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Topic Review
Application of Monolayer Graphene
Cryo-electron microscopy (Cryo-EM) has become a routine technology for resolving the structure of biological macromolecules due to the resolution revolution in recent years. The specimens are typically prepared in a very thin layer of vitrified ice suspending in the holes of the perforated amorphous carbon film. However, the samples prepared by directly applying to the conventional support membranes may suffer from partial or complete denaturation caused by sticking to the air-water-interface (AWI). With the application in materials, graphene has also been used recently to improve frozen sample preparation instead of a suspended conventional amorphous thin carbon. It has been proved that graphene or graphene oxide and various chemical modifications on its surface can effectively prevent particles from adsorbing to the AWI, which improves the dispersion, adsorbed number, and orientation preference of frozen particles in the ice layer. Their excellent properties and thinner thickness can significantly reduce the background noise, allowing high-resolution three-dimensional reconstructions using a minimum data set.
  • 1.4K
  • 16 Sep 2021
Topic Review
Chronic Rhinosinusitis and Alzheimer’s Disease
Among millions of sufferers of chronic rhinosinusitis (CRS), the challenge is not only constantly coping with CRS-related symptoms, such as congested nose, sinus pain, and headaches, but also various complications, such as attention difficulties and possible depression. These complications suggest that neural activity in the central nervous system may be altered in those patients, leading to unexpected conditions, such as neurodegeneration in elderly patients. 
  • 1.4K
  • 26 Oct 2021
Topic Review
Chemical Wood Surface Improvements
Increasing the use of wood in buildings is regarded by many as a key solution to tackle climate change. For this reason, a lot of research is carried out to develop new and innovative wood surface improvements and make wood more appealing through features such as increased durability, fire-retardancy, superhydrophobicity, and self-healing.
  • 1.4K
  • 21 Dec 2021
Topic Review
The Assembly of PPTA Nanofibers and the Applications
Poly (p-phenylene terephthalamide) (PPTA) is one kind of lyotropic liquid crystal polymer. Kevlar fibers made from PPTA is widely used in many fields due to the superior mechanical properties resulted from highly oriented macromolecular structure. However, the “infusible and insoluble” characteristic of PPTA gives rise to its poor processability, which limits its scope of application. The strong interactions and orientation characteristic of aromatic amide segments make PPTA attractive in the field of self-assembly. The chemical derivations have proved an effective way to modify the molecular structure of PPTA to improve its solubility and amphiphilicity, which resulted in different liquid crystal behaviors or supramolecular aggregates, but the modification of PPTA is usually complex and difficult. Alternatively, higher order all-PPTA structures have also been realized through the controllable hierarchical self-assembly of PPTA from the polymerization process to the formation of macroscopic products. It briefly introduces the self-assembly methods of PPTA based materials in recent years, and focuses on the polymerization-induced PPTA nanofibers which can be further fabricated into different macroscopic architectures when other self-assembly methods are combined. This monomer-started hierarchical self-assembly strategy evokes the feasible processing of PPTA, and enriches the diversity of product, which is expected to be expanded to other liquid crystal polymers.
  • 1.4K
  • 20 Jul 2022
Topic Review
GIS and BIM and HBIM Integration
3D virtual management is a topic of growing interest. The AEC industry is undergoing a real revolution because of the technological changes that are taking place. Synchronized 3D visualization is one of the tools being deployed at an accelerated pace. This, together with collaborative work, contributes to optimal management for all stakeholders. The integration of geographic information systems and building information modeling and heritage building information modeling (BIM) is one of the most innovative concepts; it enables the generation of collaborative, fluid systems. 
  • 1.4K
  • 09 Nov 2022
Biography
John Pell
John Pell (1 March 1611 – 12 December 1685) was an English mathematician and political agent abroad. He was born at Southwick in Sussex. His father, also named John Pell, was from Southwick, and his mother was Mary Holland, from Halden in Kent. The second of two sons, Pell's older brother was Thomas Pell. By the time he was six, they were orphans, their father dying in 1616 and their mother
  • 1.4K
  • 06 Dec 2022
Biography
Fred Cuny
Frederick C. Cuny (November 14, 1944 – April 15, 1995) was an American humanitarian whose work spanned disaster relief, refugee emergency management, recovery from war and civil conflict as well as disaster and emergency preparedness, mitigation and peacebuilding. He was first and foremost a practitioner, but also a prolific author, an educator and a field-based researcher. He has been describ
  • 1.4K
  • 27 Dec 2022
Topic Review
Molecular Mechanisms in Autoimmune Thyroid Disease
The most common cause of acquired thyroid dysfunction is autoimmune thyroid disease, which is an organ-specific autoimmune disease with two presentation phenotypes: hyperthyroidism (Graves-Basedow disease) and hypothyroidism (Hashimoto’s thyroiditis). Hashimoto’s thyroiditis is distinguished by the presence of autoantibodies against thyroid peroxidase and thyroglobulin. Meanwhile, autoantibodies against the thyroid-stimulating hormone (TSH) receptor have been found in Graves-Basedow disease. Numerous susceptibility genes, as well as epigenetic and environmental factors, contribute to the pathogenesis of both diseases. 
