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Topic Review
In Vivo/In Vitro Electrochemical Detection of Neurochemicals
Neurochemicals, crucial for nervous system function, influence vital bodily processes and their fluctuations are linked to neurodegenerative diseases and mental health conditions. Monitoring these compounds is pivotal, yet the intricate nature of the central nervous system poses challenges. Researchers have devised methods, notably electrochemical sensing with micro-nanoscale electrodes, offering high-resolution monitoring despite low concentrations and rapid changes. Implantable sensors enable precise detection in brain tissues with minimal damage, while microdialysis-coupled platforms allow in vivo sampling and subsequent in vitro analysis, addressing the selectivity issues seen in other methods.
  • 44
  • 27 Mar 2024
Topic Review
Applications of Magnet Integrated Fabric Phase Sorptive Extraction
In 2014, Kabir and Furton invented fabric phase sorptive extraction (FPSE), which was considered as a new breakthrough in microextraction technologies at that time, while two years later, the same research group introduced an advantageous innovative configuration of FPSE that combines stirring and extraction mechanism into a single sample preparation device, keeping all benefits originally offered by FPSE. Magnet integrated fabric phase sorptive extraction (MI-FPSE) was eventually emerged as a new, advantageous implementation of FPSE.
  • 51
  • 12 Mar 2024
Topic Review
Fluorescence Imaging with Chemical Sensors in Marine Research
Fluorescence imaging in combination with optical chemical sensors has become a powerful analytical tool that enables the visualization and quantification of chemical species within a sample or on sample surfaces. By the use of fluorescent sensor parameters which exhibit no intrinsic color or fluorescence, e.g., oxygen, pH, CO2, and H2O2, various metal cations or temperature can be imaged. Imaging methods by the means of optical sensors are applied in diverse scientific areas such as medical research and diagnostics, aerodynamics, environmental analysis, or marine research.
  • 55
  • 06 Mar 2024
Topic Review
Applications of Gas Chromatography for Tricyclic Antidepressants Analysis
Tricyclic antidepressant drugs (TCAs) are a main category of antidepressants, which are widely used for the treatment of psychological disorders due to their low cost and their high efficiency. Therefore, there is a great demand for method development for the determination of TCAs in biofluids, especially for therapeutic drug monitoring. Gas chromatography (GC) was the first chromatographic technique implemented for this purpose. With the development in the field of sample preparation, many novel GC applications have been developed. 
  • 60
  • 05 Mar 2024
Topic Review
Electrochemical Impedance Spectroscopy Detection of Endocrine Disruptors
Endocrine disruptors (EDs) are contaminants that may mimic or interfere with the body’s hormones, hampering the normal functions of the endocrine system in humans and animals. These substances, either natural or man-made, are involved in development, breeding, and immunity, causing a wide range of diseases and disorders. The traditional detection methods such as enzyme linked immunosorbent assay (ELISA) and chromatography are still the golden techniques for EDs detection due to their high sensitivity, robustness, and accuracy. Nevertheless, they have the disadvantage of being expensive and time-consuming, requiring bulky equipment or skilled personnel. On the other hand, early stage detection of EDs on-the-field requires portable devices fulfilling the Affordable, Sensitive, Specific, User-friendly, Rapid and Robust, Equipment free, Deliverable to end users (ASSURED) norms. Electrochemical impedance spectroscopy (EIS)-based sensors can be easily implemented in fully automated, sample-to-answer devices by integrating electrodes in microfluidic chips.
  • 75
  • 04 Mar 2024
Topic Review
Signal Modulation for SPR and SPRi Sensors
Advances in near-field optics have emerged, resulting in the development of surface plasmon resonance (SPR) imaging (SPRi) as a powerful optical, label-free monitoring tool for multiplexed detection and monitoring of biomolecular events. The microarrays design of the SPRi chips incorporating various metallic nanostructures make these optofluidic devices more suitable for diagnosis and near-patient testing than the traditional SPR sensors.
  • 63
  • 04 Mar 2024
Topic Review
Sensors for Dairy Food Safety Monitoring
One of the most consumed foods is milk and milk products, and guaranteeing the suitability of these products is one of the major concerns in our society. This has led to the development of numerous sensors to enhance quality controls in the food chain. However, this is not a simple task, because it is necessary to establish the parameters to be analyzed and often, not only one compound is responsible for food contamination or degradation. To attempt to address this problem, a multiplex analysis together with a non-directed (e.g., general parameters such as pH) analysis are the most relevant alternatives to identifying the safety of dairy food. In recent years, the use of new technologies in the development of devices/platforms with optical or electrochemical signals has accelerated and intensified the pursuit of systems that provide a simple, rapid, cost-effective, and/or multiparametric response to the presence of contaminants, markers of various diseases, and/or indicators of safety levels.
  • 65
  • 27 Feb 2024
Topic Review
Digital PCR for Single-Cell Analysis
Single-cell analysis provides an overwhelming strategy for revealing cellular heterogeneity and new perspectives for understanding the biological function and disease mechanism. Moreover, it promotes the basic and clinical research in many fields at a single-cell resolution. A digital polymerase chain reaction (dPCR) is an absolute quantitative analysis technology with high sensitivity and precision for DNA/RNA or protein. With the development of microfluidic technology, digital PCR has been used to achieve absolute quantification of single-cell gene expression and single-cell proteins. For single-cell specific-gene or -protein detection, digital PCR has shown great advantages. 
  • 79
  • 23 Feb 2024
Topic Review
Meta-Analysis and Analytical Methods in Cosmetics Formulation
The ever-evolving cosmetic industry requires advanced analytical techniques to explore, understand, and optimize product performance at nano, micro, and macroscopic levels. Nowadays, these insights are crucial for translating microstructure behavior into macroscopic properties. This knowledge is essential to formulate products with a lower carbon footprint and a higher sustainability profile, incorporating, at the same time, natural or biobased raw materials.
  • 76
  • 22 Feb 2024
Topic Review
Characteristics and Extraction Capacity of Deep Eutectic Solvents
A renewed understanding of eco-friendly principles is moving the industrial sector toward a shift in the utilization of less harmful solvents as a main strategy to improve manufacturing. Green analytical chemistry (GAC) has definitely paved the way for this transition by presenting green solvents to a larger audience. Among the most promising, surely DESs (deep eutectic solvents), NaDESs (natural deep eutectic solvents), HDESs (hydrophobic deep eutectic solvents), and HNaDESs (hydrophobic natural deep eutectic solvents), with their unique features, manifest a wide-range of applications, including their use as a means for the extraction of small bioactive compounds.
  • 58
  • 22 Feb 2024
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