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Topic Review
4-Hydroxybutyrate Containing Polyhydroxyalkanoates Production for Biomedical Applications
Polyhydroxyalkanoates (PHA) are polyesters having high promise in biomedical applications. Among different types of PHA, poly-4-hydroxybutyrate (P4HB) is the only polymer that has received FDA approval for medical applications. However, most PHA producing microorganisms lack the ability to synthesize P4HB or PHA comprising 4-hydroxybutyrate (4HB) monomer due to their absence of a 4HB monomer supplying pathway. Thus, most microorganisms require supplementation of 4HB precursors to synthesize 4HB polymers. 
  • 2.4K
  • 09 Dec 2021
Topic Review
Argonaut Class Reactor
The Argonaut class reactor is a design of small nuclear research reactor. Many have been built throughout the world, over a wide range of power levels. Its functions are to teach nuclear reactor theory, nuclear physics and for use in engineering laboratory experiments.
  • 2.4K
  • 15 Nov 2022
Topic Review
Use of ChatGPT in Education
The use of ChatGPT in education has generated considerable interest due to its potential to enrich the learning experience of students. By providing quick and personalised responses, this system has the ability to address individual student needs, offer immediate feedback and facilitate the understanding of complex concepts. In this way, it becomes a promising tool that promotes a student’s active participation and cognitive advancement by adapting to their learning pace and offering continuous support in their knowledge acquisition process.
  • 2.4K
  • 29 Aug 2023
Topic Review
Microwave Irradiation and Wastewater
Every year, the human impact on the world’s water sources becomes more pronounced. One of the triggers to this increase is the use of ineffective wastewater and sludge treatment systems. Recently, the number of studies of microwave processing in handling liquid municipal and industrial waste has increased. This paper discusses heat treatment, change in properties, decomposition of substances, removal of metals, demulsification, pyrolysis, biogas processing, disinfection, and other topics. 
  • 2.4K
  • 04 Aug 2021
Topic Review
In Vitro Maturation (IVM) of Human Oocyte
The clinical human oocyte IVM refers to in vitro maturation of the immature oocytes retrieved from follicles after no follicle stimulating hormone (FSH) or minimal FSH stimulation (usually 3 days' stimulation), followed by no human chorionic gonadotrophin (hCG) or minimal hCG priming (single 10,000 IU injection).
  • 2.4K
  • 28 Dec 2021
Topic Review
The Larva of the Ascidian Halocynthia roretzi
The swimming larva represents the dispersal phase of ascidians, marine invertebrates belonging to tunicates. Due to its adhesive papillae, the larva searches the substrate, adheres to it, and undergoes metamorphosis, thereby becoming a sessile filter feeding animal. The papillae of H. roretzi, previously described as simple and conform, exhibit dynamic changes during settlement. This opens up new considerations on papillae morphology and evolution and deserves to be further investigated.
  • 2.4K
  • 31 Dec 2021
Topic Review
Copper Metabolism in Heart Disease
Copper is an essential trace metal element that significantly affects human physiology and pathology by regulating various important biological processes, including mitochondrial oxidative phosphorylation, iron mobilization, connective tissue crosslinking, antioxidant defense, melanin synthesis, blood clotting, and neuron peptide maturation. Increasing lines of evidence obtained from studies of cell culture, animals, and human genetics have demonstrated that dysregulation of copper metabolism causes heart disease, which is the leading cause of mortality in the US. Defects of copper homeostasis caused by perturbed regulation of copper chaperones or copper transporters or by copper deficiency resulted in various types of heart disease, including cardiac hypertrophy, heart failure, ischemic heart disease, and diabetes mellitus cardiomyopathy. 
  • 2.4K
  • 11 Mar 2022
Topic Review
Ciclosporin
Ciclosporin, also spelled cyclosporine and cyclosporin, is a calcineurin inhibitor, used as an immunosuppressant medication. It is a natural product. It is taken orally or intravenously for rheumatoid arthritis, psoriasis, Crohn's disease, nephrotic syndrome, and in organ transplants to prevent rejection. It is also used as eye drops for keratoconjunctivitis sicca (dry eyes). Common side effects include high blood pressure, headache, kidney problems, increased hair growth, and vomiting. Other severe side effects include an increased risk of infection, liver problems, and an increased risk of lymphoma. Blood levels of the medication should be checked to decrease the risk of side effects. Use during pregnancy may result in preterm birth; however, ciclosporin does not appear to cause birth defects. Ciclosporin is believed to work by decreasing the function of lymphocytes. It does this by forming a complex with cyclophilin to block the phosphatase activity of calcineurin, which in turn decreases the production of inflammatory cytokines by T-lymphocytes. Ciclosporin was isolated in 1971 from the fungus Tolypocladium inflatum and came into medical use in 1983. It is on the World Health Organization's List of Essential Medicines. In 2019, it was the 195th most commonly prescribed medication in the United States, with more than 2 million prescriptions that year. It is available as a generic medication.
  • 2.4K
  • 27 Oct 2022
Topic Review
15 Minute City
The 15-minute city is a residential urban concept in which all city residents are able to meet most of their needs within a short walk or bicycle ride from their homes. The concept was popularized by Mayor Anne Hidalgo of Paris, who was in turn inspired by French-Colombian scientist Carlos Moreno. It has been described as a "return to a local way of life. 15-minute cities are built from a series of 15-minute neighborhoods, also known as complete communities or walkable neighborhoods.
