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Topic Review
Theranostic Radiopharmaceuticals
Theranostic Radiopharmaceuticals (Radiotheranostics) is a term in the medical field to define the combination of therapeutic and diagnostic techniques by a suitable radiopharmaceutical agent. Radionuclides are isotopes that emit radiation or have excess nuclear energy, making them chemically unstable and tend to change into another atom. Various types of radiation can be emitted by radionuclides e.g. alpha particles, beta particles, and gamma energy. In radiotheranostics, a pharmaceutical agent (drug) is needed to be a carrier molecule that introduces the radionuclide to its target. Radionuclides are then used as a source of radiation in radiotheranostics that are responsible for diagnosing or treating various diseases.
  • 1.7K
  • 24 May 2022
Topic Review
Posteromedial Lesions of the Chest Wall
A heterogeneous group of tumors can affect the posteromedial chest wall. They form diverse groups of benign and malignant (primary or secondary) pathologies that can arise from different chest wall structures, i.e., fat, muscular, vascular, osseous, or neurogenic tissues. Chest radiography is very nonspecific for the characterization of chest wall lesions. The modality of choice for the initial assessment of the chest wall lesions is computed tomography (CT). More advanced cross-sectional modalities such as magnetic resonance imaging (MRI) and positron emission tomography (PET) with fluorodeoxyglucose are usually used for further characterization, staging, treatment response, and assessment of recurrence. A systematic approach based on age, clinical history, and radiologic findings is required for correct diagnosis. It is essential for radiologists to be familiar with the spectrum of lesions that might affect the posteromedial chest wall and their characteristic imaging features. Although the imaging findings of these tumors can be nonspecific, cross-sectional imaging helps to limit the differential diagnosis and determine the further diagnostic investigation (e.g., image-guided biopsy). Specific imaging findings, e.g., location, mineralization, enhancement pattern, and local invasion, occasionally allow a particular diagnosis.
  • 1.4K
  • 16 Feb 2022
Topic Review
Renal Artery Ultrasound
Renal artery stenosis (RAS) is one of the major causes of secondary hypertension and renal impairment. Ultrasound (US) is a noninvasive, real-time examination method for detecting RAS. The available US scanners enable the depiction of small vessels or organs. Gray-scale US can assess the morphology of the renal artery and kidney. Hemodynamic changes in the renal artery and kidney are evaluated with color and spectral Doppler US. Contrast-enhanced US may directly show the diameter change in the renal artery with intravascular contrast material that is not harmful to patients with poor renal function. Therefore, US is a useful examination method for detecting RAS, regardless of patient renal function. 
  • 1.3K
  • 14 Oct 2022
Topic Review
COVID-19 Pneumonia and Lung Cancer
Oncological patients are more prone to present severe forms of COVID-19 pneumonia and are subject to worse complications. Radiologists have the challenging role of suggesting a differential diagnosis with lung cancer and treatment-induced lung diseases or suggesting an overlap between these pathologies. Despite similarities or overlapping findings, the combination of clinics and some specific radiological findings, which are also identified by comparison with previous and follow-up CT scans, may guide differential diagnosis.
  • 1.2K
  • 01 Apr 2022
Topic Review
MRS in Hepatic Fat
Magnetic resonance spectroscopy (MRS) is a powerful tool that allows direct quantification of metabolites in tissue or areas of interest. MRS has been applied in both research and clinical studies to assess liver fat noninvasively in vivo. MRS has also demonstrated excellent performance in liver fat assessment with high sensitivity and specificity compared to biopsy and other imaging modalities. Because of these qualities, MRS has been generally accepted as the reference standard for the noninvasive measurement of liver steatosis. MRS is an evolving technique with high potential as a diagnostic tool in the clinical setting. 
  • 1.1K
  • 12 Oct 2021
Topic Review
Imaging Findings of Lung Nodule or Mass
Systemic endemic mycoses are a group of dimorphic fungi prevalent in specific geographical locations. Histoplasma capsulatum, Coccidioides spp., Blastomyces dermatitidis, Cryptococcosis gattii, and Paracoccidioides brasiliensis are the primary pulmonary fungal pathogens of otherwise healthy people. Acute or chronic fungal infections may manifest as solitary or multiple lung nodules or masses. The most frequent pathogens are histoplasmosis, coccidioidomycosis, cryptococcosis, and blastomycosis. The nodules have a nonspecific appearance, may be ill or well-defined, have regular or spiculated borders, and may also demonstrate cavitation or ground glass halo.
  • 1.1K
  • 04 Nov 2022
Topic Review
Clinical Applications of MR Spectroscopy in Pediatrics
In vivo MR spectroscopy is a non-invasive methodology that provides information about the biochemistry of tissues. It is available as a “push-button” application on state-of-the-art clinical MR scanners. MR spectroscopy has been used to study various brain diseases including tumors, stroke, trauma, degenerative disorders, epilepsy/seizures, inborn errors, neuropsychiatric disorders, and others.
