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Topic Review
Electrospinning Proteins for Wound Healing
In recent years, there has been a growing interest for electrospun polymeric wound dressings with fiber diameters in the nano- and micrometer range. Such wound dressings display a number of properties, which support and accelerate wound healing. For instance, they provide physical and mechanical protection, exhibit a high surface area, allow gas exchange, are cytocompatible and biodegradable, resemble the structure of the native extracellular matrix, and deliver antibacterial agents locally into the wound.
  • 1.2K
  • 22 Feb 2021
Topic Review
Small Peptides of Marine Origin
Cancer is one of the leading causes of death in the world, and antineoplastic drug research continues to be a major field in medicine development. The marine milieu has thousands of biological species that are a valuable source of novel functional proteins and peptides, which have been used in the treatment of many diseases, including cancer. In contrast with proteins and polypeptides, small peptides (with a molecular weight of less than 1000 Da) have overwhelming advantages, such as preferential and fast absorption, which can decrease the burden on human gastrointestinal function. Besides, these peptides are only connected by a few peptide bonds, and their small molecular weight makes it easy to modify and synthesize them. Specifically, small peptides can deliver nutrients and drugs to cells and tissues in the body. These characteristics make them stand out in relation to targeted drug therapy. Nowadays, the anticancer mechanisms of the small marine peptides are still largely not well understood; however, several marine peptides have been applied in preclinical treatment. 
  • 1.2K
  • 10 Mar 2021
Topic Review
Gene Therapy in PolyQ SCAs
Polyglutamine spinocerebellar ataxias (PolyQ SCAs) are a group of 6 rare autosomal dominant diseases, which arise from an abnormal CAG repeat expansion in the coding region of their causative gene. These neurodegenerative ataxic disorders are characterized by progressive cerebellar degeneration, which translates into progressive ataxia, the main clinical feature, often accompanied by oculomotor deficits and dysarthria. Currently, PolyQ SCAs treatment is limited only to symptomatic mitigation, and no therapy is available to stop or delay the disease progression, which culminates with death.
  • 1.2K
  • 27 Apr 2021
Topic Review
Interleukin-7 Signaling in Lymphoid Malignancies
The cytokine interleukin-7 (IL-7) and its receptor are critical for lymphocyte development and homeostasis. The loss of IL-7 signaling causes severe combined immunodeficiency, whereas gain-of-function of the pathway contributes to malignant transformation. It has become increasingly clear that in lymphoid malignancies, especially in T-cell leukemia, many components of the IL-7 signaling pathway carry genetic alterations leading to increased signaling. Moreover, the majority of leukemic cells express the wild type IL-7 receptor and remain dependent on IL-7 signaling for survival, cell cycle progression and proliferation. In this review, we discuss the role of deregulated IL-7-induced JAK-STAT signaling in lymphoid malignancies of T- and B-cell origin.
  • 1.2K
  • 18 May 2021
Topic Review
Photodynamic Therapy in Orthodontics
Treatment of malocclusions using fixed orthodontic appliances makes it difficult for patients to perform hygiene procedures. Insufficient removal of bacterial biofilm can cause enamel demineralization, manifesting by visible white spot lesions or periodontal diseases, such as gingivitis periodontitis or gingival hyperplasia. The classic methods of preventing the above problems include, in addition to proper hygiene, ultrasonic scaling, periodontal debridement, and oral rinses based on chlorhexidine. There is a growing interest among researchers in the possibility of using photodynamic therapy in orthodontics.
  • 1.2K
  • 03 Jun 2021
Topic Review
Korean Wild Soybeans
Domesticated crops suffer from major genetic bottlenecks while wild relatives retain higher genomic diversity. Wild soybean (Glycine soja Sieb. & Zucc.) is the presumed ancestor of cultivated soybean (Glycine max [L.] Merr.), and is an important genetic resource for soybean improvement. Among the East Asian habitats of wild soybean (China, Japan, Korea, and Northeastern Russia), the Korean peninsula is of great importance based on archaeological records, domestication history, and higher diversity of wild soybeans in the region. The collection and conservation of these wild soybean germplasms should be put on high priority. Chung’s Wild Legume Germplasm Collection maintains more than 10,000 legume accessions with an intensive and prioritized wild soybean germplasm collection (>6000 accessions) guided by the international code of conduct for plant germplasm collection and transfer. The center holds a library of unique wild soybean germplasms collected from East Asian wild habitats including the Korean mainland and nearby islands. The collection has revealed interesting and useful morphological, biochemical, and genetic diversity. This resource could be utilized efficiently in ongoing soybean improvement programs across the globe.
