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Topic Review
Robotics in Gastrointestinal Endoscopy
Recent advances in endoscopic technology allow clinicians to not only detect digestive diseases early, but also provide appropriate treatment. The development of various therapeutic endoscopic technologies has changed the paradigm in the treatment of gastrointestinal diseases, contributing greatly to improving the quality of life of patients. The application of robotics for gastrointestinal endoscopy improves the maneuverability and therapeutic ability of gastrointestinal endoscopists, but there are still technical limitations. With the development of minimally invasive endoscopic treatment, clinicians need more sophisticated and precise endoscopic instruments. Novel robotic systems are being developed for application in various clinical fields, to ultimately develop into minimally invasive robotic surgery to lower the risk to patients. Robots for endoscopic submucosal dissection, autonomous locomotive robotic colonoscopes, and robotic capsule endoscopes are currently being developed.
  • 1.4K
  • 13 Dec 2021
Topic Review
Ethidium Bromide-Degrading Bacteria from Laboratory Gel Electrophoresis Waste
The bacterium Proteus terrae is a non-pathogenic and natural microflora of humans, but Morganella morganii is an opportunistic pathogen. These organisms belong to risk group II. Screening the sensitivity of these isolates to antibiotics revealed a sufficient number of antibiotics, which can be used to control them, if required. BR3 and BR4 exhibited resistance to individual antibiotics, ampicillin and vancomycin, whereas only BR3 was resistant to tetracycline. The current investigation, along with earlier reported work on these isolates, identifies BR3 as a useful isolate in the industrial application for the degradation of EtBr. Identical and related microorganisms, which are available in the culture collection repositories, can also be explored for such potential to formulate a microbial consortium for the bioremediation of ethidium bromide prior to its disposal. 
  • 1.4K
  • 03 Mar 2022
Topic Review
CRISPR/Cas9 for Functional Analysis in Soybean
CRISPR/Cas9 is the most powerful reverse genetics approach for fast and precise functional analysis of candidate genes/mutations of interest. Rapid and large-scale analyses of CRISPR/Cas-induced mutagenesis is achievable through Agrobacterium rhizogenes-mediated hairy root transformation. The combination of A. rhizogenes hairy root-CRISPR/Cas provides an extraordinary platform for rapid, precise, easy, and cost-effective “in root” functional analysis of genes of interest in legume plants, including soybean.
  • 1.4K
  • 26 Apr 2022
Topic Review
Tungsten Inert Gas Welding Process of Dissimilar Metals
Special attention is required when joining two materials with distinct chemical, physical and thermal properties in order to make the joint bond robust and rigid. Welded samples employing ER-309L filler wires had a microstructure consisting of a delta ferrite network in an austenite matrix. The tensile strength experimental results revealed that welding current, followed by GFR, was a highly influential parameter on tensile strength. Weld metals had higher hardness and flexural strength than stainless steel and carbon steel base metals. 
  • 1.4K
  • 15 Jul 2022
Topic Review
Forensic Limnology
Forensic limnology is a sub-field of freshwater ecology, which focuses especially on the presence of diatoms in crime scene samples and victims. Different methods are used to collect this data but all identify the ratios of different diatom colonies present in samples and match those samples with locations at the crime scene.
  • 1.4K
  • 21 Oct 2022
Topic Review
Event
In philosophy, events are objects in time or instantiations of properties in objects. On some views, only changes in the form of acquiring or losing a property can constitute events, like the lawn's becoming dry. According to others, there are also events that involve nothing but the retaining of a property, e.g. the lawn's staying wet. Events are usually defined as particulars that, unlike universals, cannot repeat at different times. Processes are complex events constituted by a sequence of events. But even simple events can be conceived as complex entities involving an object, a time and the property exemplified by the object at this time. Traditionally, metaphysicians tended to emphasize static being over dynamic events. This tendency has been opposed by so-called process philosophy or process ontology, which ascribes ontological primacy to events and processes.
  • 1.4K
  • 24 Oct 2022
Topic Review
The NK-1 Receptor Signaling in the Eye
Neurokinin-1 receptor (NK1R) signaling pathways play a crucial role in a number of biological processes in the eye. Specifically, in the ocular surface, their activity modulates epithelial integrity, inflammation, and generation of pain, while they have a role in visual processing in the retina. The NK1R is broadly expressed in the eye, in both ocular and non-ocular cells, such as leukocytes and neurons. 
