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Topic Review
Photodynamic Therapy
Photodynamic therapy (PDT) is a promising therapeutic strategy for cancers where surgery and radiotherapy cannot be effective. PDT relies on the photoactivation of photosensitizers, most of the time by lasers to produced reactive oxygen species and notably singlet oxygen. The major drawback of this strategy is the weak light penetration in the tissues. To overcome this issue, recent studies proposed to generate visible light in situ with radioactive isotopes emitting charged particles able to produce Cerenkov radiation. In vitro and preclinical results are appealing, but the existence of a true, lethal phototherapeutic effect is still controversial.
  • 1.6K
  • 15 Dec 2020
Topic Review
Agricultural Soils
Globally, agricultural soils are being evaluated for their role in climate change regulation as a potential sink for atmospheric carbon dioxide (CO2) through sequestration of organic carbon as soil organic matter. Scientists and policy analysts increasingly seek to develop programs and policies which recognize the importance of mitigation of climate change and insurance of ecological sustainability when managing agricultural soils.
  • 1.6K
  • 09 Aug 2021
Topic Review
Application of CFD to Food 3D Printing
CFD (Computational Fluid Dynamics) is one of the computer simulation methods used to characterize fluid flow behavior under certain geometries with boundary conditions. The criterion for its performance is how well numerical simulation outcomes align with experimental results conducted under specific conditions, and how well simulations can predict extremely complicated processes that cannot be analyzed in the real world. CFD has gained recognition as an emerging science around the world, particularly since the late 2000s when there was a significant increase in the development and application of CFD to all areas related to fluid behaviors associated with momentum, heat, and mass transfer.
  • 1.6K
  • 12 Nov 2021
Topic Review
Benefits of the Phytoestrogen Resveratrol for Perimenopausal Women
Endometriosis, characterized by macroscopic lesions in the ovaries, is a serious problem for women who desire conception. Damage to the ovarian cortex is inevitable when lesions are removed via surgery, which finally decreases the ovarian reserve, thereby accelerating the transition to the menopausal state. Resveratrol, a plant-derived molecule that promotes the function and expression of the sirtuin, SIRT1, has been attracting attention, and many reports have shown that resveratrol might exert cardiovascular protective effects. 
  • 1.6K
  • 17 Nov 2021
Topic Review
Development of Anticancer Agents with Peptide-Based Drugs
Peptides are increasingly being developed for use as therapeutics to treat many ailments, including cancer. Therapeutic peptides have the advantages of target specificity and low toxicity. The anticancer effects of a peptide can be the direct result of the peptide binding its intended target, or the peptide may be conjugated to a chemotherapy drug or radionuclide and used to target the agent to cancer cells. Peptides can be targeted to proteins on the cell surface, where the peptide–protein interaction can initiate internalization of the complex, or the peptide can be designed to directly cross the cell membrane. Peptides can induce cell death by numerous mechanisms including membrane disruption and subsequent necrosis, apoptosis, tumor angiogenesis inhibition, immune regulation, disruption of cell signaling pathways, cell cycle regulation, DNA repair pathways, or cell death pathways. 
  • 1.6K
  • 25 Nov 2021
Topic Review
Cybersickness in Virtual Environments - Factors, Best Practices
Cybersickness is a form of simulation sickness experienced when using head mounted displays (HMDs) and is a critical issue that needs to be addressed before virtual reality technology is widely accepted. The concept of cybersickness has existed since the early stages of VR system development. Cybersickness is a type of simulation sickness that is experienced in virtual reality. 
  • 1.6K
  • 18 Apr 2022
Topic Review
Osgood-Schlatter Disease
Osgood-Schlatter disease is the most common osteochondritis of the lower limb in sport-practicing children and adolescents. Its manifestation usually coincides with the appearance of the secondary ossification center of the tibia and is linked to the practice of sports with an explosive component. 