  • 1.4K
  • 24 Mar 2023
Topic Review
Classification of Various Ligands
Enantioselective gold catalysis has flourished due to its distinct performance. In particular, a series of valuable chiral ligands have been identified, including aryl phosphine ligands bearing the proximal chiral sulfinamide motif, phosphoramidite and phosphonite ligands, phosphine ligands comprising the ferrocene scaffold, bifunctional phosphine ligands, biphosphine ligands, chiral counterion-based ligands derived from chiral phosphoric acids and chiral carbene ligands for gold(I) catalysis, along with unique ligand frameworks for cyclometalated gold(III) catalysis. 
  • 1.4K
  • 25 Sep 2023
Topic Review
Human Capital Management and Business Performance
Human capital (HC) is a key factor of the performance and competitiveness of enterprises. HC as an element of intellectual capital, efficiency of invested capital and efficiency of human capital positively affect firms' return on equity (ROE) and business performance.
  • 1.4K
  • 25 Jan 2024
Topic Review
Shprintzen-Goldberg Syndrome
Shprintzen-Goldberg syndrome is a disorder that affects many parts of the body.
  • 1.4K
  • 25 Dec 2020
Topic Review
Challenges in Recycling of Multi-Material Composites
Transformation of waste into resources is an important part of the circular economy. The recovery of materials in the most effective way is crucial for sustainable development. Composite materials offer great opportunities for product development and high performance in use, but their position in a circular economy system remains challenging, especially in terms of material recovery.
  • 1.4K
  • 17 Oct 2023
Topic Review
Differentiation of Genes Encoding Peroxisome Proliferator-Activated Receptors
The heritability of the tendency to obesity is estimated to vary widely (from 5% to 90%), depending on the research method and the hypotheses being tested. Genetic components may play an important role, both in regulating metabolism and influencing behavioral aspects-in the presence of certain critical genetic variants, the dysregulation of energy metabolism can undoubtedly lead to an increased risk of obesity. Genes code for protein products that are directly involved in the processes of digestion, assimilation, and physiological utilization of nutrients supplied to the body. There are also genes whose products are important factors that influence the activation and regulation of various metabolic pathways and also determine the maintenance of the balance of metabolic changes and the shift of this balance in a specific direction. Finally, there are the genes that code for factors that influence human behavior, eating habits, dietary preferences and so on. Systemic regulation of metabolism takes place in human cells at many levels. At the deepest molecular level, metabolic flexibility depends on the configuration of many different metabolic pathways regulated by key transcription factors, many of which interact closely with each other. From this point of view, transcription factors are considered very important elements of metabolic regulatory networks. In this group, genes encoding peroxisome proliferator-activated receptors (PPARs) are among the best studied. PPARs provide balance in nutrient and energy metabolism and maintain metabolic flexibility important for lipid metabolism, glucose homeostasis, cholesterol metabolism, and other important metabolic networks. Differentiation of PPAR genes may affect the efficacy of reduction diets and post-exercise weight loss.
  • 1.4K
  • 06 Jan 2023
Topic Review
Cancer Immunotherapy and Delivery System
Immunotherapy is a powerful clinical strategy for the treatment of various diseases, including cancer, and an understanding of cancer immunology is important to the optimization of this strategy to achieve higher efficacy. 
  • 1.4K
  • 15 Aug 2022
Topic Review
Peptide Drug Conjugates in Cancer Therapy
Drug conjugates have become a significant focus of research in the field of targeted medicine for cancer treatments. Peptide-drug conjugates (PDCs), a subset of drug conjugates, are composed of carrier peptides ranging from 5 to 30 amino acid residues, toxic payloads, and linkers that connect the payload to the peptide. PDCs are further broken down into cell-penetrating peptides (CPPs) and cell-targeting peptides (CTPs), each having their own differences in the delivery of cytotoxic payloads. Generally, PDCs as compared to other drug conjugates—like antibody-drug conjugates (ADCs)—have advantages in tumor penetration, ease of synthesis and cost, and reduced off-target effects. Further, as compared to traditional cancer treatments (e.g., chemotherapy and radiation), PDCs have higher specificity for the target cancer with generally less toxic side effects in smaller doses. 
