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Topic Review
Sulfur in Seeds
Sulfur is a growth-limiting and secondary macronutrient as well as an indispensable component for several cellular components of crop plants. 
  • 1.7K
  • 09 Feb 2022
Topic Review
Eating Competence, Food Consumption and Health Outcomes
Eating Competence (EC) is one behavioral perspective of eating practices that has been associated with a healthy lifestyle. It emphasizes eating pleasure, self-regulation of eating, body weight satisfaction, and regular meal frequency that includes food variety without focusing on dietary guidelines. EC is composed of four components (Eating Attitude, Food Acceptance, Internal Regulation, and Contextual Skill), and its assessment is performed using the Eating Competence Satter Inventory (ecSI2.0™), developed and validated in English for an adult population. EC has been associated with diet quality and health indicators for various population groups and the development of skills that increase EC might be a strategy to improve nutritional health, and prevent obesity and other chronic diseases. 
  • 1.7K
  • 14 Apr 2022
Topic Review
Intracellular Lifestyle of Staphylococcus aureus
Staphylococcus aureus (S. aureus) is part of the normal skin and nasal microbiota, with approximately 30% of the healthy adult population colonized mainly in the nasopharyngeal cavity. While colonization is usually asymptomatic, a symptomatic infection can occur if there is a breach in the mucosal barrier or skin. The severity of symptomatic infections ranges from superficial skin and soft tissue infections, to devastating complications, such as necrotizing pneumonia, endocarditis, toxic shock syndrome, and sepsis. In the pre-antibiotic era, S. aureus bacteremia mortality rates were astonishingly high, ranging between 75% and 83%. Even though antibiotics have reduced this number significantly, S. aureus bloodstream infections still account for over 19,000 deaths annually in the United States. With every new antibiotic that is developed, S. aureus resistance has been quickly observed. MRSA strains that are resistant to all penicillin-like β-lactam antibiotics pose a particularly serious threat to the community. Two types of MRSA exist: hospital-acquired (HA-)MRSA and community-acquired (CA-)MRSA. CA-MRSA strains are typically regarded as more virulent and can cause infections in otherwise healthy individuals. This notion is further supported by experimental animal studies, whereas HA-MRSA strains are less virulent than CA-MRSA and cause fewer disseminating diseases. Although in animal models, mice are typically not treated with antibiotics, which is unlike a hospital setting.
  • 1.7K
  • 05 Sep 2022
Topic Review
Atmospheric Carbon Cycle
The atmosphere is one of the Earth's major carbon reservoirs and an important component of the global carbon cycle, holding approximately 720 gigatons of carbon. Atmospheric carbon plays an important role in the greenhouse effect. The most important carbon compound in this respect is the gas carbon dioxide (CO2). Although it is a small percentage of the atmosphere (approximately 0.04% on a molar basis), it plays a vital role in retaining heat in the atmosphere and thus in the greenhouse effect. Other gases with effects on the climate containing carbon in the atmosphere are methane and chlorofluorocarbons (the latter is entirely anthropogenic). Emissions by humans in the past 200 years have almost doubled the amount carbon dioxide in the atmosphere.
  • 1.7K
  • 17 Oct 2022
Topic Review
Clinical Presentations of Human Anthrax
Anthrax is one of the most important zoonotic diseases which primarily infects herbivores and occasionally humans. The etiological agent is Bacillus anthracis which is a Gram-positive, aerobic, spore-forming, nonmotile, rod-shaped bacillus. The spores are resistant to environmental conditions and remain viable for a long time in contaminated soil, which is the main reservoir for wild and domestic mammals. Infections still occur in low-income countries where they cause suffering and economic hardship. Humans are infected by contact with ill or dead animals, contaminated animal products, directly exposed to the spores in the environment or spores released as a consequence of a bioterrorist event. Three classical clinical forms of the disease, cutaneous, gastrointestinal and inhalation, are seen, all of which can potentially lead to sepsis or meningitis.
