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Topic Review
Hydrogen Bond Energy
Hydrogen bonds (HBs) play a crucial role in many physicochemical and biological processes. Theoretical methods can reliably estimate the intermolecular HB energies. Quantifying an intramolecular hydrogen bond (IHB) strength is not as straightforward as the intermolecular one. The main difficulty lies in isolating the X–H···Y interaction present within a molecule than in a dimer or a complex. However, the procedure discussed (viz. molecular tailoring approach) in this article, allows the generation of fragments so that the atoms/functional groups involved in the HB formation are parts of two different fragments. The energies of these fragments are added or substracted, using the inclusion exclusion principle in set theory, to obtained the energy of HB bond.
  • 3.0K
  • 19 May 2021
Topic Review
Solar Radiation Management
Solar radiation management (SRM) proposals are a type of climate engineering which would seek to reflect sunlight and thus reduce global warming. Proposed methods include increasing the planetary albedo, for example using stratospheric sulfate aerosols. Restorative methods have been proposed regarding the protection of natural heat reflectors like sea ice, snow and glaciers with engineering projects. Their principal advantages as an approach to climate engineering is the speed with which they can be deployed and become fully active, their potential low financial cost, and the reversibility of their direct climatic effects. Solar radiation management projects could serve as a temporary response while levels of greenhouse gases can be brought under control by mitigation and greenhouse gas removal techniques. They would not reduce greenhouse gas concentrations in the atmosphere, and thus do not address problems such as ocean acidification caused by excess carbon dioxide (CO2).
  • 3.0K
  • 24 Nov 2022
Topic Review
Genomics Improve Abiotic Stress Tolerance in Tomato Plant
Solanum lycopersicum L. (Solanaceae), generally known as tomato, is one of the most significant fruits that are nutritionally classified as a vegetable. It contains carotenoids (lycopene and carotene), phenolic compounds (flavonoids), vitamins (ascorbic acid, -tocopherol, vitamin A), glycoalkaloids (tomatine), and phytosterols (-sitosterol, campesterol, and stigmasterol).
  • 3.0K
  • 21 Apr 2023
Topic Review
Neo-Advaita
Neo-Advaita, also called the Satsang-movement and Nondualism, is a New Religious Movement, emphasizing the direct recognition of the non-existence of the "I" or "ego," without the need of preparatory practice. Its teachings are derived from, but not authorised by, the teachings of the 20th century sage Ramana Maharshi, as interpreted and popularized by H. W. L. Poonja and several of his western students. It is part of a larger religious current called immediatism by Arthur Versluis, which has its roots in both western and eastern spirituality. Western influences are western esoteric traditions like Transcendentalism, and "New Age millennialism, self-empowerment and self-therapy". Neo-Advaita makes little use of the "traditional language or cultural frames of Advaita Vedanta", and some have criticised it for its lack of preparatory training, and regard enlightenment-experiences induced by Neo-Advaita as superficial.
  • 3.0K
  • 16 Nov 2022
Topic Review
Halitosis
Halitosis, also known as fetor ex ore, bad breath or oral malodor, is a common disorder meaning unpleasant smell from the mouth. Halitosis is a common problem that manifests as an unpleasant and disgusting odor emanating from the mouth[1]. Malodor is mainly caused by putrefactive actions of microorganisms on endogenous or exogenous proteins and peptides. Oral malodor is an embarrassing condition that affects a large percentage of the human population. This condition often results in nervousness, humiliation, and social difficulties, such as the inability to approach people and speak to them[2][3][4][5][6].
  • 3.0K
  • 11 Sep 2020
Topic Review
Electrical Transcription
Electrical transcriptions are special phonograph recordings made exclusively for radio broadcasting, which were widely used during the 'Golden Age of Radio', wherein, they provided material—from station-identification jingles and commercials to full-length programs—for use by local stations, affiliates of one of the radio networks. Physically, electrical transcriptions look much like long-playing records that were popular for decades. They differ from consumer-oriented recordings, however, in that they were "distributed to radio stations for the purpose of broadcast, and not for sale to the public.... The ET had higher quality audio than was available on consumer records" largely because they had less surface noise than commercial recordings,
  • 3.0K
  • 01 Oct 2022
Topic Review
Phenobarbital Pharmacokinetics in Neonates
Phenobarbital is a first-line treatment of various seizure types in newborns. Dosage individualization maximizing the proportion of patients with drug levels in therapeutic range or sufficient treatment response is still challenging. The available evidence on phenobarbital pharmacokinetics in neonates and its possible covariates suitable for individualization of initial drug dosing was therefore summarized.
  • 3.0K
  • 22 Apr 2021
Topic Review
PPIs' Drug Dosage Forms Development - Formulation Challenges
Proton Pump Inhibitors, also known as PPIs, belong to a group of antisecretory drugs. Since their introduction to pharmacotherapy, PPIs have been widely used in the treatment of numerous diseases manifested by excessive secretion of gastric acid. There are still unmet needs regarding their availability for patients of all age groups. Their poor stability hinders the development of formulations in which dose can be easily adjusted.
