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Biography
James R. Rice
James Robert Rice (born December 3, 1940) is an American engineer, scientist, geophysicist,[1][2] and Mallinckrodt Professor of Engineering Sciences and Geophysics at the Harvard John A. Paulson School of Engineering and Applied Sciences, .[3] Rice is known as mechanician, who has made fundamental contributions to various aspects of solid mechanics. Two of his early contributions are the concep
  • 1.5K
  • 27 Dec 2022
Topic Review
Role of p300 and Tumours
p300 acts as a transcription coactivator and an acetyltransferase that plays an important role in tumourigenesis and progression. In previous studies, it has been confirmed that p300 is an important regulator in regulating the evolution of malignant tumours and it also has extensive functions. From the perspective of non-posttranslational modification, it has been proven that p300 can participate in regulating many pathophysiological processes, such as activating oncogene transcription, promoting tumour cell growth, inducing apoptosis, regulating immune function and affecting embryo development. p300 has been found to act as an acetyltransferase that catalyses a variety of protein modification types, such as acetylation, propanylation, butyylation, 2-hydroxyisobutyration, and lactylation. Under the catalysis of this acetyltransferase, it plays its crucial tumourigenic driving role in many malignant tumours. Therefore, the function of p300 acetyltransferase has gradually become a research hotspot. From a posttranslational modification perspective, p300 is involved in the activation of multiple transcription factors and additional processes that promote malignant biological behaviours, such as tumour cell proliferation, migration, and invasion, as well as tumour cell apoptosis, drug resistance, and metabolism.
  • 1.5K
  • 13 Mar 2023
Topic Review
Genomic and Udder Evaluation for Dairy Cattle Selection
Genomic and phenotypic selection criteria have been crucial in dairy cattle. Udder health and milk production are important factors affecting productivity in dairy cattle. Furthermore, genomic and phenotypic selection are essential tools for increasing milk supply for human consumption, decreasing the use of antimicrobial products, improving animal health and welfare, and developing efficient dairy cattle production systems. 
  • 1.5K
  • 19 May 2023
Topic Review
Use of Electrocoagulation in Wastewater Treatment
Electrocoagulation (EC) is a wastewater treatment method based on chemical reactions between a coagulant formed under the influence of an electric current released from a given electrode. Electrocoagulation is a technology that properly combines electrochemistry, coagulation, and flotation (or sedimentation). This technology consists of four main stages: electrolytic reaction on the surface of the electrode, formation of metal hydroxides (coagulants), adsorption of soluble (colloidal) particles on coagulants, and removal by sedimentation or flotation. Reactions between the coagulant and pollutants lead to precipitation of sediments which are removed by sedimentation or flotation.
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  • 14 Aug 2023
Topic Review
The Melanocortin System in Inflammatory Bowel Diseases
The melanocortin system is a complex set of molecular mediators and receptors involved in many physiological and homeostatic processes. These include the regulation of melanogenesis, steroidogenesis, neuromodulation and the modulation of inflammatory processes. In the latter context, the system has assumed importance in conditions of chronic digestive inflammation, such as inflammatory bowel diseases (IBD), in which numerous experiences have been accumulated in mouse models of colitis.
  • 1.5K
  • 28 Sep 2023
Topic Review
Recyclable Design of Wooden Furniture
With the rapid development of the economy and the change in people’s aesthetic concepts, the renewal of furniture has become more and more frequent. Among the huge amount of used furniture, solid wood and wood-based panel furniture account for the vast majority, but the imperfective recycling system and insufficient recycling efforts result in serious waste, which is contrary to the low-carbon transition and sustainable development means. 
  • 1.5K
  • 21 Dec 2023
Topic Review
An Optimal House Price Prediction Algorithm: XGBoost
An accurate prediction of house prices is a fundamental requirement for various sectors, including real estate and mortgage lending. It is widely recognized that a property’s value is not solely determined by its physical attributes but is significantly influenced by its surrounding neighborhood. Meeting the diverse housing needs of individuals while balancing budget constraints is a primary concern for real estate developers. 
  • 1.5K
  • 18 Jan 2024
Topic Review
Heat Stress Responses in Maize
High temperatures causing heat stress disturb cellular homeostasis and impede growth and development in plants. Extensive agricultural losses are attributed to heat stress, often in combination with other stresses. Plants have evolved a variety of responses to heat stress to minimize damage and to protect themselves from further stress. A narrow temperature window separates growth from heat stress, and the range of temperatures conferring optimal growth often overlap with those producing heat stress. Heat stress induces a cytoplasmic heat stress response (HSR) in which heat shock transcription factors (HSFs) activate a constellation of genes encoding heat shock proteins (HSPs).