  • 1.7K
  • 20 Mar 2023
Topic Review
CXCL1 as Gene, Promoter and Regulation of Expression
CXCL1 is one of the most important chemokines, part of a group of chemotactic cytokines involved in the development of many inflammatory diseases. It activates CXCR2 and, at high levels, CXCR1. The expression of CXCL1 is elevated in inflammatory reactions and also has important functions in physiology, including the induction of angiogenesis and recruitment of neutrophils.
  • 1.7K
  • 15 Feb 2022
Topic Review
Control of Protein Synthesis by ERdj1, ERdj2, ERdj6
The endoplasmic reticulum (ER) of mammalian cells is the central organelle for the maturation and folding of transmembrane proteins and for proteins destined to be secreted into the extracellular space. The proper folding of target proteins is achieved and supervised by a complex endogenous chaperone machinery. BiP, a member of the Hsp70 protein family, is the central chaperone in the ER. The chaperoning activity of BiP is assisted by ER-resident DnaJ (ERdj) proteins due to their ability to stimulate the low, intrinsic ATPase activity of BiP. Besides their co-chaperoning activity, ERdj proteins also regulate and tightly control the translation, translocation, and degradation of proteins. Three ERdj co-chaperones, ERdj1, ERdj2, and ERdj6, are functionally involved in the control of translation and translocation of ER target proteins. 
  • 1.7K
  • 28 Jul 2022
Topic Review
Astronomy & Astrophysics
Astronomy & Astrophysics is a peer-reviewed scientific journal covering theoretical, observational, and instrumental astronomy and astrophysics. The journal is run by a Board of Directors representing 27 sponsoring countries plus a representative of the European Southern Observatory. The main editors of A&A are the editor-in-chief,  Thierry Forveille (fr); the Letters editor-in-chief, João Alves; and the managing editor David Elbaz. The journal is published by EDP Sciences in 12 issues per year. With an impact factor of 5.802 (2020), A&A is one of the most important academic journals in its field. Several sections of the journal are available in Open Access, and the latest issue is also available for free online reading on the journal website.
  • 1.7K
  • 09 Nov 2022
Topic Review
Vitamin K
Vitamin K has been recognized as a key factor for the synthesis of blood clotting factors in the liver, and is currently known to be involved in a wide range of biological processes and is associated with many pathological conditions.The most well-known function of vitamin K is as a cofactor for the γ-glutamyl carboxylase (GGCX) enzyme responsible for the post-translational modification of vitamin K-dependent proteins (VKDPs) through the conversion of specific glutamic acid (Glu) into calcium binding γ-carboxyglutamic acid (Gla) residues. Vitamin K deficiency has been linked to several pathological conditions such as cardiovascular diseases (CVD), chronic kidney disease (CKD), osteoarthritis (OA) , rheumatoid arthritis (RA), osteoporosis, cancer, dementia, certain skin pathologies, functional decline, and disability.  A new concept on the involvement of vitamin K in inflammation is growing. In fact, novel roles have been disclosed for vitamin K independent of its activity as a cofactor for GGCX, such as an antioxidant, anti-inflammatory, promoter of cognition, inhibition of tumor progression, and transcriptional regulator of osteoblastic genes. A growing number of studies has raised an increasing interest on the use of vitamin K as a health promoting supplement.  Aging societies represent a major economic challenge for health care systems, and diet supplements promoting healthy aging and improving the prognosis of age-related diseases, are required to be implemented in clinical practice.This work thoroughly reviews available data regarding differences between vitamin K1 and K2, contextualized with clinical aspects of vitamin K deficiency, including their sources, functions, target activity, and involvement in age-related diseases. Processes for the chemical and biological production of vitamin K1 and K2 will be briefly addressed. Additionally, novel sources with potential biotechnological application, and new formulations to improve vitamin K absorption and bioavailability are presented.
