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Topic Review
Pharmacologic and Clinical Considerations of Nalmefene
Nalmefene is a pure opioid antagonist structurally similar to naltrexone that can serve as an alternative antidote for reversing respiratory depression associated with acute opioid overdose. Nalmefene is also known as 6-methylene naltrexone. Its main features of interest are its prolonged duration of action that surpasses most opioids and its ability to serve as an antidote for acute opioid overdose.
  • 2.4K
  • 29 Mar 2022
Topic Review
Popular Uses and Botanical Description of Kalanchoe
The Crassulaceae J. St.-Hil. family is composed of 36 genera. Species of this family are distributed in Africa and Asia, predominantly in Madagascar and Arabia but are also found in the Americas and in Australia. The genus Kalanchoe Adans (Heterotypic Synonyms: Baumgartenia Tratt., Bryophyllum Salisb., Crassuvia Comm. ex Lam., Geaya Costantin and Poiss., Kitchingia Baker, Meristostylus Klotzsch, Physocalycium Vest, and Vereia Andrews) belongs to the Crassulaceae family and comprises 179 accepted species. 
  • 2.4K
  • 03 Aug 2023
Topic Review
Comprehensive Review on Wearable Sweat-Glucose Sensors for CGM
The incidence of diabetes is increasing at an alarming rate, and regular glucose monitoring is critical in order to manage diabetes. Currently, glucose in the body is measured by an invasive method of blood sugar testing. Blood glucose (BG) monitoring devices measure the amount of sugar in a small sample of blood, usually drawn from pricking the fingertip, and placed on a disposable test strip. Therefore, there is a need for non-invasive continuous glucose monitoring, which is possible using a sweat sensor-based approach.
  • 2.3K
  • 18 Jan 2022
Topic Review
BioFilms
Biofilms are aggregates formed as a protective survival state by microorganisms to adapt to the environment and can be resistant to antimicrobial agents and host immune responses due to chemical or physical diffusion barriers, modified nutrient environments, suppression of the growth rate within biofilms, and the genetic adaptation of cells within biofilms. With the widespread use of medical devices, medical device-associated biofilms continue to pose a serious threat to human health, and these biofilms have become the most important source of nosocomial infections. However, traditional antimicrobial agents cannot completely eliminate medical device-associated biofilms. New strategies for the treatment of these biofilms and targeting biofilm infections are urgently required. Several novel approaches have been developed and identified as effective and promising treatments.
  • 2.3K
  • 13 Apr 2021
Topic Review
Olive Tree and Derivatives
Olive (Olea europaea) is one of the most extensive crops in the Mediterranean countries, and an important source of extra distinctive compounds that has been widely tested due to its known health benefits. Olive derivatives, such as extra virgin olive oil (EVOO) and olive leaves are rich in antioxidant compounds such as hydroxytyrosol (HXT) and oleuropein and oleic acid, as main monounsaturated fatty acid. Because of HXT molecular structure, its regular consumption reports important beneficial properties such as anti-inflammatory, antimicrobial, antioxidant, and anticancer, which also make this compound a good preservative agent against meat deterioration and spoilage.
  • 2.3K
  • 30 Nov 2021
Topic Review
International Retirement Migration
Retirement, which marks the end of one’s working career, is an important phase in an individual’s life.
  • 2.3K
  • 30 Nov 2021
Topic Review
Diagnosis of Enamel Cracks
Cracked teeth can pose a diagnostic dilemma for a clinician as they can mimic several other conditions. The constant physiological stress along with any pathological strain like trauma or iatrogenic causes can lead to the development of microcracks in the teeth. Constant exposure to immense stress can cause the progression of these often-undiagnosed tooth cracks to cause tooth fractures. 