  • 1.6K
  • 08 Jun 2022
Topic Review
Silica Nanoparticles
Silica nanoparticles (NPs) can be categorized into two main groups: solid (non-porous) silica NPs and porous silica NPs. The latter can be further subdivided according to the size of their pores, being mesoporous silica nanoparticles (MSNs) the most studied category among porous silica NPs. 
  • 1.6K
  • 23 Aug 2022
Topic Review
Herbal Approach, Bioactive Compounds, and Mechanism of Obesity
Obesity is arising as a global pandemic throughout the world. Obesity has tripled worldwide, creating an alarming situation. The majority of people nowadays are suffering from obesity and overweight. It affects health of people of all age groups, ethnicity, gender, and sex, and is linked to a sedentary lifestyle of people, poor eating habits, and disturbed sleeping patterns. It causes several diseases such as diabetes mellitus type 2, hypertension, cardiovascular diseases, asthma, gallstones, and colon cancer. Many synthetic anti-obesity drugs such as orlistat, lorcaserin, phentermine, bupropion, and liraglutide are already available on the market. However, these drugs have side effects, including dry mouth and sleeping disorders, dizziness, blood pressure, heart rate elevation, constipation, and headache. Humans have a long and ancient history of dependency on traditional medicinal plants and their major bioactive antioxidant components, such as quercetin, anthocyanins, and ellagic acid, for treating such diseases and disorders. 
  • 1.6K
  • 30 Aug 2022
Topic Review
Bionanomaterials Based on Honey and Propolis for wounds
Wound healing is a public health concern worldwide, particularly in chronic wounds due to delayed healing and susceptibility to bacterial infection. Nanomaterials are widely used in wound healing treatments due to their unique properties associated with their size and very large surface-area-to-volume ratio compared to the same material in bulk. The properties of nanomaterials can be expanded and improved upon with the addition of honey and propolis, due to the presence of bioactive molecules such as polyphenols, flavonoids, peptides, and enzymes. These bionanomaterials can act at different stages of wound healing and through different mechanisms, including anti-inflammatory, antimicrobial, antioxidant, collagen synthesis stimulation, cell proliferation, and angiogenic effects.
  • 1.6K
  • 29 Jan 2023
Topic Review
Traffic Calming Measures
The ever-increasing use of motor vehicles causes a number of traffic safety and community issues, which are particularly severe in cities, accompanied by a scarcity of parking spaces and challenges encountered in road layout alteration projects. The commonly applied solutions include the designation of through streets, the implementation of on-street parking on residential streets, and retrofitted traffic calming measures (TCMs).
  • 1.6K
  • 10 Jan 2024
Topic Review
Pulsed Laser Ablation in Liquids
Laser synthesis emerges as a suitable technique to produce ligand-free nanoparticles, alloys and functionalized nanomaterials for catalysis, imaging, biomedicine, energy and environmental applications. In the last decade, laser ablation and nanoparticle generation in liquids has proven to be a unique and efficient technique to generate, excite, fragment and conjugate a large variety of nanostructures in a scalable and clean way. 
  • 1.6K
  • 19 Feb 2021
Topic Review
Anticancer Activities of Mushrooms
Approximately 270 species of mushrooms have been reported as potentially useful for human health. However, few mushrooms have been studied for bioactive compounds that can be helpful in treating various diseases. Like other natural regimens, the mushroom treatment appears safe, as could be expected from their long culinary and medicinal use.
  • 1.6K
  • 29 Mar 2022
Topic Review
History of Wildlife Tracking Technology
The history of wildlife tracking technology involves the evolution of technologies that have been used to monitor, track, and locate many different types of wildlife. Many individuals have an interest in tracking wildlife, including biologists, scientific researchers, and conservationists. Biotelemetry is "the instrumental technique for gaining and transmitting information from a living organism and its environment to a remote observer".
