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Topic Review
Fowler’s Syndrome
Fowler’s syndrome is characterized by a large bladder capacity, reduced sensation, increased maximal urethral closure pressure, and detrusor underactivity.
  • 1.7K
  • 22 Apr 2021
Topic Review
Stock Selection Criterion
Stock selection criteria or stock picking is a multi-method technique for investing when specifically dealing with stocks (equity markets). The stock investment or position can be "long" (bought) (to benefit from a stock price increase) or "short" (sold) (to benefit from a decrease in a stock's price), depending on the investor or financial professional's expectation of how the stock price is going to move. The stock selection criteria may include systematic stock picking methods that utilize computer software and/or data.
  • 1.7K
  • 18 Oct 2022
Topic Review
Tenascin-C-Derived Peptide, TNIIIA2
Matricellular proteins harbor functional sites within their molecular structures. These functional sites are released via proteolytic cleavage by inflammatory proteinases, and the peptides containing these hidden functional sites have unique biological activities that are often not detected in the parent molecules. A peptide containing the functional site of tenascin-C (TNC), termed TNIIIA2, which is highly released at sites of inflammation and in the tumor microenvironment, has the ability to potently and persistently activate β1-integrins. Based on these activities, TNIIIA2-containing TNC fragments/peptides are involved in the acquisition of aggressiveness in cancer progression.
  • 1.7K
  • 09 Nov 2020
Topic Review
Isotopic Imprints of Pyrite Leaching
Definition  Acid rock drainage (ARD) is one of the major environmental problems at active and closed coal and metalliferous mining sites. ARD forms naturally when sulfidic material comes in contact with atmospheric oxygen and the oxidation of sulfide minerals releases acid, sulfate and metal contaminants. The large-scale ARD that is generated within the mining area is called acid mine drainage (AMD).
  • 1.7K
  • 15 Dec 2020
Topic Review
Dentistry and Digital Revolution
Dentistry is a part of the field of medicine which is advocated in this digital revolution. The increasing trend in dentistry digitalization has led to the advancement in computer-derived data processing and manufacturing. This progress has been exponentially supported by the Internet of medical things (IoMT), big data and analytical algorithm, internet and communication technologies (ICT) including digital social media, augmented and virtual reality (AR and VR), and artificial intelligence (AI). The interplay between these sophisticated digital aspects has dramatically changed the healthcare and biomedical sectors, especially for dentistry.
  • 1.7K
  • 08 Mar 2021
Topic Review
Caffeine
Caffeine (1,3,7-trimethylxanthine) is an alkaloid widely used to improve exercise performance.
  • 1.7K
  • 19 Nov 2021
Topic Review
Nutrients for Eye-Related Diseases
The risk of macular degeneration can be reduced through the consumption of antioxidant-rich foods, supplements, and nutraceutical formulas. This study focuses on the antioxidants, vitamins, and minerals that have been reported for reducing the risk of macular degeneration and other eye-related diseases. Antioxidants including anthocyanins, carotenoids, flavonoids, and vitamins have been shown to reduce the risk of eye-related diseases. Anthocyanins extracted from berries are powerful antioxidants. Cyanidin, delphinidin, malvidin, pelargonidin, peonidin, and petunidin are anthocyanin aglycones detected in berries, currants, and other colored fruits and vegetables. β-Carotene, as well as xanthophyll lutein and zeaxanthin, have been reported to reduce the risk of macular degeneration. Flavonoids from plants help in the prevention of eye-related diseases through anti-inflammatory mechanisms. A combination of these antioxidants, vitamins, and minerals possess a synergistic effect on the prevention or risk reduction of macular degeneration. Formulas have been developed as dietary supplements to cater to the high demand from consumers and patients with eye problems. 
  • 1.7K
  • 15 Sep 2021
Topic Review
Endeavour House
Endeavour House is the Suffolk County Council headquarters located in Ipswich, Suffolk, England. Endeavour House was originally owned by the American-based energy and electric company, TXU Corporation. Located on Russell Road Ipswich, England ; Endeavour House was constructed between 2001 and 2003 by Bovis Lend Lease (now Lend Lease Project Management & Construction) contractors as well as M&S contractors and was designed by TTSP architects. The building had an original construction cost of £28 million (Suffolk County Council paid £16.75 million for the building) and is one of the most energy efficient office buildings in Europe.
  • 1.7K
  • 17 Oct 2022
Topic Review
Evolutionary Psychology of Religion
The evolutionary psychology of religion is the study of religious belief using evolutionary psychology principles. It is one approach to the psychology of religion. As with all other organs and organ functions, the brain's functional structure is argued to have a genetic basis, and is therefore subject to the effects of natural selection and evolution. Evolutionary psychologists seek to understand cognitive processes, religion in this case, by understanding the survival and reproductive functions they might serve.
  • 1.7K
  • 21 Nov 2022
Biography
Sarah Teichmann
Sarah Amalia Teichmann (born 1975)[1] FMedSci[2] is Head of Cellular Genetics at the Wellcome Sanger Institute[3] and a visiting research group leader at the European Bioinformatics Institute (EMBL-EBI).[4][5] She is also a Director of Research (equivalent to Professor)[6] in the Cavendish Laboratory,[7] at the University of Cambridge and a Senior Research Fellow at Churchill College, Cambridge.
  • 1.7K
  • 24 Nov 2022
Topic Review
Two-Dimensional Materials in Nonlinear Optical Devices
All-optical signal processing based on nonlinear optical devices is promising for ultrafast information processing in optical communication systems. Recent advances in two-dimensional (2D) layered materials with unique structures and distinctive properties have opened up new avenues for nonlinear optics and the fabrication of related devices with high performance. 
