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Topic Review
Sleeping Beauty Transposon System
Sleeping Beauty (SB) is a transposon system that has been widely used as a genetic engineering tool. Central to the development of any transposon as a research tool is the ability to integrate a foreign piece of DNA into the cellular genome. Driven by the need for efficient transposon-based gene vector systems, extensive studies have largely elucidated the molecular actors and actions taking place during SB transposition. Close transposon relatives and other recombination enzymes, including retroviral integrases, have served as useful models to infer functional information relevant to SB. Recently obtained structural data on the SB transposase enable a direct insight into the workings of this enzyme. These efforts cumulatively allowed the development of novel variants of SB that offer advanced possibilities for genetic engineering due to their hyperactivity, integration deficiency, or targeting capacity. However, many aspects of the process of transposition remain poorly understood and require further investigation. We anticipate that continued investigations into the structure–function relationships of SB transposition will enable the development of new generations of transposition-based vector systems, thereby facilitating the use of SB in preclinical studies and clinical trials.
  • 2.9K
  • 27 Jan 2021
Topic Review
PSO-1
The PSO-1 (Прицел Снайперский Оптический, Pritsel Snaipersky Optichesky, "Optical Sniper Sight") is a telescopic sight manufactured in Russia by the Novosibirsk instrument-making factory (NPZ Optics State Plant) and issued with the Russian military Dragunov sniper rifle. The PSO-1 was, at the time of its introduction on 3 July 1963 together with the Dragunov sniper rifle, the most technically advanced telescopic sight ever designed for a mass-production designated marksman or sniper rifle.
  • 2.9K
  • 31 Oct 2022
Topic Review
Dynamic Light Scattering and Its Applications
Dynamic light scattering (DLS) is a widely utilized technique in many scientific and industrial sectors where the distribution of particle size and behavior of particles in solutions is crucial. Having the capacity to measure particle size and distribution, besides measuring zeta potential and some other colloidal properties, such as molecular weight, makes DLS a practical device for various applications.
  • 2.9K
  • 03 Jan 2024
Topic Review
Hypersexuality
Hypersexuality is extremely frequent or suddenly increased libido. It is currently controversial whether it should be included as a clinical diagnosis used by mental healthcare professionals. Nymphomania and satyriasis were terms previously used for the condition in women and men, respectively. Hypersexuality may be a primary condition, or the symptom of another medical disease or condition; for example, Klüver-Bucy syndrome or bipolar disorder. Hypersexuality may also present as a side effect of medication such as drugs used to treat Parkinson's disease. Clinicians have yet to reach a consensus over how best to describe hypersexuality as a primary condition, or to determine the appropriateness of describing such behaviors and impulses as a separate pathology. Hypersexual behaviours are viewed variously by clinicians and therapists as a type of obsessive-compulsive disorder (OCD) or "OCD-spectrum disorder", an addiction, or a disorder of impulsivity. A number of authors do not acknowledge such a pathology and instead assert that the condition merely reflects a cultural dislike of exceptional sexual behavior. Consistent with there not being any consensus over what causes hypersexuality, authors have used many different labels to refer to it, sometimes interchangeably, but often depending on which theory they favor or which specific behavior they were studying. Contemporary names include compulsive masturbation, compulsive sexual behavior, cybersex addiction, erotomania, "excessive sexual drive", hyperphilia, hypersexuality, hypersexual disorder, problematic hypersexuality, sexual addiction, sexual compulsivity, sexual dependency, sexual impulsivity, "out of control sexual behavior", and paraphilia-related disorder.
  • 2.9K
  • 31 Oct 2022
Topic Review
Climate Variability
Climate variability is the term to describe variations in the mean state and other characteristics of climate (such as chances or possibility of extreme weather, etc.) "on all spatial and temporal scales beyond that of individual weather events." Some of the variability does not appear to be caused systematically and occurs at random times. Such variability is called random variability or noise. On the other hand, periodic variability occurs relatively regularly and in distinct modes of variability or climate patterns. Over the years, the definitions of climate variability and the related term climate change have shifted. While the term climate change now implies change that is both long-term and of human causation, in the 1960s the word climate change was used for what we now describe as climate variability, that is, climatic inconsistencies and anomalies.
  • 2.9K
  • 11 Nov 2022
Topic Review
Cryptography: From Ancient Secrets to Modern Encryption
This research explores the fascinating history of cryptography from its earliest origins to the modern era of digital encryption. It covers the development of various encryption methods throughout history, including substitution and transposition ciphers, the Enigma machine, and the birth of modern cryptography in the computer age. The research also discusses the breakthroughs in public key cryptography and emerging technologies such as quantum cryptography. Additionally, it highlights the pioneers in the field, including Alan Turing and Claude Shannon, and provides advice for those seeking to become experts in cryptography. Despite ongoing debates over encryption and privacy, cryptography remains an essential tool for protecting sensitive information and ensuring the privacy of individuals and organizations around the world.
