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Topic Review
Biomedical Applications of Silica Nanoparticles
Silica nanoparticles (SNPs) are available in many forms, including core-shell silica nanoparticles, nonporous SNPs, hollow mesoporous silica nanoparticles (HMSN), and mesoporous silica nanoparticles (MSN).  The advancements in nanotechnology have quickly developed a new subject with vast applications of nanostructured materials in medicine and pharmaceuticals. The enormous surface-to-volume ratio, ease of surface modification, outstanding biocompatibility, and, in the case of mesoporous nanoparticles, the tunable pore size make the SNPs a promising candidate for nano-based medical applications. 
  • 2.2K
  • 15 Dec 2022
Topic Review
Bioremediation of Heavy Metals by the Genus Bacillus
Bioremediation agents include bacteria of the genus Bacillus, among others. The best-described species in terms of the bioremediation potential of Bacillus spp. Are B. subtilis, B. cereus, or B. thuringiensis. This bacterial genus has several bioremediation strategies, including biosorption, extracellular polymeric substance (EPS)-mediated biosorption, bioaccumulation, or bioprecipitation. Due to the above-mentioned strategies, Bacillus spp. strains can reduce the amounts of metals such as lead, cadmium, mercury, chromium, arsenic or nickel in the environment. 
  • 2.2K
  • 27 Sep 2023
Topic Review
Intestinal Tryptophan Metabolism Pathways
Tryptophan (Trp) is an essential aromatic amino acid that is acquired exclusively through dietary intake in humans (since Trp is not produced by animal cells). Common sources of dietary Trp are fish, poultry, cereals, and dairy foods. The World Health Organization advises an intake of 4 mg of Trp/kg/day. Trp is a precursor of several microbial and host metabolites, including several molecules such as serotonin, melatonin, nicotinamide and vitamin B3. The intestine is a prime location of Trp metabolism. Three main metabolic pathways can process dietary Trp: (i) the kynurenine pathway (KP) via indoleamine 2,3-dioxygenase (IDO)1, mainly occurring in both immune and epithelial cells, (ii) the serotonin (5-hydroxytryptamine [5-HT]) pathway via Trp hydroxylase 1 (TpH1) in enterochromaffin cells, and finally (iii) the direct conversion of Trp by the intestinal microbiota into several. 
  • 2.2K
  • 19 Apr 2021
Topic Review
Sugarcane Biomass as Biofuel for Internal Combustion Engines
Sugarcane is one of the main agricultural crops in the world.  A deep overview of liquid biofuels produced from sugarcane bagasse is provided.
  • 2.2K
  • 01 Dec 2022
Topic Review
Glyphosate
Glyphosate [N-(phosphonomethyl) glycine CAS#1071-83-6] is one of the most extensively used broad-spectrum organophosphorus herbicides [1]. It is a widely used herbicide in agriculture against perennial and annual weeds and in silviculture, domestic gardens, and urban areas [2]. 
  • 2.2K
  • 26 Oct 2020
Topic Review
ADP-ribosylation
Adenosine diphosphate (ADP)-ribosylation is a nicotinamide adenine dinucleotide (NAD+)-dependent post-translational modification that is found on proteins as well as on nucleic acids. Promising technological advances have enabled the development of innovative tools to detect NAD+ and NAD+/NADH (H for hydrogen) ratios as well as ADP-ribosylation. These tools have significantly enhanced our current understanding of how intracellular NAD dynamics contribute to the regulation of ADP-ribosylation as well as to how mono-ADP-ribosylation integrates into various cellular processes.
  • 2.2K
  • 23 Jun 2021
Topic Review
Pyrazino[1,2-a]Indoles
The pyrazino[1,2-a]indole unit is a tricyclic aromatic nucleus combining an indole and a pyrazine linked by the N5 and C9a atoms. The Synthesis and Biological Activities of Pyrazino[1,2-a]Indole and Pyrazino[1,2-a]Indol-1-One Derivatives is presented.
  • 2.2K
  • 10 Aug 2021
Topic Review
RAASi Therapy
RAASi therapy (ACEi, ARB, MRA, and ARNi therapy) is the cornerstone therapy for patients with heart failure with reduced ejection fraction (HFrEF).
  • 2.2K
  • 13 Dec 2021
Topic Review
Dunaliella salina
Dunaliella sp. is a unicellular, halophilic, biflagellate, naked green alga Phylum Chlorophyta, Class Chlorophyceae, order Volvocales, family Polyblepharidaceae with a total of 29 species, as well as several varieties and forms.
  • 2.2K
  • 23 Sep 2022
Topic Review
Foundation (Engineering)
A foundation is the element of a structural engineering which connects it to the ground, and transfers loads from the structure to the ground. Foundations are generally considered either shallow or deep. Foundation engineering is the application of soil mechanics and rock mechanics (Geotechnical engineering) in the design of foundation elements of structures.
  • 2.2K
  • 08 Nov 2022
Topic Review
Bioinformatics in Plant Breeding and Disease Resistance
In the context of plant breeding, bioinformatics can empower genetic and genomic selection to determine the optimal combination of genotypes that will produce a desired phenotype and help expedite the isolation of these new varieties. Bioinformatics is also instrumental in collecting and processing plant phenotypes, which facilitates plant breeding. Robots that use automated and digital technologies to collect and analyze different types of information to monitor the environment in which plants grow, analyze the environmental stresses they face, and promptly optimize suboptimal and adverse growth conditions accordingly, have helped plant research and saved human resources.
