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Topic Review
Citrus Flavone Nobiletin and Circadian Rhythms
The importance of the circadian clock in maintaining human health is now widely acknowledged. Dysregulated and dampened clocks may be a common cause of age-related diseases and metabolic syndrome Thus, circadian clocks should be considered as therapeutic targets to mitigate disease symptoms. 
  • 1.4K
  • 19 Jan 2023
Topic Review
Role of Marine Macroalgae in Cosmeceuticals
The cosmetic industry uses the term ‘cosmeceutical’ to refer to a cosmetic formula that has drug-like applicative advantages. Many marine algae are rich in biologically active components that have been reported to exhibit strong benefits to the skin, mainly for photoprotection, skin whitening, moisturization, anti-aging, anti-wrinkle, antioxidants, and antimicrobial uses. 
  • 1.4K
  • 14 Mar 2022
Topic Review
Biomarker-Driven Drug Development
Biomarker-driven drug development in age of personalized medicines. A biomarker life cycle is broken down into 3 stages - discovery, translation, and qualification. Researchers review current development strategies and technologies applied at each of these stages, with emphasis on the use of real-world data as an important source of supporting evidence.
  • 1.4K
  • 28 Apr 2022
Topic Review
Conventional Event Tree Analysis on Liquefied Natural Gas
Liquefied natural gas (LNG) is stored in facilities located in urban areas and transported over public roads. A shift towards the broader use of LNG is economically and environmentally justified. Conventional event trees for LNG emergency release in three different units is a concept that is based on the physical and chemical properties of LNG. It has been designed with deep consideration and analysis of past experiences and real cases of LNG incidents. The idea of having training checkpoints, such as ‘decision points’ and ‘learning curve points’ in the continuum of a training or exercise enable the achievement of optimal learning objectives in a flexible way which take into account the trainee individual mental and physical disposition on a day, scalability of difficulty level as well as realistic scenario paths determined by the performance of the trainees facing concrete operational problems.
  • 1.4K
  • 07 Mar 2022
Topic Review
Trends of Crimes on LGTBI People in Spain
Respect for different sexual options and orientations prevents the occurrence of hate crimes against lesbian, gay, bisexual, trans and intersex (LGTBI) persons for this reason. In Spain there is an upward trend in the number of hate crime victimizations motivated by sexual identity or orientation. The effectiveness of data collection, thanks to better training and awareness of police forces regarding hate crimes and the processes of data cleansing and consolidation contributes to a greater visibility of hate crimes against LGTBI people.
  • 1.4K
  • 27 Mar 2022
Topic Review
Hyaluronic Acid for the Treatment of Gingival Recession
In periodontal surgery, hyaluronic acid exhibited better results in complete root coverage and mean root coverage when compared to the control group. Gingival recession reduction, clinical attachment level, and keratinized tissue gain were significantly increased compared to the control groups.
  • 1.4K
  • 25 Nov 2022
Topic Review
The Gender Gap in Infertility
The gender impact assessment (GIA) can be defined as an ex ante or ex post evaluation, analysis, or assessment of law, policy, or programme that helps to identify the likelihood of a decision having negative consequences for equality between women and men. GIA is aimed at improving the design and planning policy to prevent a negative effect on gender equality and improve gender equality through gender-oriented strategies.
  • 1.4K
  • 22 Jun 2021
Topic Review
Chronic Rhinosinusitis and Alzheimer’s Disease
Among millions of sufferers of chronic rhinosinusitis (CRS), the challenge is not only constantly coping with CRS-related symptoms, such as congested nose, sinus pain, and headaches, but also various complications, such as attention difficulties and possible depression. These complications suggest that neural activity in the central nervous system may be altered in those patients, leading to unexpected conditions, such as neurodegeneration in elderly patients. 
  • 1.4K
  • 26 Oct 2021
Topic Review
Consanguinity and Congenital Heart Disease Susceptibility
Congenital heart disease (CHD) encompasses a wide range of structural defects of the heart and, in many cases, the factors that predispose an individual to disease are not well understood, highlighting the remarkable complexity of CHD etiology. Evidence of familial aggregation of CHD has been demonstrated in different communities and for different cardiac lesions. Consanguinity, particularly among first cousins, is an added risk factor for these families, particularly in societies where it is considered a common cultural practice, as confirmed in previous studies conducted in Saudi Arabia and other countries.
  • 1.4K
  • 24 Feb 2022
Topic Review
Microbiological Food Safety of Seaweeds
The use of seaweeds in the human diet has a long history in Asia and has now been increasing also in the western world. Concurrent with this trend, there is a corresponding increase in cultivation and harvesting for commercial production. Edible seaweed is a heterogenous product category including species within the green, red, and brown macroalgae. Moreover, the species are utilized on their own or in combinatorial food products, eaten fresh or processed by a variety of technologies. 
  • 1.4K
  • 11 Nov 2021
Topic Review
Antiviral Activity of Nitric Oxide
Nitric oxide (NO) is a gaseous free radical that is largely produced by the enzyme NO synthase (NOS) in cells. NO produced by upper epidermal cells contributes to the inactivation of viruses and bacteria contained in air or aerosols. In addition to enzymatic production, NO can be generated by the chemical reduction of inorganic nitrite (NO2−), an alternative mechanism for NO production in living organisms. Dietary vitamin C, largely contained in fruits and vegetables, can reduce the nitrite in saliva to produce NO in the oral cavity when chewing foods. In the stomach, salivary nitrite can also be reduced to NO by vitamin C secreted from the epidermal cells of the stomach. The strong acidic pH of gastric juice facilitates the chemical reduction of salivary nitrite to produce NO. It is evident that NO exhibits substantial antiviral activity against many types of viruses, including SARS-CoV-2.
