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Topic Review
The Structure of Carbon Dots
Carbon allotropes are multifunctional materials, due to their unique physical and chemical properties. Carbon allotropes can be chemically modified by other elements via functionalization or doping, and they can also be used in combination with other materials to form carbon–carbon or metal–carbon composite materials.
  • 1.5K
  • 21 Aug 2023
Topic Review
Quercetin in Hepatocellular Carcinoma
Quercetin is a flavonoid present in fruits, vegetables and plants with beneficial effects in several human disorders, including liver cancer. The antioxidant and anti-inflammatory properties make quercetin an interesting drug to be evaluated in hepatocarcinoma (HCC), the major primary liver tumor with a high mortality rate. Moreover, increasing number of studies reported a high variety of antitumor actions which places quercetin as a promising antitumor agent, not only as single treatment but also improving current therapeutic options against advanced HCC.
  • 1.5K
  • 12 Oct 2021
Topic Review
Nuclear factor-κB in Psoriasis
Nuclear factor-κB (NF-κB) plays a central role in psoriasis and canonical Wnt/β-catenin pathway blunts the immune-mediated inflammatory cascade in psoriasis. Adenosine A2A receptor activation blocks NF-κB and boosts the Wnt/β-catenin signaling. PDRN (Polydeoxyribonucleotide) is a biologic agonist of the A2A receptor and its effects were studied in an experimental model of psoriasis. Psoriasis-like lesions were induced by a daily application of imiquimod (IMQ) on the shaved back skin of mice for 7 days. Animals were randomly assigned to the following groups: Sham psoriasis challenged with Vaseline; IMQ animals challenged with imiquimod; and IMQ animals treated with PDRN (8 mg/kg/ip). An additional arm of IMQ animals was treated with PDRN plus istradefylline (KW6002; 25 mg/kg/ip) as an A2A antagonist. PDRN restored a normal skin architecture, whereas istradefylline abrogated PDRN positive effects, thus pointing out the mechanistic role of the A2A receptor. PDRN decreased pro-inflammatory cytokines, prompted Wnt signaling, reduced IL-2 and increased IL-10. PDRN also reverted the LPS repressed Wnt-1/β-catenin in human keratinocytes and these effects were abolished by ZM241385, an A2A receptor antagonist. Finally, PDRN reduced CD3+ cells in superficial psoriatic dermis. PDRN anti-psoriasis potential may be linked to a “dual mode” of action: NF-κB inhibition and Wnt/β-catenin stimulation.
  • 1.5K
  • 03 Nov 2020
Topic Review
Oxidative Stress and Retinitis Pigmentosa
Degenerative retina in RP is exposed to high-level O2 and thereby damaged by ROS. Microglia as well as photoreceptor cells are injured by ROS. Oxidative microglial activation promotes microgliosis and photoreceptor cell death in RP. Oxidative DNA damage mediates MUTYH-SSBs-PARP signaling to induce microglial activation.
  • 1.5K
  • 26 Oct 2020
Topic Review
Obesity on Anti-Cancer Immunity
Cancer is one of the leading causes of morbidity and mortality worldwide. Traditional treatments include surgery, chemotherapy and radiation therapy, and more recently targeted therapies including immunotherapy are becoming routine care for some cancers. Immunotherapy aims to upregulate the patient’s own immune system, enabling it to destroy cancerous cells. Obesity is a metabolic disorder characterized by significant weight that is an important contributor to many different diseases, including cancers. Obesity impacts the immune system and causes, among other things, a state of chronic low-grade inflammation. This is hypothesized to impact the efficacy of the immunotherapies, such as immune checkpoint inhibitors, although not necessarily in a negative way. Data from several studies show that even though obesity causes a state of chronic low-grade inflammation with reductions in effector immune populations, it has a beneficial effect on patient survival following anti-PD-1/PD-L1 and anti-CTLA-4 treatment.
  • 1.5K
  • 10 Nov 2020
Topic Review
Mycotoxins
Mycotoxins are secondary metabolites produced by fungal species that commonly have a toxic effect on human and animal health. Different foodstuff can be contaminated and are considered the major source of human exposure to mycotoxins, but occupational and environmental exposure can also significantly contribute to this problem.
