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Topic Review
Paradoxical Duel Role of Collagen in Rheumatoid Arthritis
In biology, collagen-biomaterial regulates several signaling mechanisms of bone and immune cells involved in tissue repair and any imbalance in collagen turnover may affect the homeostasis of cells, becoming a major cause of several complications. The administration of oral collagen may play a potential role in returning cells to their normal function. For several decades, the beneficial effects of collagen have been explored widely, and thus many commercial products are available in cosmetics, food, and biomedical fields. For instance, collagen-based-products have been widely used to treat the complications of cartilage-related-disorders. Many researchers are reporting the anti-arthritogenic properties of collagen-based materials. In contrast, collagen, especially type-II collagen (CII), has been widely used to induce arthritis by immunization in an animal-model with or without adjuvants, and the potentially immunogenic-properties of collagen have been continuously reported for a long time. Additionally, the immune tolerance of collagen is mainly regulated by the T-lymphocytes and B-cells. This controversial hypothesis is getting more and more evidence nowadays from both sides to support its mechanism. 
  • 1.5K
  • 22 Jul 2022
Topic Review
Polar Forests of the Cretaceous
Cretaceous polar forests were temperate forests that grew at polar latitudes during the final period of the Mesozoic Era, known as the Cretaceous Period 145–66 Ma. During this period, global average temperature was about 10 °C (18 °F) higher and carbon dioxide (CO2) levels were approximately 1000 parts per million (ppm), 2.5 times the current concentration in Earth's atmosphere. The abundance of atmospheric carbon dioxide had a very significant impact on global climate and Earth's natural systems as its concentration is considered one of the main factors in the development of a pronounced greenhouse Earth during the Cretaceous with a very low average global temperature gradient. As a consequence, high paleolatitudes in both hemispheres were much warmer than at present. This temperature gradient was partly responsible for the lack of continental ice sheets in polar regions. As a response to elevated global temperatures, the Earth's hydrologic cycle was significantly enhanced due to greater volume of moisture evaporation from the surface of the ocean. In turn, the absolute sea level during this time period stood at elevations much higher than the present level. Continental encroachment of seawater formed widespread shallow seas, including expanses of epeiric seas. An increase in surface area between shallow, warm epeiric seawater and the atmosphere permits higher evaporation rates and more precipitation at various latitudes, producing a more temperate global climate. A widespread temperate climate also had significant effects on high latitude ecosystems.
  • 1.5K
  • 02 Nov 2022
Biography
Luigi Magni
Luigi Magni (21 March 1928 – 27 October 2013) was an Italian screenwriter and film director. Born in Rome, Magni started his career as a screenwriter, in 1956, with Tempo di villeggiatura.[1] In 1968 he collaborated with Mario Monicelli to a real "event" of the Italian cinema as the transformation of Monica Vitti in a comedic actress with The Girl with the Pistol, and the critical and comme
  • 1.5K
  • 15 Nov 2022
Topic Review
Banking Union
The Banking Union in the European Union is the transfer of responsibility for banking policy from the national to the EU level in several countries of the European Union, initiated in 2012 as a response to the Eurozone crisis. The motivation for banking union was the fragility of numerous banks in the Eurozone, and the identification of vicious circle between credit conditions for these banks and the sovereign credit of their respective home countries ("bank-sovereign vicious circle"). In several countries, private debts arising from a property bubble were transferred to sovereign debt as a result of banking system bailouts and government responses to slowing economies post-bubble. Conversely, weakness in sovereign credit resulted in deterioration of the balance sheet position of the banking sector, not least because of high domestic sovereign exposures of the banks. As of mid-2020, the Banking Union mainly consists of two main initiatives, the Single Supervisory Mechanism and Single Resolution Mechanism, which are based upon the EU's "single rulebook" or common financial regulatory framework. The SSM took up its authority on 4 November 2014, and the SRM entered into full force on 1 January 2015. Most accounts of banking union view it as incomplete in the absence of a European deposit insurance. The European Commission made a legislative proposal for a European Deposit Insurance Scheme in November 2015, but it has not been adopted by the EU co-legislators. Also as of mid-2020, the geographical scope of the Banking Union is identical to that of the euro area. In future, other non-euro member states of the EU may join the Banking Union under a procedure known as close cooperation. Bulgaria and Croatia have initiated requests for close cooperation, respectively in July 2018 and May 2019.
