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Topic Review
Enteroviruses
Enteroviruses (EV) are a group of positive-sense RNA viruses that belong to Picornaviridae. Most of the infections caused by EV are asymptomatic. However, EV can cause serious infections such as neurological and cardiac infections. Different chronic diseases have been linked to EVs, as causative agents, such as dilated cardiomyopathy and type 1 diabetes. 
  • 1.5K
  • 06 May 2023
Topic Review
Oral Submucous Fibrosis
Betel quid (BQ) chewing increased the risk of oral cancer and oral submucous fibrosis (OSMF), an oral premalignant disorder (OPMD) with malignant transformation potential. BQ components such as areca nut (AN), trauma by coarse AN fiber, catechin, copper, alkaloids, stimulated reactive oxygen species (ROS), inflammation and cytotoxicity are suggested to be the contributing factors. In this review, the expression of extracellular matrix (ECM) turnover related genes and proteins in OSMF and the relation to betel quid chewing habit is discussed. Genetic susceptibility of ECM-related genes to OSMF is also mentioned. These results can facilitate our understanding the pathogenesis of OSMF and its possible prevention/treatment in the future.
  • 1.5K
  • 08 Dec 2020
Topic Review
Chromosome 22
Humans normally have 46 chromosomes (23 pairs) in each cell. Two copies of chromosome 22, one copy inherited from each parent, form one of the pairs.
  • 1.5K
  • 04 Jan 2021
Topic Review
Bile Acids and Microbiota
After their synthesis from cholesterol in hepatic tissues, bile acids (BAs) are secreted into the intes-tinal lumen. Most BAs are subsequently re-absorbed in the terminal ileum and are transported back for recycling to the liver. Some of them, however, reach the colon and change their physico-chemical properties upon modification by gut bacteria, and vice versa, BAs also shape the compo-sition and function of the intestinal microbiota. This mutual interplay of both BAs and gut micro-biota regulates many physiological processes, including the lipid, carbohydrate and energy metab-olism of the host. Emerging evidence also implies an important role of this enterohepatic BA cir-cuit in shaping mucosal colonization resistance as well as local and distant immune responses, tissue physiology and carcinogenesis.
  • 1.5K
  • 20 Feb 2021
Topic Review
NF-κB Signaling and Virus Infection
The nuclear factor κB (NF-κB) family are the master transcription factors that control cell proliferation, apoptosis, the expression of interferons and proinflammatory factors, and viral infection. During viral infection, host innate immune system senses viral products, such as viral nucleic acids, to activate innate defense pathways, including the NF-κB signaling axis, thereby inhibiting viral infection. In these NF-κB signaling pathways, diverse types of ubiquitination have been shown to participate in different steps of the signal cascades. Recent advances find that viruses also modulate the ubiquitination in NF-κB signaling pathways to activate viral gene expression or inhibit host NF-κB activation and inflammation, thereby facilitating viral infection. Understanding the role of ubiquitination in NF-κB signaling during viral infection will advance our knowledge of regulatory mechanisms of NF-κB signaling and pave the avenue for potential antiviral therapeutics. 
  • 1.5K
  • 07 Apr 2021
Topic Review
KRAS
The RAS family consists of membrane-associated small GTPases which play essential roles in cell survival, proliferation, and differentiation. There are four RAS protein isoforms in humans: HRAS, NRAS, and two splice variants, KRAS4A and KRAS4B. 
  • 1.5K
  • 12 Oct 2021
Topic Review
Diesel Engines Emissions Reduction
Compression ignition engines play a significant role in the development of a country. They are widely used due to their innate properties such as high efficiency, high power output, and durability. However, they are considered one of the key contributors to transport-related emissions and have recently been identified as carcinogenic. Thus, it is important to modify the designs and processes before, during, and after combustion to reduce the emissions to meet the strict emission regulations.
  • 1.5K
  • 13 Apr 2021
Topic Review
Supramolecular Chemistry: Host–Guest Molecular Complexes
The host–guest (HG) interactions in two-dimensional (2D) permeable porous linkages are growing expeditiously due to their future applications in biocatalysis, separation technology, or nanoscale patterning. In host–guest (HG) interaction, distinctive structural complexes development occurs via non-covalent associations. There is a growing curiosity in executing supramolecular HG structures for assembling organic solvents and aqueous solutions on compact planes.
  • 1.5K
  • 09 Jul 2021
Topic Review
Hardware Heritage
Hardware heritage is the history of both hardware and software. Human knowledge, experience, and skills are translated into computation models (binary code) in software and computer environment (‘digital ecosystem’). The history of software is a history of how different communities of practitioners ‘put their world into a computer’.
  • 1.5K
  • 23 Sep 2021
Topic Review
Glyphosate Pollution Treatment
Glyphosate (N-Phosphonomethyl-glycine) is a broad-spectrum herbicide extensively used worldwide to eliminate weeds in agricultural areas, control vegetation in urban areas, and accelerate the harvest of several crops. Recently was classified as a potentially carcinogenic compound, due to this several countries banned or are in the process of banning its use.
