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Topic Review
Arginine Metabolism and Cancer
Arginine availability and activation of arginine-related pathways at cancer sites have profound effects on the tumor microenvironment, far beyond their well-known role in the hepatic urea cycle. Arginine metabolism impacts not only malignant cells but also the surrounding immune cells behavior, modulating growth, survival, and immunosurveillance mechanisms, either through an arginase-mediated effect on polyamines and proline synthesis, or by the arginine/nitric oxide pathway in tumor cells, antitumor T-cells, myeloid-derived suppressor cells, and macrophages. 
  • 1.8K
  • 24 Dec 2021
Topic Review
Overview of Colicins and Microcins
The family Enterobacteriaceae is a large, heterogeneous group of Gram-negative bacteria, which includes strains that naturally inhabit the gastrointestinal tract (GIT) of animals and humans. Being considered normal commensal members of the GIT microbiota, these microbes can also live and multiply in food environments. Additionally, Enterobacteriaceae are acknowledged as indicators of food production hygiene, preservation, and storage, often being used as indicators of food quality and safety. Additionally, Salmonella spp., Yersinia enterocolitica, pathogenic Escherichia coli, including Escherichia coli O157:H7, and Shigella spp., among others, are important foodborne pathogens. Moreover, some members of this group, namely Citrobacter, Enterobacter, Erwinia, Klebsiella, Kluyvera, Pantoea, and Serratia, have been described both as harboring plant growth-promoting characteristics and attaining pathogenicity potential.
  • 1.8K
  • 17 Oct 2022
Topic Review
Environmental Audio Extensions
The Environmental Audio Extensions (or EAX) are a number of digital signal processing presets for audio, present in Creative Technology Sound Blaster sound cards starting with the Sound Blaster Live and the Creative NOMAD/Creative ZEN product lines. Due to the release of Windows Vista in 2007, which deprecated the DirectSound3D API that EAX was based on, Creative discouraged EAX implementation in favour of its OpenAL-based EFX equivalent – though at that point relatively few games used the API.
  • 1.8K
  • 11 Nov 2022
Topic Review
Switchgear
In an electric power system, switchgear is the combination of electrical disconnect switches, fuses or circuit breakers used to control, protect and isolate electrical equipment. Switchgear is used both to de-energize equipment to allow work to be done and to clear faults downstream. This type of equipment is directly linked to the reliability of the electricity supply. The earliest central power stations used simple open knife switches, mounted on insulating panels of marble or asbestos. Power levels and voltages rapidly escalated, making opening manually operated switches too dangerous for anything other than isolation of a de-energized circuit. Oil-filled equipment allowed arc energy to be contained and safely controlled. By the early 20th century, a switchgear line-up would be a metal-enclosed structure with electrically operated switching elements, using oil circuit breakers. Today, oil-filled equipment has largely been replaced by air-blast, vacuum, or SF6 equipment, allowing large currents and power levels to be safely controlled by automatic equipment. High-voltage switchgear was invented at the end of the 19th century for operating motors and other electric machines. The technology has been improved over time and can now be used with voltages up to 1,100 kV. Typically, switchgear in substations are located on both the high- and low-voltage sides of large power transformers. The switchgear on the low-voltage side of the transformers may be located in a building, with medium-voltage circuit breakers for distribution circuits, along with metering, control, and protection equipment. For industrial applications, a transformer and switchgear line-up may be combined in one housing, called a unitized substation (USS).