  • 1.5K
  • 28 Nov 2022
Topic Review
M9 Armored Combat Earthmover
The M9 Armored Combat Earthmover (ACE) is a highly mobile armored tracked vehicle that provides combat engineer support to front-line forces. Fielded by the United States Army, its tasks include eliminating enemy obstacles, maintenance and repair of roads and supply routes, and construction of fighting positions.
  • 1.5K
  • 02 Dec 2022
Topic Review
Nutrition in Endometriosis
Endometriosis is a chronic, painful, estrogen-related inflammatory disease that affects approximately 10% of the female population. Endometriosis has a significant negative impact on quality of life. Nutrition may be involved in the development and severity of endometriosis. 
  • 1.5K
  • 14 Dec 2022
Topic Review
Clinical Applications in Endodontics
Bioceramics, with excellent bioactivity and biocompatibility, have been widely used in dentistry, particularly in endodontics. Mineral trioxide aggregate (MTA) is the most widely used bioceramic in endodontics. Many new bioceramics have been developed, showing good potential for the treatment of endodontic diseases. 
  • 1.5K
  • 23 Mar 2023
Topic Review
Implementing Differentiated Instruction Amid the COVID-19 Pandemic
Differentiated instruction (DI) has been introduced as a viable approach for accommodating the diverse learning needs of students in the same classroom. Despite the significant advantages attributed to this approach, it can still be a challenge for teachers to incorporate DI into practice. 
  • 1.5K
  • 06 Nov 2023
Topic Review
Cathepsin Proteases and Bcl-2 Proteins
Taken with the growing importance of cathepsin-mediated substrate proteolysis in tumor biology and progression, the focus and emphasis placed on therapeutic design and development is coming into fruition. Underpinning this approach is the invariable progression from the direction of fully characterizing cathepsin protease members and their substrate targets, towards targeting such an interaction with tangible therapeutics. The two groups of such substrates that have gained much attention over the years are the pro- and anti- apoptotic protein intermediates from the extrinsic and intrinsic signaling arms of the apoptosis pathway.
  • 1.5K
  • 08 May 2021
Topic Review
Treating Traumatic Brain Injuries
Traumatic brain injury (TBI) is defined as an injury caused by an external force that results in the disruption of normal brain function. In the United States, between 2016–2017, there were approximately 451,000 cases of TBI that resulted in hospitalization. The most common mechanisms of injury contributing to TBI were unintentional falls and motor vehicle crashes.
  • 1.5K
  • 05 Aug 2021
Topic Review
Histone Post-Translational Modifications
The emergence of a nucleosome-based chromatin structure accompanied the evolutionary transition from prokaryotes to eukaryotes. In this scenario, histones became the heart of the complex and precisely timed coordination between chromatin architecture and functions during adaptive responses to environmental influence by means of epigenetic mechanisms. Notably, such an epigenetic machinery involves an overwhelming number of post-translational modifications at multiple residues of core and linker histones. 
  • 1.5K
  • 17 Nov 2021
Topic Review
SARS-CoV-2 Main Protease Inhibitors
The main protease (M-pro) or 3C-like protease of coronaviruses plays an essential role in virus replication. This protease contributes to the cleavage of the ppa1a and pp1ab polyproteins to produce several non-structural proteins, including M-pro itself. Since the beginning of the COVID-19 pandemic, the SARS-CoV-2 M-pro enzyme has been extensively studied, and its inhibitors are promising effective drugs for fighting against SARS-CoV-2. The first attempts to discover SARS-CoV-2 M-pro inhibitors used previously developed protease inhibitors or tried to repurpose drugs from other diseases. Covalent inhibitors form a covalent bond, usually with catalytic Cys145. Non-covalent inhibitors bind by non-covalent interactions at the active site of the enzyme, inhibiting its function.
