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Topic Review
Extracellular Vesicles Mediated Regulation
Small noncoding RNAs (sRNA) appear to play a key role in extracellular vesicle (EV)-mediated information transfer. Within the vesicular envelope, RNAs are well protected from degradation and can be shuttled between individuals from one and the same species and beyond. Various communication routes have been discovered such as mother-infant-interaction via breast milk, diverse host-pathogen-relations, and dietary uptake of food derived EVs, proving that EV-mediated inter-kingdom regulation is more than a random event.
  • 1.8K
  • 23 Oct 2020
Topic Review
Endocrine Disrupting Chemicals
Endocrine-disrupting chemicals (EDCs) are exogenous substances able to mimic or to interfere with the endocrine system, thus altering key biological processes such as organ development, reproduction, immunity, metabolism and behavior. High concentrations of EDCs are found in several everyday products including plastic bottles and food containers and they could be easily absorbed by dietary intake. In recent years, considerable interest has been raised regarding the biological effects of EDCs, particularly Bisphenol A (BPA) and phthalates, on human pregnancy and fetal development. Several evidence obtained on in vitro and animal models as well as by epidemiologic and population studies strongly indicated that endocrine disruptors could negatively impact fetal and placental health by interfering with the embryonic developing epigenome, thus establishing disease paths into adulthood. Moreover, EDCs could cause and/or contribute to the onset of severe gestational conditions as Preeclampsia (PE), Fetal Growth Restriction (FGR) and gestational diabetes in pregnancy, as well as obesity, diabetes and cardiovascular complications in reproductive age. Therefore, despite contrasting data being present in the literature, endocrine disruptors must be considered as a therapeutic target. Future actions aimed at reducing or eliminating EDC exposure during the perinatal period are mandatory to guarantee pregnancy success and preserve fetal and adult health.
  • 1.8K
  • 27 Oct 2020
Topic Review
Quiescent Cancer Cells
Quiescent cancer cells (QCCs) are cancer cells that are reversibly suspended in G0 phase with the ability to re-enter the cell cycle and initiate tumor growth, and, ultimately, cancer recurrence and metastasis.
  • 1.8K
  • 23 Mar 2021
Topic Review
Iron Ore Reduction with Hydrogen
The steel industry represents about 7% of the world’s anthropogenic CO2 emissions due to the high use of fossil fuels. The CO2-lean direct reduction of iron ore with hydrogen is considered to offer a high potential to reduce CO2 emissions, and this direct reduction of Fe2O3 powder is investigated in this research.
  • 1.8K
  • 18 Sep 2021
Topic Review
Thermal Analysis to 3D Printing
Thermal analysis (TA) comprises various measuring techniques with a common feature: the measure of the material response when heated or cooled (or, in some cases, held isothermally).
  • 1.8K
  • 29 Mar 2022
Topic Review
Parallel K-Means Algorithms in Java
K-means is a well-known clustering algorithm often used for its simplicity and potential efficiency. K-means, though, suffers from computational problems when dealing with large datasets with many dimensions and great number of clusters. 
  • 1.8K
  • 21 Apr 2022
Topic Review
Pharmacological Potential of Spatholobus suberectus Dunn on Cancer
Spatholobus suberectus Dunn (SSD, Leguminosae) is a perennial woody vine, indigenous to tropical and subtropical forests in China and other Southeast Asian countries. The vine stem of SSD is called “Jixueteng” (literally means ‘chicken blood vines’) in Chinese, due to the blood-like outflow from its vine stem when it is injured. SSD has been extensively employed in Traditional Chinese Medicine to treat several ailments. SSD and its active compounds are effective therapeutic agents for treating a variety of diseases with negligible side effects. SSD has been frequently attributed to having antioxidant, anti-diabetic, anti-inflammatory, hematopoietic, neuroprotective, antimicrobial, and anticancer properties. 
