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Topic Review
Gene Mutations in Systemic Mastocytosis
Systemic mastocytosis (SM) is a rare hematologic disease characterized by an abnormal expansion and accumulation of pathological mast cells (MCs) in skin and/or other several extracutaneous tissues such as bone marrow (BM) and the gastro-intestinal tract. Currently, SM is divided into five different diagnostic subtypes according to the World Health Organization (WHO) 2016 classification. These include indolent SM (ISM), smouldering SM (SSM), aggressive SM (ASM), SM with associated haematological neoplasms (SM-AHN) and MC leukaemia (MCL). Additionally, the inclusion of two new subtypes of SM into the classification of the disease is currently under consideration: a variant of ISM known as BM mastocytosis (BMM), which is characterized by a low BM MC burden in the absence of skin lesions, and a very rare (<5%) variant of mastocytosis, which shows tumour mast cells (MCs) with a well-differentiated morphology together with a CD25− CD2− immunophenotype and unique clinical, biological and molecular features, termed well-differentiated SM (WDSM). From a prognostic point of view, all these diagnostic subtypes of SM can be grouped into (i) non-advanced forms of SM (Non-AdvSM), which include BMM, ISM and SSM, typically characterized by a more stable and indolent course of the disease and a life expectancy similar or close to that of a sex- and age-matched population; and (ii) advanced SM (AdvSM) including ASM, SM-AHN and MCL, which typically display an adverse prognosis associated with a significantly shortened life expectancy requiring cytoreductive therapy. Despite this, some ISM patients (<5%) can eventually evolve to SSM and AdvSM. Conversely, a small proportion of AdvSM patients may also show a relatively stable disease course over years or even decades.
  • 1.1K
  • 27 May 2022
Topic Review
Learning Architectures of Deep Vision Multimodal Learning
Deep vision multimodal learning aims at combining deep visual representation learning with other modalities, such as text, sound, and data collected from other sensors. With the fast development of deep learning, vision multimodal learning has gained much interest from the community. The construction of a learning architecture and framework is the core technology of deep multimodal learning. The design of feature extraction, modality aggregation, and multimodal loss function will be discussed.
  • 1.1K
  • 06 Jul 2022
Topic Review
Multiple Facets of Nitrogen
Nitrogen is a gas present in the air with an atomic mass of 14.007, a boiling and melting points of 77.36 K and 63.15 K, respectively, and a density of 0.0012506 g·cm–3. N was first discovered in 1772 by the Scottish physician and chemist Daniel Rutherford. The multiple facets of N are described. A paradigm shift is important to shape to the future use of N-rich fertilizers in crop production and their contribution to the current global greenhouse gases (GHGs) budget would help tackle current global environmental challenges toward a sustainable agriculture.
  • 1.1K
  • 25 Aug 2022
Topic Review
Engineering Extracellular Vesicles for Targeted Drug Delivery
Extracellular vesicles (EVs) are membranous nanosized particles produced by nearly all cell types, including eukaryotic and prokaryotic cells, and they carry their parent cell’s cytosolic components in their lumen, including RNA and various proteins. EVs can be broadly classified into three types by their biogenesis pathway: exosomes, microvesicles (ectosomes) and apoptotic bodies. EVs can be decorated with surface molecules to enhance their targeting abilities. This can be accomplished by directly attaching targeting moieties to the EV surface or modifying EV-producing cells.
  • 1.1K
  • 27 Sep 2022
Topic Review
SCIgen
SCIgen is a paper generator that uses context-free grammar to randomly generate nonsense in the form of computer science research papers. Its original data source was a collection of computer science papers downloaded from CiteSeer. All elements of the papers are formed, including graphs, diagrams, and citations. Created by scientists at the Massachusetts Institute of Technology, its stated aim is "to maximize amusement, rather than coherence." Originally created in 2005 to expose the lack of scrutiny of submissions to conferences, the generator subsequently became used, primarily by Chinese academics, to create large numbers of fraudulent conference submissions, leading to the retraction of 122 SCIgen generated papers and the creation of detection software to combat its use.
  • 1.1K
  • 03 Nov 2022
Topic Review
Neural Tube Defect
Neural tube defects (NTDs) are a group of birth defects in which an opening in the spine or cranium remains from early in human development. In the third week of pregnancy called gastrulation, specialized cells on the dorsal side of the embryo begin to change shape and form the neural tube. When the neural tube does not close completely, an NTD develops. Specific types include: spina bifida which affects the spine, anencephaly which results in little to no brain, encephalocele which affects the skull, and iniencephaly which results in severe neck problems. NTDs are one of the most common birth defects, affecting over 300,000 births each year worldwide. For example, spina bifida affects approximately 1,500 births annually in the United States, or about 3.5 in every 10,000 (0.035% of US births), which has decreased from around 5 per 10,000 (0.05% of US births) since folate fortification of grain products was started. The number of deaths in the US each year due to neural tube defects also declined from 1,200 before folate fortification was started to 840.
