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Topic Review
IP6K
Inositol and its phosphate metabolites play a pivotal role in several biochemical pathways and gene expression regulation: inositol pyrophosphates (PP-IPs) have been increasingly appreciated as key signaling modulators. Fluctuations in their intracellular levels hugely impact the transfer of phosphates and the phosphorylation status of several target proteins. Pharmacological modulation of the proteins associated with PP-IP activities has proved to be beneficial in various pathological settings. IP7 has been extensively studied and found to play a key role in pathways associated with PP-IP activities. Three inositol hexakisphosphate kinase (IP6K) isoforms regulate IP7 synthesis in mammals. Genomic deletion or enzymic inhibition of IP6K1 has been shown to reduce cell invasiveness and migration capacity, protecting against chemical-induced carcinogenesis. IP6K1 could therefore be a useful target in anticancer treatment.
  • 2.0K
  • 14 Oct 2020
Topic Review
Metabolomics
Metabolomics is the latest trend in the “-omics” sciences, of which technologies are widely used today in all life sciences. Metabolomics gave impetus to the description of biochemical processes that occur in many organisms by means of measuring of low molecular compounds by high-throughout technologies, search for new biomarkers of disease, and laid the foundation for new clinical laboratory diagnostics. The purpose of this entry is to show how metabolomics is represented in the science and to demonstrate the successes and main achievements of scientists in this field.
  • 2.0K
  • 15 Feb 2021
Topic Review
Power systems stability with IBGs
Electrical power system stability is of upmost importance for a secure and reliable supply of electrical energy to residential, commercial and industrial premises. Voltage stability of microgrids, as new components of a power system, is an emerging research area within the concept of power system stability. The main purpose of developing microgrids is to facilitate the integration of renewable energy sources into the power grid. Renewable energy sources are normally connected to the grid via power electronic inverters. As various types of renewable energy sources are increasingly connected to the electrical power grid, power systems of the near future will have more inverter-based generators (IBGs) instead of synchronous generators (SGs). Since IBGs have significant differences in their characteristics compared to SGs , particularly with regard to their inertia and capability to provide reactive power, their impacts on the system dynamics are different compared to SGs. A comprehensive review on voltage stability of power systems with the inclusion of inverter-based generators is presented. 
  • 2.0K
  • 05 Mar 2021
Topic Review
BCL-2 Proteins in Pathogenesis
The ability to inhibit mitochondrial apoptosis is a hallmark of B-cell non-Hodgkin lymphomas (B-NHL). Activation of mitochondrial apoptosis is tightly controlled by members of B-cell leukemia/lymphoma-2 (BCL-2) family proteins via protein-protein interactions. Altering the balance between anti-apoptotic and pro-apoptotic BCL-2 proteins leads to apoptosis evasion and extended survival of malignant cells. The pro-survival BCL-2 proteins: B-cell leukemia/lymphoma-2 (BCL-2/BCL2), myeloid cell leukemia-1 (MCL-1/MCL1) and B-cell lymphoma-extra large (BCL-XL/BCL2L1) are frequently (over)expressed in B-NHL, which plays a crucial role in lymphoma pathogenesis, disease progression, and drug resistance. 
  • 2.0K
  • 23 Jun 2021
Topic Review
Technical Lignins
Lignin is a complex, amorphous, natural polymer, and one of the most abundant in nature, only behind cellulose. Technical lignins are co-products of the manufacture of cellulose pulp for paper. Some examples of technical lignins that will be addressed in this study are lignosulphonates alongside kraft, soda and organosolv lignins.
  • 2.0K
  • 19 Dec 2021
Topic Review
Endoscopic Ultrasound-Guided Hepaticogastrostomy
Endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) is widely performed worldwide for various benign and malignant biliary diseases in cases of difficult or unsuccessful endoscopic transpapillary cholangiopancreatography (ERCP). Furthermore, its applicability as primary drainage has also been reported. Although recent advances in EUS systems and equipment have made EUS-HGS easier and safer, the risk of serious adverse events such as bile leak and stent migration still exists. Physicians and assistants need not only sufficient skills and experience in ERCP-related procedures and basic EUS-related procedures such as fine needle aspiration and pancreatic fluid collection drainage, but also knowledge and techniques specific to EUS-HGS.
