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Topic Review
Biorefinery of Sewage Sludge
The disposal of excess biological sewage sludge from wastewater treatment is a growing environmental issue due to the vast quantities generated worldwide. Due to its composition, sewage sludge could be potentially exploited as a renewable carbon source, rather than being considered an inevitable “nuisance” linked to the main task of wastewater treatment. Biorefinery encompasses any technology used to process excess biological sewage sludge (EBSS) for biofuel and/or resource recovery: proper process integration can contribute to generating multiple possible final products (energy and/or materials).
  • 1.5K
  • 10 Apr 2023
Topic Review
Antisocial Disorders
Transdiagnostic causal variables have been identified that have allowed understanding the origin and maintenance of psychopathologies in parsimonious explanatory models of antisocial disorders. However, it is necessary to systematize the information published in the last decade. The main findings indicated that at a structural level there is a general psychopathological factor (psychopathy or externalizing), non-emotional callousness and impulsivity from behavioral inhibition and activation systems, and negative affect traits as base structures. In the emotional level, the study found a risk component from emotional dysregulation and experiential avoidance. In the cognitive level, a key role of anger-rumination and violent ideation as explanatory variables of antisocial disorders. We concluded that the interaction of these identified variables makes it possible to generate an evidence-based transdiagnostic model.
  • 1.5K
  • 30 Oct 2020
Topic Review
Hip Implant Applications
Three-dimensional (3D) printing offers significant potential as an efficient fabrication technique on personalized organs as it is capable of biomimicking the intricate designs found in nature. In this review, the determining factors for hip replacement and the different fabrication techniques such as direct 3D printing, Fused Deposition Modelling (FDM), Selective Laser Sintering (SLS) and stereolithography (SLA) for hip replacement. The study also covers surface modifications of 3D printed implants and provides an overview on 3D tissue regeneration. To appreciate the current conventional hip replacement practices, the conventional metallic and ceramic materials are covered, highlighting their rationale as the material of choice. Next, the challenges, ethics and trends in the implants’ 3D printing, outlook and challenges are also presented. 
  • 1.5K
  • 26 Nov 2020
Topic Review
Cocoa/Dark Chocolate and Obesity
Obesity remains a major public health problem due to its increasing prevalence and the role it plays in contributing to the occurrence of chronic disease. Natural products have become common as adjunct therapeutic agents for treating obesity and preventing metabolic diseases. Cocoa and its products are a rich source of polyphenols are commonly consumed worldwide and recently received attention in the management of obesity.  This entry also depicts the relation between cocoa polyphenols and dark chocolate and obesity.
  • 1.5K
  • 11 Feb 2021
Topic Review
MTOR
The mammalian target of the rapamycin (mTOR) system regulates various cellular functions, such as growth, proliferation, metabolism and survival/death. In systemic organs, it is critically involved in multiple processes, including neurogenesis, nutrition and immunity. In the brain, its roles are essential in the cerebral cortical development, synaptic functions, and brain activities such as learning, cognition and social functions.
  • 1.5K
  • 22 Sep 2021
Topic Review
Graphene/Tourmaline-Composite-Modified Asphalt
In graphene/tourmaline-composite-modified asphalt, graphene can be used to further improve the road performance and emission reduction effect of tourmaline-modified asphalt. The temperature susceptibility, high temperature, anti-aging properties and rheological performance of the graphene/tourmaline-composite-modified asphalt are better than those of the tourmaline-modified asphalt and base asphalt. The asphalt fume reduction rate of graphene/tourmaline-composite-modified asphalt is higher than that of tourmaline-modified asphalt. With the increase of graphene content, the emission reduction performance increases gradually, and the enhancement effect of graphene on tourmaline performance is more obvious.
  • 1.5K
  • 24 Aug 2021
Topic Review
APOE and NF-κB in Alzheimer’s Disease
Apolipoprotein E (APOE) has three different isoforms, with APOE4 carriers representing a major risk factor for the development of Alzheimer’s disease (AD). The APOE4 isoform is associated with many pathological mechanisms, such as increased neuroinflammation. The presence of APOE4 can increase neuroinflammation via overactivation of the nuclear factor kappa B (NF-kB) pathway. The NF-kB pathway is a family of transcription factors involved with regulating over 400 genes involved with inflammation. AD is associated with sustained inflammation and an overactivation of the NF-kB pathway. Therefore, targeting the APOE4 isoform and suppressing the NF-kB pathway using anti-inflammatory compounds may result in the development of novel therapeutics for the prevention/treatment of AD.
