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Topic Review
ESG Transparency and Firm Valuation in Palm Oil
Environmental, social, and governance (ESG) integration is an increasingly popular and innovative investing strategy that requires companies to be transparent about their ESG practices to facilitate investors’ decisions. In the palm oil sector, companies are addressing ESG risks by adopting and disclosing ESG efforts to improve access to financing. 
  • 1.5K
  • 28 Nov 2023
Topic Review
BCAAs Metabolism during Chronic Liver Disease in Humans
Branched-chain amino acids (BCAAs), indispensable for protein synthesis and metabolic pathways, undergo unique tissue-specific processing in skeletal muscle and liver. The liver, responsible for amino acid metabolism, plays a distinctive role in sensing BCAAs catabolism, influencing glucose regulation and contributing to the systemic metabolism of BCAAs.
  • 1.5K
  • 18 Mar 2024
Topic Review
Seaweeds and Gut Health Benefits
Macroalgae, or seaweeds, are a rich source of components which may exert beneficial effects on the mammalian gut microbiota through the enhancement of bacterial diversity and abundance. An imbalance of gut bacteria has been linked to the development of disorders such as inflammatory bowel disease, immunodeficiency, hypertension, type-2-diabetes, obesity, and cancer. This review outlines current knowledge from in vitro and in vivo studies concerning the potential therapeutic application of seaweed-derived polysaccharides, polyphenols and peptides to modulate the gut microbiota through diet. Polysaccharides such as fucoidan, laminarin, alginate, ulvan and porphyran are unique to seaweeds. Several studies have shown their potential to act as prebiotics and to positively modulate the gut microbiota. Prebiotics enhance bacterial populations and often their production of short chain fatty acids, which are the energy source for gastrointestinal epithelial cells, provide protection against pathogens, influence immunomodulation, and induce apoptosis of colon cancer cells. The oral bioaccessibility and bioavailability of seaweed components is also discussed, including the advantages and limitations of static and dynamic in vitro gastrointestinal models versus ex vivo and in vivo methods. Seaweed bioactives show potential for use in prevention and, in some instances, treatment of human disease. 
  • 1.5K
  • 06 Jul 2021
Topic Review
Citrus Flavone Nobiletin and Circadian Rhythms
The importance of the circadian clock in maintaining human health is now widely acknowledged. Dysregulated and dampened clocks may be a common cause of age-related diseases and metabolic syndrome Thus, circadian clocks should be considered as therapeutic targets to mitigate disease symptoms. 
  • 1.5K
  • 19 Jan 2023
Topic Review
People with Aphasia
People with Aphasia (PWA) are individuals who experience difficulties in one or more aspects of communication, such as the ability to speak, understand, read and write, due to acquired brain damage (e.g.stroke, dementia, brain tumour, traumatic brain injury).  
  • 1.5K
  • 27 Oct 2020
Topic Review
Microbial Colonization of Stone
Colonization and deterioration of stone heritage buildings by microorganisms, especially cyanobacteria. Aesthetic, chemical and physical types of deterioration are covered. Future changes in climate will affect these processes. Seven figures illustrate various aspects and organisms involved.
  • 1.5K
  • 16 Dec 2020
Topic Review
CFTR Gene
Cystic fibrosis transmembrane conductance regulator
  • 1.5K
  • 04 Jan 2021
Topic Review
ROR and Melatonin Nuclear Receptor
Retinoic acid-related orphan receptor (ROR)  is implicated in modulating a variety of physiological processes, including cerebellar development, lymphoid tissue development, retinal development, bone formation, lipid metabolism, circadian rhythm, oxidative stress, and inflammation suppression. Furthermore, ROR is also a promising therapeutic target for autoimmune diseases, tumours, obesity, diabetes, and other diseases. Melatonin (N-acetyl-5-methoxytryptamine) is an evolutionary molecule found in bacteria, fungi, algae, plants, invertebrates, and vertebrates. It regulates multiple functions that have developed along the evolutionary timescale. In humans, melatonin is pleiotropic [5]. Melatonin modulates sleep-wake rhythms, reproduction, and bone metabolism; it also affects the immune, neurological, cardiovascular, digestive, urinary, and endocrine systems. Moreover, it exhibits anti-inflammatory, antioxidant, anti-infective, and anti-tumour properties while also being a potential therapeutic agent for obesity, cardiovascular diseases, and neurodegenerative disorders.  A debate is ongoing on whether ROR is a nuclear receptor of melatonin. 