  • 1.4K
  • 30 Nov 2022
Topic Review
Eastern Equine Encephalitis
Eastern equine encephalitis (EEE), commonly called Triple E or sleeping sickness (not to be confused with African trypanosomiasis), is a disease caused by a zoonotic mosquito vectored Togavirus that is present in North, Central, and South America, and the Caribbean. EEE was first recognized in Massachusetts , United States, in 1831, when 75 horses died mysteriously of viral encephalitis. Epizootics in horses have continued to occur regularly in the United States. It can also be identified in donkeys and zebras. Due to the rarity of the disease, its occurrence can cause economic impact beyond the cost of horses and poultry. EEE is found today in the eastern part of the United States and is often associated with coastal plains. It can most commonly be found in East Coast and Gulf Coast states. In Florida, about one to two human cases are reported a year, although over 60 cases of equine encephalitis are reported. In years in which conditions are favorable for the disease, the number of equine cases is over 200. Diagnosing equine encephalitis is challenging because many of the symptoms are shared with other illnesses and patients can be asymptomatic. Confirmations may require a sample of cerebral spinal fluid or brain tissue, although CT scans and MRI scans are used to detect encephalitis. This could be an indication that the need to test for EEE is necessary. If a biopsy of the cerebral spinal fluid is taken, it is sent to a specialized laboratory for testing. Eastern equine encephalitis virus (EEEV) is closely related to Venezuelan equine encephalitis virus and western equine encephalitis virus.
  • 1.4K
  • 05 Dec 2022
Topic Review
Effect of Precipitates on Hot Ductility of Steels
Hot ductility of high-strength microalloyed steel is of great importance since it affects cracking during metal production. This characteristic is controlled by the presence of phase precipitates of microalloying elements depending on the chemical composition and parameters of temperature-deformation treatment of steel.
  • 1.4K
  • 25 Jun 2023
Topic Review
Magnesium Deficiency and Cardiometabolic Disease
Magnesium (Mg2+) has many physiological functions within the body. These include important roles in maintaining cardiovascular functioning, where it contributes to the regulation of cardiac excitation–contraction coupling, endothelial functioning and haemostasis. The haemostatic roles of Mg2+ impact upon both the protein and cellular arms of coagulation. 
  • 1.4K
  • 26 Jul 2023
Topic Review
Spices as Sustainable Food Preservatives
Throughout history, spices have been employed for their pharmaceutical attributes and as a culinary enhancement. The food industry widely employs artificial preservatives to retard the deterioration induced by microbial proliferation, enzymatic processes, and oxidative reactions. Nevertheless, the utilization of these synthetic preservatives in food products has given rise to significant apprehension among consumers, primarily stemming from the potential health risks that they pose. These risks encompass a spectrum of adverse effects, including but not limited to gastrointestinal disorders, the disruption of gut microbiota, allergic reactions, respiratory complications, and concerns regarding their carcinogenic properties. Consequently, consumers are displaying an increasing reluctance to purchase preserved food items that contain such additives. Spices, known for their antimicrobial value, are investigated for their potential as food preservatives. 
  • 1.4K
  • 09 Nov 2023
Topic Review
Cross-Laminated Timber in Finland
Although cross-laminated timber (CLT) construction, driven by only a few domestic manufacturers, is relatively new in Finland, sustainability concerns may increase interest in renewable materials, and therefore, CLT may be more accepted in the Finnish construction market. Additionally, active communication about successful projects and new applications can open new avenues for CLT to gain popularity in the Finnish construction market.
  • 1.4K
  • 28 Dec 2023
Topic Review
The Disease of Sympathetic Overdrive (DSO)
The sympathetic nervous system (SNS) is one of components of the autonomic system (ANS), whose overall ultimate function is to prepare the body for activities, which is a systemic response that affects many organs and systems. Accumulating evidence suggests that the SNS plays a crucial role in human numerous diseases. In the present article, we review the SNS dysfunction and even the disease of sympathetic overdrive (DSO) impact on cardiovascular, digestive, endocrine and metabolic as well as mental nervous system and various systems of the body. Despite the fact that the existence of this disease has not been truly recognized and confirmed. Here we proposed a hypothesis of the disease as DSO for the first time. The aim of the study is identifying the framework of the DSO, including the risk-factors, symptoms, end-points, mechanisms, and the strategies of management in order to improve both of the theory and clinical practice.As the hypothesis of DSO is novel born , the enrichment and improvement of hypothesis of the DSO are surely needed.
