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Topic Review
Concrete 3D Printing
In Singapore, there is an increasing need for independence in manpower within the Building and Construction (B&C) Industry. Prefabricated Prefinished Volumetric Construction (PPVC) production is mainly driven by its benefits in environmental pollution reduction, improved productivity, quality control, and customizability. However, its overall cost savings have been counterbalanced by new cost drivers like modular precast moulds, transportation, hoisting, manufacturing & holding yards, and supervision costs. The highly modular requirements for PPVC places additive manufacturing in an advantageous position due to its high customisability, and low volume manufacturing capabilities for faster manufacturing response time, faster production changeovers, and lower inventory requirements however Concrete 3D Printing (C3DP) has only begun to move away from early-stage development, where there is a need to closely evaluate the process parameters across buildability, extrudability, and pumpability aspects. As many parameters have been identified to have considerable influence in C3DP processes, monitoring systems for feedback applications seem to be an inevitable step forward to automation in construction. 
  • 1.1K
  • 03 Apr 2023
Topic Review
Sclerotinia sclerotiorum (Lib.) de Bary against Host Defense
Sclerotinia sclerotiorum (Lib.) de Bary is a broad host-range fungus that infects an inclusive array of plant species and afflicts significant yield losses globally. S. sclerotiorum possesses an immense arsenal of disease weaponry to subsist and succeed under widespread environmental conditions. The massive pathogenic arsenal of S. sclerotiorum, including oxalic acid (OA), CWDEs, and small secretory proteins (effectors), has long been associated with virulence. A subtle interplay between these virulence factors serves various regulatory functions in host cells, allowing S. sclerotiorum to colonize the host, evade or inhibit the host defense system, and cause disease. Understanding and studying these mechanisms is crucial for detecting pathways of genetic interventions that could result in improved control of this disease.
  • 1.1K
  • 13 Apr 2023
Topic Review
Performance Analysis in MANET
A mobile ad hoc network (MANET) is an infrastructure-less network where mobile nodes can share information through wireless links without dedicated hardware that handles the network routing. MANETs’ nodes create on-the-fly connections with each other to share information, and they frequently join and leave MANET during run time. Therefore, flexibility in MANETs is needed to be able to handle variations in the number of existing network nodes. An effective routing protocol should be used to be able to route data packets within this dynamic network. Lacking centralized infrastructure in MANETs makes it harder to secure communication between network nodes, and this lack of infrastructure makes network nodes vulnerable to harmful attacks. Testbeds might be used to test MANETs under specific conditions, but researchers prefer to use simulators to obtain more flexibility and less cost during MANETs’ environment setup and testing. A MANET’s environment is dependent on the required scenario, and an appropriate choice of the used simulator that fulfills the researcher’s needs is important. Furthermore, researchers need to define the simulation parameters and the other parameters required by the routing protocol used. In addition, if the MANET’s environment handles some conditions where malicious nodes perform network attacks, the parameters affecting the MANET from the attack perspective need to be understood.
  • 1.1K
  • 26 Apr 2023
Topic Review
DNA Data Storage
The demand for data storage is growing at an unprecedented rate, and current methods are not sufficient to accommodate such rapid growth due to their cost, space requirements, and energy consumption. Therefore, there is a need for a new, long-lasting data storage medium with high capacity, high data density, and high durability against extreme conditions. DNA is one of the most promising next-generation data carriers, with a storage density of 10¹⁹ bits of data per cubic centimeter, and its three-dimensional structure makes it about eight orders of magnitude denser than other storage media.
  • 1.1K
  • 07 Jun 2023
Topic Review
Treatment of Post-Traumatic Headache
Post-traumatic headache (PTH) is a common and debilitating consequence of mild traumatic brain injury (mTBI) that can occur over one year after the head impact event. Thus, better understanding of the underlying pathophysiology and risk factors could facilitate early identification and management of PTH. There are several factors that could influence the reporting of PTH prevalence, including the definition of concussion and PTH. The main risk factors for PTHs include a history of migraines or headaches, female gender, younger age, greater severity of the head injury, and co-occurring psychological symptoms, such as anxiety and depression. 