  • 1.5K
  • 27 May 2021
Topic Review
Live Cell and Antioxidant Activities
Plant extracts and pharmacopoeias represent an exceptional breeding ground for the discovery of new antioxidants. Until recently, the antioxidant activity was only measured by chemical hydrogen atom transfer (HAT) and single-electron transfer (SET) cell-free assays that do not inform about the actual effect of antioxidants in living systems. By providing information about the mode of action of antioxidants at the subcellular level, recently developed live cell assays are now changing the game.
  • 1.5K
  • 21 Jun 2021
Topic Review
Nox4
The NADPH oxidase Nox4 is a hydrogen peroxide (H2O2)-producing enzyme, with the highest expression in the kidney. As the kidney is involved in volume and blood pressure control through sodium handling, we set out to determine the impact of a low sodium diet on these parameters in WT and Nox4-/- mice. Nox4 expression in the murine kidney was restricted to the proximal tubule. Nevertheless, low-sodium-induced weight loss and sodium sparing function was similar in WT and Nox4-/- mice, disputing an important function of renal Nox4 in sodium handling. In contrast, a low sodium diet resulted in a reduction in systolic blood pressure in Nox4-/- as compared to WT mice. This was associated with a selectively lower pressure to heart-rate ratio, as well as heart to body weight ratio. In general, a low sodium diet leads to activation of sympathetic tone and the renin angiotensin system, which subsequently increases peripheral resistance. Our observations suggest that the control by this system is attenuated in Nox4-/- mice, resulting in lower blood pressure in response to low sodium.
  • 1.5K
  • 24 Aug 2021
Topic Review
Irrigation-Water and Cotton
A decrease in water resources, as well as changing environmental conditions, calls for efficient irrigation-water management in cotton-production systems. Cotton (Gossypium sp.) is an important cash crop in many countries, and it is used more than any other fiber in the world. 
  • 1.5K
  • 06 Feb 2022
Topic Review
Unmanned Aerial Vehicles in Precision Agriculture Sensing Applications
Precision agriculture (PA) is becoming highly significant in today’s technologically advanced world and has been considered as the farm for the future. This is a modern farming management concept using digital techniques to monitor and optimize agricultural production processes by using technological advancement. PA uses modern technology and principles to manage the spatial and temporal variability in all aspects of agricultural production for the goal of improving crop performance. 
  • 1.5K
  • 01 Apr 2022
Topic Review
Gut Microbiota and Parkinson’s Disease
Parkinson’s disease (PD) is the second-most prevalent neurodegenerative or neuropsychiatric disease, affecting 1% of seniors worldwide. The gut microbiota (GM) is one of the key access controls for most diseases and disorders. Disturbance in the GM creates an imbalance in the function and circulation of metabolites, resulting in unhealthy conditions. Any dysbiosis could affect the function of the gut, consequently disturbing the equilibrium in the intestine, and provoking pro-inflammatory conditions in the gut lumen, which send signals to the central nervous system (CNS) through the vagus enteric nervous system, possibly disturbing the blood–brain barrier. The neuroinflammatory conditions in the brain cause accumulation of α-syn, and progressively develop PD. An important aspect of understanding and treating the disease is access to broad knowledge about the influence of dietary supplements on GM.
