Your browser does not fully support modern features. Please upgrade for a smoother experience.
Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort by:
Most Viewed Latest Alphabetical (A-Z) Alphabetical (Z-A)
Filter:
All Topic Review Biography Peer Reviewed Entry Video Entry
Topic Review
Polyphenols Analysis in Plants Matrices
Phenolic compounds are plants’ bioactive metabolites that have been studied for their ability to confer extensive benefits to human health. As currently there is an increased interest in natural compounds identification and characterization, new analytical methods based on advanced technologies have been developed. 
  • 1.5K
  • 27 May 2021
Topic Review
Coronary Vasculitis
The term coronary “artery vasculitis” is used for a diverse group of diseases with a wide spectrum of manifestations and severity. Clinical manifestations may include pericarditis or myocarditis due to involvement of the coronary microvasculature, stenosis, aneurysm, or spontaneous dissection of large coronaries, or vascular thrombosis. As compared to common atherosclerosis, patients with coronary artery vasculitis are younger and often have a more rapid disease progression. Several clinical entities have been associated with coronary artery vasculitis, including Kawasaki’s disease, Takayasu’s arteritis, polyarteritis nodosa, ANCA-associated vasculitis, giant-cell arteritis, and more recently a Kawasaki-like syndrome associated with SARS-COV-2 infection.
  • 1.5K
  • 11 Jun 2021
Topic Review
CUT Domain Proteins in Cancer
Recent studies revealed that CUT domains function as accessory factors that accelerate DNA repair by stimulating the enzymatic activities of the base excision repair enzymes OGG1, APE1, and DNA pol β. Strikingly, the role of CUT domain proteins in DNA repair is exploited by cancer cells to facilitate their survival. Cancer cells in which the RAS pathway is activated produce an excess of reactive oxygen species (ROS) which, if not counterbalanced by increased production of antioxidants, causes sustained oxidative DNA damage and, ultimately, cell senescence. These cancer cells can adapt by increasing their capacity to repair oxidative DNA damage in part through elevated expression of CUT domain proteins such as CUX1, CUX2, or SATB1. In particular, CUX1 overexpression was shown to cooperate with RAS in the formation of mammary and lung tumors in mice. Conversely, knockdown of CUX1, CUX2, or SATB1 was found to be synthetic lethal in cancer cells exhibiting high ROS levels as a consequence of activating mutations in KRAS, HRAS, BRAF, or EGFR. Importantly, as a byproduct of their adaptation, cancer cells that overexpress CUT domain proteins exhibit increased resistance to genotoxic treatments such as ionizing radiation, temozolomide, and cisplatin.
  • 1.5K
  • 22 Jun 2021
Topic Review
Ubiquitination of ETS Transcription Factors
Genome expansion, whole genome and gene duplication events during metazoan evolution produced an extensive family of ETS genes whose members express transcription factors with a conserved winged helix-turn-helix DNA-binding domain. Key determinants of the cellular repertoire of ETS proteins are their stability and turnover, controlled largely by the actions of selective E3 ubiquitin ligases and deubiquitinases. Here we discuss the known relationships between ETS proteins and enzymes that determine their ubiquitin status, their integration with other developmental signal transduction pathways and how suppression of ETS protein ubiquitination contributes to the malignant cell phenotype in multiple cancers.
  • 1.5K
  • 21 Jul 2021
Topic Review
CD123
The interleukin-3 receptor alpha chain (IL-3R), more commonly referred to as CD123, is widely overexpressed in various hematological malignancies, including acute myeloid leukemia (AML), B-cell acute lymphoblastic leukemia, hairy cell leukemia, Hodgkin lymphoma and particularly, blastic plasmacytoid dendritic neoplasm (BPDCN). Importantly, CD123 is expressed at both the level of leukemic stem cells (LSCs) and more differentiated leukemic blasts, which makes CD123 an attractive therapeutic target. Various agents have been developed as drugs able to target CD123 on malignant leukemic cells and on the normal counterpart. Tagraxofusp (SL401, Stemline Therapeutics), a recombinant protein composed of a truncated diphtheria toxin payload fused to IL-3, was approved for use in patients with BPDCN in December of 2018 and showed some clinical activity in AML. Different monoclonal antibodies directed against CD123 are under evaluation as antileukemic drugs, showing promising results either for the treatment of AML minimal residual disease or of relapsing/refractory AML or BPDCN. 
