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Topic Review
Eosinophil Structure and Biology
Eosinophils are granulocytes with unique biology. The fact that these cells have been largely preserved during evolution strongly suggests that they play relevant physiological functions. Eosinophils have traditionally been classified as effector cells with prevalent cytotoxic activity, although recent evidence indicates that these cells may play a role in a wide range of homeostatic and regulatory functions.
  • 9.3K
  • 09 Sep 2022
Topic Review
Lipsticks History, Formulations, and Production
Lipsticks are one of the most widely used cosmetic products. Social, psychological, and therapeutic benefits can be attained from using lipstick. The beauty and attractiveness of a person are enhanced as lipsticks colour the lips and protect them from the external environment.
  • 8.5K
  • 02 Mar 2022
Topic Review
Effective Self-Management in Chronic Kidney Disease?
The role of self-management is gaining increasing attention in the management of long-term conditions, including chronic kidney disease (CKD). Self-management refers to the means by which people take an active role in their healthcare. In the UK, supported self-management is part of the National Health Service’s (NHS’s) commitment to make personalised care the norm. This emphasises the need to encourage, support and empower people to manage their ongoing health themselves In order for an individual to be able to look after their health and effectively manage their long-term condition, they need to have the knowledge to understand what to do and why, the skills to be able to perform the required tasks or behaviours, and the confidence that they can do it—this has been termed patient activation.
  • 3.5K
  • 10 Mar 2022
Topic Review
Neurobiological Links between Stress and Traumatic Brain Injury
Neurological dysfunctions commonly occurs after mild or moderate traumatic brain injury (TBI). Although most TBI patients recover from such dysfunction in a short period of time, some present with persistent neurological deficits. Stress is a potential factor that is involved in recovery from neurological dysfunction after TBI. However, there has been limited research on the effects and mechanisms of stress on neurological dysfunctions due to TBI. The effects of TBI and stress on neurological dysfunctions and different brain regions such as the prefrontal cortex, hippocampus, amygdala, and hypothalamus are investigated, and the neurobiological links and mechanisms between stress and TBI are explored.
  • 3.2K
  • 07 Sep 2022
Topic Review
Host Defenses to Viruses
The constant battle between viruses and their hosts leads to their reciprocal evolution. Viruses regularly develop survival strategies against host immunity, while their ability to replicate and disseminate is countered by the antiviral defense mechanisms that host mount. Although most viral infections are generally controlled by the host’s immune system, some viruses do cause overt damage to the host. The outcome can vary widely depending on the properties of the infecting virus and the circumstances of infection but also depends on several factors controlled by the host, including host genetic susceptibility to viral infections.
  • 3.2K
  • 16 Feb 2022
Topic Review
Glass Ionomer Cement
The glass ionomer cement (GIC) is a translucent, water-based cement invented in 1972 by Wilson and Kent.
  • 3.1K
  • 30 Nov 2021
Topic Review
Music and Obsessive-Compulsive Disorder
Obsessive-compulsive disorder (OCD) is a severe psychiatric disorder, which can be associated with music-related symptoms. Music may also be used as an adjunct treatment for OCD. Patients with OCD might benefit from music therapy, which includes listening to music.
  • 3.1K
  • 22 Nov 2021
Topic Review
NF-κB
The family of NF-κB is composed of five members of proteins linking to DNA, (RelA, RelB, RelC, NFκ-B1, and NFκ-B2) that trigger a set of inflammatory downstream effectors after nuclear translocation, involved in a broad range of biological processes. Either a canonical or a non-canonical pathway can be responsible for their activation; the canonical pathway mediates inflammatory responses and leads to a rapid but transient NF-κB activation, while the non-canonical signalling is a slow, long-lasting pathway.
  • 2.8K
  • 27 Oct 2020
Topic Review
SARS-CoV-2 and COVID-19
Morbidity and mortality of coronavirus disease 2019 (COVID-19) are due in large part to severe cytokine storm and hypercoagulable state brought on by dysregulated host-inflammatory immune response, ultimately leading to multi-organ failure. Exacerbated oxidative stress caused by increased levels of interleukin (IL)-6 and tumor necrosis factor α (TNF-α) along with decreased levels of interferon α and interferon β (IFN-α, IFN-β) are mainly believed to drive the disease process. Based on the evidence attesting to the ability of glutathione (GSH) to inhibit viral replication and decrease levels of IL-6 in human immunodeficiency virus (HIV) and tuberculosis (TB) patients, as well as beneficial effects of GSH on other pulmonary diseases processes, we believe the use of liposomal GSH could be beneficial in COVID-19 patients.