  • 1.7K
  • 13 Feb 2023
Topic Review
Carbon Dioxide Separation Technologies
Carbon dioxide (CO2) emissions from burning fossil fuels play a crucial role in global warming/climate change. The effective removal of CO2 from the point sources or atmosphere (CO2 capture), its conversion to value-added products (CO2 utilization), and long-term geological storage, or CO2 sequestration, has captured the attention of several researchers and policymakers. 
  • 1.7K
  • 15 Aug 2023
Topic Review
Biological Activities of Rhamnan Sulfate
Monostroma nitidum is a green single-cell layered algae that grows on the southwest coast of Japan. It is often used for salad ingredients, boiled tsukudani, soups, etc., due to its health benefits. M. nitidum is composed of many cell aggregates, and the various substances that fill the intercellular space are dietary fibers, vitamins, and minerals. Rhamnan sulfate (RS), a sulfated polysaccharide, is main the component of the fiber extracted from M. nitidum. Recently, some biological properties of RS have been demonstrated by in vitro and in vivo studies that probably protect human subjects from viruses and ameliorate vascular dysfunction caused by metabolic disorders, especially lifestyle-related diseases. 
  • 1.7K
  • 08 Apr 2022
Topic Review
The Low-Tech Perspective on Energy Flexibility
Energy flexibility, one of the key pillars of the energy transition, is an umbrella term that covers multiple innovative solutions implemented at all levels of the electric grid to ensure power quality standards, amongst other objectives. Low-tech, on the other hand, emphasizes designing, producing, and sustainably implementing solutions that address the core needs of individuals and organisations.  
  • 1.7K
  • 27 Apr 2023
Topic Review
Mechanisms of Neutrophil Extracellular Trap Formation and Regulation
As one of the most important components of the innate immune system, neutrophils are always at the forefront of the response to diseases. The immune functions of neutrophils include phagocytosis, degranulation, production of reactive oxygen species, and the production of neutrophil extracellular traps (NETs). NETs are composed of deconcentrated chromatin DNA, histones, myeloperoxidase (MPO) and neutrophil elastase (NE), playing an important role in the resistance to some pathogenic microbial invasions.
  • 1.7K
  • 25 Jun 2023
Topic Review
Deep Eutectic Systems as Alternative Solvents
Chemists in the medicinal chemistry field are constantly searching for alternatives towards more sustainable and eco-friendly processes for the design and synthesis of drug candidates. The pharmaceutical industry is one of the most polluting industries, having a high E-factor, which is driving the adoption of more sustainable processes not only for new drug candidates, but also in the production of well-established active pharmaceutical ingredients. Deep eutectic systems (DESs) have emerged as a greener alternative to ionic liquids, and their potential to substitute traditional organic solvents in drug discovery has raised interest among scientists. 
  • 1.7K
  • 28 Feb 2024
Topic Review
IL-10 in Neurodegenerative Diseases
IL-10, an immunosuppressive cytokine, is considered an important anti-inflammatory modulator of glial activation, preventing inflammation-mediated neuronal degeneration under pathological conditions. In this narrative review, we summarize recent insights about the role of IL-10 in the neurodegeneration associated with neuroinflammation, in diseases such as Multiple Sclerosis, Traumatic Brain Injury, Amyotrophic lateral sclerosis, Alzheimer's Disease, and Parkinson's Disease, focusing on the contribution of this cytokine not only in terms of protective action, but also as possibly responsible for clinical worsening. The knowledge of this double face of the same coin, regarding the biological role of the IL-10, could aid the development of targeted therapies useful for limiting neurodegenerative processes.
  • 1.7K
  • 17 Jul 2020
Topic Review
The Technology of Blockchain
Blockchain is a system of records created using cryptography to link and secure blocks (of records) and is stored on a peer-to-peer network that adheres to a “consensus protocol” which enables it to work without centralized management. It is a revolutionary technology that has immense potential to create a long-lasting impact. It is speculated to be a key technology that shall be part of the Industry 4.0 revolution.
  • 1.7K
  • 27 Oct 2020
Topic Review
Tissue Biopsy-Based MSI Testing
Colorectal cancer (CRC) is the third most commonly-diagnosed cancer in the world and ranked second for cancer-related mortality in humans. Microsatellite instability (MSI) is an indicator for Lynch syndrome (LS), an inherited cancer predisposition, and a prognostic marker which predicts the response to immunotherapy. A recent trend in immunotherapy has transformed cancer treatment to provide medical alternatives that have not existed before. It is believed that MSI-high (MSI-H) CRC patients would benefit from immunotherapy due to their increased immune infiltration and higher neo-antigenic loads. MSI testing such as immunohistochemistry (IHC) and PCR MSI assay has historically been a tissue-based procedure that involves the testing of adequate tissue with a high concentration of cancer cells, in addition to the requirement for paired normal tissues. The invasive nature and specific prerequisite of such tests might hinder its application when surgery is not an option or when the tissues are insufficient. The application of next-generation sequencing, which is highly sensitive, in combination with liquid biopsy, therefore, presents an interesting possibility worth exploring. This review aimed to discuss the current body of evidence supporting the potential of liquid biopsy as a tool for MSI testing in CRC.
  • 1.7K
  • 16 Nov 2021
Topic Review
Sulfur in Seeds
Sulfur is a growth-limiting and secondary macronutrient as well as an indispensable component for several cellular components of crop plants. 
  • 1.7K
  • 09 Feb 2022
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