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Topic Review
Additives to immobilize Heavy Metals
This experimental work assessed the efficiency of different additives (MWCNTs, montmorillonite and Portland cement) to immobilize the heavy metals lead, cooper, nickel and zinc in a soil in conditions similar to a real case scenario (percolation tests).  
  • 1.1K
  • 12 Nov 2020
Topic Review
Fragile XE Syndrome
Fragile XE syndrome is a genetic disorder that impairs thinking ability and cognitive functioning. Most affected individuals have mild intellectual disability. In some people with this condition, cognitive function is described as borderline, which means that it is below average but not low enough to be classified as an intellectual disability. Females are rarely diagnosed with fragile XE syndrome, likely because the signs and symptoms are so mild that the individuals function normally.
  • 1.1K
  • 25 Dec 2020
Topic Review
CADASIL
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, usually called CADASIL, is an inherited condition that causes stroke and other impairments. This condition affects blood flow in small blood vessels, particularly cerebral vessels within the brain. The muscle cells surrounding these blood vessels (vascular smooth muscle cells) are abnormal and gradually die. In the brain, the resulting blood vessel damage (arteriopathy) can cause migraines, often with visual sensations or auras, or recurrent seizures (epilepsy).
  • 1.1K
  • 04 Jan 2021
Topic Review
Plug-in Electric Vehicles Review
Plug-in electric vehicles refer to vehicles that are powered by electricity from off-vehicle sources or can be self-contained with a battery, solar panels, fuel cells, or an electric generator to convert fuel to electricity. EVs include, but are not limited to, road and rail vehicles, surface and underwater vessels, electric aircraft, and electric spacecraft. The literature covering Plug-in Electric Vehicles (EVs) contains many charging/discharging strategies. However, none of the review papers covers such strategies in a complete fashion where all patterns of EVs charging/discharging are identified.
  • 1.1K
  • 01 Feb 2021
Topic Review
D Adenovirus Oncolytic Viral Vectors
Oncolytic adenoviruses (Ad) have shown promising results in the therapeutic treatment of cancer. Ad type 5 (Ad5) is the most extensively utilized Ad type. However, several limitations exist to using Ad5 as an oncolytic virus, including high levels of anti-Ad5 neutralizing antibodies in the population, binding of the Ad5 hexon to blood coagulation factor X leading to liver sequestration and toxicity, and reduced expression of the primary receptor CAR on many tumors. Here, we use in vitro methods to explore the oncolytic potential of four alternative Ad types (Ad26, 28, 45, and 48) belonging to the species D Ad subgroup and developed replication-competent species D Ads expressing the human sodium iodide symporter protein (hNIS) for combination radiovirotherapy. We evaluated the species D Ad vectors transduction, replication, cytotoxicity, and gene expression in six different cancer cell lines. Species D Ads showed the greatest transduction and cytotoxic killing in the SKBR3 breast cancer cells, followed by 293, A549, and HepG2 cells, however the cytotoxicity was less than the wild type Ad5 virus. In contrast, species D Ads showed limited transduction and cytotoxicity in the Hela and SKOV3 cancer cell lines. These species D Ad vectors also successfully expressed the hNIS gene during infection leading to increased iodide uptake in multiple cancer cell lines. These results, the low seroprevalence of anti-species D antibodies, and the lack of binding to blood coagulation FX, support further exploration of species D Ads as alternative oncolytic adenoviruses against multiple types of cancer.
  • 1.1K
  • 22 Sep 2021
Topic Review
Dipeptidyl Peptidase-4 Inhibitors
The pharmacologic action of DPP-4 inhibitors is similar to that of GLP-1R agonists. The major therapeutic effects of DPP-4 inhibitors protect against degradation of the substrates GLP-1 and glucose-dependent insulinotropic polypeptide (GIP), which are physiological substrates that affect insulin and glucagon secretion in a glucose-dependent manner.
