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Topic Review
Cryogenic Carbon Capture Process
The cryogenic carbon capture (CCC) process is a promising post-combustion CO2 removal method. This method is very novel compared with conventional and well-developed methods. However, cryogenic carbon capture is not yet commercially available despite its techno-economic benefits. Thus, a model-based design approach for this process can provide valuable information. 
  • 2.3K
  • 15 Mar 2023
Topic Review
MDM2-Based Proteolysis-Targeting Chimeras (PROTACs)
Proteolysis-targeting chimeras (PROTACs) are molecules that selectively degrade a protein of interest (POI). The incorporation of ligands that recruit mouse double minute 2 (MDM2) into PROTACs, forming the so-called MDM2-based PROTACs, has shown promise in cancer treatment due to its dual mechanism of action: a PROTAC that recruits MDM2 prevents its binding to p53, resulting not only in the degradation of POI but also in the increase of intracellular levels of the p53 suppressor, with the activation of a whole set of biological processes, such as cell cycle arrest or apoptosis. In addition, these PROTACs, in certain cases, allow for the degradation of the target, with nanomolar potency, in a rapid and sustained manner over time, with less susceptibility to the development of resistance and tolerance, without causing changes in protein expression, and with selectivity to the target, including the respective isoforms or mutations, and to the cell type, overcoming some limitations associated with the use of inhibitors for the same therapeutic target.
  • 2.3K
  • 15 Oct 2022
Topic Review
HIF-1α in IVD Treatment
The intervertebral disc (IVD) is a complex joint structure comprising three primary components—namely, nucleus pulposus (NP), annulus fibrosus (AF), and cartilaginous endplate (CEP). The IVD retrieves oxygen from the surrounding vertebral body through CEP by diffusion and likely generates ATP via anaerobic glycolysis. IVD degeneration is characterized by a cascade of cellular, compositional, structural changes. With advanced age, pronounced changes occur in the composition of the disc extracellular matrix (ECM). NP and AF cells in the IVD possess poor regenerative capacity compared with that of other tissues. Hypoxia-inducible factor (HIF) is a master transcription factor that initiates a coordinated cellular cascade in response to a low oxygen tension environment, including the regulation of numerous enzymes in response to hypoxia. HIF-1α is essential for NP development and homeostasis and is involved in various processes of IVD degeneration process, promotes ECM in NP, maintains the metabolic activities of NP, and regulates dystrophic mineralization of NP, as well as angiogenesis, autophagy, and apoptosis during IVD degeneration. HIF-1α may, therefore, represent a diagnostic tool for early IVD degeneration and a therapeutic target for inhibiting IVD degeneration
  • 2.3K
  • 06 Jun 2021
Topic Review
Secoiridoids from Olea europaea L.
Iridoids, which have beneficial health properties, include a wide group of cyclopentane [c] pyran monoterpenoids present in plants and insects. The cleavage of the cyclopentane ring leads to secoiridoids. Mainly, secoiridoids have shown a variety of pharmacological effects including anti-diabetic, antioxidant, anti-inflammatory, immunosuppressive, neuroprotective, anti-cancer, and anti-obesity, which increase the interest of studying these types of bioactive compounds in depth. Secoiridoids are thoroughly distributed in several families of plants such as Oleaceae, Valerianaceae, Gentianaceae and Pedialaceae, among others. Specifically, Olea europaea L. (Oleaceae) is rich in oleuropein (OL), dimethyl-OL, and ligstroside secoiridoids, and their hydrolysis derivatives are mostly OL-aglycone, oleocanthal (OLE), oleacein (OLA), elenolate, oleoside-11-methyl ester, elenoic acid, hydroxytyrosol (HTy), and tyrosol (Ty). These compounds have proved their efficacy in the management of diabetes, cardiovascular and neurodegenerative disorders, cancer, and viral and microbial infections. Particularly, the antioxidant, anti-inflammatory, and immunomodulatory properties of secoiridoids from the olive tree (Olea europaea L. (Oleaceae)) have been suggested as a potential application in a large number of inflammatory and reactive oxygen species (ROS)-mediated diseases.
  • 2.3K
  • 28 Jun 2021
Topic Review
Aquaculture System Using Cloud-Based Autonomous Drones
Aquaculture System Using Cloud-Based Autonomous Drones incorporated artificial intelligence (AI) services using computer vision and combined various deep learning recognition models to achieve scalability and added functionality, in order to perform aquaculture surveillance tasks. The recognition model is embedded in the aquaculture cloud, to analyze images and videos captured by the autonomous drone. The recognition models detect people, cages, and ship vessels at the aquaculture site. The inclusion of AI functions for face recognition, fish counting, fish length estimation and fish feeding intensity provides intelligent decision making. For the fish feeding intensity assessment, the large amount of data in the aquaculture cloud can be an input for analysis using the AI feeding system to optimize farmer production and income. The autonomous drone and aquaculture cloud services are cost-effective and an alternative to expensive surveillance systems and multiple fixed-camera installations. The aquaculture cloud enables the drone to execute its surveillance task more efficiently with an increased navigation time. The mobile drone navigation app is capable of sending surveillance alerts and reports to users. Our multifeatured surveillance system, with the integration of deep-learning models, yielded high-accuracy results. 