  • 3.0K
  • 31 Oct 2022
Topic Review
Nitrogen, Phosphorus and Microalgal
Microalgae can be used as a source of alternative food, animal feed, biofuel, fertilizer, cosmetics, nutraceuticals and for pharmaceutical purposes. The extraction of organic constituents from microalgae cultivated in the different nutrient compositions is influenced by microalgal growth rates, biomass yield and nutritional content in terms of lipid and fatty acid production. In this context, nutrient composition plays an important role in microalgae cultivation, and depletion and excessive sources of this nutrient might affect the quality of biomass. Investigation on the role of nitrogen and phosphorus, which are crucial for the growth of algae, has been addressed. However, there are challenges for enhancing nutrient utilization efficiently for large scale microalgae cultivation. Hence, this study aims to highlight the level of nitrogen and phosphorus required for microalgae cultivation and focuses on the benefits of nitrogen and phosphorus for increasing biomass productivity of microalgae for improved lipid and fatty acid quantities. Furthermore, the suitable extraction methods that can be used to utilize lipid and fatty acids from microalgae for biofuel have also been reviewed.
  • 3.0K
  • 03 Mar 2021
Topic Review
Climate Change Impacts on Sunflower Plants
Elevated concentrations of atmospheric carbon dioxide (CO2) and increased temperatures, carbon and nitrogen metabolism will  affect the plant’s oxidative state in sunflower (Helianthus annus L.) plants
  • 3.0K
  • 24 Jan 2022
Biography
Julius Edgar Lilienfeld
Julius Edgar Lilienfeld (April 18, 1882 – August 28, 1963) was a Jewish Austro-Hungarian-born German-American physicist and electronic engineer, credited with the first patents on the field-effect transistor (FET) (1925) and electrolytic capacitor (1931). Because of his failure to publish articles in learned journals and because high-purity semiconductor materials were not available yet, his
  • 3.0K
  • 10 Nov 2022
Topic Review
Filamentous Bacteriophage Delivery System
Bacteriophages are a powerful platform with outstanding potential in the biomedical and chemical engineering field that have been exploited for diverse applications including theranostics, batteries, drug delivery, and vaccine development. Filamentous bacteriophages are single-strand DNA virions belonging to the Inoviridae family, a sub-group of non-lytic, rod-like shaped Escherichia coli viruses with a repeated and ordered capsid structure, and that includes phages f1, fd, and M13. Fd filamentous bacteriophage is a bio nano-fiber with a modifiable surface that is a promising vehicle for antigen expression.
  • 3.0K
  • 30 Oct 2020
Topic Review
Visegrád Group
The Visegrád Group, Visegrád Four, or V4, is a cultural and political alliance of four Central European countries – the Czech Republic, Hungary, Poland and Slovakia, that are members of the European Union (EU) and NATO – for the purposes of advancing military, cultural, economic and energy cooperation with one another along with furthering their integration in the EU. The Group traces its origins to the summit meetings of leaders from Czechoslovakia, Hungary, and Poland held in the Hungarian castle-town of Visegrád on 15 February 1991. Visegrád was chosen as the location for the 1991 meeting as an intentional allusion to the medieval Congress of Visegrád in 1335 between John I of Bohemia, Charles I of Hungary and Casimir III of Poland. After the dissolution of Czechoslovakia in 1993, the Czech Republic and Slovakia became independent members of the group, thus increasing the number of members from three to four. All four members of the Visegrád Group joined the European Union on 1 May 2004.
  • 3.0K
  • 15 Nov 2022
Topic Review
Mad Pride
Mad Pride is a mass movement of the users of mental health services, former users, and the aligned, and that individuals with mental illness should be proud of their 'mad' identity. It was formed in 1993 in response to local community prejudices towards people with a psychiatric history living in boarding homes in the Parkdale area of Toronto, Ontario, Canada, and an event has been held every year since then in the city except for 1996. A similar movement began around the same time in the United Kingdom. By the late 1990s similar events were being organized under the Mad Pride name around the globe, including Australia, Ireland, Portugal, Brazil, Madagascar, South Africa and the United States. Events draw thousands of participants, according to MindFreedom International, a United States mental health advocacy organization that promotes and tracks events spawned by the movement. Mad Pride activists seek to reclaim terms such as "mad", "nutter", and "psycho" from misuse, such as in tabloid newspapers and in order to switch it from a negative message into a positive one. Through a series of mass media campaigns, Mad Pride activists seek to re-educate the general public on such subjects as the causes of mental disabilities, the experiences of those using the mental health system, and the global suicide pandemic. One of Mad Pride's founding activists in the UK was Pete Shaughnessy, who later died by suicide. Mark Roberts, Robert Dellar (who died in 2016) and Simon Barnet were among the other founders of the movement. Mad Pride: A celebration of mad culture records the early Mad Pride movement. On Our Own: Patient-Controlled Alternatives to the Mental Health System, published in 1978 by Judi Chamberlin, is a foundational text in the Mad Pride movement, although it was published before the movement was launched. The first known event, specifically organized as a Pride event by people who identified as survivors, consumers or ex-patients of psychiatric practices, was held on 18 September 1993, when it was called "Psychiatric Survivor Pride Day".