  • 2.9K
  • 22 May 2023
Topic Review
Resilience Optimization of Post-Quantum Cryptography Key Encapsulation Algorithms
The developments in quantum computing have shed light on the shortcomings of the conventional public cryptosystem. Even while Shor’s algorithm cannot yet be implemented on quantum computers, it indicates that asymmetric key encryption will not be practicable or secure in the near future. The National Institute of Standards and Technology (NIST) has started looking for a post-quantum encryption algorithm that is resistant to the development of future quantum computers as a response to this security concern. 
  • 2.9K
  • 21 Aug 2023
Topic Review
Thermoresponsive Hydrogel Molecule
Temperature-induced, rapid changes in the viscosity and reproducible 3-D structure formation makes thermos-sensitive hydrogels an ideal delivery system to act as a cell scaffold or a drug reservoir. Moreover, the hydrogels’ minimum invasiveness, high biocompatibility, and facile elimination from the body have gathered a lot of attention from researchers.
  • 2.9K
  • 08 Aug 2022
Topic Review
Centaur (Minor Planet)
Centaurs are small solar system bodies with a semi-major axis between those of the outer planets. They generally have unstable orbits because they cross or have crossed the orbits of one or more of the giant planets; almost all their orbits have dynamic lifetimes of only a few million years, but there is one centaur, (514107) 2015 BZ509, which may be in a stable (though retrograde) orbit. Centaurs typically behave with characteristics of both asteroids and comets. They are named after the mythological centaurs that were a mixture of horse and human. It has been estimated that there are around 44,000 centaurs in the Solar System with diameters larger than 1 kilometer. The first centaur to be discovered, under the definition of the Jet Propulsion Laboratory and the one used here, was 944 Hidalgo in 1920. However, they were not recognized as a distinct population until the discovery of 2060 Chiron in 1977. The largest confirmed centaur is 10199 Chariklo, which at 260 kilometers in diameter is as big as a mid-sized main-belt asteroid, and is known to have a system of rings. It was discovered in 1997. However, the lost centaur 1995 SN55 may be somewhat larger. No centaur has been photographed up close, although there is evidence that Saturn's moon Phoebe, imaged by the Cassini probe in 2004, may be a captured centaur that originated in the Kuiper belt. In addition, the Hubble Space Telescope has gleaned some information about the surface features of 8405 Asbolus. (As of 2008), three centaurs have been found to display comet-like comas: 2060 Chiron, 60558 Echeclus, and 166P/NEAT. Chiron and Echeclus are therefore classified as both asteroids and comets. Other centaurs, such as 52872 Okyrhoe, are suspected of having shown comas. Any centaur that is perturbed close enough to the Sun is expected to become a comet.
  • 2.9K
  • 25 Nov 2022
Topic Review
Hospital Gown
A hospital gown, also called a johnny gown or johnny, is "a long loose piece of clothing worn in a hospital by someone doing or having an operation". It can be used as clothing for bedridden patients.
  • 2.9K
  • 02 Dec 2022
Topic Review
Emblica officinalis for the Treatment of Hyperlipidemia
The ayurvedic herb Emblica officinalis (E. officinalis) is a gift to mankind to acquire a healthy lifestyle. It has great therapeutic and nutritional importance. Emblica officinalis, also known as Indian gooseberry or Amla, is a member of the Euphorbiaceae family. Amla is beneficial for treating illnesses in all its forms. The most crucial component is a fruit, which is also the most common. It is used frequently in Indian medicine as a restorative, diuretic, liver tonic, refrigerant, stomachic, laxative, antipyretic, hair tonic, ulcer preventive, and for the common cold and fever. Hyperlipidemia is also known as high cholesterol or an increase in one or more lipid-containing blood proteins. Various phytocompounds, including polyphenols, vitamins, amino acids, fixed oils, and flavonoids, are present in the various parts of E. officinalis. E. officinalis has been linked to a variety of pharmacological effects in earlier studies, including hepatoprotective, immunomodulatory, antimicrobial, radioprotective, and hyperlipidemic effects.