  • 1.1K
  • 13 May 2021
Topic Review
KRAS Mutation in PDAC
The vast majority of patients with pancreatic ductal adenocarcinomas harbor KRAS mutations in their tumors. Functionally, mutated KRAS is not only dedicated to tumor cell proliferation, survival and invasiveness, but also causing the immunosuppression in this cancer. 
  • 1.1K
  • 23 Jun 2021
Topic Review
Sphingolipids in Central Nervous System
Bioactive lipids are a newly defined class of lipids that are actively involved in the regulation of a variety of cellular events. As the name indicates, these molecular factors are subjected to action at the arrival of a specific stimulus and undergo subsequent transitions to cope up with the insult. Among these bioactive lipids, sphingolipids have emerged as distinctive mediators of various cellular processes, ranging from cell growth and proliferation to cellular apoptosis, executing immune responses to regulating inflammation. Recent studies have made it clear that sphingolipids, their metabolic intermediates (ceramide, sphingosine-1-phosphate, and N-acetyl sphingosine), and enzyme systems (cyclooxygenases, sphingosine kinases, and sphingomyelinase) harbor diverse yet interconnected signaling pathways in the central nervous system (CNS), orchestrate CNS physiological processes, and participate in a plethora of neuroinflammatory and neurodegenerative disorders.
  • 1.1K
  • 05 Aug 2021
Topic Review
Engineered Polymer Nanoparticle
Engineering polymeric nanoparticles for their shape, size, surface chemistry, and functionalization using various targeting molecules has shown improved biomedical applications for nanoparticles. Polymeric nanoparticles have created tremendous therapeutic platforms, particularly applications related to chemo- and immunotherapies in cancer.
  • 1.1K
  • 08 Sep 2021
Topic Review
Air Pollutants on Airway Diseases
Air pollutants include toxic particles and gases emitted in large quantities from many different combustible materials. They also include particulate matter (PM) and ozone, and biological contaminants, such as viruses and bacteria, which can penetrate the human airway and reach the bloodstream, triggering airway inflammation, dysfunction, and fibrosis. 
  • 1.1K
  • 26 Oct 2021
Topic Review
RNA-Based Vaccines
Vaccine development using ribonucleic acid (RNA) has become the most promising and studied approach to produce safe and effective new vaccines, not only for prophylaxis but also as a treatment. The use of messenger RNA (mRNA) as an immunogenic has several advantages to vaccine development compared to other platforms, such as lower coast, the absence of cell cultures, and the possibility to combine different targets.
  • 1.1K
  • 24 Dec 2021
Topic Review
The Sanjiangyuan Nature Reserve for Mitigating Human Pressures
This entry developed a human footprint (HF) dataset for the Sanjiangyuan region in China, which was localized the global HF model, then used it to assess the effectiveness of Sanjiangyuan natural reserve.
  • 1.1K
  • 30 Dec 2021
Topic Review
Types of COVID-19 Vaccines
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly contagious virus that emerged at the end of 2019 and has caused an upper respiratory disease pandemic, currently known as Coronavirus Disease 2019 (COVID-19). Vaccine clinical studies are developing promptly with the aim of obtaining vaccines that are effective in suppressing the spread of the virus; however, the development of viral mutations raises concerns about the decreasing effectiveness of the resulting vaccine, which also results in the need for more in-depth studies. There have been 330 vaccines developed, including 136 clinical developments and 194 pre-clinical developments. 
  • 1.1K
  • 12 Jan 2022
Topic Review
Elite Triathlete Profiles in Draft-Legal Triathlons
Triathlon is a sport that combines three disciplines: swimming, cycling, and running. These are carried out consecutively and in this order. 
