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Topic Review
YAP/TAZ Activation in Head and Neck Cancer
The Hippo signaling pathway, originally discovered as a mechanism regulating tissue growth and organ size, transduces intracellular and extracellular signals to regulate the transcriptional co-activators YAP and TAZ. Alterations in the Hippo pathway resulting in persistent YAP and TAZ activation have emerged as major oncogenic drivers. The researchers' analysis of the human Head and neck squamous cell carcinoma (HNSCC) oncogenome revealed multiple genomic alterations impairing Hippo signaling and activating YAP and TAZ, which in turn contribute to HNSCC development. This includes mutations and deletions of the FAT1 gene (29%) and amplification of the WWTR1 (encoding TAZ, 14%) and YAP1 genes (8%), together representing one of the most genetically altered signaling mechanisms in this malignancy. 
  • 2.7K
  • 11 May 2022
Topic Review
Biological Activities of Thiophenes
Thiophenes represent a small family of natural metabolites featured by one to five thiophene rings. Numerous plant species belonging to the family Asteraceae commonly produce thiophenes. These metabolites possessed remarkable bioactivities, including antimicrobial, antiviral, anti-inflammatory, larvicidal, antioxidant, insecticidal, cytotoxic, and nematicidal properties.
  • 2.7K
  • 16 Jan 2024
Topic Review
LABs and Silage Production
Lactic acid bacteria (LAB) are considered potent natural additives for animal feed production due to the efficient production of biological metabolites—notably, higher lactic acid content with marginal level acetic acid and other organic acids. Furthermore, LAB can utilize water-soluble carbohydrates and convert them into valuable organic acids, which increase the acidification of the surrounding environment. Rapid acidification (lower pH) could help to prevent undesirable microbial growth and toxic secondary metabolite secretion.
  • 2.7K
  • 07 Jan 2022
Topic Review
Technology Studies
Technology society and life or technology and culture refers to cyclical co-dependence, co-influence, and co-production of technology and society upon the other (technology upon culture, and vice versa). This synergistic relationship occurred from the dawn of humankind, with the invention of simple tools and continues into modern technologies such as the printing press and computers. The academic discipline studying the impacts of science, technology, and society, and vice versa is called science and technology studies.
  • 2.7K
  • 07 Nov 2022
Biography
G. E. Moore
George Edward Moore OM FBA (4 November 1873 – 24 October 1958), usually cited as G. E. Moore, was an English philosopher. He was, with Bertrand Russell, Ludwig Wittgenstein, and (before them) Gottlob Frege, one of the founders of the analytic tradition in philosophy. Along with Russell, he led the turn away from idealism in British philosophy, and became well known for his advocacy of common s
  • 2.7K
  • 22 Nov 2022
Topic Review
Circulating Tumors Cells in Metastasis
Tumor-related death is primarily caused by metastasis; consequently, understanding, preventing, and treating metastasis is essential to improving clinical outcomes. Metastasis is mainly governed by the dissemination of tumor cells in the systemic circulation: so-called circulating tumor cells (CTCs). CTCs typically arise from epithelial tumor cells that undergo epithelial-to-mesenchymal transition (EMT), resulting in the loss of cell–cell adhesions and polarity, and the reorganization of the cytoskeleton.
  • 2.7K
  • 25 Nov 2022
Topic Review
Corsac Fox
The Corsac Fox (Vulpes corsac) is a small wild canid species native to the steppes and semi-arid regions of Central Asia. Renowned for its distinctive sandy to pale gray fur and black-tipped tail, the Corsac Fox is well-adapted to its harsh desert environment. As an omnivorous opportunist, it preys on small mammals, birds, insects, and vegetation, exhibiting a versatile diet that allows it to thrive in diverse habitats.
  • 2.7K
  • 28 Feb 2024
Topic Review
Bioremediation
Bioremediation can reduce pesticide contamination of agricultural soils by biodegradation processes via the metabolic activities of microorganisms. It is an efficient, cost-effective, and environment-friendly treatment.