  • 3.0K
  • 17 Nov 2022
Topic Review
Cultural Capital
Cultural capital is a sociological concept introduced by French sociologist Pierre Bourdieu. It refers to the cultural assets and knowledge that an individual possesses, which can be used to gain social advantages and achieve upward mobility within a particular society. Cultural capital encompasses various forms of cultural knowledge, skills, education, and tastes that are valued by a particular social group.
  • 3.0K
  • 25 Jan 2024
Topic Review
Aztreonam/Avibactam
The epidemiology of infections sustained by multidrug-resistant Gram-negative bacteria is rapidly evolving. New drugs are available or are on the horizon. Most are combinations of a β-lactam and a β-lactamase inhibitor. One part is the antibiotic cefiderocol that has a peculiar antibacterial mechanism of action. Dispensing of such an armamentarium requires in-depth knowledge of their microbiological spectrum of activity, pharmacokinetic/pharmacodynamic (PK/PD) properties, and clinical study results. The following will describe the antibacterial strategy of aztreonam in combination with avibactam.
  • 3.0K
  • 09 May 2022
Topic Review
Innovations and Emerging Cooling Technologies for Greenhouses
The climate control inside the greenhouse constitutes an efficient methodology for maintaining a satisfactory environment that fulfills the requirements of high-yield crops and reduced energy and water resource consumption. In hot climates, the cooling systems, which are assisted by an effective control technique, constitute a suitable path for maintaining an appropriate climate inside the greenhouse, where the required temperature and humidity distribution is maintained.
  • 3.0K
  • 11 Mar 2022
Topic Review
Effects of Berberine against Pancreatic Cancer
The pancreas is a glandular organ with endocrine and exocrine functions necessary for the maintenance of blood glucose homeostasis and secretion of digestive enzymes. Pancreatitis is characterized by inflammation of the pancreas leading to temporary or permanent pancreatic dysfunction. Inflammation and fibrosis caused by chronic pancreatitis exacerbate malignant transformation and significantly increase the risk of developing pancreatic cancer, the world’s most aggressive cancer with a 5-year survival rate less than 10%. Berberine (BBR) is a naturally occurring plant-derived polyphenol present in a variety of herbal remedies used in traditional medicine to treat ulcers, infections, jaundice, and inflammation.
  • 3.0K
  • 20 Dec 2022
Topic Review
Hypopigmented mycosis fungoides
Hypopigmented mycosis fungoides (HMF) is a variant of cutaneous T-cell lymphoma (CTCL), a heterogeneous group of extranodal non-Hodgkin’s lymphomas. HMF and classic (erythematous patch/plaque) Mycosis Fungoides (MF) display contrasting clinical characteristics: (i) HMF presents with light colored to achromic patches, as opposed to classic MF, which presents with erythematous scaly patches, plaques, tumors or erythroderma, (ii) HMF primarily affects individuals with darker skin types (Fitzpatrick phototypes IV-VI), while classic MF affects mostly Caucasians, (iii) HMF is commonly seen in pediatric/adolescents and young adults, whereas classic MF is more prevalent in elderly individuals, and (iv) the predominant malignant cells in HMF are CD8+T-cells, as opposed to CD4+T-cells in classic MF. Our recent review paper highlights that active antitumor immune response, specifically a Th1/cytotoxic antitumor immune response seen robustly in HMF, is likely responsible for the differential behavior between these two MF variants. Furthermore, we propose that the hypopigmentation (clinical sign) may serve as a surrogate marker for the presence of antitumor immune response and may portend better prognosis. 
  • 3.0K
  • 21 Oct 2020
Topic Review
Herfindahl Index
The Herfindahl index (also known as Herfindahl–Hirschman Index, HHI, or sometimes HHI-score) is a measure of the size of firms in relation to the industry and an indicator of the amount of competition among them. Named after economists Orris C. Herfindahl and Albert O. Hirschman, it is an economic concept widely applied in competition law, antitrust and also technology management. It is defined as the sum of the squares of the market shares of the firms within the industry (sometimes limited to the 50 largest firms), where the market shares are expressed as fractions. The result is proportional to the average market share, weighted by market share. As such, it can range from 0 to 1.0, moving from a huge number of very small firms to a single monopolistic producer. Increases in the Herfindahl index generally indicate a decrease in competition and an increase of market power, whereas decreases indicate the opposite. Alternatively, if whole percentages are used, the index ranges from 0 to 10,000 "points". For example, an index of .25 is the same as 2,500 points. The major benefit of the Herfindahl index in relationship to such measures as the concentration ratio is that it gives more weight to larger firms. The measure is essentially equivalent to the Simpson diversity index, which is a diversity index used in ecology; the inverse participation ratio (IPR) in physics; and the effective number of parties index in politics.
  • 3.0K
  • 19 Oct 2022
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