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Topic Review
OPPO R7s
OPPO R7s is a line of Android-based smartphone manufactured by Oppo that were released in October, 2015. OPPO R7 series has all-metal flashing, the fit and finish and the arcs towards its display edges. OPPO Company developed after OPPO R5s. However, the phone was discontinued with the release of more developed version like OPPO R15 and OPPO R17. The phone offers an improved screen, battery and design comparing to the pervious phones. Reviewer had a mix review. Its design and battery quality were universally praised, also, its display received the positive feedback after tests. Reviews had both positive and negative comments, with no finger print sensor or face ID like Apple system. This would result insecurity of personal privacy.
  • 1.5K
  • 07 Nov 2022
Topic Review
DNA-Based Methods for Cheese Origin Authentication
Metabolic activities of cheese microbiota play a crucial role in the development of cheese typicity. For geographical origin authentication, microbiota fingerprinting is therefore of high interest as traditional and artisanal cheeses are produced with a more diversified microbiota associated with the cheese-making process (e.g., use of raw milk, starter, brine, equipment and materials, and ripening rooms). While cheese microbial diversity was traditionally investigated using culture-dependent methods, hence overlooking unculturable or subdominant species, nowadays, culture-independent methods (HTS) have unravelled this diversity and provided further means to connect microbiota composition to cheese quality and typicity, but also origin. This success is due to the availability of new sequencing platforms, bioinformatic pipelines, and a continuous decrease in cost. While complete microbial genome sequencing (i.e. metagenomics) can be used, metabarcoding (also known as metagenetics and corresponding to the selective amplification of taxonomically relevant followed by NGS sequencing) is the most widely reported in the scientific literature. Herein researchers report recent scientific literature about metabarcoding analysis of cheese microbiota, highlighting what factors contribute to its formation and how it could be used to authenticate cheese origin.
  • 1.5K
  • 11 Nov 2022
Topic Review
Marketing Performance Measurement
Marketing performance measurement (MPM), or marketing performance management, is the systematic management of marketing resources and processes to achieve measurable gain in return on investment and efficiency, while maintaining quality in customer experience. Marketing performance management is a central facet of the marketing operations function within marketing departments. Marketing performance management relies on a set of measurable performance standards, a pointed focus on outcomes, and clear lines of accountability (i.e. roles and consequences). Measurement management is based on six success factors: 1) alignment, 2) accountability, 3) analytics, 4) automation, 5) alliances, and 6) assessment.
  • 1.5K
  • 15 Nov 2022
Topic Review
5-Oxo-Eicosatetraenoic Acid
5-Oxo-eicosatetraenoic acid (i.e. 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid; also termed 5-oxo-ETE and 5-oxoETE) is a Nonclassic eicosanoid metabolite of arachidonic acid and the most potent naturally occurring member of the 5-HETE family of cell signaling agents. Like other cell signaling agents, 5-oxo-ETE is made by a cell and then feeds back to stimulate its parent cell (see Autocrine signaling) and/or exits this cell to stimulate nearby cells (see paracrine signaling). 5-Oxo-ETE can stimulate various cell types particularly human leukocytes but possesses its highest potency and power in stimulating the human eosinophil type of leukocyte. It is therefore suggested to be formed during and to be an important contributor to the formation and progression of eosinophil-based allergic reactions; it is also suggested that 5-oxo-ETE may also contribute inflammation, cancer cell growth, and other pathophysiological responses.
  • 1.5K
  • 30 Nov 2022
Topic Review
Wide Band Gap Devices
A decisive property that regulates semiconductor’s electrical and optical properties is the band gap, which is an important physical parameter for designating a wide band gap (WBG) semiconductor, and is defined as the energy needed for electrons to transition to the conduction band from the valence band. The magnetic property of the semiconducting materials also plays an important role for choosing of power devices in terms of energy efficiency with hysteresis and eddy current losses. The WBG semiconductor materials exhibit larger band gaps (2–4 eV) than their silicon (1–1.5 eV) counterparts and offer greater power efficiency, lower overall cost, smaller size, lighter weight, and lower energy consumption. WBG-based components in semiconductor devices permit its operation at high temperatures, which can be problematic when using conventional silicon semiconductors with smaller band gaps. The wider the bandgap, the higher the temperature at which the semiconductor power devices can function.