  • 2.3K
  • 03 Nov 2021
Topic Review
Heme Metabolism
Mitochondria are essential organelles of mammalian cells, often emphasized for their function in energy production, iron metabolism and apoptosis as well as heme synthesis. The heme is an iron-loaded porphyrin behaving as a prosthetic group by its interactions with a wide variety of proteins. These complexes are termed hemoproteins and are usually vital to the whole cell comportment, such as the proteins hemoglobin, myoglobin or cytochromes, but also enzymes such as catalase and peroxidases. The building block of porphyrins is the 5-aminolevulinic acid, whose exogenous administration is able to stimulate the entire heme biosynthesis route. In neoplastic cells, this methodology repeatedly demonstrated an accumulation of the ultimate heme precursor, the fluorescent protoporphyrin IX photosensitizer, rather than in healthy tissues.
  • 2.3K
  • 27 Jul 2022
Topic Review
Lead–Acid Battery Faults
Lead–acid battery technology has been effectively fulfilling a variety of energy needs, ranging from classic car industry requirements to current plug-in hybrid electric vehicle requirements through any stationary system. Depending on the operating conditions, the battery can be affected in many ways. The same deterioration mechanisms affect all types of lead–acid batteries but to varying degrees. Two electrodes with the aqueous H2SO4 electrolyte (sulfuric acid) and the terminals are the main components of a lead–acid battery. A grid and the active material—PbO2 as the positive active material and Pb as the negative active material—make up the electrodes.
  • 2.3K
  • 05 Mar 2024
Topic Review
European Policy Preventing Internet Addiction
Internet use-related addiction problems are increasingly being recognized on a European scale due to international health organizations considering gaming addiction. In April 2013, the American Psychiatric Association recognized Internet Gaming Disorder in the fifth Diagnostic and Statistical Manual of Mental Disorders, and in April 2018, the World Health Organization included Gaming Disorder in the eleventh International Classification of Diseases. However, findings on these problems within this period are lacking in Europe, and a preventive approach is missing globally. A detailed critical literature review was conducted using PsycINFO and Web of Science in this five-year period. A total of 19 studies were reviewed and problems identified were: generalized Internet addiction and online gaming and gambling addictions across seven European countries (i.e., Spain, Germany, France, Italy, Greece, The Netherlands, and Denmark). The individuals with problematic use were found to be educated adolescents, usually young males with comorbid disorders, and gaming and gambling disorders were implicated in the most severe cases. Cognitive behavioral therapy was the main treatment, sometimes combined with a systemic approach for adolescents. Prevalence, high-risk populations, and factors contributing to these addiction problems are discussed, and a set of policy options are developed for this region. The implications for early detection, diagnosis, treatment, and prevention in Europe are considered.
  • 2.3K
  • 06 Nov 2020
Topic Review
Bioavailability of Phenolic Compounds
Phenolic compounds (quercetin, rutin, cyanidin, tangeretin, hesperetin, curcumin, resveratrol, etc.) are known to have health‐promoting effects and they are accepted as one of the main proposed nutraceutical group. However, their application is limited owing to the problemsrelated with their stability and water solubility as well as their low bioaccessibility and bioavailability. These limitations can be overcome by encapsulating phenolic compounds by physical, physicochemical and chemical encapsulation techniques.
  • 2.3K
  • 15 Dec 2020
Topic Review
Architectural Lighting Design
Architectural lighting design is a field within architecture, interior design and electrical engineering that is concerned with the design of lighting systems, including natural light, electric light, or both, to serve human needs. The aim of lighting design is the human response, to see clearly and without discomfort. The objective of architectural lighting design is to further the design of architecture or the experience of buildings and other physical structures.
  • 2.3K
  • 21 Nov 2022
Topic Review
Diamond DA20
The Diamond DV20/DA20 Katana is an Austrian-designed two-seat tricycle gear general aviation light aircraft. Developed and manufactured by Austrian aircraft manufacturer Diamond Aircraft, it was originally produced in Austria as the DV20. The DV20 shares many features from the earlier Diamond HK36 Super Dimona. It was introduced to service during 1993. During the 1990s, production of the type was commenced at a new facility in Canada in order to meet demand for the type within the North American market. The Canadian-produced aircraft are designated as the DA20. It has been a relative success on the market, having sold in excess of 1,000 aircraft by 2008 and multiple improved variants of the DA20 have been developed. Additionally, it has been further developed into the four-seat Diamond DA40 Star.
