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Topic Review
Cytokines in Inflammatory Disease
This review aims to briefly discuss a short list of a broad variety of inflammatory cytokines. Numerous studies have implicated that inflammatory cytokines exert important effects with regard to various inflammatory diseases, yet the reports on their specific roles are not always consistent. They can be used as biomarkers to indicate or monitor disease or its progress, and also may serve as clinically applicable parameters for therapies. Yet, their precise role is not always clearly defined. Thus, in this entry, researchers focus on the existing literature dealing with the biology of cytokines interleukin (IL)-6, IL-1, IL-33, tumor necrosis factor-alpha (TNF-α), IL-10, and IL-8. We will briefly focus on the correlations and role of these inflammatory mediators in the genesis of various inflammatory impacts.
  • 4.5K
  • 13 Oct 2021
Topic Review
Collagen Injectables for Aesthetic and Regenerative Medicine Applications
Soft tissues diseases significantly affect patients quality of life and usually require targeted, costly and sometimes constant interventions. With the average lifetime increase, a proportional increase of age-related soft tissues diseases has been witnessed. Due to this, the last two decades have seen a tremendous demand for minimally invasive one-step resolutive procedures. Intensive scientific and industrial research has led to the recognition of injectable formulations as a new advantageous approach in the management of complex diseases that are challenging to treat with conventional strategies. Among them, collagen-based products are revealed to be one of the most promising among bioactive biomaterials-based formulations. Collagen is the most abundant structural protein of vertebrate connective tissues and, because of its structural and non-structural role, is one of the most widely used multifunctional biomaterials in the health-related sectors, including medical care and cosmetics. Indeed, collagen-based formulations are historically considered as the “gold standard” and from 1981 have been paving the way for the development of a new generation of fillers. A huge number of collagen-based injectable products have been approved worldwide for clinical use and have routinely been introduced in many clinical settings for both aesthetic and regenerative surgery. 
  • 4.5K
  • 06 May 2023
Topic Review
Human Factors and Road Traffic Safety
Human factors play a huge role in road traffic safety. Research has found that a huge proportion of traffic crashes occur due to some form of human error. Improving road user behavior has been the major strategy that has been emphasized for improving road traffic safety. Meanwhile, despite the training efforts, and testing for drivers, the global status of road traffic safety is alarming.
  • 4.5K
  • 02 Feb 2024
Topic Review
Cry Proteins in Biotechnology
A hallmark of Bacillus thuringiensis bacteria is the formation of one or more parasporal crystal (Cry) proteins during sporulation. The toxicity of these proteins is highly specific to insect larvae, exerting lethal effects in different insect species but not in humans or other mammals. In 1989, a nomenclature was proposed to classify proteins according to their sequence and specificity. In this initial nomenclature, there were only four classes. The first class included proteins with action against Lepidoptera with a size of approximately 130–140 kDa. The second class included smaller proteins (65 kDa) with activity against Lepidoptera and Diptera; this class included only two members: CryIIA and CryIIB. The third class constituted the active toxin against Coleoptera, CryIIIA. The last class was Cry1A, the members of which were closely related: they were called Cry1Aa, Cry1Ab, and Cry1Ac.
  • 4.5K
  • 01 Feb 2022
Topic Review
The Potent Phytoestrogen 8-Prenylnaringenin
8-prenylnaringenin (8-PN) is a prenylated flavonoid, occurring, in particular, in hop, but also in other plants. It has proven to be one of the most potent phytoestrogens in vitro known to date, and in the past 20 years, research has unveiled new effects triggered by it in biological systems. These findings have aroused the hopes, expectations, and enthusiasm of a “wonder-drug” for a host of human diseases. However, the majority of 8-PN effects require such high concentrations that they cannot be reached by normal dietary exposure, only pharmacologically; thus, adverse impacts may also emerge.