  • 1.5K
  • 23 Dec 2022
Topic Review
Estrogen Receptor Positive Breast Cancer
Breast cancer is the most common cancer and the deadliest among women worldwide. Estrogen signaling is closely associated with hormone-dependent breast cancer (estrogen and progesterone receptor positive), which accounts for two-thirds of tumors.  Approximately 70% of patients have hormone-dependent breast cancer with tumor cells, called luminal A and B, expressing the estrogen receptor (ER). In these tumors, estrogens are the principal signals that play a major role in tumor cell growth and progression. The cellular action of estrogens is primarily mediated by the nuclear ERα, ERβ and the membrane G protein-coupled ER (GPER, called also GPR30). The ERα, being considered to be the receptor most involved in the development of breast cancer, constitutes therefore a pivotal target for breast cancer therapy.
  • 1.5K
  • 14 Apr 2023
Topic Review
Lignin-First Biorefinery
Conventional lignocellulosic-biomass-utilization strategies have difficulty in avoiding the undesirable condensation of reactive intermediates during biomass deconstruction, which poses fundamental challenges for commercial applications. Lignin-first biorefinery inhibits the condensation of reactive intermediates either by selectively catalyzing the conversion of these intermediates to stable derivatives or by avoiding their formation by functionalizing natural structures or intermediates. This strategy has attracted wide attention from researchers since it was proposed.
  • 1.5K
  • 10 Jan 2023
Topic Review
EBV-Associated Diseases
Epstein-Barr virus (EBV), the representative of the Herpesviridae family, is a pathogen extensively distributed in the human population. One of its most characteristic features is the capability to establish latent infection in the host. The infected cells serve as a sanctuary for the dormant virus, and therefore their desensitization to apoptotic stimuli is part of the viral strategy for long-term survival. 
  • 1.5K
  • 18 Jul 2022
Topic Review
Cx43-Mediated Signaling
The immunological synapse (IS) is an intercellular communication platform, organized at the contact site of two adjacent cells, where at least one is an immune cell. Functional IS formation is fundamental for the modulation of the most relevant immune system activities, such as T cell activation by antigen presenting cells. Extensive evidence suggests that connexins, in particular connexin-43 (Cx43) hemichannels and/or gap junctions (GJ), regulate signaling events in different types of IS. Although the underlying mechanisms are not fully understood, the current evidence suggests that Cx43 channels could act as facilitators for calcium ions, cyclic adenosine monophosphate, and/or adenosine triphosphate uptake and/or release at the interface of interacting cells. These second messengers have relevant roles in the IS signaling during dendritic cell (DC)-mediated T and NK cell activation, regulatory T cell-mediated immune suppression, and cytotoxic T lymphocyte or NK cell-mediated target tumor cell killing.
  • 1.5K
  • 09 Nov 2020
Topic Review
Insulin-Like Growth Factor-1
This article details the critical roles that insulin-like growth factor-1 and its receptor insulin-like growth factor-1 receptor (GFR1) play in maintaining bone homeostasis and how exposure of bone cells to microgravity affects the function of these growth factors. 
  • 1.5K
  • 14 Jul 2020
Topic Review
Macrophages and Cholesterol-Dependent Cytolysins
Cholesterol-dependent cytolysins (CDCs) are key virulence factors involved in many lethal bacterial infections, including pneumonia, necrotizing soft tissue infections, bacterial meningitis, and miscarriage. Host responses to these diseases involve myeloid cells, especially macrophages. Macrophages use several systems to detect and respond to cholesterol-dependent cytolysins, including membrane repair, mitogen-activated protein (MAP) kinase signaling, phagocytosis, cytokine production, and activation of the adaptive immune system. However, CDCs also promote immune evasion by silencing and/or destroying myeloid cells. While there are many common themes between the various CDCs, each CDC also possesses specific features to optimally benefit the pathogen producing it.
  • 1.5K
  • 09 Nov 2020
Topic Review
Photothermal Therapy Mediated by Nanomaterial
Photothermal therapy (PTT) mediated by nanomaterial has become an attractive tumor treatment method due to its obvious advantages. Among various nanomaterials, melanin-like nanoparticles with nature biocompatibility and photothermal conversion properties have attracted more and more attention. Melanin is a natural biological macromolecule widely distributed in the body and displays many fascinating physicochemical properties such as excellent biocompatibility and prominent photothermal conversion ability. Due to the similar properties, Melanin-like nanoparticles have been extensively studied and become promising candidates for clinical application.
  • 1.5K
  • 29 Jan 2021
Topic Review
RNA–Protein
RNA–protein interactions are the nodes in a complex regulatory network that controls the fate of each RNA expressed in a cell.