  • 2.3K
  • 07 Sep 2022
Topic Review
Bioactive Mycocompounds of Selected Medicinal Mushrooms for HPV
Medicinal mushrooms have been used as a medicinal tool for many centuries and, nowadays, are used in the prevention and therapy of various diseases, including as an adjunct to cancer treatment. It is estimated that 14–16% of global cancer cases are caused by infectious events; one well-known infectious agent that leads to cancer is the human papillomavirus (HPV). HPV is responsible for more than 99.7% of cervical cancer cases and also may play a role in vaginal, vulvar, penile, anal, rectal, and oropharyngeal carcinogenesis. Coriolus versicolor, a basidiomycetes class mushroom, consists of glycoproteins called polysaccharide-K (PSK) and polysaccharopeptide (PSP), which are mainly responsible for its effectiveness in the fight against a variety of cancers. Its beneficial effect lies in its ability to arrest different phases of the cell cycle, immunomodulation or induction of apoptosis. Coriolus versicolor extractcan reduces BCL-2 expression or increases the expression of p53 tumour suppressor genes in breast tumour cell lines. Inhibition of proliferation was also demonstrated with HeLa cells, while cervical cytology abnormalities improved in patients who locally applied Coriolus versicolor-based vaginal gel. Coriolus versicolor extract itself, and also its combination with another medicinal mushroom, Ganoderma lucidum, leads to improved HPV clearance in HPV cervical or oral-positive patients. Medicinal mushrooms can also increase the effectiveness of vaccination.
  • 2.2K
  • 11 Apr 2023
Topic Review
Gastric Cancer Screening in Japan
Gastric cancer is the second leading cause of cancer incidence in Japan, although gastric cancer mortality has decreased over the past few decades. This decrease is attributed to a decline in the prevalence of H. pylori infection. Radiographic examination has long been performed as the only method of gastric screening with evidence of reduction in mortality in the past. The revised 2014 Japanese Guidelines for Gastric Cancer Screening approved gastric endoscopy for use in population-based screening, together with radiography. While endoscopic gastric cancer screening has begun, there are some problems associated with its implementation, including endoscopic capacity, equal access, and cost-effectiveness. As H. pylori infection and atrophic gastritis are well-known risk factors for gastric cancer, a different screening method might be considered, depending on its association with the individual’s background and gastric cancer risk.
  • 2.2K
  • 08 Oct 2022
Topic Review
The Microbiota–Gut–Brain Axis in Psychiatric Disorders
The microbiota is a group of microorganisms that colonize the human body, and the composition of this group is not accidental; in turn, the term microbiome covers the genomes of all microorganisms in a particular environment. This complex ecosystem is characterized by a complicated network of positive and negative interrelationships that significantly impact the host’s health. Notably, the microbiota currently depends not only on the interdependencies occurring in this specific ecosystem but also on the cells of the macroorganism. Microorganisms inhabit various areas of the human body, ranging from the skin, through the mouth, the upper respiratory tract, the ear canal, and the vagina. However, 90% of all microorganisms colonize the initial sections of the small and large intestines. Many data indicate that the number of microorganisms that inhabit a macroorganism exceeds ten times the number of its cells.
  • 2.2K
  • 13 Oct 2022
Topic Review
RAASi Therapy
RAASi therapy (ACEi, ARB, MRA, and ARNi therapy) is the cornerstone therapy for patients with heart failure with reduced ejection fraction (HFrEF).
  • 2.2K
  • 13 Dec 2021
Topic Review
Patient-Centered Care for Depression Patients
People have specific and unique individual and contextual characteristics, so healthcare should increasingly opt for person-centered care models. Care planning focused on people with depression and/or anxiety disorder must be individualized, dynamic, flexible, and participatory. It must respond to the specific needs of the person, contemplating the identification of problems, the establishment of individual objectives, shared decision making, information and education, systematic feedback, and case management, and it should meet the patient’s preferences and satisfaction with care and involve the family and therapeutic management in care.
  • 2.2K
  • 18 Aug 2021
Topic Review Peer Reviewed
Examining and Working Across Differences—Older People from Culturally and Linguistically Diverse Backgrounds in Australia
Australia’s older population from culturally and linguistically diverse (CALD) backgrounds presents unique challenges for aged care and public policy due to their varied migration histories, cultural practices, and language barriers. This essay explores the demographic trends, historical migration perspectives, intergenerational dynamics, and health system interactions among older CALD Australians. Cultural nuances significantly influence attitudes towards caregiving, independence, and aged care, highlighting the necessity for culturally competent care models. Policies like the National Ageing and Aged Care Strategy emphasize inclusion, empowerment, and culturally appropriate service delivery. Key challenges include combating ageism, addressing healthcare access disparities, and fostering community engagement. Effective strategies involve culturally tailored interventions, enhanced communication, and proactive policy frameworks. The findings underscore the importance of a collaborative approach between communities, healthcare providers, and policymakers to ensure equitable and inclusive care for CALD populations, promoting dignity, well-being, and cultural preservation among Australia’s diverse elderly communities.