  • 1.7K
  • 30 Oct 2020
Topic Review
Non-celiac Gluten Sensitivity
Gluten is a protein contained in wheat, barley and rye and will be found in a variety of everyday food items. It allows doughs to be more elastic and pliable, this is why gluten-containing grains have been used in breads and other baked goods for many years. It can be difficult to actually know if you have intolerance to gluten as there may be little to no symptoms.  The study aims to discover if there are any correlations between gastric distress and severity of distress post gluten consumption and the variants in rs2305764 (MYO9B). The gene MYO9B encodes a member of the myosin family of actin-based molecular motor heavy chain proteins, polymorphisms in the genes are associated with celiac disease, ulcerative colitis and general autoimmunity. 89 female (24-43y/o) with no diagnosis of celiac disease were tested under a custom Illumina array in conjunction with Muhdo Health Ltd, this array analyses 1000 SNPs, one of which is rs2305764 that was read in the forward/forward orientation. Of these 21 had CC, 28 had CT and 40 had TT, there were no “no calls”.  The results show that 9.5% of those with CC (n=21) had some form of gastric distress post gluten intake, 32.1% of those with CT (n=28) had some form of gastric distress post gluten intake and 57.4% of those with TT (n=40) had some form of gastric distress post gluten intake. The average for all participants was 38.2%. On gastric distress the average score for the CC group was 2.5 (mild – somewhat uncomfortable), the average score for the CT group was 2.7 (mild – somewhat uncomfortable) and for the TT group was 5.2 (discomfort, some pain and distress).
  • 1.7K
  • 05 Nov 2020
Topic Review
Facial Expression Recognition
Facial expression recognition (FER) is a challenging problem in the fields of pattern recognition and computer vision. The recent success of convolutional neural networks (CNNs) in object detection and object segmentation tasks has shown promise in building an automatic deep CNN-based FER model. However, in real-world scenarios, performance degrades dramatically owing to the great diversity of factors unrelated to facial expressions, and due to a lack of training data plus an intrinsic imbalance in the existing facial emotion datasets. To tackle these problems, this paper not only applies deep transfer learning techniques but also proposes a novel loss function called weighted-cluster loss, which is used during the fine-tuning phase. Specifically, the weighted-cluster loss function simultaneously improves the intra-class compactness and the inter-class separability by learning a class center for each emotion class. It also takes the imbalance in a facial expression dataset into account by giving each emotion class a weight based on its proportion of the total number of images. In addition, a recent, successful deep CNN architecture, pre-trained in the task of face identification with the VGGFace2 database from the Visual Geometry Group at Oxford University, is employed and fine-tuned using the proposed loss function to recognize eight basic facial emotions from the AffectNet database of facial expression, valence, and arousal computing in the wild. Experiments on an AffectNet real-world facial dataset demonstrate that our method outperforms the baseline CNN models that use either weighted-softmax loss or center loss.
  • 1.7K
  • 09 Feb 2021
Topic Review
Hypertension
Hypertension is abnormally high blood pressure in the arteries, which are the blood vessels that carry blood from the heart to the rest of the body. As the heart beats, it forces blood through the arteries to deliver nutrients and oxygen to the rest of the body. The strength of the blood pushing against the artery walls is blood pressure, which is measured in units called millimeters of mercury (mmHg). The top number in a blood pressure reading is the pressure when the heart pumps (systolic blood pressure), and the bottom number is the pressure between heart beats (diastolic blood pressure). In adults, a normal blood pressure measurement is about 120/80 mmHg. Blood pressure is considered high when the measurement is 130/80 mmHg or greater.
  • 1.7K
  • 16 Jan 2022
Topic Review
Gap-Fillers for Outdoor Wooden Artefacts
Conservation of wooden artefacts that are exposed outdoors, mainly in open-air museums, is a very complex and difficult issue that aims to preserve both the integrity and aesthetics of valuable objects. Unceasingly subjected to several factors, such as alternating weather conditions and the activities of microorganisms, algae, and insects, they undergo continuous changes and inevitable deterioration. Their biological and physical degradation often results in the formation of gaps and cracks in the wooden tissue, which creates a need not only for wood consolidation, but also for using specialist materials to fill the holes and prevent further degradation of an object. A variety of substances, both organic and inorganic, have been used for conservation and gap filling in historic wooden objects. The filling compounds typically consist of two components, of which one is a filler, and the second a binder.