  • 1.6K
  • 10 Oct 2022
Topic Review
Bugang
Bugang is a Daoist ritual dance or walk, based upon the limping Yubu "Steps of Yu" tradition, in which a Taoist priest paces through a supernatural pattern, such as stars in the Big Dipper or numbers in the Loshu magic square. Texts from the (4th century) Shangqing School "revelations" contain the earliest descriptions of bugang, frequently with the practitioner pacing among constellations, especially the Big Dipper's stars. When religious Daoism began during the Six Dynasties period (220–589 CE), the expression bugang tadou 步罡踏斗 "pacing the guideline and treading on (the stars of) the Dipper" became popular.
  • 1.6K
  • 21 Oct 2022
Topic Review
Docking Analysis in Research for Novel Enzyme Inhibitors
Approaches for increasing effectiveness of docking analysis in Prediction of inhibitory potency of small molecules, emphasizing in selection of appropriate enzyme 3D-structure and in calculation of probability of binding factors, based on docking analysis to the target site and to the whole enzyme.
  • 1.6K
  • 22 Jan 2025
Topic Review
Mammalian Aquaporins
Mammalian aquaporins (AQPs) are transmembrane channels expressed in a large variety of cells and tissues throughout the body. They are known as water channels, but they also facilitate the transport of small solutes, gasses, and monovalent cations. To date, 13 different AQPs, encoded by the genes AQP0–AQP12, have been identified in mammals, which regulate various important biological functions in kidney, brain, lung, digestive system, eye, and skin. Consequently, dysfunction of AQPs is involved in a wide variety of disorders. AQPs are also present in the heart, even with a specific distribution pattern in cardiomyocytes, but whether their presence is essential for proper (electro)physiological cardiac function has not intensively been studied. In a recent review published in Int. J. Mol. Sci. (https://doi.org/10.3390/ijms20082039), we summarizes recent findings and highlights the involvement of AQPs in normal and pathological cardiac function. We conclude that AQPs are at least implicated in proper cardiac water homeostasis and energy balance as well as heart failure and arsenic cardiotoxicity. However, our review also demonstrates that many effects of cardiac AQPs, especially on excitation-contraction coupling processes, are virtually unexplored.
  • 1.6K
  • 06 Sep 2021
Topic Review
Encapsulation of Lipid-Soluble Bioactives
Lipid-soluble bioactives, such as vitamins A, E, D and K, carotenoids, polyunsaturated fatty acids (PUFA) and essential oils, are important nutrients in foods. However, their addition in food formulations, is often limited by limited solubility and high tendency for oxidation. Among the different encapsulation technologies, nanoemulsions are one of the most promising for protecting lipid-soluble bioactives.
  • 1.6K
  • 25 Oct 2020
Topic Review
Role of Neutrophils in Thrombosis
Neutrophils, the major innate immune cells, eliminate pathogens by phagocytosis or by releasing antimicrobial proteolytic enzymes present in their granules.
  • 1.6K
  • 19 Feb 2021
Topic Review
Creatine Supplementation
Creatine is a popular ergogenic aid among athletic populations with consistent evidence indicating that creatine supplementation also continues to be commonly used among adolescent populations. In addition, the evidence base supporting the therapeutic benefits of creatine supplementation for a plethora of clinical applications in both adults and children continues to grow. Among pediatric populations, a strong rationale exists for creatine to afford therapeutic benefits pertaining to multiple neuromuscular and metabolic disorders, with preliminary evidence for other subsets of clinical populations as well. Despite the strong evidence supporting the efficacy and safety of creatine supplementation among adult populations, less is known as to whether similar physiological benefits extend to children and adolescent populations, and in particular those adolescent populations who are regularly participating in high-intensity exercise training. While limited in scope, studies involving creatine supplementation and exercise performance in adolescent athletes generally report improvements in several ergogenic outcomes with limited evidence of ergolytic properties and consistent reports indicating no adverse events associated with supplementation.
  • 1.6K
  • 25 Apr 2021
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