  • 1.4K
  • 25 Jul 2024
Topic Review
Google Friend Connect
Google Friend Connect was a free social networking site from 2008 to 2012. Similar in practice to Facebook Platform and MySpaceID, it took a decentralised approach, allowing users to build a profile to share and update information (through messaging, photographs and video content) via third-party sites. These sites acted as a host for profile sharing and social exchanges. Google Friend Connect used open standards such as OpenID, oAuth and OpenSocial and with the intent of freeing users from having to register for additional accounts or usernames. Once authenticated they could use their existing profile and access a social graph when posting messages. It has been said that "social network APIs (how different services on the web talk to each other) such as the[MySpace API, Facebook Connect and Google Friend Connect take the online social graph beyond social networking sites to external web sites and applications". This social graph feature allowed a user to post a message on a third-party site, but allowed viewing access only to other authorised "friends" contained within the user's chosen social graph. Friend Connect was removed for all non-Blogger sites by March 1, 2012, and for Blogger sites on January 11, 2016.
  • 1.4K
  • 24 Nov 2022
Topic Review
High-Entropy Alloy
Cutting edge of high-entropy alloy superconductors from the perspective of materials research.
  • 1.4K
  • 26 Oct 2020
Topic Review
Extracellular Hsp60, Hsp70 and Hsp90
The role of three members of the Chaperone Systems (CS)—heat shock protein (Hsp)60, Hsp70, and Hsp90—in Immune Systems (IS) modulation and neuroinflammation. These three chaperones occur intra- and extracellularly, with the latter being the most likely involved in neuroinflammation because they can interact with the IS.
  • 1.4K
  • 13 Apr 2021
Topic Review
Applying CADD for Neurodegenerative Diseases
Neurodegenerative diseases (NDs) including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease are incurable and affect millions of people worldwide. The development of treatments for this unmet clinical need is a major global research challenge. Computer-aided drug design (CADD) methods minimize the huge number of ligands that could be screened in biological assays, reducing the cost, time, and effort required to develop new drugs. 
  • 1.4K
  • 07 May 2021
Topic Review
Trypsin Induced Degradation of Amyloids
Proteolytic enzymes are known to be involved in the formation and degradation of various monomeric proteins, but the effect of proteases on the ordered protein aggregates, amyloid fibrils, which are considered to be extremely stable, remains poorly understood. In this work we study resistance to proteolytic degradation of lysozyme amyloid fibrils with two different types of morphology and beta-2-microglobulun amyloids.
  • 1.4K
  • 15 Jun 2021
Topic Review
Chromatin Profiling Techniques
The genetic architecture of complex traits is multifactorial. Genome-wide association studies (GWASs) have identified risk loci for complex traits and diseases that are disproportionately located at the non-coding regions of the genome. On the other hand, we have just begun to understand the regulatory roles of the non-coding genome, making it challenging to precisely interpret the functions of non-coding variants associated with complex diseases. Additionally, the epigenome plays an active role in mediating cellular responses to fluctuations of sensory or environmental stimuli. However, it remains unclear how exactly non-coding elements associate with epigenetic modifications to regulate gene expression changes and mediate phenotypic outcomes. Therefore, finer interrogations of the human epigenomic landscape in associating with non-coding variants are warranted.
  • 1.4K
  • 21 Jul 2021
Topic Review
Hematopoietic Stem Cell Transplant Recipients
Hematopoietic stem cell transplant (HSCT) is a multi-step process with a high risk for complications during marrow ablation, during engraftment, or afterwards. Successful transplantation depends on the selection of the hematopoietic stem cell source, host preparation (conditioning regimen), and modulation of immune cell engraftment to minimize graft-versus-host disease (GVHD).
  • 1.4K
  • 07 Aug 2021
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