  • 2.9K
  • 10 Feb 2023
Topic Review Peer Reviewed
Merging Smart and Healthy Cities to Support Community Wellbeing and Social Connection
Urban planning has long pursued the improvement of health and wellbeing through the rapidly evolving scholarship and practice of health-supportive environments, underpinned by the seminal World Health Organization’s Healthy Cities Framework. Although a much more recent development, technology has been informing urban planning, as well as advancing healthcare and personal wellbeing monitoring and assessment. Known as the Smart City movement, it has much to offer regarding life in towns and cities, as well as how they are managed, maintained, and developed. There is also a growing appreciation of the potential for smart city technology to enhance human and environmental health in the context of urban planning and public place making. This has been reinforced by the COVID-19 pandemic with its reawakening of community interest in health and wellbeing, including mental illness, a greater awareness of the importance of local environments, and an explosion of technological knowhow in the embrace of remote working, online shopping, and education. Using the example of the authors’ “Smart Social Spaces” project, this entry discusses the potential benefits of an evolving integrative concept called “Smart Healthy Social Spaces”. The aim is to support community wellbeing as part of everyday living, especially associated with social connection, in densely populated and culturally diverse urban environments, where locally situated public spaces are increasingly important for all citizens.
  • 2.9K
  • 04 Sep 2023
Topic Review Video
Global Solar Radiation
An empirical model of global solar irradiance (EMGSI) under all sky conditions was developed by using solar radiation and meteorological parameters at Sodankylä. The calculated hourly global solar irradiance is in agreement with that observed at the ground during 2008–2011 and at the top of the atmosphere (TOA). Using this empirical model, the albedos at the TOA and the surface were calculated, and they are in agreement with the satellite-retrieved values. 
  • 2.9K
  • 25 Nov 2021
Topic Review
Poly(methyl methacrylate) (PMMA)
Poly (methyl methacrylate) (PMMA) is a thermoplastic synthetic polymer, which displays superior characteristics such as transparency, good tensile strength, and processability. 
  • 2.9K
  • 29 Jun 2021
Topic Review
IoT and the Energy Sector
Integration of renewable energy and optimization of energy use are key enablers of sustainable energy transitions and mitigating climate change. Modern technologies such the Internet of Things (IoT) offer a wide number of applications in the energy sector, i.e, in energy supply, transmission and distribution, and demand. IoT can be employed for improving energy efficiency, increasing the share of renewable energy, and reducing environmental impacts of the energy use.
  • 2.9K
  • 26 Sep 2021
Topic Review
UV Filters
The use of sunscreens is a recommended practice to protect skin from solar-induced damage. Around 30 UV filters can be used in sunscreen products in the European Union. However, low photostability and putative toxicity for humans and environment have been reported for some UV filters. Therefore, it is important to develop new UV filters with improved safety profile and photostability. Over the last two decades, nearly 200 new compounds have revealed promising photoprotection properties. The explored compounds were obtained through different approaches, including exploration of natural sources, synthetic pathways, and nanotechnology. Almost 50 natural products and around 140 synthetic derivatives have been studied aiming the discovery of novel, effective, and safer future photoprotective agents. 
  • 2.9K
  • 05 May 2022
Topic Review
China Intelligent Manufacturing Technology in the Steel Industry
Intelligent manufacturing, defined as the integration of manufacturing with modern information technologies such as 5G, digitalization, networking, and intelligence, has grown in popularity as a means of boosting the productivity, intelligence, and flexibility of traditional manufacturing processes. The steel industry is a necessary support for modern life and economic development, and the Chinese steel industry’s capacity has expanded to roughly half of global production.
  • 2.9K
  • 03 Nov 2022
Topic Review
Bacterial Signal Transduction Systems
Bacteria possess a large number of signal transduction systems that sense and respond to different environmental cues. Most frequently these are transcriptional regulators, two-component systems and chemosensory pathways. A major bottleneck in the field of signal transduction is the lack of information on signal molecules that modulate the activity of the large majority of these systems. 
  • 2.9K
  • 23 Apr 2021
Topic Review
NAC Transcription Factors
The NAC (NAM, ATAF1/2, and CUC2) family of proteins is one of the largest plant-specific transcription factor (TF) families and its members play varied roles in plant growth, development, and stress responses.
  • 2.9K
  • 08 Feb 2021
Topic Review
Graphene Oxide
Graphene oxide (GO) is a chemical compound with a form similar to graphene that consists of one-atom-thick two-dimensional layers of sp2-bonded carbon. Graphene oxide exhibits high hydrophilicity and dispersibility. Thus, it is difficult to be separated from aqueous solutions. Therefore, functionalization with magnetic nanoparticles is performed in order to prepare a magnetic GO nanocomposite that combines the sufficient adsorption capacity of graphene oxide and the convenience of magnetic separation. Moreover, the magnetic material can be further functionalized with different groups to prevent aggregation and extends its potential application. Until today, a plethora of magnetic GO hybrid materials have been synthesized and successfully employed for the magnetic solid-phase extraction of organic compounds from environmental, agricultural, biological, and food samples. The developed GO nanocomposites exhibit satisfactory stability in aqueous solutions, as well as sufficient surface area. Thus, they are considered as an alternative to conventional sorbents by enriching the analytical toolbox for the analysis of trace organic compounds.
  • 2.9K
  • 15 Jan 2021
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