  • 2.1K
  • 12 Mar 2025
Topic Review
Performance-Enhancing Drugs (PEDs)
Performance-enhancing drugs (PEDs) are substances used to improve athletic ability, endurance, strength, or recovery beyond the body’s natural limits. While some PEDs have legitimate medical applications, their use in competitive sports is controversial due to ethical concerns, health risks, and violations of fair play principles. Anti-doping agencies and sports governing bodies have established strict regulations and testing protocols to detect and deter PED use in both amateur and professional athletics.
  • 2.1K
  • 25 Sep 2025
Topic Review
Sprouts and Microgreens for Healthy Diets
Healthy diets prevent diet-related non-communicable diseases; they provide nutrients and health-promoting substances from nutritious foods in adequate amounts. With society's growing interest in healthy eating, the interest in fresh, ready-to-eat, functional food, such as microscale vegetables (sprouted seeds and microgreens), has been on the rise in recent years globally. This entry briefly describes the crops commonly used for microscale vegetable production, highlights Brassica vegetables because of their health-promoting secondary metabolites and looks at consumer acceptance of sprouts and microgreens. Landraces, wild food plants, and crops' wild relatives often have high phytonutrient density and exciting flavours and tastes, thus providing scope to widen the range of crops and species used for this purpose. Moreover, the nutritional value and content of phytochemicals often vary with plant growth and development stages of the same crop. Sprouted seeds and microgreens are often more nutrient-dense than ungerminated seeds or mature vegetables. This entry also describes the environmental and priming factors that may impact the nutritional value and content of phytochemicals of microscale vegetables. Due to their short growth cycle, nutrient-dense sprouts and microgreens can be produced with minimal input and without pesticides. They can even be home-grown and harvested as needed, hence having low environmental impacts and a broad acceptance among health-conscious consumers.
  • 2.1K
  • 21 Mar 2022
Topic Review Peer Reviewed
Person-Centered Care: Learning from the Evolution of Mental Health Care
A health care approach that involves service users in decisions concerning their own health. It considers service users’ beliefs, values, support system, and experiences in co-creating an action plan to address their distinct health care goal [this is de novo based on diverse publications about person-centered care].
  • 2.1K
  • 10 Mar 2025
Topic Review
Types of Short Text on Social Media
The rapid expansion of social media platforms has resulted in an unprecedented surge of short text content being generated on a daily basis. The different types of short text on social media is essential for developing effective summarization techniques that cater to the unique characteristics of each platform and user interaction.
  • 2.1K
  • 01 Dec 2023
Topic Review
Carbonic Anhydrase Inhibitors and Epilepsy
Carbonic anhydrases (CAs) are a group of ubiquitously expressed metalloenzymes that catalyze the reversible hydration/dehydration of CO2/HCO3. Thus, they are involved in those physiological and pathological processes in which cellular pH buffering plays a relevant role. The inhibition of CAs has pharmacologic applications for several diseases.
  • 2.1K
  • 02 Nov 2021
Topic Review
Sleep Quantity and Sleep Quality
Sleep is one of the basic physiological processes for human survival. Both sleep quantity and sleep quality are fundamental components of sleep. We should pay more attention to obtaining sleep of good quality (restfulness, no sleepiness, no need for more sleep, sufficient objective sleep depth, etc.), although there have not been enough studies on the associations between sleep quality and health or disorders in children and adolescents.
  • 2.0K
  • 30 Sep 2021
Topic Review
Application of Sol–Gels for Treatment of Gynaecological Conditions
Approaches for effective and sustained drug delivery to the female reproductive tract (FRT) for treating a range of gynaecological conditions remain limited. The development of versatile delivery platforms, such as soluble gels (sol–gels) coupled with applicators/devices, holds considerable therapeutic potential for gynaecological conditions. Sol–gel systems, which undergo solution-to-gel transition, triggered by physiological conditions such as changes in temperature, pH, or ion composition, offer advantages of both solution- and gel-based drug formulations. Furthermore, they have potential to be used as a suitable drug delivery vehicle for other novel drug formulations, including micro- and nano-particulate systems, enabling the delivery of drug molecules of diverse physicochemical character. Hence, such systems are are of profound significance in delivering the drugs to various parts of FRT for optimal treatment of various gynecological conditions which was not achievable using conventional drug delivery technologies.
  • 2.0K
  • 24 Feb 2022
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