  • 1.5K
  • 06 Mar 2021
Topic Review
Ovarian Cancer Biomarkers
Ovarian cancer is the eighth-most common cause of death among women worldwide. In the absence of distinctive symptoms in the early stages, the majority of women are diagnosed in advanced stages of the disease. Surgical debulking and systemic adjuvant chemotherapy remain the mainstays of treatment, with the development of chemoresistance in up to 75% of patients with subsequent poor treatment response and reduced survival. Therefore, there is a critical need to revisit existing, and identify potential biomarkers that could lead to the development of novel and more effective predictors for ovarian cancer diagnosis and prognosis. The capacity of these biomarkers to predict the existence, stages, and associated therapeutic efficacy of ovarian cancer would enable improvements in the early diagnosis and survival of ovarian cancer patients. 
  • 1.5K
  • 15 Apr 2021
Topic Review
Cripto-1 in Tumor Progression
Cripto-1 is an essential protein for human development that plays a key role in the early phase of gastrulation in the differentiation of an embryo as well as assists with wound healing processes. Importantly, Cripto-1 induces epithelial to mesenchymal transition to turn fixed epithelial cells into a more mobile mesenchymal phenotype through the downregulation of epithelial adhesion molecules such as E-cadherin, occludins, and claudins, and the upregulation of mesenchymal, mobile proteins, such as N-cadherin, Snail, and Slug. Consequently, Cripto-1’s role in inducing EMT to promote cell motility is beneficial in embryogenesis, but detrimental in the formation, progression and metastasis of malignant tumors. Indeed, Cripto-1 is found to be upregulated in most cancers, such as breast, lung, gastrointestinal, hepatic, renal, cervical, ovarian, prostate, and skin cancers. Through its role in EMT, Cripto-1 can remodel cancer cells to enable them to travel through the extracellular matrix as well as blood and lymphatic vessels to metastasize to different organs. Additionally, Cripto-1 promotes the survival of cancer stem cells, which can lead to relapse in cancer patients. 
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  • 06 Sep 2021
Topic Review
Obstructive Apnea and Hypopnea Length
Breathing is an essential function that requires both metabolic and behavioral control during wakefulness but depends on metabolic control during sleep. Breathing also depends on the maturity of the neural centers and the strength of the respiratory muscles. In patients with sleep disordered breathing, breathing after an apneic event results from the interaction between chemoreceptors relaying information to brainstem neurons responsible for generating breathing patterns and influencing respiratory motor neurons controlling the airway muscles; both of these mechanisms are also affected by sleep stage physiology.
  • 1.5K
  • 22 Oct 2021
Topic Review
Centipede Toxins Acting on the Nervous System
Centipedes are typical venomous arthropods that rely on their toxins primarily for predation and defense. Venoms are a complex cocktail of biologically active molecules, including peptides, proteins, polyamide, and enzymes widely produced by venomous organisms. Through long-term evolution, venomous animals have evolved highly specific and diversified peptides and proteins targeting key physiological elements, including the nervous system.
  • 1.5K
  • 22 Aug 2022
Topic Review
Gas-Liquid Membrane Contactors with Aqueous-Amine Solvents
Gas–liquid membrane contactor (GLMC) is a promising process intensification technology for offshore natural gas conditioning in which weight and footprint constraints impose severe limitations. Thanks to its potential for substituting conventional packed/trayed columns for acid-gas absorption and acid-gas solvent regeneration, gas-liquid membrane contactors have been investigated experimentally and theoretically, wherein aqueous-amine solvents and their blends are the most employed solvents for carbon dioxide removal from natural gas in gas-liquid membrane contactors. 
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  • 19 Sep 2022
Topic Review
Pseudo-reorganization Acquisitions
Pseudo-reorganization acquisitions are acquisitions that are done in order to repatriate income earned by foreign subsidiaries to a parent corporation while avoiding taxes ordinarily owed on the repatriation of foreign income in countries with a worldwide system of taxation. Prior to the passage of the Tax Cut and Jobs Act of 2017, multinational firms based in the United States avoided taxes on the repatriation of income earned abroad through the use of pseudo-reorganization acquisitions.
  • 1.5K
  • 06 Oct 2022
Topic Review
Strategic Urban Planning
The general objectives of strategic urban planning (SUP) include clarifying which city model is desired and working towards that goal, coordinating public and private efforts, channelling energy, adapting to new circumstances and improving the living conditions of the citizens affected. Strategic planning is a technique that has been applied to many facets of human activity; we have only to mention Sun Tzu, Arthur Thomson or Henry Mintzberg; however, the application of strategic planning to urban contexts, or cities, regions and other metropolitan areas is a relatively recent development whose beginnings were eminently practical and artistical: a mixture of thought, techniques and art or expertise. Fifteen years of practice proved to be enough time for the technique to spread and for the first “Meeting of American and European cities for the Exchange of Experiences in Strategic Planning” to be organized. Institutions sponsoring the meeting, held in Barcelona in 1993, included the Inter-American Development Bank, the European Community Commission and the Iberoamerican Cooperation Institute. The cities of Amsterdam, Lisbon, Lille, Barcelona, Toronto and Santiago de Chile participated, among others. At that meeting it was demonstrated, along with other relevant aspects, that if cooperative processes are used in large cities in order to carry out strategic planning processes, and if a reasonable degree of comprehension is reached between the administration, businesses and an ample representation of social agents, organizational synergies will develop that will eventually improve resource management and citizens’ quality of life.