  • 1.1K
  • 05 Jul 2023
Topic Review
Adenylosuccinate Lyase
Adenylosuccinate Lyase (ADSL) is a homotetrameric enzyme exhibiting a dual catalytic role: the conversion of succinylaminoimidazolecarboxamide (SAICA)-ribotide (SAICAR) into AICA-ribotide (AICAR) (de novo purine synthesis pathway) and the formation of AMP from adenylosuccinate in the purine nucleotide cycle. ADSL deficiency is a rare autosomal recessive disorder, first described by Jaeken and Van den Berghe, caused by more than 150 different mutations (most of which missense), in the ADSL gene. In all cases, the mutations lead to an ADSL enzyme that retains some residual activity, possibly because a complete loss of activity is probably lethal in humans. The clinical presentation includes neurologic symptoms, namely intellectual disability, autism spectrum disorder, microcephaly, and seizures. Three different phenotypes have been reported on the basis of the age of onset and the severity of symptoms: the fatal neonatal form, presenting with hypokinesia, intractable seizures, and respiratory failure; the type I form presenting within the first months of life, characterized by severe psychomotor retardation, microcephaly, seizures, and autistic features; and the type II form, presenting within the first years of life, with moderate or slight psychomotor retardation]. Life expectation in ADSL deficiency is variable. The neonatal form may lead to early death, whereas onset in early childhood usually results in a stable course.
  • 1.1K
  • 18 Jul 2023
Topic Review
Noise in Electric Motors
Electric machines are important devices that convert electrical energy into mechanical energy and are extensively used in a wide range of applications.
  • 1.1K
  • 26 Jul 2023
Topic Review
Coronary No-Reflow after Primary Percutaneous Coronary Intervention
Coronary no-reflow (CNR) is a frequent phenomenon that develops in patients with ST-segment elevation myocardial infarction (STEMI) following reperfusion therapy. CNR is highly dynamic, develops gradually (over hours) and persists for days to weeks after reperfusion. Microvascular obstruction (MVO) developing as a consequence of myocardial ischemia, distal embolization and reperfusion-related injury is the main pathophysiological mechanism of CNR. The frequency of CNR or MVO after primary PCI differs widely depending on the sensitivity of the tools used for diagnosis and timing of examination. Coronary angiography is readily available and most convenient to diagnose CNR but it is highly conservative and underestimates the true frequency of CNR. Cardiac magnetic resonance (CMR) imaging is the most sensitive method to diagnose MVO and CNR that provides information on the presence, localization and extent of MVO. CMR imaging detects intramyocardial hemorrhage and accurately estimates the infarct size. MVO and CNR markedly negate the benefits of reperfusion therapy and contribute to poor clinical outcomes including adverse remodeling of left ventricle, worsening or new congestive heart failure and reduced survival.
  • 1.1K
  • 01 Sep 2023
Topic Review
Impact of Carbon Dots on Crop Growth
Carbon dots are carbon-based nanoparticles, which have the characteristics of a simple preparation process, photoluminescence, biocompatibility, an adjustable surface function, water solubility, and low-level toxicity. They are widely used in biological applications, such as imaging, biosensing, photocatalysis, and molecular transfer. They have also aroused great interest among researchers in agriculture, and there has been significant progress in improving crop growth and production. 
  • 1.1K
  • 11 Oct 2023
Topic Review
Platelet-Rich Plasma Therapy for Lichen Sclerosus
Lichen sclerosus (LS) is a chronic inflammatory dermatosis mostly localized in the genital area, characterized by vulvar alterations that can severely impact a patient’s quality of life. Current treatment modalities often provide incomplete relief, and there is a need for innovative approaches to manage this condition effectively. Platelet-rich plasma (PRP) and adipose-derived stem cells (ADSCs) have emerged as potential regenerative therapies for LS, offering promising results in clinical practice.
  • 1.1K
  • 23 Nov 2023
Topic Review
Development of Thermoelectric Half-Heusler Alloys
Half-Heusler alloys are among the most promising thermoelectric materials. 
  • 1.1K
  • 29 Dec 2023
Topic Review
Gut Microbiota and Dendritic Cells in Colorectal Cancer
Colorectal cancer (CRC) is a malignancy that manifests in serial stages and has been observed to have an escalating incidence in modern societies, causing a significant global health problem. The development of CRC is influenced by various exogenous factors, including lifestyle, diet, nutrition, environment, and microbiota, that can affect host cells, including immune cells.
  • 1.1K
  • 12 Dec 2023
Topic Review
Impact of Corporate Social Responsibility on Financial Performance
In the post-epidemic era, more and more enterprises have realized the crucial significance of corporate social responsibility for enterprise development. It was found that (1) companies with good corporate social responsibility (CSR) performance show a high level of financial performance (FP); (2) the higher the media’s attention on the company, the better the CSR performance; and (3) based on the nature of the emotion, the researchers divided media attention into positive and negative reports. Positive reports weaken the positive impact of CSR on financial performance, while negative reports reinforce this positive effect. These empirical findings remain robust after controlling for endogeneity and employing alternative variable measures. 