  • 1.5K
  • 19 Feb 2021
Topic Review
Arterial Hypertension and Tension-Type Headache
Arterial hypertension (AH) is a prevalent condition worldwide and is the key risk factor for non-fatal and fatal cardiovascular complications. Tension-type headache (TTH) is the most common type of primary headache and is considered a common everyday headache.
  • 1.5K
  • 11 Oct 2021
Topic Review
Health Benefits of Ketogenic Diet
Considering the lack of a comprehensive, multi-faceted overview of the ketogenic diet (KD) in relation to health issues, we compiled the evidence related to the use of the ketogenic diet in relation to its impact on the microbiome, the epigenome, diabetes, weight loss, cardiovascular health, and cancer. The KD diet could potentially increase genetic diversity of the microbiome and increase the ratio of Bacteroidetes to Firmicutes. The epigenome might be positively affected by the KD since it creates a signaling molecule known as β-hydroxybutyrate (BHB). KD has helped patients with diabetes reduce their HbA1c and reduce the need for insulin. There is evidence to suggest that a KD can help with weight loss, visceral adiposity, and appetite control. The evidence also suggests that eating a high-fat diet improves lipid profiles by lowering low-density lipoprotein (LDL), increasing high-density lipoprotein (HDL), and lowering triglycerides (TG). Due to the Warburg effect, the KD is used as an adjuvant treatment to starve cancer cells, making them more vulnerable to chemotherapy and radiation.
  • 1.5K
  • 11 Aug 2024
Topic Review
Catalytic Cathodes for Na-CO2 Batteries
Na-CO2 batteries with high energy density are drawing tremendous attention because of their advantages of combining cost-effective energy conversion and storage with CO2 clean recycle and utilization. Nevertheless, their commercial applications are impeded by unsatisfactory electrochemical performance including large overpotentials, poor rate capability, fast capacity deterioration, and inferior durability, which mainly results from the inefficient electrocatalysts of cathode materials. 
  • 1.5K
  • 23 Jun 2021
Topic Review
PHARC Syndrome
PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa (RP) and early-onset cataract) is an acronym for a rare, neurodegenerative disease caused by biallelic variants in the ABHD12 gene
  • 1.5K
  • 12 Oct 2021
Topic Review
Prevalence of E. coli in Goats
Goat meat is the main source of animal protein in developing countries, particularly in Asia and Africa. Goat meat consumption has also increased in the US in the recent years due to the growing ethnic population. The digestive tract of goat is a natural habitat for Escherichia coli organisms. While researchers have long focused on postharvest intervention strategies to control E. coli outbreaks, recent works have also included preharvest methodologies. In goats, these include minimizing animal stress, manipulating diet a few weeks prior to processing, feeding diets high in tannins, controlling feed deprivation times while preparing for processing, and spray washing goats prior to slaughter.
  • 1.5K
  • 27 Oct 2021
Topic Review
Association between Diet and Xerostomia
Xerostomia is defined as a subjective symptom of dry mouth, which may affect swallowing, chewing, taste perception and is the most important predictor in reduced oral health-related quality of life; also, xerostomia has been associated with nutritional changes. Xerostomia is a common condition of patients with autoimmune diseases; 50% or more patients with systemic lupus erythematosus, polymyositis/dermatomyositis or systemic scleroderma reported xerostomia. Sjogren‘s syndrome is one of the three most prevalent systemic autoimmune diseases and 98% of patients reported to have xerostomia. Although xerostomia is often claimed to lead to an impaired nutrition, there is lacking knowledge of which specific food groups associate with this condition. Therefore, our study examines the association between xerostomia and 23 diet items.
  • 1.5K
  • 02 Dec 2021
Topic Review
Sarcopenia: a Cause and Consequence of Metabolic Dysregulation
Skeletal muscle mass plays a critical role in a healthy lifespan by helping to regulate glucose homeostasis. As seen in sarcopenia, decreased skeletal muscle mass impairs glucose homeostasis, but it may also be caused by glucose dysregulation. Gut microbiota modulates lipopolysaccharide (LPS) production, short-chain fatty acids (SCFA), and various metabolites that affect the host metabolism, including skeletal muscle tissues, and may have a role in the sarcopenia etiology. The evidence presented in this entry suggests that loss of muscle mass and function are not an inevitable consequence of the aging process, and that dietary and lifestyle interventions may prevent or delay sarcopenia.