  • 1.8K
  • 21 Nov 2022
Topic Review
Levellers
The Levellers were a political movement during the English Civil War (1642–1651) committed to popular sovereignty, extended suffrage, equality before the law and religious tolerance. The hallmark of Leveller thought was its populism, as shown by its emphasis on equal natural rights, and their practice of reaching the public through pamphlets, petitions and vocal appeals to the crowd. The Levellers came to prominence at the end of the First English Civil War (1642–46) and were most influential before the start of the Second Civil War (1648–49). Leveller views and support were found in the populace of the City of London and in some regiments in the New Model Army. Their ideas were presented in their manifesto "Agreement of the People". In contrast to the Diggers, the Levellers opposed common ownership, except in cases of mutual agreement of the property owners. The Levellers were not a political party in the modern sense of the term. They were organised at the national level, with offices in a number of London inns and taverns such as The Rosemary Branch in Islington, which got its name from the sprigs of rosemary that Levellers wore in their hats as a sign of identification. From July 1648 to September 1649, they published a newspaper, The Moderate, and were pioneers in the use of petitions and pamphleteering to political ends. They identified themselves by sea-green ribbons worn on their clothing. After Pride's Purge and the execution of Charles I, power lay in the hands of the Grandees in the Army (and to a lesser extent with the Rump Parliament). The Levellers, along with all other opposition groups, were marginalised by those in power and their influence waned. By 1650, they were no longer a serious threat to the established order.
  • 1.8K
  • 25 Nov 2022
Topic Review
Protein-Based Targeting Self-Assembling Nanoparticles for Biomedical Applications
Targeted nanoparticles of different origins are considered as new-generation diagnostic and therapeutic tools. Targeted protein self-assembling nanoparticles circumvent this problem since proteins are encoded in DNA and the final protein product is produced in only one possible way. The combination of the endless biomedical potential of protein carriers as nanoparticles and the standardized protein purification protocols will make significant progress in “magic bullet” creation possible, bringing modern biomedicine to a new level. The entry focused on the currently existing platforms for targeted self-assembling protein nanoparticles based on transferrin, lactoferrin, casein, lumazine synthase, albumin, ferritin, and encapsulin proteins, as well as on proteins from magnetosomes and virus-like particles. The applications of these self-assembling proteins for targeted delivery in vitro and in vivo are thoroughly discussed, including bioimaging applications and different therapeutic approaches, such as chemotherapy, gene delivery, and photodynamic and photothermal therapy. 
  • 1.8K
  • 08 Mar 2023
Topic Review
Alopecia Associated with Antiseizure Medication
The mainstay of treatment for epilepsy is antiseizure medications (ASMs). Approximately 70% of individuals with epilepsy obtain seizure freedom with adequate ASMs therapy. Adverse effects of antiseizure medications (ASMs) remain one of the major causes of non-adherence. Cosmetic side effects (CSEs) are among the most commonly reported side effects of ASMs. Alopecia is one of the CSEs that has a high intolerance rate leading to poor therapeutical compliance. 
  • 1.8K
  • 04 Sep 2023
Topic Review
Underwater Cultural Heritage
Underwater cultural heritage (UCH) means "all traces of human existence having a cultural, historical or archaeological character which have been partially or totally under water, periodically or continuously, for at least 100 years such as (i) sites, structures, buildings, artifacts and human remains, together with their archaeological and natural context; (ii) vessels, aircraft, other vehicles or any part thereof, their cargo or other contents, together with their archaeological and natural context; and (iii) objects of prehistoric character".
  • 1.8K
  • 19 Dec 2023
Topic Review Peer Reviewed
Academic Freedom in US Higher Education: Rights Emergent from the Law and the Profession
The various definitions of academic freedom in the United States reflect the influence of social and political norms in its interpretation as both a professional and legal right. Yet, underlying these interpretations is the operational understanding, which includes both legal and professional considerations, that academic freedom is a widely recognized principle that grants professors the autonomy and authority to explore intellectual questions within their academic disciplines, conduct professional work, and express their views in the public sphere without undue interference or suppression. In other words, academic freedom is a foundational principle rooted in legal and institutional frameworks that safeguards professors’ ability to engage in intellectual inquiry, professional practice, and public discourse without undue interference. This principle extends beyond mere professional courtesy. It is recognized as essential to the functioning of higher education institutions and the broader democratic exchange of ideas. The public (including policymakers, industry leaders, media, and students) generally acknowledges academic freedom as an inherent protection that protects from unjustified interferences. By doing so, professors can participate in governance, disciplinary leadership, and extramural activities without the fear of retaliation or coercion. By insulating academic work from ideological, political, or economic constraints, academic freedom maintains the legitimacy and independence of scholarly inquiry in service to both knowledge advancement and the public good.