  • 1.1K
  • 01 Jul 2022
Topic Review
Magnetic Resonance Imaging for Sjögren’s Syndrome
Primary Sjögren’s Syndrome (pSS) is a chronic autoimmune exocrinopathy affecting 0.3–3.0% of the population. Its main clinical hallmarks are the sicca symptoms (mucosal dryness manifesting mainly ocularly and orally) and extra-glandular symptoms, among which joint pain and chronic fatigue are the most important. Besides these symptoms, pSS may also manifest in the central nervous system (CNS), as noted in the original description of the disease by Sjögren himself in 1933. The most common radiological lesions in pSS are white matter hyperintensities (WMH), scattered alterations hyperlucent on T2 and FLAIR sequences, typically located periventricularly and subcortically. Cortical atrophy and ventricular dilatation can also occur in pSS. Whilst these conditions are thought to be more common in pSS than healthy controls, diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (fMRI) alterations demonstrate evident microstructural changes in pSS. As pSS is often accompanied by cognitive symptoms, these magnetic resonance imaging (MRI) alterations are expectedly related to them. 
  • 1.1K
  • 31 Jan 2023
Topic Review
Advantages and Applications of Total-Body PET Scanning
Total-body positron emission tomography (PET)  scanning can not only image faster than traditional techniques with less administered radioactivity but also perform total-body dynamic acquisition at a longer delayed time point based on its ultrahigh detection sensitivity, enhanced temporal resolution, and long scan range (194 cm). These unique characteristics create several opportunities to improve image quality and can provide a deeper understanding regarding disease detection, diagnosis, staging/restaging, response to treatment, and prognostication. 
  • 1.1K
  • 21 Feb 2022
Topic Review
HRCT of Drug-Induced ILD
Interstitial Lung Diseases (ILDs) represent a heterogeneous group of pathologies, which may be related to different causes. A low percentage of these lung diseases may be secondary to the administration of drugs or substances. Several different high resolution computed tomography (HRCT) patterns related to pulmonary drug toxicity have been reported in literature, and the most frequent ILDs patterns reported include Nonspecific Interstitial Pneumonia (NSIP), Usual Interstitial Pneumonia (UIP), Hypersensitivity Pneumonitis (HP), Organizing Pneumonia (OP), Acute Respiratory Distress Syndrome (ARDS), and Diffuse Alveolar Damage (DAD). 
  • 1.0K
  • 14 Jul 2021
Topic Review
Hepatic Vessel Skeletonization
Hepatic vessel skeletonization serves as an important means of hepatic vascular analysis and vessel segmentation. Skeletonization provides an effective and compact representation of an image object by reducing its dimensionality to a centerline while preserving the original topologic and geometric properties. Hepatic vascular analysis plays a critical role in the diagnosis and treatment of many liver diseases, classification of liver function regions and inquiry into the nature of vascular growth. Hepatic vessel skeletonization serves as an important means of hepatic vascular analysis, particularly because a hepatic vessel is a kind of thin tubular object satisfying the growth principle of Murray’s law.
  • 1.0K
  • 15 Apr 2022
Topic Review
Hydatid Cyst Radiological Pictorial Review
Hydatid cyst is a common name for the larval stage of a tapeworm species of the genus Echinococcus granulosus, which is transmitted from animals to humans via the fecal–oral route. Hydatid cysts predominantly affect the liver (75%), followed by the lung (15%), and they can affect many organs in the human body. Medical imaging modalities are the keystone for the diagnosis of hydatid cysts with high sensitivity and specificity. Ultrasound imaging with high resolution is the first choice for diagnosis, differential diagnosis, staging, establishing a role in interventional management, and follow-up, and it can differentiate Type I hydatid cysts from simple liver cysts. Unenhanced computed tomography (CT) is indicated where or when an ultrasound is unsatisfactory, such as with chest or brain hydatid cysts, when detecting calcification, and in obese patients. Magnetic resonance imaging (MRI) is superior for demonstrating cyst wall defects, biliary communication, neural involvement, and differentiating hydatid cysts from simple cysts using diffusion-weighted imaging (DWI) sequences.
  • 980
  • 03 Apr 2023
Topic Review
Transarterial Chemoembolization for Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. It is principally associated with liver cirrhosis and chronic liver disease. The major risk factors for the development of HCC include viral infections (HBV, HCV), alcoholic liver disease (ALD,) and non-alcoholic fatty liver disease (NAFLD). The optimal treatment choice is dictated by multiple variables such as tumor burden, liver function, and patient’s health status. Surgical resection, transplantation, ablation, transarterial chemoembolization (TACE), and systemic therapy are potentially useful treatment strategies. TACE is considered the first-line treatment for patients with intermediate stage HCC. 
  • 976
  • 24 Mar 2022
Topic Review
Combination Therapies with PRRT
Peptide receptor radionuclide therapy (PRRT) is a successful targeted radionuclide therapy in neuroendocrine tumors (NETs). However, complete responses remain elusive. Combined treatments anticipate synergistic effects and thus better responses by combining ionizing radiation with other anti-tumor treatments. Furthermore, multimodal therapies often have a balanced toxicity profile. To date, few studies have evaluated the effect of combination therapies with PRRT, some of them phase I/II trials. 