  • 1.5K
  • 10 Jan 2022
Topic Review
Electrode Materials for Supercapacitors in Hybrid Electric Vehicles
For hybrid electric vehicles, supercapacitors are an attractive technology which, when used in conjunction with the batteries as a hybrid system, could solve the shortcomings of the battery. Supercapacitors would allow hybrid electric vehicles to achieve high efficiency and better power control. Supercapacitors possess very good power density. Besides this, their charge-discharge cycling stability and comparatively reasonable cost make them an incredible energy-storing device. The manufacturing strategy and the major parts like electrodes, current collector, binder, separator, and electrolyte define the performance of a supercapacitor. Among these, electrode materials play an important role when it comes to the performance of supercapacitors. They resolve the charge storage in the device and thus decide the capacitance. 
  • 1.5K
  • 20 Jan 2022
Topic Review
IoT-aided Building Fire Evacuation
Internet of Things (IoT)-aided building fire evacuation is a new concept of the building evacuation mode, which improves the building evacuation process by making decisions of escape based on the real-time fire-ground information, such as the fire environment and occupant situations. 
  • 1.5K
  • 09 Feb 2022
Topic Review
Computer Vision in Self-Steering Tractors
Agricultural machinery, such as tractors, is meant to operate for many hours in large areas and perform repetitive tasks. The automatic navigation of agricultural vehicles can ensure the high intensity of automation of cultivation tasks, the enhanced precision of navigation between crop structures, an increase in operation safety and a decrease in human labor and operation costs.
  • 1.5K
  • 24 Feb 2022
Topic Review
Enzyme-Linked Immunosorbent Assay
The Enzyme-Linked Immunosorbent Assay is a versatile technique, which can be used for several applications. It has enormously contributed to the study of infectious diseases.
  • 1.5K
  • 24 Mar 2022
Topic Review
Senescence-Associated Cell Transition and Interaction
Aging is a broad process that occurs as a time-dependent functional decline and tissue degeneration in living organisms. On a smaller scale, aging also exists within organs, tissues, and cells. As the smallest functional unit in living organisms, cells “age” by reaching senescence where proliferation stops. Such cellular senescence is achieved through replicative stress, telomere erosion and stem cell exhaustion. It has been shown that cellular senescence is key to tissue degradation and cell death in aging-related diseases (ARD). However, senescent cells constitute only a small percentage of total cells in the body, and they are resistant to death during aging. This suggests that ARD may involve interaction of senescent cells with non-senescent cells, resulting in senescence-triggered death of non-senescent somatic cells and tissue degeneration in aging organs.
  • 1.5K
  • 06 Apr 2022
Topic Review
Evaluation for the Passenger Comfort in Automated Vehicles
With the development of intelligence and network connectivity, the development of the automotive industry is also moving toward intelligent systems. For passengers, the utility of intelligence is to achieve more convenience and comfort. The intelligent cockpit is the place where passengers directly interact with the car, which directly affects the experience of passengers in the car. For the intelligent cockpits that have emerged, it could be used for the evaluation of passenger comfort.
  • 1.5K
  • 22 Jun 2022
Biography
Adriano Sofo
Adriano Sofo graduated with a Master Degree in Biological Sciences at the University of Bari, Italy, in 1997. He spent three years (1999-2002) at the University of Basilicata, Italy, with a Doctorate in Crop Productivity. From 2000 to 2001, he also was a Researcher at the National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Italy. As Postdoctoral Traini
  • 1.5K
  • 11 Feb 2023
Topic Review
Ship Localization, Classification, and Detection Based on CNNs
Object detection is a common application within the computer vision area. Its tasks include the classic challenges of object localization and classification. As a consequence, object detection is a challenging task. Furthermore, this technique is crucial for maritime applications since situational awareness can bring various benefits to surveillance systems. Convolutional neural network (CNNs) have been added as part of research on ship detection because of their extraordinary ability to extract and represent visual features. For example, in automatic navigation systems, the role of CNNs is to interpret the visual data collected by the cameras. Thus, the detection information is added to the data from different sensors, allowing the data fusion processing system to have enough information for decision-making.
  • 1.5K
  • 30 Sep 2022
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