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Topic Review
Cell Therapy in Liver Fibrosis
Fibrosis is a common feature in most pathogenetic processes in the liver, and usually results from a chronic insult that depletes the regenerative capacity of hepatocytes and activates multiple inflammatory pathways, recruiting resident and circulating immune cells, endothelial cells, non-parenchymal hepatic stellate cells, and fibroblasts, which become activated and lead to excessive extracellular matrix accumulation. 
  • 1.1K
  • 19 Jan 2022
Topic Review
Role of OM in Gram-Negative Multi-Drug-Resistant Bacteria
The cell envelope in Gram-negative bacteria is made of an outer membrane (OM), peptidoglycan cell wall (CW), and inner membrane (IM). lipopolysaccharides (LPS), a peculiar glycolipid unique to Gram-negative bacteria is the hallmark of OM that consists of a glucosamine-based lipid (lipid A) attached to a core oligosaccharide followed by a distal polysaccharide chain. This incredible variability in LPS that is attained through unique organization and adaptability to multiple secondary covalent modifications plays a key role in the multi-drug-resistant (MDR) of Gram-negative bacteria.
  • 1.1K
  • 08 Oct 2022
Topic Review
Metabolic Engineering of Yeast for Bioethanol Production
Increased human population and the rapid decline of fossil fuels resulted in a global tendency to look for alternative fuel sources. Ethanol has been the primary fossil fuel alternative due to its low carbon emission rates, high octane content and comparatively facile microbial production processes. As a well-known platform microorganism and native ethanol producer, baker’s yeast Saccharomyces cerevisiae has been the primary subject of interest for both academic and industrial perspectives in terms of enhanced ethanol production processes. Metabolic engineering strategies have been primarily adopted for direct manipulation of genes of interest responsible in mainstreams of ethanol metabolism. To overcome limitations of rational metabolic engineering, an alternative bottom-up strategy called inverse metabolic engineering has been widely used. In this context, evolutionary engineering, also known as adaptive laboratory evolution (ALE), which is based on random mutagenesis and systematic selection, is a powerful strategy to improve bioethanol production of S. cerevisiae. Metabolic and evolutionary engineering strategies are intertwined and many metabolically engineered strains for bioethanol production can be further improved by powerful evolutionary engineering strategies as well as the recent advancements in directed genome evolution, including CRISPR-Cas9 technology.
  • 1.1K
  • 16 Oct 2023
Topic Review
Strategies for Entomopathogenic Fungi in Mosquito Biocontrol
Fungal diseases are widespread among insects and play a crucial role in naturally regulating insect populations. Mosquitoes, known as vectors for numerous infectious diseases, pose a significant threat to human health. Entomopathogenic fungi (EPF) have emerged as highly promising alternative agents to chemical mosquitocides for controlling mosquitoes at all stages of their life cycle due to their unique infection pathway through direct contact with the insect’s cuticle.
  • 1.1K
  • 04 Aug 2023
Topic Review
Sustainable Management by Rhizobacteria
Rhizobacteria are bacteria from diverse taxonomic genera, which are living in the rhizosphere of plants. Among the rhizobacterial bulk, several genera of bacteria have been proven for plant growth promotion are termed as ‘beneficial rhizobacteria’. There are various modes of action for plant growth promotion through the adoption of beneficial rhizobacteria. The beneficial bacteria also enhance tolerance in plants to various biotic and abiotic stresses caused by the global climate change.
  • 1.1K
  • 29 Oct 2021
Topic Review
Omics Strategies in Infectious Fish Disease Management
Aquaculture is an important industry globally as it remains one of the significant alternatives of animal protein source supplies for humankind. Yet, the progression of this industry is being dampened by the increasing rate of fish mortality, mainly the outbreak of infectious diseases. Consequently, the regress in aquaculture ultimately results in the economy of multiple countries being affected due to the decline of product yields and marketability. By 2025, aquaculture is expected to contribute approximately 57% of fish consumption worldwide. Without a strategic approach to curb infectious diseases, the increasing demands of the aquaculture industry may not be sustainable and hence contributing to the over-fishing of wild fish. A new holistic approach that utilizes multi-omics platforms including transcriptomics, proteomics, and metabolomics is unraveling the intricate molecular mechanisms of host-pathogen interaction. 
  • 1.1K
  • 23 May 2022
Topic Review
Fungi-Mediated Synthesis of Nanoparticles
Fungi are very promising biological objects for the green synthesis of nanoparticles. Biogenic synthesis of nanoparticles using different mycological cultures and substances obtained from them is a promising, easy and environmentally friendly method. By varying the synthesis conditions, the same culture can be used to produce nanoparticles with different sizes, shapes, stability in colloids and, therefore, different biological activity. Fungi are capable of producing a wide range of biologically active compounds and have a powerful enzymatic system that allows them to form nanoparticles of various chemical elements.
