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Topic Review
Respiratory Control of Crop Yield under High Temperature
Respiration and photosynthesis are indispensable plant metabolic processes that are affected by elevated temperatures leading to disruption of the carbon economy of the plants. Increasing global temperatures impose yield penalties in major staple crops that are attributed to increased respiratory carbon loss, through higher maintenance respiration resulting in a shortage of non-structural carbohydrates and an increase in metabolic processes like protein turnover and maintenance of ion concentration gradients.
  • 1.5K
  • 18 Apr 2022
Topic Review
OPPO R7s
OPPO R7s is a line of Android-based smartphone manufactured by Oppo that were released in October, 2015. OPPO R7 series has all-metal flashing, the fit and finish and the arcs towards its display edges. OPPO Company developed after OPPO R5s. However, the phone was discontinued with the release of more developed version like OPPO R15 and OPPO R17. The phone offers an improved screen, battery and design comparing to the pervious phones. Reviewer had a mix review. Its design and battery quality were universally praised, also, its display received the positive feedback after tests. Reviews had both positive and negative comments, with no finger print sensor or face ID like Apple system. This would result insecurity of personal privacy.
  • 1.5K
  • 07 Nov 2022
Topic Review
ITS Launch Vehicle
The ITS launch vehicle was a 2016-2017 design for a privately funded orbital launch vehicle planned to be developed by SpaceX. Design work was discontinued in 2017 when development was shifted to a smaller version, now called BFR. The initial design objective of the ITS launch vehicle was to launch a variety of SpaceX Interplanetary Transport System missions to Mars and other destinations in the beyond-Earth-orbit portion of the Solar System. The first launch was not expected before the 2020s. The ITS launch vehicle was to be operated as a somewhat unusual two-stage rocket. Its first stage was to have been powered by 42 Raptor rocket engines—designed and manufactured by SpaceX—operating on densified (chilled near triple point) methane/oxygen, propellants that have not been widely used as rocket propellants in the past. Like the Falcon 9 orbital launch vehicle that preceded it, the ITS launch vehicle's first stage design was intended to be reusable, following a return to the launch site and vertical landing following each launch. When announced, it was also designed to have a new feature for SpaceX launch vehicles: full reusability of even the second-stage and orbital spacecraft as well. The large payload capacity of the launch vehicle placed it into the super-heavy lift class, with the ability to place 300 tonnes (660,000 lb) into low Earth orbit in reusable configuration and 550 tonnes (1,210,000 lb) in expendable mode. The second stage of the Earth launch vehicle was planned to have two versions, the Interplanetary spaceship for passengers and cargo and the ITS tanker to deliver propellants to Earth orbit. Both were to be powered by six vacuum-optimized Raptor rocket engines with three additional sea-level-nozzle Raptor engines for maneuvering. Thus, the element of the launch vehicle that was to provide second-stage acceleration to orbital velocity on all launches from Earth would also be used as an on-orbit spacecraft. The Interplanetary spaceship was planned as a very long-duration carrier of both passengers and space cargo to interplanetary destinations, and was to have served as both a descent and ascent vehicle at Mars. The high-level specifications for the vehicle were publicly announced in September 2016, but by July 2017, SpaceX had stated they would not build the 12 m (39 ft)-diameter vehicles as previously planned, but would instead build a "still large" but much smaller launch vehicle first. Subsequently, that was revealed to be the BFR in September 2017, a vehicle intended to cost-effectively replace and supersede all existing SpaceX launch vehicles and passenger/cargo spacecraft.
  • 1.5K
  • 10 Nov 2022
Topic Review
Phosphate Minerals
Phosphate minerals contain the tetrahedrally coordinated phosphate (PO43−) anion along sometimes with arsenate (AsO43−) and vanadate (VO43−) substitutions. Chlorine (Cl−), fluorine (F−), and hydroxide (OH−) anions that also fit into the crystal structure. The phosphate class of minerals is a large and diverse group, however, only a few species are relatively common.
  • 1.5K
  • 14 Nov 2022
Topic Review
5-Oxo-Eicosatetraenoic Acid
5-Oxo-eicosatetraenoic acid (i.e. 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid; also termed 5-oxo-ETE and 5-oxoETE) is a Nonclassic eicosanoid metabolite of arachidonic acid and the most potent naturally occurring member of the 5-HETE family of cell signaling agents. Like other cell signaling agents, 5-oxo-ETE is made by a cell and then feeds back to stimulate its parent cell (see Autocrine signaling) and/or exits this cell to stimulate nearby cells (see paracrine signaling). 5-Oxo-ETE can stimulate various cell types particularly human leukocytes but possesses its highest potency and power in stimulating the human eosinophil type of leukocyte. It is therefore suggested to be formed during and to be an important contributor to the formation and progression of eosinophil-based allergic reactions; it is also suggested that 5-oxo-ETE may also contribute inflammation, cancer cell growth, and other pathophysiological responses.