  • 2.0K
  • 08 Apr 2022
Topic Review
Bioconversion of Starch Base Food Waste into Bioethanol
Food wastes are organic wastes or biodegradables. They are generated from various sources such as restaurants and cafeterias, industrial sectors, commercial and domestic kitchens, food processing plants, and other areas where a large number of people consume food. The global demand for fuel keeps increasing daily. The massive depletion of fossil fuels and their influence on the environment as pollution is a severe problem. Meanwhile, food waste disposal is also a complex problem in solid-waste management since one-third of every food consumed is discarded as waste. The standard waste management methods, including food waste incineration and landfilling, are considered hazardous to the environment. Food waste constituents are majorly starch-based and contain various biomolecules, including sugar, lipids, proteins, vitamins, cellulose, etc. These polysaccharides can be hydrolysed into monosaccharides such as glucose, which can then be fermented using microorganisms to produce ethanol through the fermenting of sugars derived from enzymatic hydrolysis treatment of food wastes. The human food system is rich in starch, which can be a potential resource for bioethanol production.
  • 2.0K
  • 20 Sep 2022
Topic Review
Anti-Cancer Properties of Vitamin K
Vitamin K is the common name for a group of compounds recognized as essential for blood clotting. The group comprises phylloquinone (K1)—a 2-methyl-3-phytyl-1,4-naphthoquinone; menaquinone (K2, MK)—a group of compounds with an unsaturated side chain in position 3 of a different number of isoprene units and a 1,4-naphthoquinone group and menadione (K3, MD)—a group of synthetic, water-soluble compounds 2-methyl-1,4-naphthoquinone. However, epidemiological studies suggest that vitamin K has various benefits that go beyond blood coagulation processes. A dietary intake of K1 is inversely associated with the risk of pancreatic cancer, K2 has the potential to induce a differentiation in leukemia cells or apoptosis of various types of cancer cells, and K3 has a documented anti-cancer effect. A healthy diet rich in fruit and vegetables ensures an optimal supply of K1 and K2, though consumers often prefer supplements. Interestingly, the synthetic form of vitamin K—menadione—appears in the cell during the metabolism of phylloquinone and is a precursor of MK-4, a form of vitamin K2 inaccessible in food.
  • 2.0K
  • 11 Nov 2022
Topic Review
ISO Image
An ISO image is a disk image of an optical disc. In other words, it is an archive file that contains everything that would be written to an optical disc, sector by sector, including the optical disc file system. ISO image files bear the .iso filename extension. The name ISO is taken from the International Organization for Standardization (ISO) ISO 9660 file system used with CD-ROM media, but what is known as an ISO image might also contain a UDF (ISO/IEC 13346) file system (commonly used by DVDs and Blu-ray Discs). ISO images can be created from optical discs by disk imaging software, or from a collection of files by optical disc authoring software, or from a different disk image file by means of conversion. Software distributed on bootable discs is often available for download in ISO image format. And like any other ISO image, it may be written to an optical disc such as CD or DVD.
  • 2.0K
  • 07 Nov 2022
Topic Review
Shipworms
The shipworms are marine bivalve molluscs in the family Teredinidae: a group of saltwater clams with long, soft, naked bodies. They are notorious for boring into (and commonly eventually destroying) wood that is immersed in sea water, including such structures as wooden piers, docks and ships; they drill passages by means of a pair of very small shells borne at one end, with which they rasp their way through. Sometimes called "termites of the sea", they also are known as "Teredo worms" or simply Teredo, from the Greek τερηδών teredōn, via Latin. Eventually biologists adopted the common name Teredo as the name for the best-known genus.
  • 2.0K
  • 15 Nov 2022
Topic Review
Neutral CB1 Receptor Antagonists
Cannabinoid receptor 1 (CB1R) has been one of the major targets in medication development for treating substance use disorders (SUDs). Early studies indicated that rimonabant, a selective CB1R antagonist with an inverse agonist profile, was highly promising as a therapeutic for SUDs.
  • 2.0K
  • 20 Jan 2023
Topic Review
Process Parameters on Friction Stir Welded Joints
Friction Stir Welding is a suitable solid-state joining technology to connect dissimilar materials. To produce an effective joint, a phase of optimization is required which leads to the definition of process parameters such as pin geometry, tool rotational speed, rotation direction, welding speed, thickness of the sheets or tool tilt angle.
  • 2.0K
  • 28 Jun 2023
Topic Review
Mechanisms of Ferroptosis
Ferroptosis, mainly mediated by iron-dependent lipid peroxidation, is closely linked to multiple physiological and pathological processes in humans and animals, including cancer, arteriosclerosis, ischemia-reperfusion injury, neurodegenerative diseases, and acute renal failure.