  • 2.3K
  • 23 Nov 2022
Topic Review
Comorbid Insomnia and Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) and insomnia are the two most common sleep disorders among the general population, and they may often coexist in patients with sleep-disordered breathing (SDB). The higher prevalence of insomnia symptoms in patients with OSA (40–60%) compared to that observed in the general population has thus led researchers to identify a new disorder named comorbid insomnia and OSA (COMISA), whose true burden has been so far largely underestimated. The combined treatment of COMISA patients with positive-airway pressure ventilation (PAP) with cognitive behavioral therapy for insomnia (CBTi) has shown a better patient outcome compared to that obtained with a single treatment. Furthermore, recent evidence has shown that an innovative patient-centered approach taking into consideration patient characteristics, treatment preferences and accessibility to treatment is recommended to optimize clinical management of COMISA patients. However, in this complex mosaic, many other sleep disorders may overlap with COMISA, so there is an urgent need for further research to fully understand the impact of these therapies on outcomes for OSA patients with comorbidity. In light of this need, the major sleep disorders comorbid with OSA and the recent advances in the management of these insomniac patients are discussed. 
  • 2.3K
  • 06 Mar 2023
Topic Review
Sports performance and systems theories
The purpose is to present a brief idea about the understanding of sports performance through the lens of systems theories.
  • 2.3K
  • 26 Oct 2020
Topic Review
DNA Dyes
Cell quantification is widely used both in basic and applied research. A typical example of its use is drug discovery research. Presently, plenty of methods for cell quantification are available. In this review, the basic techniques used for cell quantification, with a special emphasis on techniques based on fluorescent DNA dyes, are described. 
  • 2.3K
  • 23 Sep 2021
Topic Review
Transthyretin
Transthyretin (TTR) is a thyroid hormone-binding protein which transports thyroxine from the bloodstream to the brain. The structural stability of TTR in tetrameric form is crucial for maintaining its original functions in blood or cerebrospinal fluid (CSF). The altered structure of TTR due to genetic mutations or its deposits due to aggregation could cause several deadly diseases such as cardiomyopathy and neuropathy in autonomic, motor, and sensory systems.
  • 2.3K
  • 03 Dec 2021
Topic Review
Cord Factor
Cord factor, or trehalose dimycolate, is a glycolipid molecule found in the cell wall of Mycobacterium tuberculosis and similar species. It is the primary lipid found on the exterior of M. tuberculosis cells. Cord factor influences the arrangement of M. tuberculosis cells into long and slender formations, giving its name. Cord factor is virulent towards mammalian cells and critical for survival of M. tuberculosis in hosts, but not outside of hosts. Cord factor has been observed to influence immune responses, induce the formation of granulomas, and inhibit tumor growth. The antimycobacterial drug SQ109 is thought to inhibit TDM production levels and in this way disrupts its cell wall assembly.
  • 2.3K
  • 12 Oct 2022
Topic Review
Organic Piezoelectric Biomaterials
The past decade has witnessed significant advances in medically implantable and wearable devices technologies as a promising personal healthcare platform. Organic piezoelectric biomaterials have attracted widespread attention as the functional materials in the biomedical devices due to their advantages of excellent biocompatibility and environmental friendliness. Biomedical devices featuring the biocompatible piezoelectric materials involve energy harvesting devices, sensors, and scaffolds for cell and tissue engineering. This paper offers a comprehensive review of the principles, properties, and applications of organic piezoelectric biomaterials. How to tackle issues relating to the better integration of the organic piezoelectric biomaterials into the biomedical devices is discussed. Further developments in biocompatible piezoelectric materials can spark a new age in the field of biomedical technologies.
  • 2.3K
  • 30 Oct 2020
Topic Review
Staphylococcus Aureus and Septic Arthritis
Staphylococcus aureus (S. aureus) infections are a major healthcare challenge and new treatment alternatives are needed. S. aureus septic arthritis, a debilitating joint disease, causes permanent joint dysfunction in almost 50% of the patients. S. aureus bacteremia is associated with higher mortalities than bacteremia caused by most other microbes and can develop to severe sepsis and death. The key to new therapies is understanding the interplay between bacterial virulence factors and host immune response, which decides the disease outcome. S. aureus produces numerous virulence factors that facilitate bacterial dissemination, invasion into joint cavity, and cause septic arthritis. Monocytes, activated by several components of S. aureus such as lipoproteins, are responsible for bone destructions. In S. aureus sepsis, cytokine storm induced by S. aureus components leads to the hyperinflammatory status, DIC, multiple organ failure, and later death. 
  • 2.3K
  • 10 May 2021
Topic Review
Human Gut Microbiome and Quercetin
The existing evidence suggests that gut microbiota is capable of flavonoid biotransformation to generate bioactive metabolites including 2,4,6-trihydroxybenzoic acid (2,4,6-THBA), 3,4-dihydroxybenzoic acid (3,4-DHBA), and 3,4-dihydroxyphenylacetic acid (DOPAC).
  • 2.3K
  • 08 Jul 2021
Topic Review
Sensory Neurons
Four sensory systems (vestibular, lateral line, electroreception, auditory) are unique and project exclusively to the brainstem of vertebrates. All sensory neurons depend on a common set of genes (Eya1, Sox2, Neurog1, Neurod1) that project to a dorsal nucleus and an intermediate nucleus, which differentiate into the vestibular ear, lateral line and electroreception in vertebrates. 
  • 2.3K
  • 23 Sep 2021
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