  • 1.5K
  • 05 Aug 2022
Topic Review
Bioactive Properties of Lamiaceae Herbs
Numerous plants, plant extracts, and plant-derived compounds are being explored for their beneficial effects against overweight and liver diseases. Many herbs of the Lamiaceae family are widely employed as food and spices in the Mediterranean area, but also in folk medicine, and their use for the management of metabolic disorders is well documented. 
  • 1.5K
  • 05 Sep 2022
Topic Review
Sugarcane Genome Editing via CRISPR/Cas9 for Sustainable Production
Sugarcane crop constitutes one of the most vital sources of sugar and bioenergy globally; however, higher level of polyploidy makes its genome editing an intricate task. Recently, genome editing has become easier with CRISPR/Cas9 system that uses Cas9 to target sequence-specific regions and introduce double-strand breaks into the target region. This technique has been successfully employed to develop new varieties of sugarcane having desired phenotypic and physiological traits. Several genes can be fused with the CRISPR/Cas9 system leading to successful metabolic engineering and biological improvement for ensuring sustainable enhancement in sugarcane production. This simple RNA-guided genome editing technique has become a revolutionary tool and innovative application in biology that might be effectively employed for inducing specified genomic modifications in plant tissues.
  • 1.5K
  • 18 Oct 2022
Topic Review
List of Sequence Alignment Software
This list of sequence alignment software is a compilation of software tools and web portals used in pairwise sequence alignment and multiple sequence alignment. See structural alignment software for structural alignment of proteins.
  • 1.5K
  • 08 Nov 2022
Topic Review
Death of Lazarus Averbuch
Lazarus Averbuch (1889–1908) was a Russian-born Jewish immigrant to Chicago who was shot and killed by Chicago Chief of Police George Shippy on March 2, 1908. The incident occurred during an era of public fear of foreign-born anarchists in the United States, following their involvement with the Haymarket affair in 1886. The exact circumstances of the shooting remain contested, but Averbuch's death has inspired speculation, ideological arguments, and works of fiction.
  • 1.5K
  • 24 Nov 2022
Topic Review
Probe for Single-Molecule Fluorescence Microscopy
Probe choice in single-molecule microscopy requires deeper evaluations than those adopted for less sensitive fluorescence microscopy studies. Fluorophore characteristics can alter or hide subtle phenomena observable at the single-molecule level, wasting the potential of the sophisticated instrumentation and algorithms developed for this kind of advanced applications. The three typical groups of fluorophores are fluorescent proteins, organic dyes and quantum dots; here their advantages, drawbacks and use in single-molecule microscopy are discussed. Some requirements are common to all applications, such as high brightness and photostability, specific and efficient labeling, controlled stoichiometry, no perturbation on the system. Other requirements depend on the specific type of single-molecule technique; some of them are here described with their specific requirements for probe choice.
  • 1.5K
  • 13 Feb 2023
Topic Review
Estrogen Receptor Positive Breast Cancer
Breast cancer is the most common cancer and the deadliest among women worldwide. Estrogen signaling is closely associated with hormone-dependent breast cancer (estrogen and progesterone receptor positive), which accounts for two-thirds of tumors.  Approximately 70% of patients have hormone-dependent breast cancer with tumor cells, called luminal A and B, expressing the estrogen receptor (ER). In these tumors, estrogens are the principal signals that play a major role in tumor cell growth and progression. The cellular action of estrogens is primarily mediated by the nuclear ERα, ERβ and the membrane G protein-coupled ER (GPER, called also GPR30). The ERα, being considered to be the receptor most involved in the development of breast cancer, constitutes therefore a pivotal target for breast cancer therapy.
  • 1.5K
  • 14 Apr 2023
Topic Review
Endophytes in Agricultural Crops
Endophytes—both bacteria and fungi—have emerged as highly potent natural resources, which have been utilised to improve stress tolerances of plants post-inoculation and decreased susceptibility to diseases and predators.
  • 1.5K
  • 19 May 2023
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