  • 1.2K
  • 23 Jun 2021
Topic Review
Mutant p53 Functions
Active p53 is a homotetramer of four identical chains of 393 amino acids. Each monomer presents a modular structure divided into different domains: an acidic disorderedN-terminal region, comprising the transactivation domain (TAD) and the proline-rich region (PRR); a central core sequence-specific DNA-binding domain (DBD); aC-terminal region, encompassing an oligomerization domain (OD) and a disordered regulatory domain (CRD)().
  • 1.2K
  • 29 Jul 2021
Topic Review
Cyclodextrin Multicomponent Complexes: Pharmaceutical Applications
Cyclodextrins (CD) are a family of macromolecules obtained by enzymatic degradation of starch. Their structure resembles a truncated cone, with a somewhat lipophilic central cavity and an external hydrophilic surface.  Due to these characteristics the pharmaceutical applications are mostly related to the ability of CDs to form inclusion complexes, formed by interactions between guest (drug) and host (CD) molecules, and they have the ability to modulate several properties positively affecting the performances and therapeutic profiles of drugs. Besides, a drug–CD complex with the addition of an auxiliary substance, that are called multicomponent or ternary complex, can have a synergic effect, allowing the use of low concentrations of the host compounds, thereby optimizing the cost, toxicity and formulation volume in the final product. Also, these additives such as amino acids, organic acids and bases, and water-soluble polymers interacting with CDs can modulate in vitro and in vivo drug dissolution, thereby modifying the drug’s pharmacokinetic profile.
  • 1.2K
  • 30 Aug 2021
Topic Review
Hybrid rGO@TiO2/CN Nanocomposite
The three-component hybrid (rGO/TiO2/CN) nanocomposite was prepared in order to enhance the photocatalytic properties of anatase TiO2 nanoparticles (NPs) under solar-like irradiation. The rGO/TiO2/CN was prepared in a mixture of the reduced graphene oxide (rGO, 8 wt%), anatase TiO2 nanoparticles (NPs), and graphitic carbon nitride (g-C3N4, 16 wt%).
  • 1.2K
  • 16 Sep 2021
Topic Review
PRDM12 in Health and Diseases
PRDM12 is a member of the PRDI-BF1 (positive regulatory domain I-binding factor 1) homologous domain (PRDM)-containing protein family, a subfamily of Kruppel-like zinc finger proteins, controlling key processes in the development of cancer. PRDM12 is expressed in a spatio-temporal manner in neuronal systems where it exerts multiple functions. PRDM12 is essential for the neurogenesis initiation and activation of a cascade of downstream pro-neuronal transcription factors in the nociceptive lineage.
  • 1.2K
  • 12 Nov 2021
Topic Review
Surface Glucan Structures in Aeromonas spp.
Aeromonas spp. are generally found in aquatic environments, although they have also been isolated from both fresh and processed food. These Gram-negative, rod-shaped bacteria are mostly infective to poikilothermic animals, although they are also considered opportunistic pathogens of both aquatic and terrestrial homeotherms, and some species have been associated with gastrointestinal and extraintestinal septicemic infections in humans. Several cell-surface glucans have been shown to contribute to colonization and survival of Aeromonas pathogenic strains in different hosts, playing important roles in bacterial–host interactions related to pathogenesis These include lipopolysaccharide (LPS), capsule, α-glucan, and glycosylated polar and lateral flagella.
  • 1.2K
  • 06 Dec 2021
Topic Review
Social Capital and Walkability
Empirical evidence suggests that it is possible to socially renew neighbourhoods through the formation of social capital (SC) as an effect of walking. The characteristics of the built environment that influence walkability and SC have been relatively well established by previous research, but contrasts remain. Therefore, this document seeks to investigate the relationship between SC and walkability, through a Scoping Review of empirical studies published in indexed journals in the Web of Science and Scopus. The findings indicate that the formation of SC as an effect of walking is associated with land use and the design of neighbourhood facilities; the provision of urban furniture (benches) and green spaces; and that the design and configuration of the neighbourhoods affects SC even more than the excess density. In addition, the methodological strategies used to arrive at these results were reviewed. The conclusions suggest the need to study this issue from an updated perspective, where new neighbourhood interaction systems can be tracked (that provide new indicators), using advanced tools and technologies that help streamline and make measurements more objective.
  • 1.2K
  • 23 Dec 2021
Topic Review
Alternatively Spliced Isoforms in MAPK Signaling
The mitogen-activated protein kinase (MAPK) cascades are key signaling components  that transmit signals to many cellular processes. Each of the cascades operates by a sequential activation of protein kinases organized in three or more tiers that provide a seemingly linear signal transmission. However, the cellular effects regulated by each cascade may vary significantly. To achieve these diverse effects, the specificity of each cascade is extended by distinct regulators.  Here we describe the importance of having distinct components in each tier of the cascades, particularly alternatively spliced isoforms of the MAPK components. This mode of regulation extends the cascade’s specificity and allows accurate, fine-tuned signaling outcomes that lead to proper cell fates. 