  • 1.5K
  • 13 Sep 2021
Topic Review
Hybrid Graphene/Fiber Reinforced Cementitious Composites
Graphene with fascinating properties has been deemed as an excellent reinforcement for cementitious composites, enabling construction materials to be smarter, stronger, and more durable. However, some challenges such as dispersion issues and high costs, hinder the direct incorporation of graphene-based reinforcement fillers into cementitious composites for industrial production. The combination of graphene with conventional fibers to reinforce cement hence appears as a more promising pathway especially towards the commercialization of graphene for cementitious materials.  This entry introduces the preparation and the enhancement of hybrid graphene-fiber reinforced cementitious composites.
  • 1.5K
  • 09 Oct 2021
Topic Review
Internet-of-Things technologies for Assisted Living
An ambient assisted living (AAL) environment is an integration of stand-alone assistive technologies, solutions, and services. AAL (or simply assisted living) solutions can provide a positive influence on the health and quality of life of people, especially older people. 
  • 1.5K
  • 14 Sep 2021
Topic Review
Nanomaterials for Viral Diseases Diagnosis, Prevention, and Treatment
Nanomaterials can be tailored for specific uses by modulating physical and chemical properties, including size, morphology, surface charge, and solubility. Due to these controllable properties, nanomaterials have been used in biosensors to potentiate target-specific reactions that respond to biochemical environments, such as temperature, pH, and the presence of enzymes.
  • 1.5K
  • 14 Oct 2021
Topic Review
Ultra-Processed Food Consumption and Risk of Diabetes Mellitus
Ultra-processed foods (UPFs) are products that have undergone a series of industrial processes, including physical, biological, or chemical processes, coupled with the use of additives such as colorings, emulsifiers, and preservatives. UPF consumption has grown dramatically over the last few decades worldwide. This growth is accompanied by the increasing prevalence of non-communicable diseases (NCDs) such as cardiovascular diseases, hypertension, and type 2 diabetes. UPFs represent three main health concerns: (i) they are generally high in non-nutritive compounds such as sugars, sodium, and trans fat and low in nutritional compounds such as proteins and fibers, (ii) they contain different types of additives that may cause severe health issues, and (iii) they are presented in packages made of synthetic materials that may also cause undesirable health side-effects.
  • 1.5K
  • 15 Jun 2022
Topic Review
Digital Finance Contributes to Promotion of Financial Sustainability
Digital finance, which is defined as the digitalization of the financial industry, has shown growing importance in recent years. It has helped promote financial inclusion, providing means to address the problem of financial depressions in developing and emerging economies. Digital finance possesses three key features including a high capacity for acquiring and processing information, instant cross-spatial information dissemination, and a low marginal cost effect.
  • 1.5K
  • 12 Jul 2022
Topic Review
Therapeutic Potential of Marine Peptides in Prostate Cancer
Prostate cancer (PCa) is the leading cause of cancer death in men, and its treatment is commonly associated with severe adverse effects. Thus, new treatment modalities are required. In this context, natural compounds have been widely explored for their anti-PCa properties. Aquatic organisms contain numerous potential medications. Anticancer peptides are less toxic to normal cells and provide an efficacious treatment approach via multiple mechanisms, including altered cell viability, apoptosis, cell migration/invasion, suppression of angiogenesis and microtubule balance disturbances.
  • 1.5K
  • 01 Aug 2022
Topic Review
Bone Health in Prostate Cancer Disease
Prostate cancer (PCa) is the second-leading cause of cancer-related deaths in men. PCa cells require androgen receptor (AR) signaling for their growth and survival. Androgen deprivation therapy (ADT) is the preferred treatment for patients with locally advanced and metastatic PCa disease. Bone-metastasis-induced early changes in the bone that proceed the osteoblastic response in the bone matrix are monitored and detected via modern magnetic resonance and PET/CT imaging technologies.
  • 1.5K
  • 14 Sep 2022
Topic Review
HFE Hereditary Haemochromatosis
Hereditary haemochromatosis (or hemochromatosis) is a genetic disorder characterized by excessive intestinal absorption of dietary iron, resulting in a pathological increase in total body iron stores. Humans, like most animals, have no means to excrete excess iron. Excess iron accumulates in tissues and organs, disrupting their normal function. The most susceptible organs include the liver, adrenal glands, heart, skin, gonads, joints, and the pancreas; patients can present with cirrhosis, polyarthropathy, adrenal insufficiency, heart failure, or diabetes. The hereditary form of the disease is most common among those of Northern European ancestry, in particular those of Celtic descent. The disease is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. Most often, the parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but do not show signs and symptoms of the condition.