  • 1.5K
  • 24 Nov 2021
Topic Review
Raman Spectroscopy Applied to Biomedical Research
Nowadays, there is an interest in biomedical and nanobiotechnological studies, such as studies on carotenoids as antioxidants and studies on molecular markers for cardiovascular, endocrine, and oncological diseases. Also, interest in industrial production of microalgal biomass for biofuels and bioproducts has stimulated studies on microalgal physiology and mechanisms of synthesis and accumulation of valuable biomolecules in algal cells. Biomolecules such as neutral lipids and carotenoids are being actively explored by the biotechnology community. Raman spectroscopy (RS) has become an important tool for researchers to understand biological processes at the cellular level in medicine and biotechnology.
  • 1.5K
  • 05 May 2022
Topic Review
BFR Spaceship
The Big Falcon Rocket (officially shortened to BFR) is a privately funded fully reusable launch vehicle and spacecraft system in development by SpaceX. The overall space vehicle architecture includes both launch vehicles and spacecraft, as well as ground infrastructure for rapid launch and relaunch, and zero-gravity propellant transfer technology to be deployed in low Earth orbit (LEO). The payload capacity to Earth orbit of at least 100,000 kg (220,000 lb) makes BFR a super heavy-lift launch vehicle. The first orbital flight is tentatively planned for 2020. SpaceX has been developing a super heavy-lift launch vehicle for many years, with the exact design and nomenclature of the vehicle undergoing multiple revisions over time. Before 2016, the vehicle was referred to as the Mars Colonial Transporter (MCT), though very few details about the design of the MCT were ever made public. Starting from 2016, SpaceX began sharing annual updates with the public, detailing the designs and uses of their upcoming new launch vehicle. In 2016, SpaceX CEO Elon Musk presented the vehicle at the International Astronautical Congress as the ITS launch vehicle, forming a core part of Musk's comprehensive vision for an Interplanetary Transport System (ITS). The ITS vehicle had a 12-meter (39 ft) core diameter, but was only intended for interplanetary travel. In September 2017, the design (now known as the BFR) was scaled down to 9 meters (30 ft) While the ITS had been solely aimed at Mars transit and other interplanetary uses, SpaceX pivoted to a plan that would support all SpaceX launch service provider capabilities with a single set of 9-meter vehicles: Earth orbit, lunar orbit, Interplanetary spaceflight, and potentially, even intercontinental passenger transport on Earth. In September 2018, a redesign of the second stage was announced, adding steerable canards, two radially adjustable fins also acting as landing legs, and a third leg that looks like a vertical stabilizer but has no aerodynamic function due to the special re-entry profile of the spacecraft. The launch vehicle design is dependent on the concurrent development work on the Raptor rocket engines, which are cryogenic methalox-fueled engines to be used for both stages of the BFR launch vehicle. Development on the Raptor began in 2012, leading to engine testing which began in 2016. The BFR system is intended to completely replace all of SpaceX's existing space hardware (the Falcon 9 and Falcon Heavy launch vehicles, and the Dragon spacecraft), initially aiming at the Earth-orbit launch market, but explicitly adding substantial capability to support long-duration spaceflight in the cislunar and Mars transport flight environments.
  • 1.5K
  • 14 Oct 2022
Topic Review
Aprotinin
The drug aprotinin (Trasylol, previously Bayer and now Nordic Group pharmaceuticals), is a small protein bovine pancreatic trypsin inhibitor (BPTI), or basic trypsin inhibitor of bovine pancreas, which is an antifibrinolytic molecule that inhibits trypsin and related proteolytic enzymes. Under the trade name Trasylol, aprotinin was used as a medication administered by injection to reduce bleeding during complex surgery, such as heart and liver surgery. Its main effect is the slowing down of fibrinolysis, the process that leads to the breakdown of blood clots. The aim in its use was to decrease the need for blood transfusions during surgery, as well as end-organ damage due to hypotension (low blood pressure) as a result of marked blood loss. The drug was temporarily withdrawn worldwide in 2007 after studies suggested that its use increased the risk of complications or death; this was confirmed by follow-up studies. Trasylol sales were suspended in May 2008, except for very restricted research use. In February 2012 the European Medicines Agency (EMA) scientific committee reverted its previous standpoint regarding aprotinin, and has recommended that the suspension be lifted. Nordic became distributor of aprotinin in 2012.
  • 1.5K
  • 20 Oct 2022
Topic Review
Research Trends on Exercise-Induced Muscle Damage
Exercise-induced muscle damage (EIMD) is a phenomenon that occurs following novel or unaccustomed exercise, particularly if the exercise includes a high number of eccentric contractions. The damage process is normally accompanied by a temporary decrease in muscle function (both muscle force and range of motion), increased swelling of the involved muscle group, increased circulation of muscle-specific proteins, and delayed-onset muscle soreness (DOMS). Most of the symptoms and signs of EIMD are present immediately after the initial exercise bout and persist for up to 14 days. 