  • 1.5K
  • 30 Nov 2022
Topic Review
Cyber-Ethnography
Cyber-ethnography, also known as virtual ethnography, digital ethnography and most commonly online ethnography, is an online research method that adapts ethnographic methods to the study of the communities and cultures created through computer-mediated social interaction. As modifications of the term ethnography, cyber-ethnography, online ethnography and virtual ethnography (as well as many other methodological neologisms) designate particular variations regarding the conduct of online fieldwork that adapts ethnographic methodology. There is no canonical approach to cyber-ethnography that prescribes how ethnography is adapted to the online setting. Instead individual researchers are left to specify their own adaptations. Netnography is another form of online ethnography or cyber-ethnography with more specific sets of guidelines and rules, and a common multidisciplinary base of literature and scholars. This article is not about a particular neologism, but the general application of ethnographic methods to online fieldwork as practiced by anthropologists, sociologists, and other scholars.
  • 1.5K
  • 30 Nov 2022
Topic Review
Guitarrón Chileno
The Guitarrón Chileno (literally: "large Chilean guitar") is a guitar-shaped plucked string instrument from Chile , with 25 or 24 (rarely) strings. Its primary contemporary use is as the instrumental accompaniment for the traditional Chilean genre of singing poetry known as Canto a lo Poeta, though a few virtuosi have also begun to develop the instrument's solo possibilities.
  • 1.5K
  • 02 Dec 2022
Topic Review
High-Frequency Ultrasound Technology for Biofuel Production
High-frequency ultrasound (HFU) is an ultrasound technology with a frequency higher than 1000 kHz. It has become increasingly recognized as an emerging process intensification technology in various fields, such as biofuel production, carbon dioxide absorption, and wastewater treatment. HFU is seen as a potential intensifier technology for biofuel production, as its mechanisms, such as cavitational phenomena, microstreaming, and fountain formation, can benefit biofuel production.
  • 1.5K
  • 06 May 2023
Topic Review
Polyethylene Terephthalate Recycling Techniques
Polyethylene terephthalate (PET) is a widely used thermoplastic with excellent properties, making it a popular choice for various packaging and single-use plastic products. Its exceptional tensile strength, processability, transparency, thermal stability, barrier properties, toughness-to-weight ratio, and chemical resistance have contributed to its widespread use. However, the significant consumption of PET has led to a substantial amount of PET waste, especially in the form of single-use packaging. This has raised concerns about the environmental impact of plastic waste, such as marine pollution and landfill accumulation.
  • 1.5K
  • 14 Aug 2023
Topic Review
Sensorial Impact of Alcohol in Wine
The quality of grapes and wine quality, flavor, stability, and sensory characteristics depend on the content and composition of several different groups of compounds from grapes. One of these groups of compounds is sugars and, consequently, the alcohol content quantified in wines after alcoholic fermentation. During grape berry ripening, sucrose transported from the leaves is accumulated in the berry vacuoles as glucose and fructose. The wine alcohol content continues to be a challenge in enology, as it is also the study of the role of chemosensory factors in alcohol intake and consumer preferences. Several technical and scientific advances have occurred, such as identifying receptors and other essential molecules involved in the transduction mechanisms of flavor. In addition, consumers know that wines with high alcohol content can cause a gustatory disequilibrium affecting wine sensory perceptions, leading to unbalanced wines.
  • 1.5K
  • 13 Sep 2023
Topic Review
Discrimination
Discrimination is the unjust or prejudicial treatment of individuals or groups based on certain characteristics such as race, gender, age, religion, sexual orientation, or other distinguishing features. It involves the act of making distinctions or differentiating between people in a way that results in unequal opportunities, privileges, or access to resources. Discrimination can manifest in various forms, including direct actions, policies, or practices that may intentionally or unintentionally disadvantage certain individuals or communities based on perceived differences. It is a social issue that contributes to systemic inequalities and can have significant consequences for the well-being, opportunities, and overall experiences of those who are targeted. Legal frameworks and human rights initiatives aim to address and prevent discrimination, promoting principles of equality, justice, and inclusivity in societies around the world.
  • 1.5K
  • 25 Jan 2024
Topic Review
Urogenital Schistosomiasis
Schistosomiasis is the most important helminthiasis worldwide in terms of morbidity and mortality. Most of the infections occurs in Africa, which about two thirds are caused by Schistosoma haematobium. The infection with S. haematobium is considered carcinogenic leading to squamous cell carcinoma (SCC) and urothelial carcinoma of the urinary bladder.
  • 1.5K
  • 30 Sep 2021
Topic Review
Flow Cytometry and Spermatogenesis
Flow cytometry has become an invaluable tool for the analysis of testicular heterogeneity, and for the purification of stage-specific spermatogenic cell populations, both for basic research and for clinical applications.