  • 1.8K
  • 27 Sep 2022
Topic Review
Agricultural Drainage
Practicing agricultural drainage strategies is necessary to manage excess water in poorly drained irrigated farmlands to protect them from induced waterlogging and salinity problems. 
  • 1.8K
  • 16 Jan 2023
Topic Review
Gamma-Sarcoglycanopathy
Limb-girdle muscular dystrophies (LGMDs) represent a group of muscle diseases due to monogenic mutations encoding muscle proteins that are defective for heterozygous and homozygous mutations prevalent in certain regions.
  • 1.8K
  • 20 Apr 2023
Topic Review
Geopolymer Composites Designed for Water and Wastewater Treatment
Since the discovery of geopolymers four decades ago, they have come quite a long way successfully and gained attention, mostly due to the effortlessness for geo-synthesis with lesser emission of greenhouse gases (GHG). Their admirable properties, such as toughness, heat and fire resistance, refractory nature and radiation hardness, altogether make them promising for applications for radioactive waste containment, as well as for pozzolanic action, making them multi-functional. In realism, lots of industrial materials are derived using geopolymers. For example, fiber-based geopolymer composites are regarded as fire-resistant. Quite a lot of geopolymeric composites are positioned in metal tool coatings and the construction of cabinets of airplanes and buildings, with a view to trim down the intensity of inferno incidents. The polymeric chain-like structure of geopolymers contributes higher chemical resistance, lower shrinkage and enhanced resistance to abrasion with high early mechanical strength. This entry describes that applications and interaction of geopolymer.
  • 1.8K
  • 30 Dec 2021
Topic Review
Nanoemulsions
Nanoemulsions (NEs) are lipophilic systems with nanoscale globules that can be absorbed e.g. through the nasal mucosa, and are therefore being explored for nose-to-brain delivery of drugs. These can be either oil-in-water (o/w) or water-in-oil (w/o) emulsions. Especially, o/w NEs are a promising option for the encapsulation of lipophilic drugs, protecting them from enzymatic degradation, increasing their solubility in liquid media, modulating their drug release, and improving their bioavailability.
  • 1.8K
  • 04 Jan 2021
Topic Review
Water-Soluble Organic Matter
Inspired by studies on outdoor organic aerosols (OA), recent studies discusses and prioritizes issues related to indoor water-soluble OA and their effects on human health, providing a basis for future research in the field. The following three main topics are addressed: (1) what is known about the origin, mass contribution, and health effects of water-soluble organic matter (WSOM) in outdoor air particles; (2) the current state-of-the-art on the WSOM in indoor air particles, the main challenges and opportunities for its chemical characterization and cytotoxicity evaluation; and (3) why the aerosol WSOM should be considered in future indoor air quality studies.
  • 1.8K
  • 08 Nov 2021
Topic Review
NLRP3 Inflammasome and Skeletal Muscle
Nucleotide-binding oligomerization domain (NOD-), leucine-rich repeat (LRR-) and pyrin domain-containing protein 3 (NLRP3) is a protein coded by the Nlrp3 (CIAS1) gene and is composed of an amino-terminal pyrin domain (PYD), a central nucleotide-binding domain (NACHT), and a C-terminal leucine rich repeat (LRR) motif. To date, NLRP3 has been extensively studied in the heart, where its effects and actions have been broadly documented in numerous cardiovascular diseases. 
  • 1.8K
  • 30 Nov 2021
Topic Review
Climate Change on Smallholder Irrigation Schemes in Zimbabwe
Smallholder irrigation schemes (SISs) have been portrayed as a panacea to climate change adaptation. However, there is an emerging discourse that established schemes are becoming vulnerable to increased climate variability and change, particularly increased water stress. The change in climate experienced world-wide already has negative implications for 21st-century agriculture in Zimbabwe. There is mounting evidence that large investments have been made in Zimbabwe’s SISs in an attempt to depart from rain-fed agriculture through judicious harnessing of available water resources. However, there is rising concern about the need to build the resilience of these schemes to protect investments in light of a more variable climate. 