  • 936
  • 15 Oct 2021
Topic Review
Pulsed Laser Ablation in Liquid for Gold Nanoparticle
The unique physiochemical properties and biocompatibility of gold nanoparticles have developed a breakthrough in molecular imaging, which allows exploration of gold nanoparticles in drug delivery for diagnostic purpose.  The pulsed laser ablation in liquid (PLAL) technique is a versatile synthetic and convincing technique due to its high efficiency, eco-friendly and facile method to produce gold nanoparticle.
  • 931
  • 16 May 2022
Topic Review
225Ac-Labeled Somatostatin Analogs in Neuroendocrine Tumors Management
The widespread use of peptide receptor radionuclide therapy (PRRT) represents a major therapeutic breakthrough in nuclear medicine, particularly since the introduction of 177Lu-radiolabeled somatostatin analogs. These radiopharmaceuticals have especially improved progression-free survival and quality of life in patients with inoperable metastatic gastroenteropancreatic neuroendocrine tumors expressing somatostatin receptors. In the case of aggressive or resistant disease, the use of somatostatin derivatives radiolabeled with an alpha-emitter could provide a promising alternative. Among the currently available alpha-emitting radioelements, actinium-225 has emerged as the most suitable candidate, especially regarding its physical and radiochemical properties.
  • 916
  • 30 Mar 2023
Topic Review
Surface-Enhanced Raman Spectroscopy
As medicine continues to advance our understanding of and knowledge about the complex and multifactorial nature of cancer, new major technological challenges have emerged in the design of analytical methods capable of characterizing and assessing the dynamic heterogeneity of cancer for diagnosis, prognosis and monitoring, as required by precision medicine. With this aim, novel nanotechnological approaches have been pursued and developed for overcoming intrinsic and current limitations of conventional methods in terms of rapidity, sensitivity, multiplicity, non-invasive procedures and cost. Eminently, a special focus has been put on their implementation in liquid biopsy analysis. Among optical nanosensors, those based on surface-enhanced Raman scattering (SERS) have been attracting tremendous attention due to the combination of the intrinsic prerogatives of the technique (e.g., sensitivity and structural specificity) and the high degree of refinement in nano-manufacturing, which translate into reliable and robust real-life applications.
  • 909
  • 15 Sep 2021
Topic Review
AAZTA-Derived Chelators as Innovative Radiopharmaceuticals
The chelating agent AAZTA features a mesocyclic seven-membered diazepane ring, conferring some of the properties of both acyclic and macrocyclic chelating agents. Described in the early 2000s, AAZTA and its derivatives exhibited interesting properties once complexed with metals and radiometals, combining a fast kinetic of formation with a slow kinetic of dissociation. Importantly, the extremely short coordination reaction times allowed by AAZTA derivatives were particularly suitable for short half-life radioelements (i.e., 68Ga).
  • 909
  • 28 Feb 2022
Topic Review
Scoring-Systems for Colon Capsule Endoscopy
Colon capsule endoscopy is a safe diagnostic tool with low adverse event rates. As with other endoscopic modalities, various colon capsule endoscopy scores allow the standardisation of reporting and reproducibility. As bowel cleanliness affects CCE’s diagnostic yield, a few operator-dependent scores (Leighton–Rex and CC-CLEAR scores) and a computer-dependent score (CAC score) have been developed to grade bowel cleanliness objectively. 
  • 885
  • 17 Jun 2021
Topic Review
COVID-19 Pneumonia/Idiopathic Interstitial Pneumonias
COVID-19 pneumonia represents a challenging health emergency, due to the disproportion between the high transmissibility, morbidity, and mortality of the virus and healthcare systems possibilities. Literature has mainly focused on COVID-19 pneumonia clinical-radiological diagnosis and therapy, and on the most common differential diagnoses, while few papers investigated rare COVID-19 pneumonia differential diagnoses or the overlapping of COVID-19 pneumonia on pre-existing lung pathologies. This article presents the main radiological characteristics of COVID-19 pneumonia and Idiopathic Interstitial Pneumonias (IIPs) to identify key radiological features for a differential diagnosis among IIPs, and between IIPs and COVID-19 pneumonia. COVID-19 pneumonia differential diagnosis with IIPs is challenging, since these entities may share common radiological findings as ground glass opacities, crazy paving patterns, and consolidations. Multidisciplinary discussion is crucial to reach a final and correct diagnosis. Radiologists have a pivotal role in identifying COVID-19 pneumonia patterns, reporting possible overlapping with long-lasting lung diseases, and suggesting potential differential diagnoses. An optimal evaluation of HRTC may help in containing the disease, in promoting better treatment for patients, and in providing an efficient allocation of human and economic resources. 
  • 884
  • 24 Sep 2021
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