  • 2.7K
  • 25 Dec 2020
Topic Review
Almond Allergens
Tree nuts are considered an important food in healthy diets. However, for part of the world’s population, they are one of the most common sources of food allergens causing acute allergic reactions that can become life-threatening. They are part of the Big Eight food groups which are responsible for more than 90% of food allergy cases in the United States, and within this group, almond allergies are persistent and normally severe and life-threatening. Almond is generally consumed raw, toasted or as an integral part of other foods. Its dietary consumption is generally associated with a reduced risk of cardiovascular diseases. Several almond proteins have been recognized as allergens. Six of them, namely Pru du 3, Pru du 4, Pru du 5, Pru du 6, Pru du 8 and Pru du 10, have been included in the WHO-IUIS list of allergens. Nevertheless, further studies are needed in relation to the accurate characterization of the already known almond allergens or putative ones and in relation to the IgE-binding properties of these allergens to avoid misidentifications.
  • 2.7K
  • 30 Sep 2021
Topic Review
Amyloidosis in Alzheimer’s Disease
Amyloidosis is a clinical and pathological condition in which amyloid accumulates in various organs and cells of the body, forming amyloid plaques for complex reasons, leading to organ dysfunction. It can be hereditary or acquired. Depending on the location of amyloid fibers’ deposition, amyloidosis is divided into two groups, one is localized amyloidosis, that occurs in a specific area of a single tissue, and the other is systemic amyloidosis, which occurs throughout the body. Amyloid plaques are made up of amyloid proteins. Amyloid β peptide (Aβ) is the main component that plays a significant role in the pathogenesis of AD and is considered to be the leading cause of Alzheimer’s disease (AD) development.
  • 2.6K
  • 21 Feb 2022
Topic Review
Dietary Natural Compounds and Vitamins Impact Uterine Fibroids
Within the past 20 year-span concerning risks of uterine fibroids (UFs) occurrence and dietary factors was carried out. A link between Vitamin D deficiency and UFs formation is strongly indicated, making it a potent compound in leiomyoma therapy. Analogs of the 25-hydroxyvitamin D3, not susceptible to degradation by tissue 24-hydroxylase, appear to be especially promising and tend to show better therapeutic results. Although research on the role of Vitamin A in the formation of fibroids is contradictory, Vitamin A-enriched diet, as well as synthetic retinoid analogues, may be preventative or limit the growth of fibroids. Unambiguous conclusions cannot be drawn regarding Vitamin E and C supplementation, except for alpha-tocopherol. Alpha-tocopherol as a phytoestrogen taking part in the modulation of estrogen receptors (ERs) involved in UF etiology, should be particularly avoided in therapy. A diet enriched in fruits and vegetables, as sources of carotenoids, polyphenols, quercetin, and indole-3-carbinol, constitutes an easily modifiable lifestyle element with beneficial results in patients with UFs. Other natural substances, such as curcumin, can reduce the oxidative stress and protect against inflammation in leiomyoma. Although the exact effect of probiotics on uterine fibroids has not yet been thoroughly evaluated at this point, the protective role of dairy products, i.e., yogurt consumption, has been indicated. Trace elements such as selenium can also contribute to antioxidative and anti-inflammatory properties of a recommended diet.
  • 2.6K
  • 11 Mar 2022
Topic Review
L-Citrulline
L-citrulline (CIT) is an organic compound and a non-essential amino acid, and the body can synthesize it endogenously. Diet is a poor source of CIT and endogenous synthesis the its main source in the body. Watermelon is the principal source of that amino acid in the diet; the name citrulline comes from Citrullus lanatus (Thunb.), the scientific name for watermelon. CIT concentration in watermelon depends on the type of cultivir and usually ranges between 0.7 and 3.6 g/kg of fresh weight. CIT is present in both the flesh and in the ring.
  • 2.5K
  • 06 May 2021
Topic Review
BioFilms
Biofilms are aggregates formed as a protective survival state by microorganisms to adapt to the environment and can be resistant to antimicrobial agents and host immune responses due to chemical or physical diffusion barriers, modified nutrient environments, suppression of the growth rate within biofilms, and the genetic adaptation of cells within biofilms. With the widespread use of medical devices, medical device-associated biofilms continue to pose a serious threat to human health, and these biofilms have become the most important source of nosocomial infections. However, traditional antimicrobial agents cannot completely eliminate medical device-associated biofilms. New strategies for the treatment of these biofilms and targeting biofilm infections are urgently required. Several novel approaches have been developed and identified as effective and promising treatments.