  • 1.8K
  • 01 Jun 2022
Topic Review
Metabolic Reprogramming in Cancer
Reprogramming is a process mediated by multiple factors, including oncogenes, growth factors, hypoxia-induced factors, and the loss of suppressor gene function, which support malignant transformation and tumor development in addition to cell heterogeneity. Consequently, this hallmark promotes resistance to conventional anti-tumor therapies by adapting to the drastic changes in the nutrient microenvironment that these therapies entail. Therefore, it represents a revolutionary landscape during cancer progression that could be useful for developing new and improved therapeutic strategies targeting alterations in cancer cell metabolism, such as the deregulated mTOR and PI3K pathways.
  • 1.8K
  • 27 Jun 2022
Topic Review
Mathematics Models in Reverse Osmosis Evaluation Processes
An effective alternative for water purification is reverse osmosis (RO). Laboratory-scale RO modeling is widely applied worldwide, and allows the evaluation of the behavior of the system to find the most convenient operating variables to be applied in future industrial scale-ups. Statistical models provide a wide range of information that allows a statistical prediction of the operation of the plant, and allows people to obtain efficiency indices in its development; these are useful in the planning, operation and monitoring process in RO plants. The mathematical models describe the physical behavior of the membrane and allow the identification of optimal operating conditions, taking into account economic aspects, guaranteeing a greater implementation of RO technology in developing countries which have problems with water contaminated with toxic heavy metals. A comparative method is proposed to establish the advantages and selection criteria to apply the different models in IO.
  • 1.8K
  • 28 Oct 2022
Topic Review
SPIF (Patent Identification Format)
SPIF is a standard format for representing patent identification information. SPIF stands for (Simple/Standard/Specific/Special) Patent Identification Format. SPIF restricts the use of non-standard characters in listing patent publication and patent application. At its core, SPIF is a simple asset identification and disambiguation solution. SPIF does not seek to guarantee the existence of an asset, rather, SPIF seeks to uniquely identify assets. SPIF was created with the following principles in mind: The first version of SPIF was released January 29, 2021. SPIF was launched publicly on March 22, 2021. SPIF is managed by the Linux Foundation's Joint Development Foundation Projects, LLC, SPIF Series, Project Name: SPIF Patent Identification Format.
  • 1.8K
  • 30 Oct 2022
Topic Review
Dairy Buffalo Behavior: Calving, Imprinting and Allosuckling
Maternal behavior, in water buffalo and other ruminants, is a set of patterns of a determined species, including calving, imprinting, and suckling. Since the success of dairy farms depends on parturition, lactation, and the welfare of both the dam and the calf, calving behavior in water buffalo is a research area that could help researchers understand this process.
  • 1.8K
  • 18 Nov 2022
Topic Review
Carbon-LiFePO4 Cathodes for Lithium-Ion Batteries
Li-ion batteries are in demand due to technological advancements in the electronics industry; thus, expanding the battery supply chain and improving its electrochemical performance is crucial. Carbon materials are used to increase the cyclic stability and specific capacity of cathode materials, which are essential to batteries. LiFePO4 (LFP) cathodes are generally safe and have a long cycle life. However, the common LFP cathode has a low inherent conductivity, and adding a carbon nanomaterial significantly influences how well it performs electrochemically.
  • 1.8K
  • 28 Nov 2022
Topic Review
Vascular Sources of Nitric Oxide
Nitric oxide (NO) is implicated in numerous physiological processes, including vascular homeostasis. Reduced NO bioavailability is a hallmark of endothelial dysfunction, a prequel to many cardiovascular diseases. Biomarkers of an early NO-dependent endothelial dysfunction obtained from routine venous blood sampling would be of great interest but are currently lacking.
  • 1.8K
  • 01 Dec 2022
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