metal Laminates (FMLs) have attracted the interest of the aerospace and automotive industries due to their high strength to weight ratio, but to use them as structures it is necessary to master the manufacturing and wiring techniques of these materials. The process parameters used in multi-material machining, such as drilling and milling, tool geometry, tool coating, lubricants and coolants, must be well established to achieve a successful machining process in FLM materials. Failure of any of these parameters can cause irreparable damage to the material, wasting the process and making it less sustainable. Understanding the failure process is essential to improve the accuracy of the analysis, to supplement the information and to provide a deterrent to adjusting process parameters.
  • 2.0K
  • 19 Apr 2023
Topic Review
Effectiveness of Intermittent Hypoxia–Hyperoxia Therapy in Different Pathologies
Intermittent oxygen therapy (IHT), initially used in the hypoxic administration variant, has been shown to be effective in various pathologies studied, from cardiopulmonary to vascular and metabolic pathologies and more. IHT used to prevent and treat various diseases has thus gained more and more attention as the years have passed. The mechanisms underlying the beneficial effects have been investigated at multiple biological levels, from systemic physiological reactions to genomic regulation. In the last decade, a new method of intermittent oxygen therapy has been developed that combines hypoxic and hyperoxic periods. They can be applied both at rest and during physical exercise, hence the specific indications in sports medicine. It has been hypothesized that replacing normoxia with moderate hyperoxia may increase the adaptive response to the intermittent hypoxic stimulus by upregulating reactive oxygen species and hypoxia-inducible genes. 
  • 2.0K
  • 25 May 2023
Topic Review
Multimedia Steganalysis
Steganography techniques aim to hide the existence of secret messages in an innocent-looking medium, where the medium before and after embedding looks symmetric. Steganalysis techniques aim to breach steganography techniques and detect the presence of invisible messages. 
  • 2.0K
  • 08 Feb 2022
Topic Review
Overview of viable Bacteria Immobilisation
Bioremediation is a key process for reclaiming polluted soil and water by the use of biological agents. A commonly used approach aims to neutralise or remove harmful pollutants from contaminated areas using live microorganisms. Generally, immobilised microorganisms rather than planktonic cells have been used in bioremediation methods. Activated carbon, inorganic minerals (clays, metal oxides, zeolites), and agricultural waste products are acceptable substrates for the immobilisation of bacteria, although there are limitations with biomass loading and the issue with leaching of bacteria during the process. Various synthetic and natural polymers with different functional groups have been used successfully for the efficient immobilisation of microorganisms and cells. Promise has been shown using macroporous materials including cryogels with entrapped bacteria or cells in applications for water treatment and biotechnology. A cryogel is a macroporous polymeric gel formed at sub-zero temperatures through a process known as cryogelation. Macroporous hydrogels have been used to make scaffolds or supports for immobilising bacterial, viral, and other cells. The production of composite materials with immobilised cells possessing suitable mechanical and chemical stability, porosity, elasticity, and biocompatibility suggests that these materials are potential candidates for a range of applications within applied microbiology, biotechnology, and research. 
  • 2.0K
  • 25 Apr 2021
Topic Review
Antibiotics Detection in Food Products
Overuse of antibiotics leads to their circulation in the food chain due to unmanaged discharge. These circulating antibiotics and their residues are a major cause of antimicrobial resistance (AMR), so comprehensive and multifaceted measures aligning with the One Health approach are crucial to curb the emergence and dissemination of antibiotic resistance through the food chain. Different chromatographic techniques and capillary electrophoresis (CE) are being widely used for the separation and detection of antibiotics and their residues from food samples.
  • 2.0K
  • 02 Sep 2021
Topic Review
Trindade and Martin Vaz
Trindade and Martin Vaz (Portuguese: Trindade e Martim Vaz, pronounced [tɾĩˈdadʒi i mɐʁˈtʃĩ ˈvas]) is an archipelago located in the South Atlantic Ocean about 1,100 kilometres (680 miles) east of the coast of the Brazilian state of Espírito Santo, of which it forms a part. The archipelago has a total area of 10.4 square kilometres (4.0 square miles) and a population of 32 (Brazilian Navy personnel).The archipelago consists of five islands and several rocks and stacks; Trindade is the largest island, with an area of 10.1 square kilometres (3.9 square miles); about 49 kilometres (30 miles) east of it are the tiny Martin Vaz islets, with a total area of 0.3 square kilometres (30.0 hectares). The islands are of volcanic origin and have rugged terrain. They are largely barren, except for the southern part of Trindade. They were discovered in 1502 by Portuguese explorer Estêvão da Gama and stayed Portuguese until they became part of Brazil at its independence in 1822. From 1895 to 1896, Trindade was occupied by the United Kingdom until an agreement with Brazil was reached. During the period of British occupation, Trindade was known as South Trinidad. The islands are situated some 2,100 kilometres (1,300 miles) southwest of Ascension Island and 2,550 kilometres (1,580 miles) west of Saint Helena, and the distance to the west coast of Africa is 4,270 kilometres (2,650 miles).
