CADASIL

Version	Summary	Created by	Modification	Content Size	Created at	Operation
1		Peter Tang	+ 501 word(s)	501	2020-12-15 07:19:10

Cite

If you have any further questions, please contact Encyclopedia Editorial Office.

Select a Style

Tang, P. CADASIL. Encyclopedia. Available online: https://encyclopedia.pub/entry/6025 (accessed on 25 September 2026).

Tang P. CADASIL. Encyclopedia. Available at: https://encyclopedia.pub/entry/6025. Accessed September 25, 2026.

Tang, Peter. "CADASIL" Encyclopedia, https://encyclopedia.pub/entry/6025 (accessed September 25, 2026).

Tang, P. (2021, January 04). CADASIL. In Encyclopedia. https://encyclopedia.pub/entry/6025

Tang, Peter. "CADASIL." Encyclopedia. Web. 04 January, 2021.

CADASIL

Edit

This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/cerebral-autosomal-dominant-arteriopathy-with-subcortical-infarcts-and-leukoencephalopathy

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, usually called CADASIL, is an inherited condition that causes stroke and other impairments. This condition affects blood flow in small blood vessels, particularly cerebral vessels within the brain. The muscle cells surrounding these blood vessels (vascular smooth muscle cells) are abnormal and gradually die. In the brain, the resulting blood vessel damage (arteriopathy) can cause migraines, often with visual sensations or auras, or recurrent seizures (epilepsy).

genetic conditions

References

Buffon F, Porcher R, Hernandez K, Kurtz A, Pointeau S, Vahedi K, Bousser MG,Chabriat H. Cognitive profile in CADASIL. J Neurol Neurosurg Psychiatry. 2006Feb;77(2):175-80.
Dichgans M. Cerebral autosomal dominant arteriopathy with subcortical infarctsand leukoencephalopathy: phenotypic and mutational spectrum. J Neurol Sci. 2002Nov 15;203-204:77-80. Review.
Haritunians T, Boulter J, Hicks C, Buhrman J, DiSibio G, Shawber C, WeinmasterG, Nofziger D, Schanen C. CADASIL Notch3 mutant proteins localize to the cellsurface and bind ligand. Circ Res. 2002 Mar 22;90(5):506-8.
Joutel A, Corpechot C, Ducros A, Vahedi K, Chabriat H, Mouton P, Alamowitch S,Domenga V, Cécillion M, Marechal E, Maciazek J, Vayssiere C, Cruaud C, CabanisEA, Ruchoux MM, Weissenbach J, Bach JF, Bousser MG, Tournier-Lasserve E. Notch3mutations in CADASIL, a hereditary adult-onset condition causing stroke anddementia. Nature. 1996 Oct 24;383(6602):707-10.
Kalaria RN, Viitanen M, Kalimo H, Dichgans M, Tabira T; CADASIL Group ofVas-Cog. The pathogenesis of CADASIL: an update. J Neurol Sci. 2004 Nov15;226(1-2):35-9. Review.
Louvi A, Arboleda-Velasquez JF, Artavanis-Tsakonas S. CADASIL: a critical lookat a Notch disease. Dev Neurosci. 2006;28(1-2):5-12. Review.
Opherk C, Peters N, Herzog J, Luedtke R, Dichgans M. Long-term prognosis andcauses of death in CADASIL: a retrospective study in 411 patients. Brain. 2004Nov;127(Pt 11):2533-9.
Rufa A, Guideri F, Acampa M, Cevenini G, Bianchi S, De Stefano N, StromilloML, Federico A, Dotti MT. Cardiac autonomic nervous system and risk ofarrhythmias in cerebral autosomal dominant arteriopathy with subcortical infarctsand leukoencephalopathy (CADASIL). Stroke. 2007 Feb;38(2):276-80.

©Text is available under the terms and conditions of the Creative Commons-Attribution ShareAlike (CC BY-SA) license; additional terms may apply. By using this site, you agree to the Terms and Conditions and Privacy Policy.

Upload a video for this entry

Information

Subjects: Genetics & Heredity

Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Peter Tang

View Times: 1.1K

Entry Collection: MedlinePlus

Update Date: 04 Jan 2021

Table of Contents

Video Upload Options

References