  • 1.1K
  • 15 Nov 2022
Topic Review
Energy Transitions Commission
The Energy Transition Commission (ETC) is an international think tank, focusing on economic growth and climate change mitigation. It was created in September 2015 and is based in London. The commission currently contains 32 commissioners from a selection of individuals and company and government leaders.
  • 1.1K
  • 29 Nov 2022
Topic Review
Educational Neuroscience
Compared to other primates, humans are late bloomers, with exceptionally long childhood and adolescence. The extensive developmental period of humans is thought to facilitate the learning processes required for the growth and maturation of the complex human brain. During the first two and a half decades of life, the human brain is a construction site, and learning processes direct its shaping through experience-dependent neuroplasticity. Formal and informal learning, which generates long-term and accessible knowledge, is mediated by neuroplasticity to create adaptive structural and functional changes in brain networks. Since experience-dependent neuroplasticity is at full force during school years, it holds a tremendous educational opportunity. In order to fulfill this developmental and learning potential, educational practices should be human-brain-friendly and “ride” the neuroplasticity wave. Neuroscience can inform educators about the natural learning mechanisms of the brain to support student learning.
  • 1.1K
  • 29 Jan 2023
Topic Review
Metal Materials Used in Selective Laser Melting Equipment
SLM (Selective Laser Melting) is a unique additive manufacturing technology which plays an irreplaceable role in the modern industrial revolution. 3D printers can directly process metal powder quickly to obtain the necessary parts faster. Shortly, it will be possible to manufacture products at unparalleled speeds. Advanced manufacturing technology is used to produce durable and efficient parts with different metals that have good metal structure performance and excellent metal thermal performance, to lead the way for laser powder printing technology. Traditional creative ways are usually limited by time, and cannot respond to customers’ needs fast enough; for some parts with high precision and complexity, conventional manufacturing methods are inadequate. Contrary to this, SLM technology offers some advantages, such as requiring no molds this decreases production time and helps to reduce costs. In addition, SLM technology has strong comprehensive functions, which can reduce assembly time and improve material utilization. Parts with complex structures, such as cavities and three-dimensional grids, can be made without restricting the shape of products. Products or parts can be printed quickly without the use of expensive production equipment. The product quality is better, and the mechanical load performance is comparable to traditional production technologies (such as forging). Although the development of SLM has gradually accelerated and is becoming commercialized, there are still few available metal materials.
  • 1.1K
  • 11 Apr 2023
Topic Review
Relationship between Occupants’ Thermal Behavior and Energy Consumption
Despite an increased awareness about energy conservation, the energy consumed for water heating has increased by 7% from 2008 (17%) to 2018 (24%) in Hong Kong.
  • 1.1K
  • 02 Jul 2023
Topic Review
Sensors on IoT Systems for Urban Disaster Management
The occurrence of disasters has the potential to impede the progress of sustainable urban development. For instance, it has the potential to result in significant human casualties and substantial economic repercussions. Sustainable cities, as outlined in the United Nations Sustainable Development Goal 12, prioritize the objective of disaster risk reduction. According to the Gesi Smarter 2030, the Internet of Things (IoT) assumes a pivotal role in the context of smart cities, particularly in domains including smart grids, smart waste management, and smart transportation. IoT has emerged as a crucial facilitator for the management of disasters, contributing to the development of cities that are both resilient and sustainable. 
  • 1.1K
  • 17 Oct 2023
Topic Review
Phenological Mapping of Invasive Insects
Phenological maps can depict the development and seasonal activities (phenology) of invasive insects at area-wide scales, such as counties, states, or entire nations. When regularly updated using real-time and forecast climate data, these maps may improve the timeliness of early detection and control tactics that target specific life stages. Rapid responses to invasive insects may increase the likelihood that populations are eradicated or controlled before they can spread or increase in size. Phenological maps may also be used to assess pest establishment risk, investigate pest–host interactions, and measure climate-driven changes in pest phenology.
  • 1.1K
  • 29 Dec 2023
Topic Review
Sign2Pose: A Pose-Based Approach for Gloss Prediction
Word-level sign language recognition (WSLR) is the backbone for continuous sign language recognition (CSLR) that infers glosses from sign videos. Finding the relevant gloss from the sign sequence and detecting explicit boundaries of the glosses from sign videos is a persistent challenge. A Sign2Pose Gloss prediction transformer that can significantly identify the intermediate gloss for the given input video sequence.