  • 2.0K
  • 31 Oct 2022
Topic Review
Multilevel Inverters in  Battery Electric Vehicles
All electric vehicles are the only way to decarbonize transport quickly and substantially. Although multilevel inverters have already been used in some transportation modes, they are rarely used in road transportation, especially in light-duty passenger battery electric vehicles (BEVs). With the transition to a high 800-V DC link to extend the driving range and enable extreme fast charging, the possibility of using multilevel inverters in commercial light-duty passenger BEVs becomes feasible. Higher efficiency, higher power density, better waveform quality, lower switching frequency, the possibility of using low-rated switches, and inherent fault tolerance are known advantages of multilevel inverters that make them an efficient option for replacing 2-level inverters in high DC link passenger BEVs.
  • 2.0K
  • 12 Mar 2024
Topic Review
Flow Field Design of PEMFC
Climate change and the major threat it poses to the environment and human lives is the major challenge the world faces today. To overcome this challenge, it is recommended that future automobiles have zero carbon exhaust emissions. Even though battery electric vehicles reduce carbon emissions relative to combustion engines, a carbon footprint still remains in the overall ecosystem unless the battery is powered by renewable energy sources. The proton exchange membrane fuel cell (PEMFC) is an alternate source for automotive mobility which, similar to battery electric vehicles, has zero carbon emissions from its exhaust pipe. Moreover, the typical system level efficiency of a PEMFC is higher than an equivalent internal combustion powertrain.
  • 2.0K
  • 27 Sep 2023
Topic Review
Natural Product-Derived Extracts for Longitudinal Bone Growth
Several herbal formulations based on traditional medicine have the potential to improve bone growth, although their effectiveness is controversial. It was confirmed that the majority of extracts containing herbal formulations were orally administered over a short period, ranging from 4 to 10 days during the experimental phase. 
  • 2.0K
  • 22 Dec 2023
Topic Review
Hybrid and Electric Vehicles
Even though electric vehicles (EV) were invented over a century ago, their popularity has grown significantly within the last 10 years due to the development of Li-ion battery technology. This evolution created an increase in the fire risk and hazards associated with this type of high-energy battery.
  • 2.0K
  • 08 Feb 2022
Topic Review
Beneficiation of Rare Earth Elements
The rapid depletion of high-grade rare earth elements (REE) resources implies that future supplies may be augmented with low-grade ores, tailings, and other unconventional resources to meet cut-off grades and, subsequently, supply demands. There are distinct differences in the beneficiation response of REE and gangue minerals in the tailings. Gravity, wet magnetic, and froth flotation separation methods produced significantly varying REE recoveries and upgrades. Tabling presented a better potential for REE minerals upgrade compared to the Knelson Concentrator (KC). However, wet magnetic separation produced two REE “rich” preconcentrates. The two REE preconcentrates were subsequently upgraded via froth flotation. In terms of recovery, the best result was achieved during the multistage flotation process carried out on the tailings “feed” in the presence of hydroxamic acid and depressants. With high recoveries obtained using such readily available conventional separation methods, the tailings provide additional REE value to the primary commodities.
  • 2.0K
  • 24 May 2022
Topic Review
Catheter
In medicine, a catheter is a thin tube made from medical grade materials serving a broad range of functions. Catheters are medical devices that can be inserted in the body to treat diseases or perform a surgical procedure. By modifying the material or adjusting the way catheters are manufactured, it is possible to tailor catheters for cardiovascular, urological, gastrointestinal, neurovascular, and ophthalmic applications. Catheters can be inserted into a body cavity, duct, or vessel. Functionally, they allow drainage, administration of fluids or gases, access by surgical instruments, and also perform a wide variety of other tasks depending on the type of catheter. The process of inserting a catheter is "catheterization". In most uses, a catheter is a thin, flexible tube ("soft" catheter) though catheters are available in varying levels of stiffness depending on the application. A catheter left inside the body, either temporarily or permanently, may be referred to as an "indwelling catheter" (for example, a peripherally inserted central catheter). A permanently inserted catheter may be referred to as a "permcath" (originally a trademark).
  • 2.0K
  • 11 Oct 2022
Topic Review
Chrysler Minivan (AS)
The second-generation Chrysler minivans are a series of minivans that were manufactured and marketed by Chrysler Corporation in North America and Europe from 1991 to 1995. Officially designated the AS platform by Chrysler, the second-generation minivans were again sold in passenger and cargo configurations by the Chrysler, Plymouth, and Dodge divisions. Launched in late 1990 for the 1991 model year, the second-generation minivans were an extensive revision of the first-generation chassis and body. The model range became the first minivans offered with driver-side airbags (1991) and with optional integrated child safety seats (1992). While adding all-wheel drive as an option for the first time, the AS platform would also mark the last offering of a manual transmission. As with its predecessor, Chrysler assembled second-generation minivans at Windsor Assembly in Windsor, Ontario, Canada, with additional production at Saint Louis (North) Assembly in Fenton, Missouri from 1990 to 1994. In 1992, to supplement exports from the United States, the Chrysler Voyager began production in Graz, Austria (in the Eurostar joint venture factory between Chrysler and Steyr-Daimler-Puch). For the 1996 model year, the AS-generation minivans were replaced by the NS platform, marking the first complete redesign of the Chrysler minivans since their introduction.
