Your browser does not fully support modern features. Please upgrade for a smoother experience.
Submitted Successfully!
+1 credit
Thank you for your contribution! You can also upload a video entry or images related to this topic.
For video creation, please contact our Academic Video Service.
| Version | Summary | Created by | Modification | Content Size | Created at | Operation |
|---|---|---|---|---|---|---|
| 1 | Peter Tang | + 1265 word(s) | 1265 | 2020-12-30 02:31:19 |
Video Upload Options
We provide professional Academic Video Service to translate complex research into visually appealing presentations. Would you like to try it?
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
Tang, P. Atopic Dermatitis. Encyclopedia. Available online: https://encyclopedia.pub/entry/5933 (accessed on 26 September 2026).
Tang P. Atopic Dermatitis. Encyclopedia. Available at: https://encyclopedia.pub/entry/5933. Accessed September 26, 2026.
Tang, Peter. "Atopic Dermatitis" Encyclopedia, https://encyclopedia.pub/entry/5933 (accessed September 26, 2026).
Tang, P. (2020, December 31). Atopic Dermatitis. In Encyclopedia. https://encyclopedia.pub/entry/5933
Tang, Peter. "Atopic Dermatitis." Encyclopedia. Web. 31 December, 2020.
Copy Citation
Atopic dermatitis (also known as atopic eczema) is a disorder characterized by inflammation of the skin (dermatitis). The condition usually begins in early infancy, and it often disappears before adolescence. However, in some affected individuals the condition continues into adulthood; in others, it does not begin until adulthood. Hallmarks of atopic dermatitis include dry, itchy skin and red rashes that come and go. The rashes can occur on any part of the body, although the pattern tends to be different at different ages. In affected infants, the rashes commonly occur on the face, scalp, hands, and feet. In children, the rashes are usually found in the bend of the elbows and knees and on the front of the neck. In adolescents and adults, the rashes typically occur on the wrists, ankles, and eyelids in addition to the bend of the elbows and knees. Scratching the itchy skin can lead to oozing and crusting of the rashes and thickening and hardening (lichenification) of the skin. The itchiness can be so severe as to disturb sleep and impair a person's quality of life.
genetic conditions
References
- Bieber T. Atopic dermatitis. N Engl J Med. 2008 Apr 3;358(14):1483-94. doi:10.1056/NEJMra074081. Citation on PubMed
- Dadi H, Jones TA, Merico D, Sharfe N, Ovadia A, Schejter Y, Reid B, Sun M,Vong L, Atkinson A, Lavi S, Pomerantz JL, Roifman CM. Combined immunodeficiencyand atopy caused by a dominant negative mutation in caspase activation andrecruitment domain family member 11 (CARD11). J Allergy Clin Immunol. 2018May;141(5):1818-1830.e2. doi: 10.1016/j.jaci.2017.06.047. Epub 2017 Aug 19. Citation on PubMed
- Irvine AD, McLean WH, Leung DY. Filaggrin mutations associated with skin andallergic diseases. N Engl J Med. 2011 Oct 6;365(14):1315-27. doi:10.1056/NEJMra1011040. Review. Citation on PubMed
- Liang Y, Chang C, Lu Q. The Genetics and Epigenetics of AtopicDermatitis-Filaggrin and Other Polymorphisms. Clin Rev Allergy Immunol. 2016Dec;51(3):315-328. Review. Citation on PubMed
- Ma CA, Stinson JR, Zhang Y, Abbott JK, Weinreich MA, Hauk PJ, Reynolds PR,Lyons JJ, Nelson CG, Ruffo E, Dorjbal B, Glauzy S, Yamakawa N, Arjunaraja S, VossK, Stoddard J, Niemela J, Zhang Y, Rosenzweig SD, McElwee JJ, DiMaggio T,Matthews HF, Jones N, Stone KD, Palma A, Oleastro M, Prieto E, Bernasconi AR,Dubra G, Danielian S, Zaiat J, Marti MA, Kim B, Cooper MA, Romberg N, Meffre E,Gelfand EW, Snow AL, Milner JD. Germline hypomorphic CARD11 mutations in severeatopic disease. Nat Genet. 2017 Aug;49(8):1192-1201. doi: 10.1038/ng.3898. Epub2017 Jun 19. Erratum in: Nat Genet. 2017 Oct 27;49(11):1661. Citation on PubMed
- O'Regan GM, Irvine AD. The role of filaggrin loss-of-function mutations inatopic dermatitis. Curr Opin Allergy Clin Immunol. 2008 Oct;8(5):406-10. doi:10.1097/ACI.0b013e32830e6fb2. Review. Citation on PubMed
- Shaker M. New insights into the allergic march. Curr Opin Pediatr. 2014Aug;26(4):516-20. doi: 10.1097/MOP.0000000000000120. Review. Citation on PubMed
- Shi JH, Sun SC. TCR signaling to NF-κB and mTORC1: Expanding roles of theCARMA1 complex. Mol Immunol. 2015 Dec;68(2 Pt C):546-57. doi:10.1016/j.molimm.2015.07.024. Epub 2015 Aug 8. Review. Citation on PubMed or Free article on PubMed Central
- Weidinger S, Novak N. Atopic dermatitis. Lancet. 2016 Mar12;387(10023):1109-1122. doi: 10.1016/S0140-6736(15)00149-X. Epub 2015 Sep 13.Review. Citation on PubMed
More
Information
Subjects:
Genetics & Heredity
Contributor
MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register
:
View Times:
1.1K
Entry Collection:
MedlinePlus
Revision:
1 time
(View History)
Update Date:
31 Dec 2020
Table of Contents
Notice
You are not a member of the advisory board for this topic. If you want to update advisory board member profile, please contact office@encyclopedia.pub.
OK
Confirm
Only members of the Encyclopedia advisory board for this topic are allowed to note entries. Would you like to become an advisory board member of the Encyclopedia?
Yes
No
${ textCharacter }/${ maxCharacter }
Submit
Cancel
Back
Comments
${ item }
|
${ item.createdUser.fullName }
${ item.createdAt }
${ item.vote }
${ item.reply }
Delete
${ reply.createdUser.fullName }
${ reply.createdAt }
${ reply.vote }
Delete
There is no reply to this comment~
${ item.replyTextCharacter }/${ item.replyMaxCharacter }
Submit
Cancel
More
No more~
There is no comment~
${ textCharacter }/${ maxCharacter }
Submit
Cancel
${ selectedItem.replyTextCharacter }/${ selectedItem.replyMaxCharacter }
Submit
Cancel
Confirm
Are you sure to Delete?
Yes
No