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Topic Review
UV Filters
The use of sunscreens is a recommended practice to protect skin from solar-induced damage. Around 30 UV filters can be used in sunscreen products in the European Union. However, low photostability and putative toxicity for humans and environment have been reported for some UV filters. Therefore, it is important to develop new UV filters with improved safety profile and photostability. Over the last two decades, nearly 200 new compounds have revealed promising photoprotection properties. The explored compounds were obtained through different approaches, including exploration of natural sources, synthetic pathways, and nanotechnology. Almost 50 natural products and around 140 synthetic derivatives have been studied aiming the discovery of novel, effective, and safer future photoprotective agents. 
  • 2.9K
  • 05 May 2022
Topic Review
Metal Bis(trimethylsilyl)amides
Metal bis(trimethylsilyl)amides (often abbreviated as metal silylamides) are coordination complexes composed of a cationic metal with anionic bis(trimethylsilyl)amide ligands and are part of a broader category of metal amides. Due to the bulky hydrocarbon backbone metal bis(trimethylsilyl)amide complexes have low lattice energies and are lipophilic . For this reason, they are soluble in a range of nonpolar organic solvents, in contrast to simple metal halides, which only dissolve in reactive solvents. These steric bulky complexes are molecular, consisting of mono-, di-, and tetramers. Having a built-in base, these compounds conveniently react with even weakly protic reagents. The class of ligands and pioneering studies on their coordination compounds were described by Bürger and Wannagat. The ligands are often denoted hmds (e.g. M(N(SiMe3)2)3 = M(hmds)3) in reference to the hexamethyldisilazane from which they are prepared.
  • 2.9K
  • 02 Dec 2022
Topic Review
Cultural Heritage Sites in Kano
Historical buildings have inhabited every epoch of history. Some of these built legacies are now in ruins and dying whilst others are somewhat undamaged. Knowledge of conservation techniques available today has allowed us to understand more innovative ways of conserving the built heritage. Such techniques are, however, incompatible with the building materials available in our historical epoch and environment. People seek to reclaim the forgotten cultural heritage in the midst of the heritage conservation era while bearing in mind that previous work seldom takes into account the inventive preservation methods of today.
  • 2.9K
  • 10 Aug 2023
Topic Review
Industrial Crystallization of Citrate
The citrate industry has a wide range of applications in food, pharmaceutical, and other fields. As a common class of food additives and functional supplements with tremendous development potential and strong core competitiveness, particles with good powder characteristics and functionalization are becoming one of the primary directions in the evolution of citrate into the high-end market.
  • 2.9K
  • 11 Aug 2023
Topic Review Peer Reviewed
Social Aspects of Smart Urban Mobility
There is a growing interest in sustainable urban transport solutions in cities around the world. These changes, known as “smart urban mobility”, aim to reduce the negative effects of transport on the natural environment and enhance the standard of living for urban dwellers. It should be noted that in addition to this transformation’s technological aspects, modifying the city’s structure and architecture also has a social dimension. The transformation of urban mobility has a significant impact on social relations. Introducing new modes of transport, such as city bikes and electric scooters, creates new ways of moving around the city and can impact social interactions. This can increase social integration and a community’s sense of belonging. At the same time, it is necessary to consider the differences between social groups to ensure equal access to the benefits of these changes in addition to deeper social elements, such as changing the habits and expectations of residents and adapting solutions to the specific needs of each city. This paper aims to look at the social aspects of smart urban mobility, including the impact of these changes on the lives and relationships of city residents.
  • 2.9K
  • 22 May 2024
Topic Review
Parliamentary Train
A Parliamentary train is a passenger service operated in the United Kingdom to comply with the Railway Regulation Act 1844 that required train companies to provide inexpensive and basic rail transport for less affluent passengers. The act required that at least one such service per day be run on every railway route in the UK. Now no longer a legal requirement (although most franchise agreements require such trains), the term describes train services that continue to be run to avoid the cost of formal closure of a route or station but with reduced services often to just one train per week and without specially low prices. Such services are often called "ghost trains".
  • 2.9K
  • 10 Nov 2022
Topic Review
Molecular Mechanisms and Signaling Pathways in Gastric Cancer
Gastric cancer (GC) is common but often diagnosed late. Advances in chemotherapy, targeted therapy, and immunotherapy offer promising treatments. Perioperative chemotherapy is now the standard for resectable gastric cancer. Progress has also been made in treating metastatic disease using targeted immunotherapies. Molecular biomarkers such as programmed cell death protein ligand 1 (PD-L1), microsatellite instability (MSI), and human epidermal growth factor receptor 2 (HER2) guide personalized treatment approaches. 