  • 2.7K
  • 14 Jul 2021
Topic Review
PC-12 Cell Line
PC-12 cells have been widely used as a neuronal line study model in many biosensing devices, mainly due to the neurogenic characteristics acquired after differentiation, such as high level of secreted neurotransmitter, neuron morphology characterized by neurite outgrowth, and expression of ion and neurotransmitter receptors. 
  • 2.7K
  • 18 Jul 2022
Topic Review
Isotopes of Unbiunium
Check temperatures Ubu: no input for C, K, F. Check temperatures Ubu: no input for C, K, F. Unbiunium, also known as eka-actinium or simply element 121, is the hypothetical chemical element with symbol Ubu and atomic number 121. Unbiunium and Ubu are the temporary systematic IUPAC name and symbol respectively, until a permanent name is decided upon. In the periodic table of the elements, it is expected to be the first of the superactinides, and the third element in the eighth period: analogously to lanthanum and actinium, it could be considered the fifth member of group 3 and the first member of the fifth-row transition metals. It has attracted attention because of some predictions that it may be in the island of stability, although newer calculations expect the island to actually occur at a slightly lower atomic number, closer to copernicium and flerovium. Unbiunium has not yet been synthesized. Nevertheless, because it is only three elements away from the heaviest known element, oganesson (element 118), its synthesis may come in the near future; it is expected to be one of the last few reachable elements with current technology, and the limit may be anywhere between element 120 and 124. It will also likely be far more difficult to synthesize than the elements known so far up to 118, and still more difficult than elements 119 and 120. The team at RIKEN in Japan has plans to attempt the synthesis of element 121 in the future after its attempts on elements 119 and 120. The position of unbiunium in the periodic table suggests that it would have similar properties to its lighter congeners, scandium, yttrium, lanthanum, and actinium; however, relativistic effects may cause some of its properties to differ from those expected from a straight application of periodic trends. For example, unbiunium is expected to have a s2p valence electron configuration instead of the s2d of its lighter congeners in group 3, but this is not expected to significantly affect its chemistry, which is predicted to be that of a normal group 3 element; it would on the other hand significantly lower its first ionisation energy beyond what would be expected from periodic trends.
  • 2.7K
  • 26 Oct 2022
Topic Review
Private Equity Fund
A private equity fund is a collective investment scheme used for making investments in various equity (and to a lesser extent debt) securities according to one of the investment strategies associated with private equity. Private equity funds are typically limited partnerships with a fixed term of 10 years (often with annual extensions). At inception, institutional investors make an unfunded commitment to the limited partnership, which is then drawn over the term of the fund. From the investors' point of view, funds can be traditional (where all the investors invest with equal terms) or asymmetric (where different investors have different terms). A private equity fund is raised and managed by investment professionals of a specific private equity firm (the general partner and investment advisor). Typically, a single private equity firm will manage a series of distinct private equity funds and will attempt to raise a new fund every 3 to 5 years as the previous fund is fully invested.
  • 2.7K
  • 02 Nov 2022
Topic Review
Fundamentals of Water-Splitting Reaction
A viable energy source, hydrogen has the advantages of clean energy, high conversion efficiency, and environmental friendliness. One of the possible routes for the generation of hydrogen in this context is the solar water splitting reaction under direct sunlight. To succeed on a commercial basis, though, there remains a very long way to go. 
  • 2.7K
  • 07 Nov 2022
Topic Review
Ciolo (Apulia)
Ciolo is a narrow coastal inlet and a site of historical and environmental interest, which is located in Apulia, Italy. The location is also known as a geological site and for the presence of numerous sea caves, the largest one being the Grotta del Ciolo. Since October 2006 the Ciolo's area has become part of the Regional Park "Costa Otranto - Santa Maria di Leuca e Bosco di Tricase", created by the Apulia region to protect the eastern coast of Salento, specifically the architectural assets as well as important animal and plant species. The name Ciolo comes from the noun in salentino dialect "ciole", which refers to crows or magpies, which are widespread in this region.