  • 1.5K
  • 26 Oct 2022
Topic Review
Crystalline Silicon-Based Tunnel Oxide Passivated Contact Solar Cells
Contact selectivity is a key parameter for enhancing and improving the power conversion efficiency (PCE) of crystalline silicon (c-Si)-based solar cells. Carrier selective contacts (CSC) are the key technology which has the potential to achieve a higher PCE for c-Si-based solar cells closer to their theoretical efficiency limit. A recent and state-of-the-art approach in this domain is the tunnel oxide passivated contact (TOPCon) approach, which is completely different from the existing classical heterojunction solar cells. The main and core element of this contact is the tunnel oxide, and its main role is to cut back the minority carrier recombination at the interface. 
  • 1.5K
  • 03 Feb 2023
Topic Review
Ketone Bodies and SIRT1
Ketone bodies (KBs) and Sirtuin-1 (SIRT1) have received increasing attention over the past two decades given their pivotal function in a variety of biological contexts, including transcriptional regulation, cell cycle progression, inflammation, metabolism, neurological and cardiovascular physiology, and cancer. As a consequence, the modulation of KBs and SIRT1 is considered a promising therapeutic option for many diseases.
  • 1.5K
  • 22 Feb 2023
Topic Review
Motility of Helicobacter spp.
Helicobacter spp., including the well-known human gastric pathogen H. pylori, can cause gastric diseases in humans and other mammals. They are Gram-negative bacteria that colonize the gastric epithelium and use their multiple flagella to move across the protective gastric mucus layer. Different Helicobacter spp. differ in the number and arrangement of flagella, as well as in the size and shape of their cell body. The most well-studied of these is H. pylori, which is unipolar and lophotrichous (multiple flagella at one pole). Some of these bacteria are bipolar, e.g., the lophotrichous H. suis, and the monotrichous H. cetorum. The motility of H. pylori, H. suis, and H. cetorum was described in the review in Microorganisms 2023 linked above. 
  • 1.5K
  • 20 Mar 2023
Topic Review
Glyphosate Effection on Marine Invertebrates
Glyphosate is the active ingredient of numerous commercial formulations of herbicides applied in different sectors, from agriculture to aquaculture. Due to its widespread use around the world, relatively high concentrations of glyphosate have been detected in soil and aquatic environments. The presence of glyphosate in aquatic ecosystems has aroused the attention of researchers because of its potential negative effects on living organisms, both animals and plants. Generally, data obtained in acute toxicity tests indicate that glyphosate and its commercial formulations are lethal at high concentrations (not environmentally realistic), whereas results of long-lasting experiments indicate that glyphosate can affect markedly biological responses of marine invertebrates. This review intends to summarize results of studies aimed at evaluating the effects of glyphosate (both as active ingredient and component of commercial formulations) on marine invertebrates.
  • 1.5K
  • 27 Oct 2020
Biography
Edward Gibson
Edward George Gibson (born November 8, 1936) is a former NASA astronaut, pilot, engineer, and physicist. Before becoming a NASA astronaut, Gibson graduated from the University of Rochester and the California Institute of Technology. He became a research assistant in jet propulsion while completing his studies and eventually became a research scientist for Philco Corporation until joining NASA.
  • 1.5K
  • 15 Nov 2022
Topic Review
Computational Modeling of Human Microbiome
The human microbiome has been identified as a potentially significant contributor to human health, but the composition and role that the microbiome plays varies across body sites.  Technological improvements have enabled large-scale studies of the human microbiome and this review focuses on the data and health impacts that have been analyzed to date associated with the skin, oral, gut, and vaginal microbiomes.  One major challenge in this area that remains is to gain a better mechanistic understanding of the microbial consortium function and dynamics and how it impacts the human host.  Computational approaches can help analyze some of the interactions and complexity of the microbiome-host interactions and thus, discussion on relevant computational studies associated with the human microbiome are also presented.
  • 1.5K
  • 01 Nov 2020
Topic Review
Mindfulness for Preventing Psychosocial Risks
Mindfulness-based intervention programs in the context of the workplace must be supported by a synthesis of empirical evidence in which the heterogeneity of the different studies shows their efficacy. Meta-analytical studies are intended to overcome the deficiencies and contradictions found in the literature by analyzing the empirical evidence available [38]. This meta-analytical review emphasizes exactly which results the various interventions now show and what influence they exert on psychological variables of employees. Therefore, the main objective of this study was to analyze the efficacy of MBIs on psychological variables of employees.
  • 1.5K
  • 29 Oct 2020
  • Page
  • of
  • 2800
Featured Entry Collections
>>

Featured Reprints

>>
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Encyclopedia of Engineering
Encyclopedia of Social Sciences
Encyclopedia of Medieval Royal Iconography
Academic Video Service
Feedback