  • 2.0K
  • 10 Dec 2021
Topic Review
Mitochondria-Targeted, Nanoparticle-Based Drug-Delivery Systems
Mitochondria play a key role in the production of metabolic energy in eukaryotic cells. However, apart from energy production, mitochondria also perform several other functions, namely, calcium signaling, cell proliferation, cell cycle regulation, and apoptosis. With growing interest in mitochondria, significant efforts are being made in mitochondria-targeting pharmaceutical interventions, resulting in ‘mitochondrial medicine’ as an emerging area of healthcare research. Mitochondria-targeting nanoparticles (NPs) are now a promising field of drug-delivery systems.
  • 2.0K
  • 19 May 2022
Topic Review
Loosening and Preload Loss of Threaded Connections
Threaded fasteners are vastly used in the industry due to ease of mounting and dismounting and flexibility of design. Nonetheless, several researchers indicate that most failures recorded on nearly any kind of machinery and vehicles are initiated at fasteners. Loosening is a process of rotation of the bolt in a direction opposite to the tightening. This can cause a loss of preload (tension created in the screw shank upon tightening) which can cause failures in the machinery. 
  • 2.0K
  • 14 Feb 2023
Topic Review
Post-Translational Modifications in Regulation of NLRP3 Inflammasome Activation
Pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) induce NLRP3 inflammasome activation, and subsequent formation of active caspase-1 as well as the maturation of interleukin-1β (IL-1β) and gasdermin D (GSDMD), mediating the occurrence of pyroptosis and inflammation. Aberrant NLRP3 inflammasome activation causes a variety of diseases. Therefore, the NLRP3 inflammasome pathway is a target for prevention and treatment of relative diseases. 
  • 2.0K
  • 26 Apr 2023
Topic Review
Neutrophil Extracellular Traps
"Neutrophil extracellular traps" (NETs) are released by neutrophils. Neutrophils act as the first line of defense during infection and inflammation. Once activated, they are able to fulfil numerous tasks to fight inflammatory insults while keeping a balanced immune response. Besides well-known functions, such as phagocytosis and degranulation, neutrophils are also able to release “neutrophil extracellular traps” (NETs).. In response to most stimuli, the neutrophils release decondensed chromatin in a NADPH oxidase-dependent manner decorated with histones and granule proteins, such as neutrophil elastase, myeloperoxidase, and cathelicidins. Although primarily supposed to prevent microbial dissemination and fight infections, there is increasing evidence that an overwhelming NET response correlates with poor outcome in many diseases. Lung-related diseases especially, such as bacterial pneumonia, cystic fibrosis, chronic obstructive pulmonary disease, aspergillosis, influenza, and COVID-19, are often affected by massive NET formation. Highly vascularized areas as in the lung are susceptible to immunothrombotic events promoted by chromatin fibers. Keeping this fragile equilibrium seems to be the key for an appropriate immune response. Therapies targeting dysregulated NET formation might positively influence many disease progressions.
  • 2.0K
  • 13 Aug 2021
Topic Review
Carbohydrate-Binding Modules of Potential Resources
Carbohydrate-binding modules (CBMs) are a class of multi-module enzyme proteins and their function is to respond to bind to the carbohydrate substrate. Cellulose-binding domains (CBDs) are the earliest-discovered CBMs which were used to be catergozied based on their sequence homology. However, with the in-depth study of carbohydrate hydrolases, more modules in carbohydrate-active enzymes were discovered that could bind, in addition to cellulose, to other types of carbohydrates such as chitin, glucan, xylan, or starch. 
  • 2.0K
  • 07 May 2022
Topic Review
Storage, Preservation and Processing of Toona sinensis
Toona sinensis, a perennial and deciduous tree belonging to the Meliaceae family, has been cultivated for more than 2000 years in China. Storing the buds of T. sinensis is difficult, as it is easy for them to rot during storage, which seriously affects their edible and commodity value. There are three kinds of storage and preservation methods of T. sinensis buds; although they can extend the shelf life of T. sinensis, the nutrients in this vegetable plant experience different degrees of loss. Because bio-preservation methods have the advantages of being natural, safe, and simple, it has become one of the research hotspots of food preservation technology. Furthermore, in order to extend the consumption period of T. sinensis, it is processed into a wide variety of foods.
  • 2.0K
  • 19 Jul 2022
Topic Review
Health Benefits of Mentha
A poor diet, resulting in malnutrition, is a critical challenge that leads to a variety of metabolic disorders, including obesity, diabetes, and cardiovascular diseases. Mentha species are famous as therapeutic herbs and have long served as herbal medicine. Recently, the demand for its products, such as herbal drugs, medicines, and natural herbal formulations, has increased significantly.
  • 2.0K
  • 28 Oct 2022
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