  • 1.7K
  • 25 May 2021
Topic Review
Indole Derivatives as Anti-Lung Cancer Agents
Indole scaffold is considered one of the most privileged scaffolds in heterocyclic chemistry. Indole may serve as an effective probe for the development of new drug candidates against challenging diseases, including lung cancer. 
  • 1.7K
  • 12 Nov 2021
Topic Review
Biomineralization Forming Process
Biomineralization is a process in which organic matter and inorganic matter combine with each other under the regulation of living organisms. 
  • 1.7K
  • 23 Nov 2021
Topic Review
Penicillium digitatum
Penicillium digitatum is a widespread pathogen responsible for the postharvest decay of citrus, one of the most economically important crops worldwide. Currently, chemical fungicides are still the main strategy to control the green mould disease caused by the fungus. In this scenario, understanding the molecular determinants underlying P. digitatum’s response to biological and chemical antifungals may help in the development of safer and more effective non-chemical control methods.
  • 1.7K
  • 20 Mar 2022
Topic Review
Pulsed Laser Ablation in Liquid for Gold Nanoparticle
The unique physiochemical properties and biocompatibility of gold nanoparticles have developed a breakthrough in molecular imaging, which allows exploration of gold nanoparticles in drug delivery for diagnostic purpose.  The pulsed laser ablation in liquid (PLAL) technique is a versatile synthetic and convincing technique due to its high efficiency, eco-friendly and facile method to produce gold nanoparticle.
  • 1.7K
  • 16 May 2022
Topic Review
Deep Learning for Image Annotation in Agriculture
The implementation of intelligent technology in agriculture is seriously investigated as a way to increase agriculture production while reducing the amount of human labor. In agriculture, recent technology has seen image annotation utilizing deep learning techniques. Due to the rapid development of image data, image annotation has gained a lot of attention. The use of deep learning in image annotation can extract features from images and has been shown to analyze enormous amounts of data successfully. Deep learning is a type of machine learning method inspired by the structure of the human brain and based on artificial neural network concepts. Through training phases that can label a massive amount of data and connect them up with their corresponding characteristics, deep learning can conclude unlabeled data in image processing. For complicated and ambiguous situations, deep learning technology provides accurate predictions. This technology strives to improve productivity, quality and economy and minimize deficiency rates in the agriculture industry.
  • 1.7K
  • 27 Jul 2022
Topic Review
Monitoring of Humans in Bed
Indeed, humans typically spend a significant portion of their daily lives in bed. This time becomes even longer in cases where the human is unwell. This is particularly the case for sick or older people, who spend even more time in bed. Their physical activity or inactivity patterns provide useful signatures that reflect the “state” of the person under observation. In the frame of activity monitoring endeavors, behavioral situations that are abnormal (these situations are more/extremely rare within the observation time window) are the ones that are of the highest interest when compared to behavioral situations that are rather normal (these ones occupy most of the observation time window).
  • 1.7K
  • 24 Aug 2022
Topic Review
Migrants during the COVID-19 Pandemic Lockdown in France
The coronavirus disease 2019 (COVID-19) pandemic led to governments in 157 countries introducing lockdowns or re-strictions to people’s movement and access to health and welfare support services as well as other rules including social distancing, use of masks, and quarantine. The French government introduced its first mandatory national lockdown on 17 March 2020 due to elevated cases and death rates of COVID-19 in the country. This public health measure required the general population to stay at home except those carrying out an essential job (referred to as a ‘key worker’ in the domains of transportation, education, food, and health), to buy necessary items, or to engage in physical activity. Evidence demonstrates that the pandemic disproportionately affected socially vulnerable populations, including migrants. The pandemic exposed and exacerbated health and social inequities among migrant and ethnic/racial groups. Less is known about the firsthand impact of the COVID-19 lockdowns, specifically on migrant populations in France.
  • 1.7K
  • 31 Oct 2022
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