  • 2.4K
  • 15 Nov 2022
Topic Review
Environmental Stability of Perovskite
This entry introduces the environmental stability of MAPbI3 perovskite thin film and MAPbBr3 perovskite single crystal.
  • 2.4K
  • 05 May 2021
Topic Review
Magnetic Guiding
Magnetic guidance is understood as a remote, untethered and contact-free control of the movements of an object via magnetic interactions. The movements should happen on arbitrary trajectories inside a container caused by an external device. The concept of remote magnetic guiding is developed from the underlying physics for bijective force generation over the inner volume of magnet systems. This concept can equally be implemented by electro- or permanent magnets. 
  • 2.4K
  • 07 Dec 2021
Topic Review
Mesenchymal Cells in the Lung
Mesenchymal cells are an essential cell type because of their role in tissue support, their multilineage differentiation capacities and their potential clinical applications. They play a crucial role during lung development by interacting with airway epithelium, and also during lung regeneration and remodeling after injury. However, much less is known about their function in lung disease.
  • 2.4K
  • 01 Mar 2022
Topic Review
Base 16 Floating Point
IBM System/360 computers, and subsequent machines based on that architecture (mainframes), support a hexadecimal floating-point format (HFP). In comparison to IEEE 754 floating-point, the IBM floating-point format has a longer significand, and a shorter exponent. All IBM floating-point formats have 7 bits of exponent with a bias of 64. The normalized range of representable numbers is from 16−65 to 1663 (approx. 5.39761 × 10−79 to 7.237005 × 1075). The number is represented as the following formula: (−1)sign × 0.significand × 16exponent−64.
  • 2.4K
  • 01 Dec 2022
Topic Review
Aspergillus oryzae
Aspergillus oryzae is a powerful heterologous expression host for the production of polyketides and terpenoids.
  • 2.4K
  • 25 Jun 2021
Topic Review
Energy Efficiency
The importance and urgency of energy efficiency in sustainable development are increasing. Patterson [3] first proposed the concept of energy efficiency, considering that it means using fewer resources at the same output, and gave four indicators of energy efficiency measurement. According to this definition, the indicators that measure energy efficiency can be divided into economic energy efficiency and physical energy efficiency. In order to measure energy efficiency more accurately, many scholars have studied the measurement of energy efficiency. Among them, Hu and Wang [4] proposed the concept of total factor energy efficiency (TFEE), which was widely recognized.The TFEE index incorporates energy, labor, and capital into the input system to generate economic output. Energy efficiency is defined as the ratio of target energy input to actual energy input. As a total factor efficiency assessment method, DEA method can better deal with the efficiency evaluation of decision-making units under the complicated situation of multiple inputs–outputs, it has been widely used to study energy efficiency.
  • 2.4K
  • 28 Jan 2022
Topic Review
Drug Cue Reactivity
Drug cue reactivity is a type of learned response which is observed in individuals with drug addiction and involves significant physiological and subjective reactions to presentations of drug-related stimuli.
  • 2.4K
  • 27 Oct 2020
Topic Review
Spatial-Frequency Domain Imaging
Measurement of optical properties is critical for understanding light-tissue interaction, properly interpreting measurement data, and gaining better knowledge of tissue physicochemical properties. However, conventional optical measuring techniques are limited in point measurement, which partly hinders the applications on characterizing spatial distribution and inhomogeneity of optical properties of biological tissues. Spatial-frequency domain imaging (SFDI), as an emerging non-contact, depth-varying and wide-field optical imaging technique, is capable of measuring the optical properties in a wide field-of-view on a pixel-by-pixel basis. 
  • 2.4K
  • 01 Jun 2021
Topic Review
β-glucan in Dairy and Milk-Based Products
β-glucan is a polysaccharide found naturally in the cell walls of cereals, yeasts, seaweeds, bacteria, and fungi. The physicochemical, functional, and technological properties of β-glucan are extremely different, depending on the source of origin. This polysaccharide is used in the therapeutic, cosmetic, fitness, and professional sports fields. Interest in β-glucan has arisen because it is a powerful immunostimulant, prebiotic, and dietary fiber. Interest in the use of β-glucan in the food industry is associated not only with its positive impact on the health of consumers but also with its functional and technological properties, which significantly improve the consumer characteristics of food products. The use of oat β-glucan in the food industry became possible when the EFSA confirmed in 2010 that the daily consumption of oat β-glucan in the amount of 3 g can reduce the risk of coronary disease and have a positive effect on the cardiovascular system, provided that a diet with low saturated fat content is followed. β-glucan made from yeast has been recognized as a novel ingredient and authorized for release since 2011.
  • 2.4K
  • 30 Sep 2022
Topic Review
Hydrogels Classification
Hydrogels are attractive biomaterials with favorable characteristics due to their water uptake capacity. However, hydrogel properties are determined by the cross-linking degree and nature, the tacticity, and the crystallinity of the polymer. 
  • 2.4K
  • 08 Dec 2021
Topic Review
High-Performance Computing in Meteorology
High-performance computing (HPC) enables atmospheric scientists to better predict weather and climate because it allows them to develop numerical atmospheric models with higher spatial resolutions and more detailed physical processes. 
  • 2.4K
  • 17 Aug 2022
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