  • 2.7K
  • 14 Nov 2022
Topic Review
Basic Components of Osmotic Pump Systems
Novel drug delivery systems (NDDS) is a broad term that encompasses many dosage forms, one of which is osmotic pumps. Osmotic pumps are considered to be the most reliable source of controlled drug delivery, both in humans and in animals. These pumps are osmotically controlled and release active agents through osmotic pressure. To a large extent, drug release from such a system is independent of gastric fluids. Based on such unique properties and advantages, osmotic pumps have made their mark on the pharmaceutical industry. 
  • 2.7K
  • 07 Dec 2022
Topic Review
Atlantic Council
The Atlantic Council is an United States Atlanticist think tank in the field of international affairs, founded in 1961. It manages ten regional centers and functional programs related to international security and global economic prosperity. It is headquartered in Washington, D.C.. It is a member of the Atlantic Treaty Association.
  • 2.7K
  • 24 Nov 2022
Topic Review
Applications of Zinc Oxide Nanoparticles in Food/Agriculture
Zinc oxide nanoparticles (ZnO-NPs) have gained significant interest in the agricultural and food industry as a means of killing or reducing the activity of microorganisms. The antibacterial properties of ZnO-NPs may improve food quality, which has a direct impact on human health. ZnO-NPs are one of the most investigated inorganic nanoparticles and have been used in various related sectors, with the potential to rapidly gain attention and increase interest in the agriculture and food industries. 
  • 2.7K
  • 20 Apr 2023
Topic Review
Perylene Diimide Bioconjugates
Perylene diimide (PDI) has attracted attention owing to its chemical robustness, thermal and photo-stability, and outstanding optical and electronic properties.
  • 2.7K
  • 18 Feb 2023
Topic Review
In-Vehicle Intrusion Detection Systems
Breaches in the cyberspace due to cyber-physical attacks can harm the physical space, and any type of vehicle is an alluring target for wrongdoers for an assortment of reasons. Especially, as the automobiles are becoming increasingly interconnected within the Cooperative Intelligent Transport System (C-ITS) realm and their level of automation elevates, the risk for cyberattacks augments along with the attack surface, thus inexorably rendering the risk of complacency and inaction sizable. Next to other defensive measures, intrusion detection systems (IDS) already comprise an inextricable component of modern automobiles in charge of detecting intrusions in the system while in operation.
  • 2.7K
  • 07 May 2022
Topic Review
Photoplethysmography
Optical sensors play an increasingly important role in the development of medical diagnostic devices. They can be very widely used to measure the physiology of the human body. Optical methods include PPG, radiation, biochemical, and optical fiber sensors. Optical sensors offer excellent metrological properties, immunity to electromagnetic interference, electrical safety, simple miniaturization, the ability to capture volumes of nanometers, and non-invasive examination. In addition, they are cheap and resistant to water and corrosion. The use of optical sensors can bring better methods of continuous diagnostics in the comfort of the home and the development of telemedicine in the 21st century.
  • 2.7K
  • 27 May 2022
Topic Review
Electromagnetic Vibrational Energy Harvesting Principles
As industries need more real-time monitoring and interconnected systems, the demand for wireless sensors expands. Vibrational energy harvesters are a potential solution for powering these sensors, as vibrations commonly exist where monitoring occurs. Developments in low-power circuitry have also led to the feasibility of these types of harvesters. Electromagnetic harvesters are a standout among various types of vibrational harvesters due to their ability to capture kinetic energy in a low-frequency range. This leads to these devices being more applicable in real-world applications where ambient vibrations are typical of having low frequencies.
  • 2.7K
  • 04 Aug 2022
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