  • 1.5K
  • 03 Nov 2022
Topic Review
Diffusion Tensor Imaging in Prognostic of Acute/Hyperacute Stroke
Clinical manifestation of stroke is characterized by great diversity, ranging from minor disability to considerable neurological impairment interfering with activities of daily living and even death. Prognostic ambiguity has stimulated the interest for implementing stroke recovery biomarkers, including those provided by structural neuroimaging techniques, i.e., diffusion tensor imaging (DTI) and tractography for the study of white matter (WM) integrity. Diffusion tensor imaging (DTI) is an extension of magnetic resonance imaging (MRI) for in vivo mapping of white matter (WM) directionality and organization, allowing the qualitative and quantitative evaluation of major WM tracts and their microstructural integrity. DTI is based on the random diffusion of water molecules. Research on DTI metrics as stroke outcome biomarker is not limited to the acute and subacute phases, as it is also implemented on chronic stroke patients. Direct visualization of long tracts and their potential disruption provides insight into pathogenesis of functional deficits in stroke survivors as well as compensatory mechanisms on a microstructural level. Such knowledge may elucidate which group of patients is most likely to benefit from rehabilitation, and even help personalize treatment plans after the acute stroke phase according to each individual’s needs. 
  • 1.5K
  • 23 Nov 2022
Topic Review
Quote Notation
Quote notation is a representation of the rational numbers based on Kurt Hensel's p-adic numbers. In quote notation, arithmetic operations take particularly simple, consistent forms, producing exact answers with no roundoff error. Quote notation’s arithmetic algorithms work in a right-to-left direction; addition, subtraction, and multiplication algorithms are the same as for natural numbers, and division is easier than the usual division algorithm. The notation was invented by Eric Hehner of the University of Toronto and Nigel Horspool, then at McGill University, and published in the SIAM Journal on Computing, v.8, n.2, May 1979, pp. 124–134.
  • 1.5K
  • 24 Nov 2022
Topic Review
Black Sea Climate and Ecology
Short-term climatic variation in the Black Sea region is significantly influenced by the operation of the North Atlantic oscillation, the climatic mechanisms resulting from the interaction between the north Atlantic and mid-latitude air masses. While the exact mechanisms causing the North Atlantic Oscillation remain unclear, it is thought the climate conditions established in western Europe mediate the heat and precipitation fluxes reaching Central Europe and Eurasia, regulating the formation of winter cyclones, which are largely responsible for regional precipitation inputs and influence Mediterranean Sea surface temperatures (SST's). The relative strength of these systems also limits the amount of cold air arriving from northern regions during winter. Other influencing factors include the regional topography, as depressions and storms systems arriving from the Mediterranean are funneled through the low land around the Bosporus, Pontic and Caucasus mountain ranges acting as waveguides, limiting the speed and paths of cyclones passing through the region.
  • 1.5K
  • 25 Nov 2022
Topic Review
Exclusion Clause
An exclusion clause is a term in a contract that seeks to restrict the rights of the parties to the contract. Traditionally, the district courts have sought to limit the operation of exclusion clauses. In addition to numerous common law rules limiting their operation, in England and Wales Consumer Contracts Regulations 1999. The Unfair Contract Terms Act 1977 applies to all contracts, but the Unfair Terms in Consumer Contracts Regulations 1999, unlike the common law rules, do differentiate between contracts between businesses and contracts between business and consumer, so the law seems to explicitly recognize the greater possibility of exploitation of the consumer by businesses.
  • 1.5K
  • 29 Nov 2022
Topic Review
NK Cell and NK Cell-Based Immunotherapy for Cancer
Glioblastoma (GBM) is the most aggressive and malignant primary brain tumor in adults. Despite multimodality treatment involving surgical resection, radiation therapy, chemotherapy, and tumor-treating fields, the median overall survival (OS) after diagnosis is approximately 2 years and the 5-year OS is poor. Considering the poor prognosis, novel treatment strategies are needed, such as immunotherapies. Natural killer (NK) cell-based immunotherapy involves the new feature of recognizing GBM via differing mechanisms from that of T cell-based immunotherapy. 
  • 1.5K
  • 15 Feb 2023
Topic Review
Oromucosal Administration of Oxytocin: The Development of ‘Oxipops’
The neuropeptide oxytocin is synthesized by cells in the hypothalamic paraventricular and supraoptic nuclei and transported to the posterior pituitary for release into the blood, where it is most well-known for acting on smooth muscle to stimulate uterine contractions during labor and milk-ejection from the breast. The role of the hypothalamic neuropeptide oxytocin in influencing the brain and behavior has been the subject of widespread research due, most notably, to its reported involvement in promoting social cognition and motivation, reducing anxiety, and relieving pain. It is also increasingly being considered as an important therapeutic intervention in a variety of disorders with social dysfunction as a symptom.  There is increasing evidence that many of its functional effects can be peripherally mediated via increasing its concentration in the blood. This has opened up an oromucosal administration route as an alternative, which is beneficial since the oral consumption of peptides is problematic due to their rapid breakdown in the acidic environment of the gastrointestinal system. 
  • 1.5K
  • 18 Mar 2024
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