  • 1.1K
  • 22 Feb 2022
Topic Review
Artificial Intelligence in Alzheimer’s Disease
Alzheimer’s disease (AD) represents most of the dementia cases and stands as the most common neurodegenerative disease. A shift from a curative to a preventive approach is imminent, and we are moving towards the application of personalized medicine, whereas we can shape the best clinical intervention for each patient at a given point. This new step in medicine requires the most recent tools and the analysis of huge amounts of data where the application of artificial intelligence (AI) plays a critical part in the depiction of disease-patient dynamics, critical to reach early/optimal diagnosis, monitoring and intervention. Predictive models and algorithms are the key elements in this innovative field. 
  • 1.1K
  • 02 Mar 2022
Topic Review
MiRNAs Relevant for Asthma
There is an imbalance in asthma between classically activated macrophages (M1 cells) and alternatively activated macrophages (M2 cells) in favor of the latter. MicroRNAs (miRNAs) play a critical role in regulating macrophage proliferation and differentiation and control the balance of M1 and M2 macrophage polarization, thereby controlling immune responses. 
  • 1.1K
  • 05 May 2022
Topic Review
Neo/Post-Fordist Perspective of European Countries’ Official Tourism Websites
It is generally believed, with ample evidence, that there has been a change in demographics and people’s behaviour. The change of demographics has been described as a shift to a postmodern society with a flexible form of production and consumption, characterised as the neo/post-Fordist era. Neo/post-Fordist calls of destinations’ production are illustrated in the content of the websites and call upon the new practices that destinations use to attract the interest of potential travellers. An activity-based approach is apparent in all websites that is directly related to the retrieval of dynamic experiences. The content is culturally and naturally driven, with products associated with nature, ethnic and heritage characteristics. Online positioning associates with words that give a personal touch, urging the websites’ lookers to visit and explore the destinations. Nature has a prominent stance in the website content with places and activities. Neo/post-Fordist tourists are looking to immerse themselves in the destination and ‘create their stories or tales’. 
  • 1.1K
  • 05 May 2022
Topic Review
Exposure Routes of Micro and Nanoplastics to Human
Microplastics (MPs) are plastic particles that range from 1 μm to less than 5 mm, while nanoplastics (NPs) are plastic particles smaller than 1 μm. MNPLs are mainly classified in two ways—primary or secondary—taking into account their origin. Primary MNPLs are plastic particles intentionally manufactured to have a small size (1 μm to less than 5 mm), e.g., pellet beads, which are used as raw material for the production of cosmetics, such as toothpastes, exfoliating treatments, body wash, and other personal care products.
  • 1.1K
  • 22 Jun 2022
Topic Review
Floating Wind Energy Market
The floating technology enables the extraction of wind resources from previously expensive or complex areas to fixed-bottom turbine installation. These floating concepts have revived many countries’ interests in offshore wind energy. Europe has set ambitious renewable energy goals to reduce its environmental impact. The vast untapped offshore wind resources will play an important role in fulfilling the energy demands to achieve the renewable energy targets of the European Union (EU). Floating wind energy heavily depends on political support, especially in the beginning. The support of the national governments is highly unclear under some financial uncertainty. However, the European Union is actively engaged in realizing offshore wind projects through initiatives such as the Interreg and H2020 funds. Furthermore, the EU has a vast economy to support such projects and is attractive to developers because of its high national electricity prices.
  • 1.1K
  • 25 Jul 2022
Topic Review
Targeting KRAS in Pancreatic Ductal Adenocarcinoma
Pancreatic cancer is one of the most intractable malignant tumors worldwide, and is known for its refractory and poor prognosis. Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer. KRAS is the most commonly mutated oncogene in PDAC. It has been considered the “untargetable” oncogene for decades until the emergence of G12C inhibitors, which put an end to this dilemma by covalent binding to the switch-II pocket of the G12C mutant protein. However, G12C inhibitors showed remarkable efficacy against non-small-cell lung cancer (NSCLC), while the G12C mutation is rare in PDAC. Based on the successful experience of G12C inhibitors, targeting KRAS G12D/V, which forms the majority of KRAS mutations in PDAC, is gradually being regarded as a potential therapy.
  • 1.1K
  • 01 Nov 2022
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