  • 1.5K
  • 15 Jun 2021
Topic Review
Antioxidants and Atherosclerosis
Atherosclerosis is a chronic inflammatory disease which is a major cause of coronary heart disease and stroke in humans. It is characterized by intimal plaques and cholesterol accumulation in arterial walls. The side effects of currently prescribed synthetic drugs and their high cost in the treatment of atherosclerosis has prompted the use of alternative herbal medicines, dietary supplements, and antioxidants associated with fewer adverse effects for the treatment of atherosclerosis. Natural and synthetic antioxidants have a crucial role in the prevention and treatment of atherosclerosis through different mechanisms. These include: The inhibition of low density lipoprotein (LDL) oxidation, the reduction of reactive oxygen species (ROS) generation, the inhibition of cytokine secretion, the prevention of atherosclerotic plaque formation and platelet aggregation, the preclusion of mononuclear cell infiltration, the improvement of endothelial dysfunction and vasodilation, the augmentation of nitric oxide (NO) bioavailability, the modulation of the expression of adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) on endothelial cells, and the suppression of foam cell formation.
  • 1.5K
  • 23 Jul 2021
Topic Review
Nanocellulosic Materials for Oil Spill
Modern developments in cellulosic materials for oil spill removal are briefly showcased in this entry. Different types of lignocellulosic textures and different modification techniques and preparation methods are explained. Materials were classified into 3D-materials such as hydrophobic and oleophobic sponges and aerogels, or 2D-materials such as membranes, fabrics, films, and meshes. Majorly, 3D-materials showed clear correlation between porosity and density, and their absorption behavior. Moreover, it was shown that nanocellulosic precursors are not exclusively suitable to attain considerable absorption performance. This finding can lead to developments in cost- and energy-efficient production processes of future cellulosic oil spillage removal solutions.
  • 1.5K
  • 27 Sep 2021
Topic Review
NCAM2
NCAM2 governs neuronal morphogenesis and axodendritic architecture, and controls important neuron-specific processes such as neuronal differentiation, synaptogenesis and memory formation. In the adult brain, NCAM2 is highly expressed in dendritic spines, and it regulates synaptic plasticity and learning processes. NCAM2’s functions are related to its ability to adapt to the external inputs of the cell and to modify the cytoskeleton accordingly. Different studies show that NCAM2 interacts with proteins involved in cytoskeleton stability and proteins that regulate calcium influx, which could also modify the cytoskeleton.
  • 1.5K
  • 28 Sep 2021
Topic Review
NLRP3 Inflammasome Inhibitors
Nucleotide-binding oligomerization domain NOD-like receptors (NLRs) are conserved cytosolic pattern recognition receptors (PRRs) that track the intracellular milieu for the existence of infection, disease-causing microbes, as well as metabolic distresses. The NLRP3 inflammasome agglomerates are consequent to sensing a wide spectrum of pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs). Certain members of the NLR family have been documented to lump into multimolecular conglomerates called inflammasomes, which are inherently linked to stimulation of the cysteine protease caspase-1.
  • 1.5K
  • 28 Sep 2021
Topic Review
Direct-Seeded Rice Root System Architecture
Direct-seeded rice (DSR) is such a system of rice cultivation that has the potential to decrease water consumption, in addition to lessening labor requirements and at the same time enhance resource-use efficiency and system productivity, and check greenhouse gas emissions. Identifying ideal traits and breeding new rice varieties with efficient root system architecture (RSA) has great potential to increase resource-use efficiency and grain yield, especially under direct-seeded rice, by adapting to aerobic soil conditions. 
  • 1.5K
  • 09 Feb 2022
Topic Review
Applications of Nanotechnology in Food & Cosmetics Preservation
Cosmetic and food products containing water are prone to contamination during the production, storage, and transit process, leading to product spoilage and degraded organoleptic characteristics. The efficient preservation of food and cosmetics is one of the most important issues the industry is facing today. The use of nanotechnology in food and cosmetics for preservation purposes offers the possibility to boost the activity of antimicrobial agents and/or promote their safer distribution into the end product upon incorporation into packaging or film constructions.
  • 1.5K
  • 22 Apr 2022
Topic Review
Multiplex Tissue Imaging
Multiplex spatial analysis methods have recently been developed; these have offered insight into how cellular crosstalk dynamics and heterogeneity affect cancer prognoses and responses to treatment. Multiplex (imaging) technologies and computational analysis methods allow for the spatial visualization and quantification of cell–cell interactions and properties. These technological advances allow for the discovery of cellular interactions within the tumor microenvironment and provide detailed single-cell information on properties that define cellular behavior.
  • 1.5K
  • 08 Jul 2022
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