  • 1.4K
  • 28 Apr 2023
Topic Review
Diagnosis and Management of Mandibular Crowding
Crowding is the most frequent malocclusion in orthodontics, with a strong hereditary tendency. It already occurs in pediatric age and is mainly hereditary. It is a sign of a lack of space in the arches, and is not self-correcting, but can worsen over time. The main cause of the worsening of this malocclusion is a progressive and physiological decrease in the arch perimeter.  An orthodontic treatment cannot ignore the concept of “guide arch”, which concerns the lower arch, because of the objective difficulty in increasing its perimeter; the bone structure of the lower jaw is more compact than that of the upper one. Its expansion, in fact, is limited to a slight vestibularization of the incisors and lateral sectors that may be associated with a limited distalization of the molars. There are various therapeutic solutions available to the orthodontist, and a correct diagnosis through clinical examination, radiographs and model analysis are essential. The decision of how to deal with crowding cannot be separated from an overall assessment of the malocclusion to be treated.
  • 1.4K
  • 08 May 2023
Topic Review
Anthocyanin
Anthocyanin is a natural soluble pigment in the flavonoid group. Approximately 635 or more structures have been found in nature and more than 30 types of anthocyanins and anthocyanidins have been identified based on the number and position of the hydroxyl group. The common aglycones are pelargonidin (Pg), cyanidin (Cy), peonidin (Pn), delphinidin (Dp), petunidin (Pt), and malvidin (Mv), but Cy-3-glucoside was widely distributed. Anthocyanins are mostly absorbed through the gastric wall with absorption rates of 10–22%, depending on chemical structure, and the bioavailability is approximately 0.26–1.8%. Anthocyanins produce antimicrobial, antioxidant, and anti-inflammatory effects and play a role in the prevention and treatment of numerous chronic conditions, such as obesity, diabetes mellitus (DM), cardiovascular disease (CVD), eye diseases, and in suppressing cancer cell growth.
  • 1.4K
  • 05 Jul 2021
Topic Review
Physical Exercise and Saliva Composition
Salivary glands are exocrine organs that produce a large amount of fluid. Through the saliva, electrolytes and other substances are transferred from the inner of the glands to the oral cavity. The mean volume of the fluid is estimated to be 750 mL/day, which almost represents 20% of the overall plasma volume. Apart from the major salivary glands (2–5 mL/min), saliva is also secreted by several minor glands at a rate of 0.5 mL/min.
  • 1.4K
  • 28 Jan 2022
Topic Review
Sustainable Approaches to Medical Tourism in Greece
Medical tourism involves individuals traveling for health services outside their local environment. Sustainability factors refer to elements or aspects that contribute to the long-term viability and resilience of a system, process, or industry.
  • 1.4K
  • 05 Jan 2024
Topic Review
Minimally Invasive Capsule Panendoscopy
In the early 2000s, the introduction of single-camera wireless capsule endoscopy (CE) redefined small bowel study. Progress continued with the development of double-camera devices, first for the colon and rectum, and then, for panenteric assessment. Advancements continued with magnetic capsule endoscopy (MCE), particularly when assisted by a robotic arm, designed to enhance gastric evaluation.
  • 1.4K
  • 04 Mar 2024
Topic Review
Autism Care and Intervention Based on Mobile Apps
The mobile apps can be categorized into autism support apps, educational apps, teacher training apps, parental support apps, and data collection apps. The individuals with autism spectrum disorder (ASD) are the primary users of the first two categories of apps. Teachers of children with ASD are the primary users of the teacher training apps. Parents are the primary users of the parental support apps, while individuals with ASD are usually the primary users of the data collection apps and clinicians and autism researchers are the beneficiaries. Gamification, virtual reality, and autism-specific mechanisms have been used to improve the usability of the apps. User-centered design is the most popular approach for mobile app development. Augmentative and alternative communication, video modeling, and various behavior change practices have been used as the theoretical foundation for intervention efficacy.
  • 1.4K
  • 19 Sep 2023
Topic Review
Clinical Communication Skills in Dental Education
Effective communication skills, that is, accurate listening or observation and focused verbal or non-verbal response, enhances efficiency of diagnoses, ethical clinical decision making, positive clinical outcomes, promotes patient use of services, and patient–clinician satisfaction. It also helps to decrease patient anxiety and pain perception.
  • 1.4K
  • 19 Apr 2022
Topic Review
Circadian Rhythms and Glioblastomas
Gliomas are solid tumors of the central nervous system (CNS) that originated from different glial cells. The World Health Organization (WHO) classifies these tumors into four groups (I–IV) with increasing malignancy. Glioblastoma (GBM) is the most common and aggressive type of brain tumor classified as grade IV. GBMs are resistant to conventional therapies with poor prognosis after diagnosis even when the Stupp protocol that combines surgery and radiochemotherapy is applied. Nowadays, few novel therapeutic strategies have been used to improve GBM treatment, looking for higher efficiency and lower side effects, but with relatively modest results. The circadian timing system temporally organizes the physiology and behavior of most organisms and daily regulates several cellular processes in organs, tissues, and even in individual cells, including tumor cells.
  • 1.4K
  • 15 Aug 2021
Topic Review
Mechanism of Actions of Long Non-Coding RNAs
Long non-coding RNAs (lncRNAs) are master regulators of almost all biological processes. LncRNAs perform their function mostly through different chromatin-based mechanisms such as signals, decoys, guides, and scaffolds in chromatin remodelling. LncRNAs play a major role in genomic imprinting. 
  • 1.4K
  • 22 Nov 2022
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