  • 1.1K
  • 12 Jan 2023
Topic Review
Lactiplantibacillus plantarum and SARS-CoV-2 Vaccine
Lactiplantibacillus plantarum (Basonym Lactobacillus plantarum) is a good candidate for developing oral vaccines because it survives gastrointestinal conditions transiently colonizing the intestinal tract, it beneficially modulates the mucosal immune responses not only locally (intestinal mucosa) but in distant mucosal sites as well (respiratory mucosa) and there are molecular techniques available for the manipulation of its genome.
  • 1.1K
  • 14 Apr 2021
Topic Review
Endocrine Disruptors
Endocrine disruptors (EDs) are contaminants that may mimic or interfere with the body’s hormones, hampering the normal functions of the endocrine system in humans and animals. These substances, either natural or man-made, are involved in development, breeding, and immunity, causing a wide range of diseases and disorders. The traditional detection methods such as enzyme linked immunosorbent assay (ELISA) and chromatography are still the golden techniques for EDs detection due to their high sensitivity, robustness, and accuracy. Nevertheless, they have the disadvantage of being expensive and time-consuming, requiring bulky equipment or skilled personnel. On the other hand, early stage detection of EDs on-the-field requires portable devices fulfilling the Affordable, Sensitive, Specific, User-friendly, Rapid and Robust, Equipment free, Deliverable to end users (ASSURED) norms. Electrochemical impedance spectroscopy (EIS)-based sensors can be easily implemented in fully automated, sample-to-answer devices by integrating electrodes in microfluidic chips.
  • 1.1K
  • 01 Dec 2020
Topic Review
Applications of Antimicrobial Peptide
Antimicrobial peptides (AMPs), or host defence peptides, are short proteins in various life forms. AMPs may become a promising substitute or adjuvant in pharmaceutical, biomedical, and cosmeceutical uses. Their pharmacological potential has been investigated intensively, especially as antibacterial and antifungal drugs and as promising antiviral and anticancer agents. AMPs exhibit many properties, and some of these have attracted the attention of the cosmetic industry. AMPs are being developed as novel antibiotics to combat multidrug-resistant pathogens and as potential treatments for various diseases, including cancer, inflammatory disorders, and viral infections. In biomedicine, AMPs are being developed as wound-healing agents because they promote cell growth and tissue repair. The immunomodulatory effects of AMPs could be helpful in the treatment of autoimmune diseases. 
  • 1.1K
  • 24 May 2023
Topic Review
Approaches for Dyes Remediation
Different types of dyes emanating from textile wastewater have adverse effects on the aquatic environment. Various methods including physical, chemical, and biological strategies are applied in order to reduce the amount of dye pollution in the environment. The development of economical, ecologically acceptable, and efficient strategies for treating dye-containing wastewater is necessary. It has been shown that microbial communities have significant potential for the remediation of hazardous dyes in an environmentally friendly manner.
  • 1.1K
  • 21 Nov 2023
Topic Review
Structure, Sequence and Immunopathology of SARS-CoV-2
Since November 2019, SARS-CoV-2 has been a matter of global concern due to its rapid spread, the millions of deaths it caused, and repeated waves of infections. One after another, many variants of this novel virus have come into existence due to its constant mutability, specifically in the spike glycoprotein region. The tally for variants of concern (VOCs), which already include Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1) and Delta (B.1.617.2), has increased to five with the latest appearance of Omicron (B.1.1.529).
  • 1.1K
  • 10 Jun 2022
Topic Review
Antimicrobial Peptides Eradicate Bacterial Biofilms of Multi-Drug Resistant
Bacterial resistance is an emergency public health problem worldwide, compounded by the ability of bacteria to form biofilms, mainly in seriously ill hospitalized patients. The World Health Organization has published a list of priority bacteria that should be studied and, in turn, has encouraged the development of new drugs.
  • 1.1K
  • 05 May 2022
Topic Review
Fish Vaccines
Vaccination studies in aquaculture systems are strategically associated with the economically and environmentally sustainable management of aquaculture production worldwide. Historically, most licensed fish vaccines have been developed as inactivated pathogens combined with adjuvants and provided via immersion or injection. In comparison, live vaccines can simulate a whole pathogenic illness and elicit a strong immune response, making them better suited for oral or immersion-based therapy methods to control diseases. Advanced approaches in vaccine development involve targeting specific pathogenic components, including the use of recombinant genes and proteins. Vaccines produced using these techniques, some of which are currently commercially available, appear to elicit and promote higher levels of immunity than conventional fish vaccines. These technological advancements are promising for developing sustainable production processes for commercially important aquatic species.
  • 1.1K
  • 25 Apr 2023
Topic Review
Alveolar Regeneration in COVID-19 Patients: Network Perspective
Lung alveolar regeneration to repair the damaged tissue and restoration of normal tissue function could be achieved by transplantation of progenitor or stem cells and exosome-mediated delivery of therapeutic agents, including miRNAs. Not only as a biomarker of COVID-19but also as therapeutic agents, miRNAs have proven to play a crucial role in lung damage and repair. miRNAs can either be regulated locally in the lungsor transported to the damaged site by extracellular vehicles (EVs) secreted by stem cells to induce tissue regeneration by decreasing inflammation and apoptosis, stimulating surfactant production, regulating gene expression of junction proteins to repair microvascular permeability, and reducing fibrosis.