  • 2.2K
  • 02 Dec 2022
Topic Review
Tryptophan Metabolic Pathways in Migraine-Related Mechanisms
Migraine is a complex neurovascular disorder, which causes intense socioeconomic problems worldwide. The pathophysiology of disease is enigmatic; accordingly, therapy is not sufficient. Migraine research focused on tryptophan, which is metabolized via two main pathways, the serotonin and kynurenine pathways. Both produce neuroactive molecules that influence pain processing and stress response by disturbing neural and brain hypersensitivity and interacting with molecules that control vascular and inflammatory actions. Serotonin has a role in trigeminal pain processing, and melatonin, another product of this pathway, also has a role in these processes. One of the end products of the kynurenine pathway is kynurenic acid (KYNA), which can decrease the overexpression of migraine-related neuropeptides in experimental conditions. However, the ability of KYNA to cross the blood-brain barrier is minimal, necessitating the development of synthetic analogs with potentially better pharmacokinetic properties to exploit its therapeutic potential.
  • 2.2K
  • 05 Dec 2022
Topic Review
Soil and Irrigation Water Salinity in Ethiopia
The salt problem in Ethiopia has been further exacerbated by a number of factors, including poor water quality, ineffective on-farm water management techniques, and a lack of appropriate and technically sound drainage infrastructure at irrigation sites.  Soil and irrigation water salinity have a substantial link with crops and agricultural communities in Ethiopia. Salinity has a significant impact on soil and water fertility, resulting in poorer agricultural production, food insecurity, and poverty. Salinity has a significant impact on crops in the country, from the germination stages to the harvesting stages during the growing season. If the current state of soil and water management continues, the severity of both soil and irrigation water salinity will reach an irreversible level that significantly impedes the country’s agricultural production capacity. As a result, cultured irrigation water treatment, crop selection based on salinity and sodicity levels, irrigation water quality, leaching, and fertilizer use in combination with organic manures are scientifically proven actions to address the salinity problem. 
  • 2.2K
  • 18 Jan 2023
Topic Review
Peak Load Shaving in Microgrid
Peak load is a particularly sensitive issue for microgrids as it happens occasionally for a small percentage of the time in a day. Peak load increases the risk of microgrid failure and also leads to power quality issues. To maintain grid stability and improve power quality, the microgrids must solve the peak loading problem.
  • 2.2K
  • 30 Mar 2022
Topic Review
Anthraquinones and Derivatives from Marine-Derived Fungi
Anthraquinones and their derivatives constitute a large group of quinoid compounds with about 700 molecules described. They are widespread in fungi and their chemical diversity and biological activities attracted attention of industries in such fields as pharmaceuticals, clothes dyeing, and food colorants.  As marine microorganisms appeared as producers of an astonishing variety of structurally unique secondary metabolites, they may represent a promising resource for identifying new candidates for therapeutic drugs or daily additives. 
  • 2.2K
  • 07 Oct 2023
Topic Review
Lipids of Sulfolobus spp.
Archaea, and thereby, Sulfolobus spp. exhibit a unique lipid composition of ether lipids, which are altered in regard to the ratio of diether to tetraether lipids, number of cyclopentane rings and type of head groups, as a coping mechanism against environmental changes. Sulfolobales mainly consist of C40-40 tetraether lipids (caldarchaeol) and partly of C20-20 diether lipids (archaeol). A variant of caldarchaeol called glycerol dialkylnonitol tetraether (GDNT) has only been found in Sulfolobus and other members of the Creanarchaeota phylum so far. Altering the numbers of incorporated cyclopentane rings or the the diether to tetraether ratio results in more tightly packed membranes or vice versa.
  • 2.2K
  • 26 Oct 2020
Topic Review
Snowmelt Models
The snowmelt model is a hydrological model that simulates the processes of snow accumulation, melt, and confluence. Since the snowmelt process involves the complex energy transfer and water transfer processes between the atmosphere and snow, between different snow layers, and between snow layers and soil, it is more complicated than the formation process of rainfall runoff. If there is a rainfall event on snow, it is very difficult to simulate the runoff generation process due to the mixture of rain and snow. Snowmelt simulation is the basis for the simulation of snowmelt flood formation processes, and it plays a crucial role in accurately modelling snowmelt floods.
  • 2.2K
  • 29 Oct 2021
Topic Review
Tryptophan
Tryptophan is an essential amino acid whose metabolites play key roles in diverse physiological processes.They influence immune reactions, have antioxidant properties, and can function as anabolic signals. Apart from this, they act as regulators of the circadian rhythm, and can thus modulate sleep disorders or cognitive functions. Given these diverse roles, Trp metabolism has a significant impact on the clinical outcome of critically ill patients
  • 2.2K
  • 10 Nov 2021
Topic Review
Selenium Nanoparticles (SeNPs)
Elemental selenium (Se0) is naturally insoluble, displays a lower toxicological potential and can form selenium nanoparticles (SeNPs).
  • 2.2K
  • 25 Feb 2022
Topic Review
The Role of Wnt
Alterations in the Wnt signaling pathway are associated with the advancement of cancers; however, the exact mechanisms responsible remain largely unknown. It has recently been established that heightened intratumoral Wnt signaling correlates with tumor immunomodulation and immune suppression, which likely contribute to the decreased efficacy of multiple cancer therapeutics. Here, we review available literature pertaining to connections between Wnt pathway activation in the tumor microenvironment and local immunomodulation. We focus specifically on preclinical and clinical data supporting the hypothesis that strategies targeting Wnt signaling could act as adjuncts for cancer therapy, either in combination with chemotherapy or immunotherapy, in a variety of tumor types.
  • 2.2K
  • 29 Oct 2020
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