  • 1.1K
  • 08 Jan 2024
Topic Review
Last Deglaciation Rainfall Changes
Three drier periods (lower rainfall) (i.e., before ~17, ~1513.5, and 7–3 ka BP) and three wetter periods (higher rainfall) (i.e., ~17–15, ~13.5–7, and after ~3 ka BP) were detected on Southern Indonesia (off southwest Sumba) based on geochemical element (terrigenous input) proxies (ln Ti/Ca and K/Ca). During the Last Deglaciation, AISM rainfall responded to high latitude climatic events related to the latitudinal shifts of the austral summer ITCZ. Sea level rise, solar activity, and orbitally-induced insolation were most likely the primary driver of AISM rainfall changes during the Holocene, but the driving mechanisms behind the latitudinal shifts of the austral summer ITCZ during this period are not yet understood.
  • 1.1K
  • 27 Jan 2022
Topic Review
Major Depressive Disorder
        Despite the extensive research conducted in the last decades, the molecular mechanisms underlying major depressive disorder (MDD) and relative evidence-based treatments remain unclear. Various hypotheses have been successively proposed, involving different biological systems. This narrative review aims to critically illustrate the main pathogenic hypotheses of MDD, ranging from the historical ones based on the monoaminergic and neurotrophic theories, through the subsequent neurodevelopmental, glutamatergic, GABAergic, inflammatory/immune and endocrine explanations, until the most recent evidence postulating a role for fatty acids and the gut microbiota. Moreover, the molecular effects of established both pharmacological and non-pharmacological approaches for MDD are also reviewed. Overall, the existing literature indicates that the molecular mechanisms described in the context of these different hypotheses, rather than representing alternatives one to each other, are likely to contribute together, often with reciprocal interactions, to the development of MDD and to the effectiveness of treatments, and points at the need for further research efforts in this field. 
  • 1.1K
  • 26 Oct 2020
Topic Review
Lithuanian Forest Tree Successional Categorisation
Developing forest harvesting regimes that mimic natural forest dynamics requires knowledge on typical species behaviors and how they respond to environmental conditions. Species regeneration and survival after disturbance depends on a species’ life history traits. The four types of ecologically invariant life-history trajectories of species turnover are a core component to evaluate if the development of the forest community is progressing towards the restoration of the climatic climax.
  • 1.1K
  • 26 Oct 2020
Topic Review
ICG NIR Fluorescence
Nowadays, surgical innovations incorporate new technological conquests and must be validated by evidence-based medicine. The use of augmented reality-assisted indocyanine green (ICG) fluorescence has generated a myriad of intraoperative applications such as demonstration of key anatomical landmarks, sentinel lymph nodes, and real-time assessment of local blood flow.
  • 1.1K
  • 15 Dec 2020
Topic Review
Epigenomics in osteoporosis
Osteoporosis is a complex multifactorial condition of the musculoskeletal system. Osteoporosis and osteoporotic vertebral fracture (OVF) are associated with high medical costs and can lead to poor quality of life. Genetic factors are important in determining bone mass and structure, as well as any predisposition for bone degradation and OVF. However, genetic factors are not enough to explain osteoporosis development and OVF occurrence. Epigenetics describes a mechanism for controlling gene expression and cellular processes without altering DNA sequences. The main mechanisms in epigenetics are DNA methylation, histone modifications, and non-coding RNAs (ncRNAs). Recently, alterations in epigenetic mechanisms and their activity have been associated with osteoporosis and OVF.
  • 1.1K
  • 18 Dec 2020
Topic Review
Nutritional Therapy in Pediatric CD
The increase in incidences of pediatric Crohn’s Disease (CD) worldwide has been strongly linked with dietary shifts towards a Westernized diet, ultimately leading to altered gut microbiota and disturbance in intestinal immunity and the metabolome. Multiple clinical studies in children with CD have demonstrated the high efficacy of nutritional therapy with exclusive enteral nutrition (EEN) to induce remission with an excellent safety profile. However, EEN is poorly tolerated, limiting its compliance and clinical application. This has spiked an interest in the development of alternative and better-tolerated nutritional therapy strategies. Several nutritional therapies have now been designed not only to treat the nutritional deficiencies seen in children with active CD but also to correct dysbiosis and reduce intestinal inflammation.
  • 1.1K
  • 20 Aug 2021
Topic Review
Nanocomposites for Electrochemical Sensors
The elevated concentrations of various trace metals beyond existing guideline recommendations in water bodies have promoted research on the development of various electrochemical nanosensors for the trace metals’ early detection. Inspired by the exciting physical and chemical properties of nanomaterials, advanced functional nanocomposites with improved sensitivity, sensitivity and stability, amongst other performance parameters, have been synthesized, characterized, and applied on the detection of various trace metals in water matrices.
  • 1.1K
  • 18 Feb 2021
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