  • 4.5K
  • 01 Apr 2022
Topic Review
Medicinal Chemistry of Analgesic and Anti-Inflammatory Quinazoline Compounds
Quinazoline is an essential scaffold, known to be linked with various biological activities. Some of the prominent biological activities of this system are analgesic, anti-inflammatory, anti-hypertensive, anti-bacterial, anti-diabetic, anti-malarial, sedative–hypnotic, anti-histaminic, anti-cancer, anti-convulsant, anti-tubercular, and anti-viral activities. This diversity in the pharmacological response of the quinazoline system has encouraged medicinal chemists to study and discover this system and its multitude of potential against several biological activities.
  • 4.5K
  • 08 Dec 2022
Topic Review
Epoxides Cycloaddition for CO2 Utilization
In the present review (10.3390/pr8050548), CO2 cycloaddition can be seen as a reasonably competent alternative to CO2 transformation, offsetting the high value-added nature by extending material use defer CO2 back to the atmosphere when compared to commodities and fuels such as urea, methanol, and methane.
  • 4.5K
  • 27 Aug 2020
Topic Review
Spray Drying for Oils Encapsulation
This is a entry focused on the application of spray drying technology for the edible oils encapsulation. This entry covered most of the relevant works have done recently on the encapsulation of oils by spray drying. The factors affecting the process of encapsulation and the application in food with the properties of the final product.The application of the spray drying technique in the food industry for the production of a broad range of ingredients has become highly desirable compared to other drying techniques. Recently, the spray drying technique has been applied extensively for the production of functional foods, pharmaceuticals and nutraceuticals. Encapsulation using spray drying is highly preferred due to economic advantages compared to other encapsulation methods. Encapsulation of oils using the spray drying technique is carried out in order to enhance the handling properties of the products and to improve oxidation stability by protecting the bioactive compounds. Encapsulation of oils involves several parameters—including inlet and outlet temperatures, total solids, and the type of wall materials—that significantly affect the quality of final product.
  • 4.5K
  • 19 Apr 2022
Topic Review
Diamond DA42
The Diamond DA42 Twin Star is a four seat, twin engine, propeller-driven airplane developed and manufactured by Austrian company Diamond Aircraft Industries. It was Diamond's first twin engine design, as well as the first new European twin-engine aircraft in its category to be developed in over 25 years. In 2004, the DA42 became the first diesel-powered fixed-wing aircraft to perform a non-stop crossing of the North Atlantic. By 2012, the DA42 had become a key revenue generator for the company, having gained popularity with government and military operators in addition to the civil market that had suffered as a result of the Great Recession. Government customers have typically employed the type in the aerial surveillance role, which contributed towards the development of the Aeronautics Defense Dominator, a medium-altitude long-endurance (MALE) unmanned aerial vehicle (UAV), which had been derived from the DA42.
  • 4.5K
  • 21 Nov 2022
Topic Review
Catalysts for Synthesis of Ethylene-Propylene-Diene Rubbers
Ethylene-propylene-diene rubbers (EPDM) are one of the most important polyolefin materials widely commercialized and used in various industries in recent years. The production of EPDM is based solely on catalytic coordination polymerization processes. The development of new catalysts and processes for the synthesis of EPDM has expanded the range of products and their manufacturing in terms of energy efficiency, processability, and environmental safety.
  • 4.5K
  • 13 Sep 2022
Topic Review
Biomimicry
Biomimicry can be defined as the branch of science for developing technology by mimicking nature, where forms and structures of creatures are the basic sources of inspiration to come up with optimized design solutions.
  • 4.5K
  • 12 Mar 2021
Topic Review
Strain Rate Tensor
In continuum mechanics, the strain rate tensor is a physical quantity that describes the rate of change of the deformation of a material in the neighborhood of a certain point, at a certain moment of time. It can be defined as the derivative of the strain tensor with respect to time, or as the symmetric component of the gradient (derivative with respect to position) of the flow velocity. The strain rate tensor is a purely kinematic concept that describes the macroscopic motion of the material. Therefore, it does not depend on the nature of the material, or on the forces and stresses that may be acting on it; and it applies to any continuous medium, whether solid, liquid or gas. On the other hand, for any fluid except superfluids, any gradual change in its deformation (i.e. a non-zero strain rate tensor) gives rise to viscous forces in its interior, due to friction between adjacent fluid elements, that tend to oppose that change. At any point in the fluid, these stresses can be described by a viscous stress tensor that is, almost always, completely determined by the strain rate tensor and by certain intrinsic properties of the fluid at that point. Viscous stress also occur in solids, in addition to the elastic stress observed in static deformation; when it is too large to be ignored, the material is said to be viscoelastic.