  • 2.9K
  • 03 Nov 2023
Topic Review
Gut Microbiota and Related Diseases
Dynamic interactions between gut microbiota and a host’s innate and adaptive immune systems play key roles in maintaining intestinal homeostasis and inhibiting inflammation. The gut microbiota metabolizes proteins and complex carbohydrates, synthesize vitamins, and produce an enormous number of metabolic products that can mediate cross-talk between gut epithelial and immune cells. As a defense mechanism, gut epithelial cells produce a mucosal barrier to segregate microbiota from host immune cells and reduce intestinal permeability. An impaired interaction between gut microbiota and the mucosal immune system can lead to an increased abundance of potentially pathogenic gram-negative bacteria and their associated metabolic changes, disrupting the epithelial barrier and increasing susceptibility to infections. Gut dysbiosis, or negative alterations in gut microbial composition, can also dysregulate immune responses, causing inflammation, oxidative stress, and insulin resistance. Over time, chronic dysbiosis and the translocation of bacteria and their metabolic products across the mucosal barrier may increase prevalence of type 2 diabetes, cardiovascular disease, inflammatory bowel disease, autoimmune disease, and a variety of cancers. 
  • 2.9K
  • 23 Jan 2021
Topic Review
Lignans
This entry focuses on lignans, a non-flavonoid polyphenolic class found in plant foods for human nutrition, recently studied as potential modulators of the gut-brain axis. In particular, gut bacterial metabolism is able to convert dietary lignans into therapeutically relevant polyphenols (i.e., enterolignans), such as enterolactone and enterodiol. Enterolignans are characterized by various biologic activities, including tissue-specific estrogen receptor activation, together with anti-inflammatory and apoptotic effects. The variability in enterolignans production by the gut microbiota is strictly related to both bioaccessibility and bioavailability of parent lignans through the entire gastrointestinal tract. 
  • 2.9K
  • 06 Jan 2021
Topic Review
Bitumen and Bitumen Modification
According to the European specification (EN 12597), bitumen is defined as a virtually involatile, adhesive, and waterproofing material derived from crude oil, or present in natural asphalt, which is completely or nearly completely soluble in toluene, and very viscous or nearly solid at ambient temperatures. It is well-accepted that the original characteristics of bitumen are highly dependent on its production and processing procedure, as well as bitumen crude oil characteristics. Good crude oils and proper distillation processes can enhance bitumen properties.
  • 2.9K
  • 17 Jun 2021
Topic Review
Logical Framework with Risk Management Approach Methodology
When working with international development projects (IDPs), the use of the logical framework approach (LFA) prevails as the most important tool to plan and manage these projects. How to enrich the methodology has been studied, including risk management (logical framework with risk management approach (LFRMA)), proposing an original contribution, tested with professionals that will improve the effectiveness of IDPs by increasing their success rate and their sustainability. The steps followed to design the methodology, case study analysis and design of LFRMA  and the methodology itself are presented.
  • 2.9K
  • 28 Feb 2022
Topic Review
List of Intel Core I3 Microprocessors
The following is a list of Intel Core i3 brand microprocessors. These processors are designed with cheap price points, while still retaining the power of the Intel Core line. As such they (along with Intel's i5 series) are often found in laptops and low-end desktop computers.
  • 2.9K
  • 26 Oct 2022
Topic Review
Nuclear Receptor Superfamily
The nuclear receptor superfamily comprises a large group of proteins with functions essential for cell signaling, survival, and proliferation. There are multiple distinctions between nuclear superfamily classes defined by hallmark differences in function, ligand binding, tissue specificity, and DNA binding. In this review, we utilize the initial classification system, which defines subfamilies based on structure and functional difference. The defining feature of the nuclear receptor superfamily is that these proteins function as transcription factors. The loss of transcriptional regulation or gain of functioning of these receptors is a hallmark in numerous diseases. For example, in prostate cancer, the androgen receptor is a primary target for current prostate cancer therapies. Targeted cancer therapies for nuclear hormone receptors have been more feasible to develop than others due to the ligand availability and cell permeability of hormones. 