  • 1.8K
  • 20 May 2025
Topic Review
Antimicrobial Activity of Curcumin
Curcumin (CUR) is a natural substance extracted from turmeric that has antimicrobial properties. Due to its ability to absorb light in the blue spectrum, CUR is also used as a photosensitizer (PS) in antimicrobial Photodynamic Therapy (aPDT). 
  • 1.8K
  • 23 Jul 2021
Topic Review
Cold Stress in Arabidopsis and Rice
Cold stress, including freezing stress and chilling stress, is one of the major environmental factors that limit the growth and productivity of plants. As a temperate dicot model plant species, Arabidopsis develops a capability to freezing tolerance through cold acclimation. The past decades have witnessed a deep understanding of mechanisms underlying cold stress signal perception, transduction, and freezing tolerance in Arabidopsis. In contrast, a monocot cereal model plant species derived from tropical and subtropical origins, rice, is very sensitive to chilling stress and has evolved a different mechanism for chilling stress signaling and response.
  • 1.8K
  • 03 Nov 2021
Topic Review
Agroforestry
Agroforestry is recognized as a sustainable land use practice that creates more integrated, diverse, productive, profitable, healthy, sustainable land-use systems. However, the uptake of such a promising land use practice is slow. Through this research, carried out in a Terai district of Nepal, we thoroughly examine what influences farmers’ choice of agroforestry adoption and what discourages the adoption. For this, a total of 288 households were surveyed using a structured questionnaire. Two agroforestry practices were compared with conventional agriculture with the help of the Multinomial Logistic Regression (MNL) model. The likelihood of adoption was found to be influenced by gender: the male-headed households were more likely to adopt the tree-based farming practice. Having a source of off-farm income was positively associated with the adoption decision of farmers. Area of farmland was found as the major constraint to agroforestry adoption for smallholder farmers. Some other variables that affected positively included livestock herd size, provision of extension service, home-to-forest distance, farmers’ group membership and awareness of farmers about environmental benefits of agroforestry. Irrigation was another adoption constraint that the study area farmers were faced with. The households with a means of transport and with a larger family (household) size were found to be reluctant regarding agroforestry adoption. A collective farming practice could be a strategy to engage the smallholder farmers in agroforestry.
  • 1.8K
  • 16 Jan 2022
Topic Review
WNT Signaling
The WNT signaling pathway is an evolutionarily conserved signal transduction pathway that regulates a wide range of cellular functions during development and adulthood. It controls multiple aspects of development, including cell proliferation, cell fate determination, apoptosis, cell migration and cell polarity during development and stem cell maintenance in adults. Inappropriate activation of the WNT pathway is also a major factor in human oncogenesis.
  • 1.8K
  • 11 Mar 2022
Topic Review
Duration Approaches of Prosody
Prosody is a complex aspect of communicative speech act that requires the successful integration of multiple acoustic parameters, such as fundamental frequency (F0), duration and intensity, whose perceptual correlates are pitch, timing and loudness, respectively, all of which contribute to the perception of the suprasegmental structure of sentences. 
  • 1.8K
  • 12 May 2022
Topic Review
NRF2-Activating Compounds Bearing α,β-Unsaturated Moiety
The surge of scientific interest in the discovery of Nuclear Factor Erythroid 2 (NFE2)-Related Factor 2 (NRF2)-activating molecules underscores the importance of NRF2 as a therapeutic target especially for oxidative stress. The chemical reactivity and biological activities of several bioactive compounds have been linked to the presence of α,β-unsaturated structural systems. The α,β-unsaturated carbonyl, sulfonyl and sulfinyl functional groups are reportedly the major α,β-unsaturated moieties involved in the activation of the NRF2 signaling pathway. The carbonyl, sulfonyl and sulfinyl groups are generally electron-withdrawing groups, and the presence of the α,β-unsaturated structure qualifies them as suitable electrophiles for Michael addition reaction with nucleophilic thiols of cysteine residues within the proximal negative regulator of NRF2, Kelch-like ECH-associated protein 1 (KEAP1). The physicochemical property such as good lipophilicity of these moieties is also an advantage because it ensures solubility and membrane permeability required for the activation of the cytosolic NRF2/KEAP1 system.