  • 1.5K
  • 11 Nov 2021
Topic Review
Pandemic Nursing Framework for Nursing Homes During COVID-19
Nurses have played a vital role in the fight against COVID-19 by ensuring continuity in patient care and demonstrating clinical leadership in pandemic efforts. The pandemic nursing measures can be broadly classified into four groups: (1) infection surveillance and containment measures; (2) ensuring continuity in clinical care and operational support; (3) resource and administrative coordination; and (4) staff training and development. 
  • 1.5K
  • 29 Dec 2021
Topic Review
Testing in Microgrids
This entry covers testing in Microgrids. The most common strategies are described and some papers are critizied. Testing in Microgrids can be done in a variety of ways, among others digital simulation, co-simulation, Real-Time simulation (RTS) Hardware-In-the-Loop (HIL), Controller-Hardware-In-the-Loop (CHIL), Power-Hardware-In-the-Loop (PHIL) and emulators. To choose the desired strategy, the trade-off has to be made between the cost, test fidelity and test coverage. The entry is based on section in "Testing Smart Grid Scenarios with Small Volume Testbed and Flexible Power Inverter" by Milosz Krysik et al.  
  • 1.5K
  • 12 Jan 2022
Topic Review
Cryptocurrency
Cryptocurrency is gaining popularity worldwide, with some countries already starting to regulate and accept cryptocurrency in their financial services. Malaysia’s Securities Commission (SC) announced in October 2021 that over MYR 16 billion (USD 3.85 billion) involving digital assets and cryptocurrencies were traded between August 2020 and September 2021. Since cryptocurrencies are issued by private corporations and are technically beyond the federal government’s control, criminals may use them for illegal reasons such as money laundering and terrorist funding. Consequently, it is vital to examine why investors are engaged in cryptocurrency in the first place.
  • 1.5K
  • 25 Apr 2022
Topic Review
Treatment of Galactosemia
Galactosemia is an inborn disorder of carbohydrate metabolism characterized by the inability to metabolize galactose, a sugar contained in milk (the main source of nourishment for infants), and convert it into glucose, the sugar used by the body as the primary source of energy. Galactosemia is an autosomal recessive genetic disease that can be diagnosed at birth, even in the absence of symptoms, with newborn screening by assessing the level of galactose and the GALT enzyme activity, as GALT defect constitutes the most frequent cause of galactosemia. Currently, galactosemia cannot be cured, but only treated by means of a diet with a reduced content of galactose and lactose. Although the diet is able to reverse the neonatal clinical picture, it does not prevent the development of long-term complications. 
  • 1.5K
  • 29 Jul 2022
Topic Review
Application Scenarios of Using Knowledge Graph
In dynamic complex cyber environments, Cyber Threat Intelligence (CTI) and the risk of cyberattacks are both increasing. This means that organizations need to have a strong understanding of both their internal CTI and their external CTI. The potential for cybersecurity knowledge graphs is evident in their ability to aggregate and represent knowledge about cyber threats, as well as their ability to manage and reason with that knowledge. While most existing research has focused on how to create a full knowledge graph, how to utilize the knowledge graph to tackle real-world industrial difficulties in cyberattack and defense situations is still unclear. 
  • 1.5K
  • 12 Aug 2022
Topic Review
Impacts of COVID-19 Pandemic on Public Road Transportation
The COVID-19 pandemic has caused an unprecedented reduction in the demand for public road transportation, and it has changed passengers’ perceptions from positive to negative when it comes to using public transportation amenities. There is an increasing concern that the public road transportation systems are witnessing a new horizon, especially as developed and developing countries are trying to resume their daily activities post the COVID-19 pandemic.
  • 1.5K
  • 22 Sep 2022
Topic Review
Halloysite Nanotubes
The use of synthetic materials and the attention towards environmental hazards and toxicity impose the development of green composites with natural origins. Clay is one of the candidates for this approach. Halloysite is a natural clay mineral, a member of the Kaolin group, with characteristic tubular morphology, usually named halloysite nanotubes (HNTs).
  • 1.5K
  • 27 Oct 2022
Topic Review
Perl 6 Rules
Perl 6 rules are the regular expression, string matching and general-purpose parsing facility of Perl 6, and are a core part of the language. Since Perl's pattern-matching constructs have exceeded the capabilities of formal regular expressions for some time, Perl 6 documentation refers to them exclusively as regexes, distancing the term from the formal definition. Perl 6 provides a superset of Perl 5 features with respect to regexes, folding them into a larger framework called rules, which provide the capabilities of a parsing expression grammar, as well as acting as a closure with respect to their lexical scope. Rules are introduced with the rule keyword, which has a usage quite similar to subroutine definitions. Anonymous rules can be introduced with the regex (or rx) keyword, or simply be used inline as regexes were in Perl 5 via the m (matching) or s (substitution) operators.