  • 1.5K
  • 24 Oct 2022
Topic Review
Lamport Timestamps
The algorithm of Lamport timestamps is a simple algorithm used to determine the order of events in a distributed computer system. As different nodes or processes will typically not be perfectly synchronized, this algorithm is used to provide a partial ordering of events with minimal overhead, and conceptually provide a starting point for the more advanced vector clock method. They are named after their creator, Leslie Lamport. Distributed algorithms such as resource synchronization often depend on some method of ordering events to function. For example, consider a system with two processes and a disk. The processes send messages to each other, and also send messages to the disk requesting access. The disk grants access in the order the messages were sent. For example process [math]\displaystyle{ A }[/math] sends a message to the disk requesting write access, and then sends a read instruction message to process [math]\displaystyle{ B }[/math]. Process [math]\displaystyle{ B }[/math] receives the message, and as a result sends its own read request message to the disk. If there is a timing delay causing the disk to receive both messages at the same time, it can determine which message happened-before the other: [math]\displaystyle{ A }[/math] happens-before [math]\displaystyle{ B }[/math] if one can get from [math]\displaystyle{ A }[/math] to [math]\displaystyle{ B }[/math] by a sequence of moves of two types: moving forward while remaining in the same process, and following a message from its sending to its reception. A logical clock algorithm provides a mechanism to determine facts about the order of such events. Lamport invented a simple mechanism by which the happened-before ordering can be captured numerically. A Lamport logical clock is a numerical software counter value maintained in each process. Conceptually, this logical clock can be thought of as a clock that only has meaning in relation to messages moving between processes. When a process receives a message, it re-synchronizes its logical clock with that sender. The above-mentioned vector clock is a generalization of the idea into the context of an arbitrary number of parallel, independent processes.
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  • 24 Oct 2022
Topic Review
Photon-Counting Computed Tomography
Photon-counting computed tomography (PCCT) is a new advanced imaging technique that is going to transform the standard clinical use of computed tomography (CT) imaging. Photon-counting detectors resolve the number of photons and the incident X-ray energy spectrum into multiple energy bins. Compared with conventional CT technology, PCCT offers the advantages of improved spatial and contrast resolution, reduction of image noise and artifacts, reduced radiation exposure, and multi-energy/multi-parametric imaging based on the atomic properties of tissues, with the consequent possibility to use different contrast agents and improve quantitative imaging.
  • 1.5K
  • 22 Feb 2023
Topic Review
Graft Establishment in Fruit Trees
Plant grafting is a maneuver humans learned from nature and has been practiced since ancient times. The technique has long been applied for efficient propagation as well as for the modification of the traits of interest, such as stress tolerance, tree size, and fruit quality. Since grafting can enhance the environmental tolerance and disease resistance of a plant, its techniques are now used not only in tree species but also among vegetables. Despite such wide advantages of grafting, however, the potential cause behind a compatible graft establishment (scion-rootstock connection) is yet to be fully understood. As compared to succulent herbaceous plants, woody plants often take a longer time for the graft-take and the plants may exhibit incompatible/unsuccessful graft-establishment symptoms within a period ranging from months to years.
  • 1.5K
  • 08 Mar 2023
Topic Review
Antimicrobial Property of Spices
Antimicrobial resistance increases day by day around the world. To overcome this situation new antimicrobial agents are needed. Spices such as clove, ginger, coriander, garlic, and turmeric have the potential to fight resistant microbes.
  • 1.5K
  • 04 May 2023
Topic Review
Cybersecurity in Microgrids
The demand for clean and sustainable energy sources is increasing at a rapid pace, and microgrids (MGs) have emerged as a promising solution for achieving energy resilience, efficiency, and security. As a general definition, a microgrid is a localized power system that integrates renewable energy resources, energy storage systems, and loads to operate autonomously or in parallel with the main grid. As MGs continue to grow in popularity as a means of providing reliable and sustainable energy to communities and businesses, the issue of cybersecurity becomes increasingly important. With the use of digital technology and communication systems, MGs are vulnerable to cyberattacks that can compromise their operation and even cause physical damage. 
  • 1.5K
  • 25 Jun 2023
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