  • 2.3K
  • 13 Apr 2021
Topic Review
Immediate Hypersensitivity Reactions Induced by COVID-19 Vaccines
As the world deals with the COVID-19 pandemic, vaccination remains vital to successfully end this crisis. However, COVID-19-vaccine-induced immediate hypersensitivity reactions presenting with potentially life-threatening systemic anaphylactic reactions are one of the reasons for vaccine hesitancy. Studies have suggested that different mechanisms, including IgE-mediated and non-IgE-mediated mast cell activation, may be involved in immediate hypersensitivity. The main culprits triggering hypersensitivity reactions have been suggested to be the excipients of vaccines, including polyethylene glycol and polysorbate 80. Patients with a history of allergic reactions to drugs, foods, or other vaccines may have an increased risk of hypersensitivity reactions to COVID-19 vaccines. Various strategies have been suggested to prevent hypersensitivity reactions, including performing skin tests or in vitro tests before vaccination, administering different vaccines for the primary and following boosters, changing the fractionated doses, or pretreating the anti-IgE antibody.
  • 2.3K
  • 01 Jun 2022
Topic Review
Hedgehog Signaling Pathway
The hedgehog (Hh) pathway is a sophisticated conserved cell signaling pathway that plays an essential role in controlling cell specification and proliferation, survival factors, and tissue patterning formation during embryonic development.
  • 2.1K
  • 10 Jan 2022
Topic Review
Tryptophan
Tryptophan is an essential amino acid whose metabolites play key roles in diverse physiological processes.They influence immune reactions, have antioxidant properties, and can function as anabolic signals. Apart from this, they act as regulators of the circadian rhythm, and can thus modulate sleep disorders or cognitive functions. Given these diverse roles, Trp metabolism has a significant impact on the clinical outcome of critically ill patients
  • 2.1K
  • 10 Nov 2021
Topic Review
Balance Remains Impaired after Hip Arthroplasty
Hip arthroplasty (HA) is the end-stage intervention for patients affected by hip osteoarthritis (OA). It is the most common joint replacement procedure and the number of patients undergoing prosthetic implantation is progressively growing due to the ageing population. The evidence suggested that balance is impaired immediately after surgery and, 4–12 months after surgery, it becomes better than preoperatively, although without reaching the level of healthy subjects. A strong level of evidence was found for hip resurfacing resulting in better balance restoration than total HA (THA), and for strength and ROM exercises after surgery positively influencing balance. 
  • 2.1K
  • 23 Mar 2022
Topic Review
Treatment of Mitochondrial Neurogastrointestinal Encephalomyopathy
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder  caused by mutations in the nuclear TYMP gene, which encodes for thymidine phosphorylase, an enzyme required for the normal metabolism of deoxynucleosides, thymidine, and deoxyuridine. The subsequent elevated systemic concentrations of deoxynucleosides lead to increased intracellular concentrations of their corresponding triphosphates, and ultimately mitochondrial failure due to progressive accumulation of mitochondrial DNA (mtDNA) defects and mtDNA depletion. Currently, there are no treatments for MNGIE where effectiveness has been evidenced in clinical trials. A Phase 2, multi-centre, multiple dose, open label trial without a control will investigate the application of erythrocyte-encapsulated thymidine phosphorylase (EE-TP) as an enzyme replacement therapy for MNGIE. Three EE-TP dose levels are planned with patients receiving the dose level that achieves metabolic correction. The study duration is 31 months, comprising 28 days of screening, 90 days of run-in, 24 months of treatment and 90 days of post-dose follow-up. The primary objectives are to determine the safety, tolerability, pharmacodynamics, and efficacy of multiple doses of EE-TP. The secondary objectives are to assess EE-TP immunogenicity after multiple dose administrations and changes in clinical assessments, and the pharmacodynamics effect of EE-TP on clinical assessments.
  • 2.0K
  • 28 Oct 2020
Topic Review
Sulfur Compounds in Garlic for Asthma Treatment
Asthma is a chronic inflammatory disease in the airways with a multifactorial origin but with inflammation and oxidative stress as related pathogenic mechanisms. Garlic (Allium sativum) is a nutraceutical with different biological properties due to sulfur-containing natural compounds. Studies have shown that several compounds in garlic may have beneficial effects on cardiovascular diseases, including those related to the lungs. Therefore, it is possible to take advantage of the compounds from garlic as nutraceuticals for treating lung diseases.
  • 2.0K
  • 14 Dec 2022
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