  • 2.9K
  • 12 Aug 2021
Biography
J. Gayle Beck
J. Gayle Beck is a licensed clinical psychologist who specializes in trauma stress disorders[1] and anxiety disorders.[2] She is the Lillian and Morrie Moss Chair of Excellence in the Department of Psychology at the University of Memphis. Beck was President of the Society of Clinical Psychology, American Psychological Association (APA) Division 12, in 2012[3] and President of the Association fo
  • 2.9K
  • 04 Jan 2023
Topic Review
Nanobodies
Nanobodies are highly water-soluble and stable, have high specificity, and can bind their targets with very high affinity, often in the low nanomolar range. 
  • 2.9K
  • 10 May 2021
Topic Review
Supercapacitor
Supercapacitors are electrical devices for fast storage and release of electric energy utilizing charge accumulation in the electrochemical double layer. In terms of volumetric and gravimetric capacities they exceed conventional dielectric and electrolytic capacitors by several orders of magnitude. However, the low energy density of supercapacitors has seriously limited their wider application in many fields. Increase of energy density highly depends on development of a new generation of advanced electrode materials for supercapacitors.
  • 2.9K
  • 26 Oct 2020
Topic Review
Solidago virgaurea L
Solidago virgaurea L. (European goldenrod, Woundwort), Asteraceae, is a familiar medicinal plant in Europe and other parts of the world, widely used and among the most researched species from its genus. The aerial parts of European goldenrod have long been used for urinary tract conditions and as an anti-inflammatory agent in the traditional medicine of different peoples. Its main chemical constituents are flavonoids (mainly derived from quercetin and kaempferol), C6-C1 and C6-C3 compounds, terpenes (mostly from the essential oil), and a large number of saponin molecules (mainly virgaureasaponins and solidagosaponins). 
  • 2.9K
  • 16 Dec 2020
Topic Review
Soil and Food Crops Irrigated with Wastewater
Wastewater is actively used for irrigation of vegetable and forage crops in arid lands due to water scarcity and cost advantages. The objective of this review was to assess the effect of wastewater (mixture sources) reuse in irrigation on soil, crop (vegetable and forage crops), animal products, and human health. 
  • 2.9K
  • 31 Dec 2021
Topic Review
Internet Challenge
On the internet, a challenge is a genre of videos in which users record themselves performing an action and then dare others to repeat it. They play a role in internet meme culture, with many challenges spreading through such memes. Examples include the ALS Ice Bucket challenge, which went viral in mid-2014 and the TrashTag Challenge which went viral in 2019. An internet challenge is similar to the common children's dare game in which they dare each other to perform an action that one would not normally do. Some challenges/talks predate the internet; some periodically resurface in a somewhat different form. The popularity of internet challenges is explained by people's, especially teenagers', need to gain attention and be liked.
  • 2.9K
  • 21 Nov 2022
Topic Review
Bya (Unit)
A year is the orbital period of a planetary body, for example, the Earth, moving in its orbit around the Sun. Due to the Earth's axial tilt, the course of a year sees the passing of the seasons, marked by change in weather, the hours of daylight, and, consequently, vegetation and soil fertility. In temperate and subpolar regions around the planet, four seasons are generally recognized: spring, summer, autumn and winter. In tropical and subtropical regions, several geographical sectors do not present defined seasons; but in the seasonal tropics, the annual wet and dry seasons are recognized and tracked. A calendar year is an approximation of the number of days of the Earth's orbital period, as counted in a given calendar. The Gregorian calendar, or modern calendar, presents its calendar year to be either a common year of 365 days or a leap year of 366 days, as do the Julian calendars; see below. For the Gregorian calendar, the average length of the calendar year (the mean year) across the complete leap cycle of 400 years is 365.2425 days. The ISO standard ISO 80000-3, Annex C, supports the symbol a (for Latin annus) to represent a year of either 365 or 366 days. In English, the abbreviations y and yr are commonly used. In astronomy, the Julian year is a unit of time; it is defined as 365.25 days of exactly 86,400 seconds (SI base unit), totalling exactly 31,557,600 seconds in the Julian astronomical year. The word year is also used for periods loosely associated with, but not identical to, the calendar or astronomical year, such as the seasonal year, the fiscal year, the academic year, etc. Similarly, year can mean the orbital period of any planet; for example, a Martian year and a Venusian year are examples of the time a planet takes to transit one complete orbit. The term can also be used in reference to any long period or cycle, such as the Great Year.
  • 2.9K
  • 01 Dec 2022
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