  • 1.5K
  • 22 Nov 2022
Topic Review
3-Inch Gun M1903
The 3-inch gun M1903 and its predecessors the M1898 and M1902 were rapid fire breech-loading artillery guns with a 360-degree traverse. In some references they are called "15-pounders" due to their projectile weight. They were originally emplaced from 1899 to 1917 and served until shortly after World War II. These 3-inch guns were placed to provide fire to protect underwater mines and nets against minesweepers, and also to protect against motor torpedo boats. In some documentation they are called "mine defense guns". The 3-inch guns were mounted on pedestal mounts (or a retractable "masking parapet" mount for the M1898) that bolted into a concrete emplacement that provided cover and safety for the gun's crew.
  • 1.5K
  • 23 Nov 2022
Topic Review
Global Leadership
Global Leadership is the interdisciplinary study of the key elements that future leaders in all realms of the personal experience should acquire to effectively familiarize themselves with the psychological, physiological, geographical, geopolitical, anthropological and sociological effects of globalization. Global leadership occurs when an individual or individuals navigate collaborative efforts of different stakeholders through environmental complexity towards a vision by leveraging a global mindset. Today, global leaders must be capable of connecting "people across countries and engage them to global team collaboration in order to facilitate complex processes of knowledge sharing across the globe" As a result of trends, starting with colonialism and perpetuated by the increase in mass media, innovation, (brought about by the Internet and other forms of human interaction based on the speed of computer-mediation) a host of meaningful new concerns face mankind; consisting of but not limited to: human enterprises toward peace, international business design, and significant shifts in geopolitical paradigms. The talent and insight it will take leaders to successfully navigate humanity through these developments have been collectively focused around the phenomenon of globalization in order to embrace and effectively guide the evolution of mankind through the continued blurring and integration of national, economic and social strategies .
  • 1.5K
  • 24 Nov 2022
Topic Review
Big Science
Big science is a term used by scientists and historians of science to describe a series of changes in science which occurred in industrial nations during and after World War II, as scientific progress increasingly came to rely on large-scale projects usually funded by national governments or groups of governments. Individual or small group efforts, or Small Science, are still relevant today as theoretical results by individual authors may have a significant impact, but very often the empirical verification requires experiments using constructions, such as the Large Hadron Collider, costing between $5 and $10 billion.
  • 1.5K
  • 24 Nov 2022
Topic Review
Reuse of Municipal Solid Waste in Construction
Society is highly dependent on natural resources such as rocks (aggregates) and minerals. Although they are an abundant resource on the planet, their recovery is slow in terms of human lifespan, and from this fact, they are considered non-renewable resources. The construction industry currently consumes around 3000 million tons of natural resources annually and is responsible for 34% of greenhouse gas emissions into the atmosphere. An alternative to reduce this over-extraction is the substitution of aggregates and cement for municipal solid waste (MSW), which represents the application of the circular economy principles. This approach and the waste management hierarchy are described, with a focus on the Latin America and the Caribbean situation. MSW is composed of several fractions, such as organic waste, paper, cardboard, metals, plastic, and glass, among other valuable materials. Areas of opportunity for their reuse in the construction industry have been demonstrated worldwide: a) plastics as substitutes for aggregates or reinforcing fibers, or replaced construction elements such as bricks; b) glass in the production of concrete, mortar, and asphalt pavement; c) paper as a hygrothermal and lighting regulator in buildings, among others.  
  • 1.5K
  • 20 Dec 2022
Topic Review
Ovarian Organogenesis along the Cortical–Medullary Axis in Mammals
In most mammals, the sex of the gonads is based on the fate of the supporting cell lineages, which arises from the proliferation of coelomic epithelium (CE) that surfaces on the bipotential genital ridge in both XY and XX embryos. Genetic studies and single-cell transcriptome analyses in mice have revealed the cellular and molecular events in the two-wave proliferation of the CE that produce the supporting cells. This proliferation contributes to the formation of the primary sex cords in the medullary region of both the testis and the ovary at the early phase of gonadal sex differentiation, as well as to that of the secondary sex cords in the cortical region of the ovary at the perinatal stage. To support gametogenesis, the testis forms seminiferous tubules in the medullary region, whereas the ovary forms follicles mainly in the cortical region. The medullary region in the ovary exhibits morphological and functional diversity among mammalian species that ranges from ovary-like to testis-like characteristics. 
  • 1.5K
  • 31 Jan 2023
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