  • 1.1K
  • 03 Nov 2021
Topic Review
Interactions between Entomopathogenic Fungi and Nematodes
Entomopathogenic nematodes (EPNs) belonging to the genera Steinernema Travassos (Rhabditida: Steinernematidae) and Heterorhabditis Poinar (Rhabditida: Heterorhabditidae) are obligate and lethal parasites of insects. Their infective juveniles (IJs), non-feeding and usually soil dwelling, hold in their foregut symbiotic bacteria that play an important and essential role in killing susceptible insects. Entomopathogenic fungi, mainly Ascomycetes, are regularly found infecting insects in the environment, especially in the soil. The species of the genera Metarhizium Sorokin, and Beauveria Vuill. are the best known entomopathogenic fungi. These organisms usually attach to the external body of insects by conidia adhering to the host’s cuticle. Under the right temperature and humidity conditions, these spores germinate, grow as hyphae, and colonize the insect’s body. After a few days (4–7), the insect is usually killed, especially by fungal toxins, and new spores are formed in or on the insect (sporulation), ready to be spread in the environment.
  • 1.1K
  • 14 Jun 2023
Topic Review
Microbial Conjugation Studies of Licochalcones&Xanthohumol
Microbial conjugation studies of licochalcones (1–4) and xanthohumol (5) were performed by using the fungi Mucor hiemalis and Absidia coerulea. As a result, one new glucosylated metabolite was produced by M. hiemalis whereas four new and three known sulfated metabolites were obtained by transformation with A. coerulea. Chemical structures of all the metabolites were elucidated on the basis of 1D-, 2D-NMR and mass spectroscopic data analyses. These results could contribute to a better understanding of the metabolic fates of licochalcones and xanthohumol in mammalian systems. Although licochalcone A 4′-sulfate (7) showed less cytotoxic activity against human cancer cell lines compared to its substrate licochalcone A, its activity was fairly retained with the IC50 values in the range of 27.35–43.07 μM.
  • 1.1K
  • 12 Jul 2021
Topic Review
Classification of Ginsenosidases
Although there are multiple catalytic strategies for the conversion of major ginsenoside, biotransformation using ginsenosidases is more advantageous for the targeted production of minor ginsenosides due to the high specificity, high selectivity, high catalytic efficiency, high product purity, mild reaction conditions and clear catalytic process, which is one of the current research topics in ginsenoside biotransformation. Ginsenosidases are commonly classified as type I, type II, type III, type IV and type V according to the hydrolysis site, residues and types of sugar moieties of ginsenosides. Ginsenosidase type I simultaneously hydrolyze the glycosyl residues linked to C-20 and C-3 positions in the PPD-type ginsenosides, yielding minor ginsenosides with only one glucose residue or other glycosyl residues. Ginsenosidase type II hydrolyzes the glycosyl residues at the C-20 position of protopanaxadiol (PPD)-and protopanaxatriol (PPT)-type saponins. Ginsenosidase type III hydrolyzes the sugar moieties attached to the C-3 position of PPD-type ginsenosides. Ginsenosidase type IV only hydrolyzes the sugar moieties linked to C-6 in PPT-type ginsenosides. Ginsenosidase type V hydrolyzes the glycosyl moieties attached to the C-20 and C-6 positions of PPT-type ginsenosides to yield the corresponding aglycones.
  • 1.1K
  • 19 Jan 2023
Topic Review
Microcystins in Water
Eutrophication of surface waters caused by toxic cyanobacteria such as Microcystis aeruginosa leads to the release of secondary metabolites called Microcystins (MCs), which are heptapeptides with adverse effects on soil microbiota, plants, animals, and human health. Therefore, implementing ecotechnologies capable of handling this problem has become necessary.
  • 1.1K
  • 06 Apr 2022
Topic Review
Endophytes Acting on Secondary Metabolites in Plants
Endophytes, which are widely found in host plants and have no harmful effects, are a vital biological resource. Plant endophytes promote plant growth and enhance plants’ resistance to diseases, pests, and environmental stresses. In addition, they enhance the synthesis of important secondary metabolites in plants and improve the potential applicability of plants in agriculture, medicine, food, and horticulture. Secondary metabolites (SMs) are the products formed by interactions with the environment during plant growth and development. SMs mainly include alkaloids, flavonoids, terpenoids, peptides, phenols, sterols, and additional minor molecular organic compounds. As essential substances used by plants for self-protection to cope with their environment, SMs have various physiological functions, such as regulating plant growth and biological defense, and they are also involved in the plant response abiotic stresses, such as drought, low temperature, salinity, and metals
  • 1.1K
  • 28 Feb 2023
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