  • 2.0K
  • 28 Nov 2022
Topic Review
Lactoferrin as Supportive Therapy in Antibiotic Treatment
To date, the best-studied active ingredient in bovine colostrum (BC) and milk is lactoferrin (LF). It is an evolutionarily old protein present in excretory fluids of mammals and secondary granules of neutrophils and is released from them at sites of inflammation. This 80 KDa, single polypeptide chain protein belongs to the transferring family and has a property to bind two Fe3+ ions. Lactoferrins from various species have similar amino acid sequences and similar tertiary structures. This high interspecies homology indicates a similar function for this protein in different mammalian species.
  • 2.0K
  • 12 Apr 2023
Topic Review
HSP90 inhibitors for IPF/COVID-19
Heat shock protein 90 (HSP90) is an important chaperone that assists the late stage folding of several proteins involved in cell survival in response to environmental stressors. The inhibition of HSP90 is followed by a complex modulation of the proteome and the kinome, that has proved beneficial in cancer and various neurodegenerative diseases. Additionally, accumulating literature suggests that HSP90 may be a key target during the development of pulmonary fibrosis and that its inhibition could serve as a new and exciting therapeutic approach. We have summarized the current evidence about HSP90’s role in Idiopathic Pulmonary Fibrosis (IPF), the results from preclinical studies on its inhibition and the intracellular signaling pathways involved, in a recent review article (Review). In this Article entry, we will introduce the main findings discussed in the review and focus on its translation and possible significance in the era of the SARS-CoV-2 pandemic.
  • 2.0K
  • 07 Aug 2020
Topic Review
Circular Economy
Defining the circular economy (CE) as a material and energy model coincides with the definition given by multiple authors in which Industrial Symbiosis (IS) has been deemed as a foundational strategy to support the implementation of the CE. The consumption of secondary materials is essential to achieve a successful transformation from a linear economy to a CE focused on IS practices. In this scenario, small and medium enterprises (SMEs) play a major role as stakeholders in developing CE systems as it is not possible to create this model with each company working in isolation.
  • 2.0K
  • 01 May 2021
Topic Review
Glucagon-Like Peptide 1 and Taste
Preclinical studies provided some important insights into the action of glucagon-like peptide 1 (GLP-1) in taste perception. This review examines the literature to uncover some molecular mechanisms and connections between GLP-1 and the gustatory coding. Local GLP-1 production in the taste bud cells, the expression of GLP-1 receptor on the adjacent nerves, a functional continuum in the perception of sweet chemicals from the gut to the tongue and an identification of GLP-1 induced signaling pathways in peripheral and central gustatory coding all strongly suggest that GLP-1 is involved in the taste perception, especially sweet. However, the impact of GLP-1 based therapies on gustatory coding in humans remains largely unaddressed. Based on the molecular background we encourage further exploration of the tongue as a new treatment target for GLP-1 receptor agonists in clinical studies. Given that pharmacological manipulation of gustatory coding may represent a new potential strategy against obesity and diabetes, the topic is of utmost clinical relevance.
  • 2.0K
  • 25 Jan 2021
Topic Review
PKM2
The pyruvate kinase isoenzyme type M2 (PKM2) controls cell progression and survival through the regulation of key signaling pathways. 
  • 2.0K
  • 23 Feb 2021
Topic Review
Divine Mercy Image
The Image of the Divine Mercy is a depiction of Jesus Christ that is based on the devotion initiated by Saint Faustina Kowalska. "I promise that the soul that will venerate this image will not perish," Jesus told Faustina, according to her diary, which has been studied and authenticated by the Catholic Church over several decades. "I also promise victory over enemies already here on earth, especially at the hour of death. I myself will defend it as My own glory." (Diary 48) Jesus is shown, in most versions, as raising his right hand in blessing and pointing with his left hand on the Sacred Heart from which flow forth two rays: one red and one pale. The depiction contains the message "Jesus I trust in you" (Polish: Jezu ufam Tobie). The rays that stream out have symbolic meanings: red for the blood of Jesus (which is the Life of Souls) and pale for the water (which justifies souls) (Diary 299). The whole image is a symbol of charity, forgiveness and love of God, referred to as the "Fountain of Mercy". According to Faustina's diary, the image is based on her 1931 vision of Jesus. Faustina directed the painting of the first image in Vilnius by the artist Eugeniusz Kazimirowski. Since then, numerous versions of the image have been painted by other artists, including a popular rendition by Adolf Hyła in Kraków. They are widely venerated worldwide and are used in the celebration of Divine Mercy Sunday, observed in Roman Catholic as well as some Anglican churches.
  • 2.0K
  • 31 Oct 2022
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