  • 1.8K
  • 02 Sep 2022
Topic Review
Deep Underground Neutrino Experiment
The Deep Underground Neutrino Experiment (DUNE) is a neutrino experiment under construction, with a near detector at Fermilab and a far detector at the Sanford Underground Research Facility that will observe neutrinos produced at Fermilab. An intense beam of trillions of neutrinos from the production facility at Fermilab (in Illinois) will be sent over a distance of 1,300 kilometers (810 mi) with the goal of understanding the role of neutrinos in the universe. More than 1,000 collaborators work on the project. The experiment is designed for a 20-year period of data collection. The primary science objectives of DUNE are The science goals are so compelling that the 2014 Particle Physics Project Prioritization Panel (P5) ranked this as "the highest priority project in its timeframe" (recommendation 13).[10] The importance of these goals has led to proposals for competing projects in other countries, particularly the Hyper-Kamiokande experiment in Japan, scheduled to begin data-taking in 2027. The DUNE project, overseen by Fermilab, has suffered delays to its schedule and growth of cost from less than $2B to $3B, leading to articles in the journals Science and Scientific American described the project as "troubled."[11][12] As of 2022, the DUNE experiment has a neutrino-beam start-date in the early-2030's, and the project is now phased.[11][12]
  • 1.8K
  • 02 Oct 2022
Topic Review
Coral Gardens Incident
The Coral Gardens incident, also known as the Coral Gardens atrocities, the Coral Gardens massacre, the Coral Gardens riot, and Bad Friday refers to a series of events that occurred in Jamaica from April 11-13 1963. Following a violent altercation at a gas station in Montego Bay, Jamaican police and military forces detained Rastafarians throughout Jamaica, killing and torturing many. Exact numbers are not available, but estimates place the number of detained individuals "as high as 150". In April 2017, following a legal investigation, the government of Jamaica issued an official apology condemning the government's actions in the incident, and established a trust fund for survivors as reparations.
  • 1.8K
  • 27 Oct 2022
Topic Review
Whisking in Animals
Whisking is a behaviour in which the facial whiskers (vibrissae) of an animal are repetitively and rapidly swept back and forth. This behaviour occurs particularly during locomotion and exploration. The whisking movements occur in bouts of variable duration, and at rates between 3 and 25 whisks/second. Movements of the whiskers are closely co-ordinated with those of the head and body, allowing the animal to locate interesting stimuli through whisker contact, then investigate them further using both the macrovibrissae and an array of shorter, non-actuated microvibrissae on the chin and lips. Whisking has been reported in a wide range of mammals, including two species of marsupial. Whisking contributes both to exploratory movements, which function to acquire sensory inputs, and to palpation movements, which are used in the discrimination of objects and in the control of spatial navigation.
  • 1.8K
  • 03 Nov 2022
Topic Review
Modern Pascal
Modern Pascal (sometimes stylized as ModernPascal) is a closed source, cross-platform, interpreter, compiler, and runtime system (environment) for command line, server-side and networking applications. Modern Pascal applications are written in Pascal and Object Pascal, and can be run within the Modern Pascal runtime on the operating systems Microsoft Windows, Linux, macOS, FreeBSD, Solaris and DOS/32. Its work is hosted and supported by the 3F, LLC and partner MP Solutions, LLC. Modern Pascal provides a blocking I/O application programming interface (API) technology commonly used for operating system applications. Modern Pascal CodeRunner contains a built-in library to allow applications to act as a Web server without software such as Apache HTTP Server or Internet Information Services (IIS).
  • 1.8K
  • 04 Nov 2022
Topic Review
Invasive Alien Plant Species in European Paper Production
Invasive plant species can impede the establishment and growth of native plants and affect several ecosystem properties. These properties include soil cover, nutrient cycling, fire regimes, and hydrology. Controlling invasive plants is therefore a necessary, but usually expensive, step in restoring an ecosystem. The sustainability of materials with an emphasis on the use of local resources plays an important role in the circular economy. The use of alternative fibers from invasive plants promotes local production in smaller paper mills that offer the protection of local species and the reduction of waste and invasive plants.
  • 1.8K
  • 10 Nov 2022
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