  • 1.4K
  • 19 Jan 2023
Topic Review
Immunoglobulins with Non-Canonical Functions
Immunoglobulins are known to combine various effector mechanisms of the adaptive and the innate immune system. Classical immunoglobulin functions are associated with antigen recognition and the initiation of innate immune responses. However, in addition to classical functions, antibodies exhibit a variety of non-canonical functions related to the destruction of various pathogens due to catalytic activity and cofactor effects, the action of antibodies as agonists/antagonists of various receptors, the control of bacterial diversity of the intestine, etc. Canonical and non-canonical functions reflect the extreme human antibody repertoire and the variety of antibody types generated in the organism: antigen-specific, natural, polyreactive, broadly neutralizing, homophilic, bispecific and catalytic. The canonical and non-canonical functions of antibodies greatly enhances the functionality of the human immune system.
  • 1.4K
  • 05 Nov 2020
Topic Review
Tumor Microenvironment
In the relatively short history of anti-tumor treatment, numerous medications have been developed against a variety of targets. Intriguingly, although many anti-tumor strategies have failed in their clinical trials, metformin, an anti-diabetic medication, demonstrated anti-tumor effects in observational studies and even showed its synergistic potential with immune checkpoint inhibitors (ICIs) in subsequent clinical studies. Looking back from bedside-to-bench, it may not be surprising that the anti-tumor effect of metformin derives largely from its ability to rewire aberrant metabolic pathways within the tumor microenvironment. As one of the most promising breakthroughs in oncology, ICIs were also found to exert their immune-stimulatory effects at least partly via rewiring metabolic pathways. These findings underscore the importance of correcting metabolic pathways to achieve sufficient anti-tumor immunity. Herein, we start by introducing the tumor microenvironment, and then we review the implications of metabolic syndrome and treatments for targeting metabolic pathways in anti-tumor therapies. We further summarize the close associations of certain aberrant metabolic pathways with impaired anti-tumor immunity and introduce the therapeutic effects of targeting these routes. Lastly, we go through the metabolic effects of ICIs and conclude an overall direction to manipulate metabolic pathways in favor of anti-tumor responses.
  • 1.4K
  • 26 Oct 2020
Topic Review
Nutrition-focused QIPs in Cancer Care
Malnutrition in patients with cancer is a ubiquitous but neglected problem that can reduce patient survival/quality of life and increase treatment interruptions, readmission rates, and healthcare costs. Malnutrition interventions, including nutrition support through dietary counseling, diet fortification, oral nutrition supplements (ONS), and enteral and parenteral nutrition can help improve health outcomes. However, nutritional care standards and interventions for cancer are ambiguous and inconsistently applied. The lack of systematic malnutrition screening and intervention in ambulatory cancer care has especially significant consequences and thus the nutrition support of patients with cancer represents an area for quality improvement. United States healthcare payment models such as the Oncology Care Model are linked to quality of care and health outcomes. Quality improvement programs (QIPs) can advance patient-centered care, perfect care processes, and help healthcare professionals meet their quality measure performance goals. Malnutrition QIPs like the Malnutrition Quality Improvement Initiative (MQii) have been shown to be effective in identifying and treating malnutrition. However, little is known about or has been reported on nutrition or malnutrition-focused QIPs in cancer care. This paper provides information to support translational research on quality improvement and outlines the gaps and potential opportunities for QIPs in the nutrition support of patients with cancer.
  • 1.4K
  • 27 Oct 2020
Topic Review
A2B Adenosine Receptors
Adenosine is a signalling molecule which, by activating specific membrane receptors, acts as an important player during brain insults such as ischemia. or demyelinating injuries. Here we review data in the literature describing A2B receptor-mediated effects in preclinical in vitro and in vivo models of cerebral ischemia and myelination that point to A2B receptor ligands as putative therapeutic targets for the still unmet treatment of stroke or demyelinating diseases.
  • 1.4K
  • 14 Apr 2021
Topic Review
Multi-Walled Carbon Nanotubes-Based Sensors
Extensive use of multi-walled carbon nanotube (MWCNT) has been done for the fabrication and implementation of flexible sensors due to their enhanced electrical, mechanical, and thermal properties. These nanotubes have been deployed both in pure and composite forms for obtaining highly efficient sensors in terms of sensitivity, robustness, and longevity.
  • 1.4K
  • 17 Mar 2021
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