  • 4.5K
  • 02 Dec 2022
Topic Review
Stimuli-responsive materials
Smart or stimuli-responsive materials are an emerging class of materials used for tissue engineering and drug delivery. A variety of stimuli (including temperature, pH, redox-state, light, and magnet fields) are being investigated for their potential to change a material’s properties, interactions, structure, and/or dimensions. The specificity of stimuli response, and ability to respond to endogenous cues inherently present in living systems provide possibilities to develop novel tissue engineering and drug delivery strategies (for example materials composed of stimuli responsive polymers that self-assemble or undergo phase transitions or morphology transformations). Herein, smart materials as controlled drug release vehicles for tissue engineering are described, highlighting their potential for the delivery of precise quantities of drugs at specific locations and times promoting the controlled repair or remodeling of tissues.
  • 4.5K
  • 24 Jul 2020
Topic Review
Android Malware Detection Using ML
This systematic review discussed ML-based Android malware detection techniques. It critically evaluated 106 carefully selected articles and highlighted their strengths and weaknesses as well as potential improvements. The ML-based methods for detecting source code vulnerabilities were also discussed, because it might be more difficult to add security after the app is deployed. Therefore, this paper aimed to enable researchers to acquire in-depth knowledge in the field and to identify potential future research and development directions.
  • 4.5K
  • 19 Aug 2021
Topic Review
High-Speed Motorized Spindles of CNC Machine Tools
High-speed motorized spindles tend to develop in the direction of high precision, high speed, low energy consumption, high efficiency, and high reliability. 
  • 4.5K
  • 28 Mar 2022
Topic Review
Lockheed Martin Compact Fusion Reactor
The Lockheed Martin Compact Fusion Reactor (CFR) is a proposed nuclear fusion reactor project at Lockheed Martin’s Skunk Works. Its high-beta configuration, which implies that the ratio of plasma pressure to magnetic pressure is greater than or equal to 1 (compared to tokamak designs' 0.05), allows a compact fusion reactor (CFR) design and expedited development. The CFR chief designer and technical team lead, Thomas McGuire studied fusion as a source of space propulsion in response to a NASA desire to improve travel times to Mars.
  • 4.5K
  • 17 Oct 2022
Topic Review
Dental Plaque
Dental plaque is a community of microorganisms found on the surface of teeth or other hard surfaces like dentures and embedded in a matrix of polymers of both host and bacterial origin.
  • 4.5K
  • 23 Sep 2021
Topic Review
Halogen Bonds
A halogen bond occurs when there is evidence of a net attractive interaction between an electrophilic region associated with a halogen atom in a molecular entity and a nucleophilic region in another, or the same, molecular entity.
  • 4.5K
  • 08 Dec 2020
Topic Review
Interleukin-2 and Interleukin-15
The immune system is a complex network dedicated to protecting an organism against harmful substances, including the eradication of invading pathogens or malignant cells, maintenance of specific memory lymphocytes and elimination of autoreactive immune cells to yield self-tolerances. Homeostasis of immune systems relies on two main components—the innate and adaptive immune responses, which are regulated by a series of cytokines that are released in response to certain stimulus. One of the most extensively studied cytokines is the common cytokine receptor common gamma chain (γc) family of cytokines, including interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15 and IL-21, which is named based on the usage of γc subunit for their receptors. This set of cytokines display broad pleiotropic actions to regulate both the innate and adaptive immune system, collectively contributing to the development of various immune cell populations, modulating cell differentiation, and either promoting the survival or inducing the apoptosis depending on the cellular context.
  • 4.5K
  • 08 Feb 2021
Topic Review
Radeon HD 5000 Series
The Evergreen series is a family of GPUs developed by Advanced Micro Devices for its Radeon line under the ATI brand name. It was employed in Radeon HD 5000 graphics card series and competed directly with Nvidia's GeForce 400 Series.
  • 4.5K
  • 17 Nov 2022
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