  • 1.1K
  • 10 Jan 2024
Topic Review
N-Phenylquinoneimine
The N-phenylquinoneimine scaffold is a versatile synthetic platform that has gained significant attention in the field of drug discovery due to its structural diversity and capacity to interact with biologically relevant targets. 
  • 1.1K
  • 10 Jan 2024
Topic Review
Consumption Motivation at High-Speed Rail Stations
Exploring passengers’ consumption motivation can provide the basis for arranging commercial activities in high-speed rail (HSR) stations to generate more revenue for operations. The passenger traffic at five major HSR stations in Taiwan were evaluated. Based on the results of decision-making trial and evaluation laboratory (DEMATEL) and DEMATEL-based on the analytical network process methods, it is shown that station attributes and consumption environment attributes are key factors that impact product attributes. Moreover, store location, commercial activities offered, product diversity, time pressure, and service convenience have a “cause” characteristic and, therefore, should be focused on when deploying commercial services at HSR stations.
  • 1.1K
  • 05 May 2022
Topic Review
γ-aminobutyric Acid and Barley Seedlings
It has been revealed that high NaCl stress (>60 mmol L−1) induced phenolics accumulation in barley seedlings, with γ-aminobutyric acid (GABA) playing a key role. Interestingly, low NaCl stimulus (20 mmol L−1) enhancing phenolics synthesis and growth of barley seedlings was also reported recently. Hence, exogenous GABA and its bio-synthesis inhibitor 3-mercaptopropionic acid (3-MP) were applied to reveal the mechanism of GABA regulating phenolics metabolism in barley seedlings treated with 20 mmol L−1 NaCl. The contents of total phenolics and flavonoids significantly increased by 11.64% and 14.52% under NaCl, respectively. The addition of GABA further increased phenolics and flavonoids contents, especially for gallic acid, protocatechuic acid, caffeic acid, and quercetin, compared with NaCl treatment. Simultaneously, GABA increased the activities and mRNA levels of phenylalanine ammonia lyase (PAL), cinnamic acid 4-hydroxylase (C4H), and 4-coumalyl CoA ligase (4CL). The addition of 3-MP suppressed the above effects, except for increasing the protein levels of PAL, C4H, and 4CL. Low concentration of NaCl not only promoted growth, but also stimulated endogenous GABA metabolism to affect key enzymes activities and mRNA levels for phenolics synthesis in barley seedlings.
  • 1.1K
  • 15 Oct 2021
Topic Review
CRISPR-Cas Systems
The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas (CRISPR-associated cas) systems constitute the adaptive immune system in prokaryotes, which provides resistance against bacteriophages and invasive genetic elements. The landscape of applications in bacteria and eukaryotes relies on a few Cas effector proteins that have been characterized in detail. However, there is a lack of comprehensive studies on naturally occurring CRISPR-Cas systems in beneficial bacteria, such as human gut commensal Bifidobacterium species.
  • 1.1K
  • 28 Oct 2020
Topic Review
Cyclosporine CsA
The bioavailability of CsA was matched and enhanced with nanoparticles in the context of the physicochemical properties and the character of its interactions with lipid membranes. This study can suggest the suitability of liposome/microemulsion as promising vehicles for CsA oral or injection delivery. As the most hopeful proved to be formulation with the smaller particle size because can facilitating absorption, but none of the formulations is flawless. However, when safety of the product is assessed, relying on just the particle size cannot be the only criteria.
  • 1.1K
  • 18 Nov 2020
Topic Review
Mainzer-Saldino Syndrome
Mainzer-Saldino syndrome is a disorder characterized by kidney disease, eye problems, and skeletal abnormalities.
  • 1.1K
  • 23 Dec 2020
Topic Review
Atopic Dermatitis
Atopic dermatitis (also known as atopic eczema) is a disorder characterized by inflammation of the skin (dermatitis). The condition usually begins in early infancy, and it often disappears before adolescence. However, in some affected individuals the condition continues into adulthood; in others, it does not begin until adulthood. Hallmarks of atopic dermatitis include dry, itchy skin and red rashes that come and go. The rashes can occur on any part of the body, although the pattern tends to be different at different ages. In affected infants, the rashes commonly occur on the face, scalp, hands, and feet. In children, the rashes are usually found in the bend of the elbows and knees and on the front of the neck. In adolescents and adults, the rashes typically occur on the wrists, ankles, and eyelids in addition to the bend of the elbows and knees. Scratching the itchy skin can lead to oozing and crusting of the rashes and thickening and hardening (lichenification) of the skin. The itchiness can be so severe as to disturb sleep and impair a person's quality of life.
  • 1.1K
  • 31 Dec 2020
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