  • 1.5K
  • 08 Feb 2021
Topic Review
Progesterone as an Anti-Inflammatory Drug
The specific regulation of inflammatory processes by steroid hormones has been actively studied, especially by progesterone (P4) and progestins. The mechanisms of the anti-inflammatory and immunomodulatory P4 action are not fully clear. The anti-inflammatory effects of P4 can be defined as nonspecific, associated with the inhibition of NF-κB and COX, as well as the inhibition of prostaglandin synthesis, or as specific, associated with the regulation of T-cell activation, the regulation of the production of pro- and anti-inflammatory cytokines, and the phenomenon of immune tolerance. The specific anti-inflammatory effects of P4 and its derivatives (progestins) can also include the inhibition of proliferative signaling pathways and the antagonistic action against estrogen receptor beta-mediated signaling as a proinflammatory and mitogenic factor. The anti-inflammatory action of P4 is accomplished through the participation of progesterone receptor (PR) chaperones HSP90, as well as immunophilins FKBP51 and FKBP52, which are the validated targets of clinically approved immunosuppressive drugs. The immunomodulatory and anti-inflammatory effects of HSP90 inhibitors, tacrolimus and cyclosporine, are manifested, among other factors, due to their participation in the formation of an active ligand–receptor complex of P4 and their interaction with its constituent immunophilins. Pharmacological agents such as HSP90 inhibitors can restore the lost anti-inflammatory effect of glucocorticoids and P4 in chronic inflammatory and autoimmune diseases. By regulating the activity of FKBP51 and FKBP52, it is possible to increase or decrease hormonal signaling, as well as restore it during the development of hormone resistance. The combined action of immunophilin suppressors with steroid hormones may be a promising strategy in the treatment of chronic inflammatory and autoimmune diseases, including endometriosis, stress-related disorders, rheumatoid arthritis, and miscarriages. Presumably, the hormone receptor- and immunophilin-targeted drugs may act synergistically, allowing for a lower dose of each.
  • 1.5K
  • 26 Sep 2022
Topic Review
Supercritical CO2 Power Technology
In the late 1960s, a handful of inspired researchers predicted the great potential of supercritical CO2 (“sCO2”) cycles for the production of electricity and highlighted the prospects for dramatic reductions in component sizes and efficiency increases. Since then, considerable development programs have been deployed around the world to “tame” this new technology. 
  • 1.5K
  • 08 Mar 2024
Topic Review
Cx43-Mediated Signaling
The immunological synapse (IS) is an intercellular communication platform, organized at the contact site of two adjacent cells, where at least one is an immune cell. Functional IS formation is fundamental for the modulation of the most relevant immune system activities, such as T cell activation by antigen presenting cells. Extensive evidence suggests that connexins, in particular connexin-43 (Cx43) hemichannels and/or gap junctions (GJ), regulate signaling events in different types of IS. Although the underlying mechanisms are not fully understood, the current evidence suggests that Cx43 channels could act as facilitators for calcium ions, cyclic adenosine monophosphate, and/or adenosine triphosphate uptake and/or release at the interface of interacting cells. These second messengers have relevant roles in the IS signaling during dendritic cell (DC)-mediated T and NK cell activation, regulatory T cell-mediated immune suppression, and cytotoxic T lymphocyte or NK cell-mediated target tumor cell killing.
  • 1.5K
  • 09 Nov 2020
Topic Review
Idiopathic Osteoporosis
Osteoporosis is defined as a decrease in bone density that results in micro-architecture deterioration, predisposing the affected patients to fractures. Operationally, osteoporosis has been defined on the basis of a bone mineral density assessment using dual energy X-ray absorptiometry.
  • 1.5K
  • 28 Sep 2021
Topic Review
Quercetin in Prostate Cancer Therapy
Prostate cancer is the second most leading and prevalent malignancy around the world, following lung cancer. Prostate cancer is characterized by the uncontrolled growth of cells in the prostate gland. Prostate cancer morbidity and mortality have grown drastically, and intensive prostate cancer care is unlikely to produce adequate outcomes. The synthetic drugs for the treatment of prostate cancer in clinical practice face several challenges. Quercetin is a natural flavonoid found in fruits and vegetables. Apart from its beneficial effects, its plays a key role as an anti-cancer agent. Quercetin has shown anticancer potential, both alone and in combination. 
  • 1.5K
  • 13 May 2021
Topic Review
Organosulfur Compounds from Allium cepa
Species belonging to the genus Allium contain many organosulfur compounds (OSCs) that have been widely studied showing their biological properties and beneficial effects on intestinal health and gut microbiota (GM). 
  • 1.5K
  • 03 Sep 2021
Topic Review
Metabolic Enzymes in Saccharomyces cerevisiae
Condensate formation by a group of metabolic enzymes in the cell is an efficient way of regulating cell metabolism through the formation of “membrane-less organelles.” Because of the use of green fluorescent protein (GFP) for investigating protein localization, various enzymes were found to form condensates or filaments in living Saccharomyces cerevisiae, mammalian cells, and in other organisms, thereby regulating cell metabolism in the certain status of the cells. 
  • 1.5K
  • 26 Jan 2022
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