  • 1.5K
  • 29 Mar 2022
Topic Review
Blood–Brain Barrier (BBB)
Blood–brain barrier (BBB) is one of the most specialized biological barriers in the human body. The pathogenesis of Alzheimer’s disease (AD) includes BBB dysfunction, which leads to the failure of Aβ transport from the brain to the peripheral circulatory system, causing neuroinflammation and oxidative stress. Moreover, the BBB is the first protective defense line to prevent foreign substances from traversing from the blood to the brain.
  • 1.5K
  • 26 Apr 2022
Topic Review
Genetic and Genomic Alterations in Glioblastoma Multiforme
Glioblastoma multiforme (GBM) is a brain tumor characterized by high heterogeneity, diffuse infiltration, aggressiveness, and formation of recurrences. Patients with this kind of tumor suffer from cognitive, emotional, and behavioral problems, beyond exhibiting dismal survival rates. Current treatment comprises surgery, radiotherapy, and chemotherapy with the methylating agent, temozolomide (TMZ). GBMs harbor intrinsic mutations involving major pathways that elicit the cells to evade cell death, adapt to the genotoxic stress, and regrow.
  • 1.5K
  • 23 May 2022
Topic Review
Smart and Mechanized Agricultural Application
Smart farming can be applied to improve crop quality and profit and reduce costs by optimizing various processes such as environmental conditions, growth status, soil status, irrigation water, pest control, fertilizers, weed management, and greenhouse production environments
  • 1.5K
  • 27 Jun 2022
Topic Review
Oral Fosfomycin Formulation in Bacterial Prostatitis
Bacterial prostatitis infections are described as infections that are difficult-to-treat, due to prostate anatomic characteristics along with clinical difficulty in terms of diagnosis and management. Furthermore, the emergence of multidrug resistant (MDR) bacteria, such as extended-spectrum beta-lactamase (ESBL) producer Escherichia coli, also representing the main causative pathogen in prostatitis, poses major problems in terms of antibiotic management and favorable clinical outcome. Oral fosfomycin, an antibiotic commonly used for the treatment of uncomplicated urinary tract infections (UTIs), has been evaluated for the treatment of bacterial prostatitis due to its favorable pharmacokinetic profile, its activity against MDR gram-positive and gram-negative bacteria, safety profile, and multiple synergic effect with other antibiotics as well as the low resistance rate. 
  • 1.5K
  • 07 Sep 2022
Topic Review
Mechanical Strength and Durability of Dune Sand
According to the authors’ best information, the majority of research focuses on other waste materials, such as recycling industrial waste (glass, silica fume, marble and waste foundry sand), etc. However, some researchers suggest dune sand as an alternative material for concrete production, but knowledge is still scarce. Therefore, a comprehensive overview is required on dune sand to evaluate its current progress as well as its effects on the strength and durability properties of concrete. 
  • 1.5K
  • 26 Sep 2022
Topic Review
Varnam
Varnam (meaning ‘colours’) is a social enterprise that has been working with artisans in Channapatna, Karnataka in India , for over 4 years. It has produced a series of designs interpreting this 200-year-old toy-making craft in the home and lifestyle, women's accessories space, giving tradition a contemporary twist. Using traditional lac-turnery methods popularised by the traditional Channapatna toys range, the label produces home and lifestyle products, toys and jewelry.
  • 1.5K
  • 07 Nov 2022
Biography
Ray Jackendoff
Ray Jackendoff (born January 23, 1945) is an American linguist. He is professor of philosophy, Seth Merrin Chair in the Humanities and, with Daniel Dennett, co-director of the Center for Cognitive Studies at Tufts University. He has always straddled the boundary between generative linguistics and cognitive linguistics, committed to both the existence of an innate universal grammar (an important
  • 1.5K
  • 14 Nov 2022
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