  • 1.2K
  • 28 Jan 2022
Topic Review
Hand Hygiene in a Pandemic Context with SARS-CoV-2
Hand hygiene (HH) is the basis of any program for infection control. It's a good predictor of nosocomial infections, especially when the medical staff come in contact with a patient’s oral cavity. HH is a widespread topic among students or practitioners. Aspects regarding HH have been addressed in numerous studies conducted during the pandemic period with SARS-CoV-2.
  • 1.2K
  • 25 Feb 2022
Topic Review
Emerging Threat of Microplastic Pollution to Terrestrial Plants
Microplastics (MPs) are ubiquitous and constitute a global hazard to the environment because of their robustness, resilience, and long-term presence in the ecosystem.
  • 1.2K
  • 14 Mar 2022
Topic Review
Waste Clearance in the Brain and Neuroinflammation
Alzheimer’s disease (AD) is a multifactorial disease with a heterogeneous etiology. The pathology of Alzheimer’s disease is characterized by amyloid-beta and hyperphosphorylated tau, which are necessary for disease progression. Many clinical trials on disease-modifying drugs for AD have failed to indicate their clinical benefits. Recent advances in fundamental research have indicated that neuroinflammation plays an important pathological role in AD. Damage- and pathogen-associated molecular patterns in the brain induce neuroinflammation and inflammasome activation, causing caspase-1-dependent glial and neuronal cell death. These waste products in the brain are eliminated by the glymphatic system via perivascular spaces, the blood-brain barrier, and the blood–cerebrospinal fluid barrier. Age-related vascular dysfunction is associated with an impairment of clearance and barrier functions, leading to neuroinflammation. The proteins involved in waste clearance in the brain and peripheral circulation may be potential biomarkers and drug targets in the early stages of cognitive impairment.
  • 1.2K
  • 15 Mar 2022
Topic Review
Bimodal Processing and Learning in Insect Models
The study of sensory systems in insects has a long-spanning history of almost an entire century. Olfaction, vision, and gustation are thoroughly researched in several robust insect models and new discoveries are made every day on the more elusive thermo- and mechano-sensory systems. Few specialized senses such as hygro- and magneto-reception are also identified in some insects. In light of recent advancements in the scientific investigation of insect behavior, it is not only important to study sensory modalities individually, but also as a combination of multimodal inputs. This is of particular significance, as a combinatorial approach to study sensory behaviors mimics the real-time environment of an insect with a wide spectrum of information available to it. As a fascinating field that is recently gaining new insight, multimodal integration in insects serves as a fundamental basis to understand complex insect behaviors including, but not limited to navigation, foraging, learning, and memory. 
  • 1.2K
  • 01 Jun 2022
Topic Review
Optical Medieval Music Recognition
Optical Music Recognition (OMR) is one of the key technologies to accelerate and simplify the transcription task in an automatic way. Typically, an OMR system takes an image or manuscript of a musical composition and transforms its content encoded in some digital format such as MEI or MusicXML. 
  • 1.2K
  • 11 Jul 2022
Topic Review
Neurotransmitter Imaging in Parkinsonian Disorders
Neurodegenerative parkinsonian disorders are characterized by a great diversity of clinical symptoms and underlying neuropathology, yet differential diagnosis during lifetime remains probabilistic. Molecular imaging is a powerful method to detect pathological changes in vivo on a cellular and molecular level with high specificity. Thereby, molecular imaging enables to investigate functional changes and pathological hallmarks in neurodegenerative disorders, thus allowing to better differentiate between different forms of degenerative parkinsonism, improve the accuracy of the clinical diagnosis and disentangle the pathophysiology of disease-related symptoms. 
  • 1.2K
  • 21 Sep 2022
Topic Review
Applications of Lactic Acid Bacteria
Lactic acid bacteria (LAB) especially Lactobacillus are the vital microbiota of the gut, which is observed as having valuable effects on animals’ and human health. LAB produce lactic acid as the major by-product of carbohydrate degradation and play a significant role in innate immunity enhancement. LAB have significant characteristics to mimic pathogen infections and intrinsically possess adjuvant properties to enhance mucosal immunity. Increasing demand and deliberations are being substantially focused on probiotic organisms that can enhance mucosal immunity against viral diseases. LAB can also strengthen their host’s antiviral defense system by producing antiviral peptides, and releasing metabolites that prevent viral infections and adhesion to mucosal surfaces.
  • 1.2K
  • 11 Nov 2022
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